HUP9902076A2 - Szexuális rendellenességek kezelésére alkalmas intranazális készítmény - Google Patents
Szexuális rendellenességek kezelésére alkalmas intranazális készítményInfo
- Publication number
- HUP9902076A2 HUP9902076A2 HU9902076A HUP9902076A HUP9902076A2 HU P9902076 A2 HUP9902076 A2 HU P9902076A2 HU 9902076 A HU9902076 A HU 9902076A HU P9902076 A HUP9902076 A HU P9902076A HU P9902076 A2 HUP9902076 A2 HU P9902076A2
- Authority
- HU
- Hungary
- Prior art keywords
- derivative
- sexual disorders
- dihydrate
- mesylate
- treating sexual
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000012201 sexual and gender identity disease Diseases 0.000 title abstract 2
- 208000015891 sexual disease Diseases 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 abstract 3
- 150000004683 dihydrates Chemical class 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- WEWNUXJEVSROFW-UHFFFAOYSA-N 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4h-pyrazolo[4,3-d]pyrimidin-7-one;methanesulfonic acid Chemical compound CS(O)(=O)=O.CCCC1=NN(C)C(C(N=2)=O)=C1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 WEWNUXJEVSROFW-UHFFFAOYSA-N 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000004088 foaming agent Substances 0.000 abstract 1
- 238000013007 heat curing Methods 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
Abstract
A találmány őlyan, intranazálisan beadható gyógyászati készítményekrevőnatkőzik, amelyek hatóanyagként sildenafil-mezilátőt vagy ennekmőnő- vagy dihidrátját tartalmazzák a gyógyszergyártásban szőkásősanhasznált hőrdőzó- és/vagy egyéb segédanyagőkkal együtt intranazálisbeadásra adaptált főrmában. A találmány szerinti gyógyászatikészítmények lehetnek főlyékőny halmazállapőtúak, célszerűen pűfferőltőldatők vagy szilárd pőrkészítmények. A találmány szerinti gyógyászatikészítményekkel férfiaknál merevedési rendellenesség, illetve nőknélkülönböző szexűális zavarők kezelhetők. A találmány tővábbá magára asildenafil-mezilátra, valamint ennek mőnő- vagy dihidrátjáravőnatkőzik. ŕ
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9813452.1A GB9813452D0 (en) | 1998-06-22 | 1998-06-22 | Pharmaceutical formulations |
GBGB9820837.4A GB9820837D0 (en) | 1998-09-24 | 1998-09-24 | Pharmaceutical formulations |
GBGB9903177.5A GB9903177D0 (en) | 1999-02-13 | 1999-02-13 | Pharmaceutical formulations |
Publications (3)
Publication Number | Publication Date |
---|---|
HU9902076D0 HU9902076D0 (en) | 1999-08-30 |
HUP9902076A2 true HUP9902076A2 (hu) | 2000-05-28 |
HUP9902076A3 HUP9902076A3 (en) | 2002-03-28 |
Family
ID=27269368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9902076A HUP9902076A3 (en) | 1998-06-22 | 1999-06-21 | Intranasal formulations for treating sexual disorders |
Country Status (40)
Country | Link |
---|---|
US (2) | US20020040139A1 (hu) |
EP (1) | EP0967214B1 (hu) |
JP (1) | JP3263379B2 (hu) |
KR (1) | KR100345824B1 (hu) |
AP (1) | AP1178A (hu) |
AR (1) | AR016993A1 (hu) |
AT (1) | ATE269866T1 (hu) |
AU (1) | AU746865B2 (hu) |
BG (1) | BG64372B1 (hu) |
BR (1) | BR9903273A (hu) |
CA (1) | CA2275554C (hu) |
CZ (1) | CZ294856B6 (hu) |
DE (1) | DE69918222T2 (hu) |
DK (1) | DK0967214T3 (hu) |
DZ (1) | DZ2826A1 (hu) |
EA (1) | EA001903B1 (hu) |
ES (1) | ES2221733T3 (hu) |
GT (1) | GT199900095A (hu) |
HN (1) | HN1999000096A (hu) |
HR (1) | HRP990195B1 (hu) |
HU (1) | HUP9902076A3 (hu) |
ID (1) | ID23554A (hu) |
IL (1) | IL130539A0 (hu) |
IS (1) | IS5085A (hu) |
MA (1) | MA25089A1 (hu) |
MY (1) | MY117967A (hu) |
NO (1) | NO317365B1 (hu) |
NZ (1) | NZ336382A (hu) |
OA (1) | OA11069A (hu) |
PA (1) | PA8476301A1 (hu) |
PE (1) | PE20000702A1 (hu) |
PT (1) | PT967214E (hu) |
SG (1) | SG77246A1 (hu) |
SI (1) | SI0967214T1 (hu) |
SK (1) | SK284574B6 (hu) |
TN (1) | TNSN99129A1 (hu) |
TR (1) | TR199901444A2 (hu) |
TW (1) | TWI223598B (hu) |
UA (1) | UA59385C2 (hu) |
YU (1) | YU29699A (hu) |
Families Citing this family (69)
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US6200591B1 (en) | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
GB9828340D0 (en) * | 1998-12-22 | 1999-02-17 | Novartis Ag | Organic compounds |
CA2391968A1 (en) * | 1999-11-18 | 2001-05-25 | Natco Pharma Limited | An improved pharmaceutical composition for treating male erectile dysfunction |
KR20010016165A (ko) * | 2000-11-16 | 2001-03-05 | 정순학 | 성기능 장애 치료를 위한 피부에 적용하는 제제 |
DE10118305A1 (de) * | 2001-04-12 | 2002-10-17 | Bayer Ag | Zusammensetzungen zur nasalen Applikation |
DE10118306A1 (de) | 2001-04-12 | 2002-10-17 | Bayer Ag | Imidazotriazinonhaltige Zusammensetzungen zur nasalen Applikation |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
CA2446904A1 (en) | 2001-05-24 | 2003-04-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
AU2002310086B2 (en) * | 2001-05-24 | 2008-09-04 | Alexza Pharmaceuticals, Inc. | Delivery of erectile dysfunction drugs through an inhalation route |
DE10248601B4 (de) * | 2002-10-17 | 2006-05-24 | Goldstein, Naum, Dr.habil.nat. | Pharmazeutisches Mittel zur endonasalen Applikation bei der Behandlung von Krankheiten und Störungen des zentralen Nervensystems |
US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
US7138107B2 (en) * | 2003-02-18 | 2006-11-21 | Compellis Pharmaceuticals | Inhibition of olfactory neurosensory function to treat eating disorders and obesity |
US7638138B2 (en) * | 2003-02-21 | 2009-12-29 | Translational Research, Ltd. | Compositions for nasal administration of pharmaceuticals |
KR100974482B1 (ko) | 2003-03-27 | 2010-08-10 | 가부시키가이샤 바이오악티스 | 비강용 분말 약제 투약 장치 |
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ATE510174T1 (de) | 2003-05-21 | 2011-06-15 | Alexza Pharmaceuticals Inc | Schlag gezündete unabhängige heizeinheit |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
US8673360B2 (en) * | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
US8268791B2 (en) * | 2004-08-25 | 2012-09-18 | Aegis Therapeutics, Llc. | Alkylglycoside compositions for drug administration |
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US9895444B2 (en) | 2004-08-25 | 2018-02-20 | Aegis Therapeutics, Llc | Compositions for drug administration |
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WO2006094924A2 (en) * | 2005-03-09 | 2006-09-14 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors |
ME01609B (me) | 2005-04-19 | 2014-09-20 | Takeda Gmbh | Roflumilast za liječenje pulmonarne hipertenzije |
US8506934B2 (en) | 2005-04-29 | 2013-08-13 | Robert I. Henkin | Methods for detection of biological substances |
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GB0606234D0 (en) * | 2006-03-29 | 2006-05-10 | Pliva Istrazivanje I Razvoj D | Pharmaceutically acceptable salts and polymorphic forms |
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US8337817B2 (en) * | 2006-12-26 | 2012-12-25 | Shin Nippon Biomedical Laboratories, Ltd. | Preparation for transnasal application |
WO2008095136A2 (en) | 2007-01-31 | 2008-08-07 | Henkin Robert I | Methods for detection of biological substances |
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DE102008004893A1 (de) * | 2008-01-17 | 2009-07-23 | Add Technologies Ltd. | Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung |
WO2009098697A1 (en) * | 2008-02-08 | 2009-08-13 | Dexxon Ltd. | Modafinil and sildenafil dosage forms |
WO2009121039A2 (en) * | 2008-03-28 | 2009-10-01 | Hale Biopharma Ventures, Llc | Administration of benzodiazepine compositions |
CA2726259C (en) | 2008-06-04 | 2014-07-29 | Colgate-Palmolive Company | Oral care implement with cavitation system |
US20100104624A1 (en) * | 2008-06-11 | 2010-04-29 | Peter Langecker | Combination therapy using phosphodiesterase inhibitors |
US8580801B2 (en) | 2008-07-23 | 2013-11-12 | Robert I. Henkin | Phosphodiesterase inhibitor treatment |
US8440631B2 (en) | 2008-12-22 | 2013-05-14 | Aegis Therapeutics, Llc | Compositions for drug administration |
JP2012526726A (ja) * | 2009-05-15 | 2012-11-01 | 株式会社新日本科学 | 薬物動態が改善された鼻腔内用薬学的組成物 |
JP2011001317A (ja) * | 2009-06-19 | 2011-01-06 | Fumakilla Ltd | 鼻用洗浄剤 |
GB2472327B (en) * | 2009-07-31 | 2013-03-13 | Shin Nippon Biomedical Lab Ltd | Intranasal granisetron and nasal applicator |
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JP5840201B2 (ja) | 2010-05-10 | 2016-01-06 | ユーロ−セルティーク エス.エイ. | 活性剤を負荷した顆粒と追加の活性剤の組合せ |
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US20160030435A1 (en) * | 2013-03-15 | 2016-02-04 | Robert I HENKIN | Phosphodiesterase inhibitor treatment |
CN112716955A (zh) | 2013-11-13 | 2021-04-30 | 欧洲凯尔特公司 | 用于治疗疼痛和阿片样物质肠功能障碍综合征的氢吗啡酮和纳洛酮 |
WO2015126944A1 (en) | 2014-02-18 | 2015-08-27 | Henkin Robert I | Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell |
NO2723977T3 (hu) | 2014-03-19 | 2018-03-10 | ||
CA2994709A1 (en) * | 2015-08-03 | 2017-02-09 | Synergistic Therapeutics, Llc | Sexual dysfunction therapeutic gel |
EP3532068A4 (en) * | 2016-10-31 | 2020-04-29 | Suda Ltd | ADMINISTRATION OF ACTIVE INGREDIENTS BY MUCOSA |
WO2018158234A1 (en) | 2017-03-02 | 2018-09-07 | Dutch Renewable Energy B.V. | Intranasal administration of physiologically active substances |
US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
US11464778B2 (en) | 2017-12-26 | 2022-10-11 | Liqmeds Worldwide Limited | Liquid oral formulations for sildenafil |
JP6941224B2 (ja) | 2018-02-06 | 2021-09-29 | イージス セラピューティクス,エルエルシー | 疾患の処置のための鼻腔内エピネフリン製剤及び方法 |
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US20220111162A1 (en) * | 2020-07-29 | 2022-04-14 | Lido Ventures Llc | Apparatus, system, and method for facilitating intranasal treatment of a patient |
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-
1999
- 1999-05-29 TW TW088108934A patent/TWI223598B/zh active
- 1999-06-08 DK DK99304425T patent/DK0967214T3/da active
- 1999-06-08 PT PT99304425T patent/PT967214E/pt unknown
- 1999-06-08 SI SI9930594T patent/SI0967214T1/xx unknown
- 1999-06-08 AT AT99304425T patent/ATE269866T1/de not_active IP Right Cessation
- 1999-06-08 DE DE69918222T patent/DE69918222T2/de not_active Expired - Fee Related
- 1999-06-08 EP EP99304425A patent/EP0967214B1/en not_active Expired - Lifetime
- 1999-06-08 ES ES99304425T patent/ES2221733T3/es not_active Expired - Lifetime
- 1999-06-15 HN HN1999000096A patent/HN1999000096A/es unknown
- 1999-06-17 AP APAP/P/1999/001585A patent/AP1178A/en active
- 1999-06-17 SK SK819-99A patent/SK284574B6/sk unknown
- 1999-06-17 IL IL13053999A patent/IL130539A0/xx unknown
- 1999-06-17 SG SG1999002935A patent/SG77246A1/en unknown
- 1999-06-18 CA CA002275554A patent/CA2275554C/en not_active Expired - Fee Related
- 1999-06-18 PE PE1999000543A patent/PE20000702A1/es not_active Application Discontinuation
- 1999-06-18 OA OA9900137A patent/OA11069A/en unknown
- 1999-06-18 IS IS5085A patent/IS5085A/is unknown
- 1999-06-18 MY MYPI99002521A patent/MY117967A/en unknown
- 1999-06-18 US US09/335,628 patent/US20020040139A1/en not_active Abandoned
- 1999-06-18 AR ARP990102946A patent/AR016993A1/es unknown
- 1999-06-18 HR HR990195A patent/HRP990195B1/xx not_active IP Right Cessation
- 1999-06-21 MA MA25639A patent/MA25089A1/fr unknown
- 1999-06-21 CZ CZ19992257A patent/CZ294856B6/cs not_active IP Right Cessation
- 1999-06-21 PA PA19998476301A patent/PA8476301A1/es unknown
- 1999-06-21 NZ NZ336382A patent/NZ336382A/xx unknown
- 1999-06-21 ID IDP990592D patent/ID23554A/id unknown
- 1999-06-21 DZ DZ990126A patent/DZ2826A1/xx active
- 1999-06-21 TN TNTNSN99129A patent/TNSN99129A1/fr unknown
- 1999-06-21 EA EA199900487A patent/EA001903B1/ru not_active IP Right Cessation
- 1999-06-21 AU AU35794/99A patent/AU746865B2/en not_active Ceased
- 1999-06-21 BG BG103510A patent/BG64372B1/bg unknown
- 1999-06-21 UA UA99063463A patent/UA59385C2/uk unknown
- 1999-06-21 NO NO19993051A patent/NO317365B1/no unknown
- 1999-06-21 HU HU9902076A patent/HUP9902076A3/hu unknown
- 1999-06-21 JP JP17392599A patent/JP3263379B2/ja not_active Expired - Fee Related
- 1999-06-21 KR KR1019990023169A patent/KR100345824B1/ko not_active IP Right Cessation
- 1999-06-22 TR TR1999/01444A patent/TR199901444A2/xx unknown
- 1999-06-22 GT GT199900095A patent/GT199900095A/es unknown
- 1999-06-22 BR BR9903273-2A patent/BR9903273A/pt not_active IP Right Cessation
- 1999-06-22 YU YU29699A patent/YU29699A/sh unknown
-
2003
- 2003-03-14 US US10/389,127 patent/US20030158206A1/en not_active Abandoned
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