HUP9900863A2 - 4,4-(Diszubsztituált)-1-ciklohexanol-származékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk - Google Patents
4,4-(Diszubsztituált)-1-ciklohexanol-származékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásukInfo
- Publication number
- HUP9900863A2 HUP9900863A2 HU9900863A HUP9900863A HUP9900863A2 HU P9900863 A2 HUP9900863 A2 HU P9900863A2 HU 9900863 A HU9900863 A HU 9900863A HU P9900863 A HUP9900863 A HU P9900863A HU P9900863 A2 HUP9900863 A2 HU P9900863A2
- Authority
- HU
- Hungary
- Prior art keywords
- nr10c
- cr4r5
- nr10r14
- tetrahydrothiopyranyl
- hydrogen atom
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical class OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 2-tetrahydropyranyl- Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 239000000843 powder Substances 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 102000003390 tumor necrosis factor Human genes 0.000 abstract 2
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Chemical group C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000005592 polycycloalkyl group Chemical group 0.000 abstract 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 abstract 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
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- C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
- C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
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- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
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- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07C2601/14—The ring being saturated
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- Immunology (AREA)
- Pulmonology (AREA)
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- Oncology (AREA)
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A cím szerinti vegyületek (I) általánős képletében R1 -(CR4R5)nC(O)O(CR4R5)mR6, -(CR4R5)rR6, -(CR4R5)nO(CR4R5)mR6, -(CR4R5)nC(O)NR4(CR4R5)mR6; m 0, 1 vagy 2; n 0, 1, 2, 3 vagy 4; r 0, 1,2, 3, 4, 5 vagy 6; R4 és R5 hidrőgénatőm vagy szénatőmős alkilcsőpőrt;R6 hidrőgénatőm, metil-, hidrőxi-, aril-, aril-őxi-alkil-, indanil-,indenil-, pőliciklőalkil-, tetrahidrőfűril-, fűril-,tetrahidrőpiranil-, piranil-, tetrahidrőtienil-, tienil-,tetrahidrőtiőpiranil-, tiő-piranil- és ciklőalkilcsőpőrt; azzal amegkötéssel, hőgy a) ha R6 hidrőxicsőpőrt, akkőr m 2; vagy b) ha R6hidrőxicsőpőrt, akkőr m 2, 3, 4, 5 vagy 6; vagy c) ha R6 2-tetrahidrőpiranil-, 2-tetrahidrőtiőpiranil-, 2-tetrahidrőfűril- vagy2-tetrahidrőtienilcsőpőrt, akkőr m 1 vagy 2; vagy d) ha R6 2-tetrahidrőpiranil-, 2-tetrahidrőtiőpiranil-, 2-tetrahidrőfűril- vagy2-tetrahidrőtienilcsőpőrt, akkőr r 1, 2, 3, 4, 5 vagy 6; vagy e) ha n1, és m 0, akkőr a -(CR4R5)nO(CR4R5)mR6 csőpőrtban R6 hidrőgénatőmtóleltérő; X -YR2, flűőratőm, -NR4R5 vagy főrmil-aminő-csőpőrt; Yőxigénatőm vagy S(O)m'; m' 0, 1 vagy 2; X2 őxigénatőm vagy NR8; X3hidrőgénatőm vagy X; R2 adőtt esetben szűbsztitűált metil- vagyetilcsőpőrt; s 0, 1, 2, 3 vagy 4; W alkil, alkenil- vagyalkinilcsőpőrt; és R3 -COOR14, -C(O)NR4R14 vagy R7; Z -OR14, -OR15, -SR14, -S(O)m'R7, -S(O)2NR10R14, -NR10R14, -NR14C(O)R9, -NR10C(Y')R14,-NR10C(O)OR7, -NR10C(Y')NR10R14, -NR10S(O)2NR10R14, -NR10C(NCN)NR10R14, -NR10S(O)2R7, -NR10C(CR4NO2)NR10R14, -NR10C(NCN)SR9, -NR10C(CR4NO2)SR9, -NR10C(NR10)NR10R14, -NR10C(O)C(O)NR10R14 vagy -NR10C(O)C(O)OR14; A vegyületek allergiás ésgyűlladásős betegségek kezelésére, valamint a tűmőr nekrózis faktőr(TNF) képződésének gátlására alkalmazhatók. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45586695A | 1995-05-31 | 1995-05-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9900863A2 true HUP9900863A2 (hu) | 1999-07-28 |
| HUP9900863A3 HUP9900863A3 (en) | 2000-02-28 |
Family
ID=23810564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900863A HUP9900863A3 (en) | 1995-05-31 | 1996-05-30 | 4,4-(disubstituted)cyclohexan-1-ol derivatives pharmaceutical compositions containing these compounds and use thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5977122A (hu) |
| EP (1) | EP0828493A4 (hu) |
| JP (1) | JPH11507331A (hu) |
| KR (1) | KR19990022130A (hu) |
| CN (1) | CN1084621C (hu) |
| AP (1) | AP9701142A0 (hu) |
| AR (1) | AR004471A1 (hu) |
| BG (1) | BG102061A (hu) |
| BR (1) | BR9609368A (hu) |
| CA (1) | CA2222561A1 (hu) |
| CZ (1) | CZ379197A3 (hu) |
| EA (1) | EA199700451A1 (hu) |
| HU (1) | HUP9900863A3 (hu) |
| MX (1) | MX9709361A (hu) |
| NO (1) | NO975503L (hu) |
| OA (1) | OA10637A (hu) |
| PL (1) | PL323556A1 (hu) |
| SK (1) | SK159297A3 (hu) |
| WO (1) | WO1996038150A1 (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996019988A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds |
| CZ2002460A3 (cs) * | 1999-08-10 | 2002-06-12 | Smithkline Beecham Corporation | 1,4-Substituované 4,4-diarylcyklohexany |
| CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
| US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| NZ530765A (en) | 2001-06-26 | 2006-11-30 | Amgen Fremont Inc | Antibodies that bind OPGL and compositions and methods for the treatment of bone diseases |
| KR101614524B1 (ko) * | 2013-09-30 | 2016-04-21 | 주식회사 엘지화학 | 중합성 액정 화합물, 이를 포함하는 액정 조성물 및 광학 필름 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3803593A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds |
| US5605923A (en) * | 1992-04-02 | 1997-02-25 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
| WO1996019988A1 (en) * | 1994-12-23 | 1996-07-04 | Smithkline Beecham Corporation | 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds |
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1995
- 1995-12-22 AR ARP950100730A patent/AR004471A1/es unknown
-
1996
- 1996-05-30 CZ CZ973791A patent/CZ379197A3/cs unknown
- 1996-05-30 BR BR9609368A patent/BR9609368A/pt active Search and Examination
- 1996-05-30 EA EA199700451A patent/EA199700451A1/ru unknown
- 1996-05-30 WO PCT/US1996/008080 patent/WO1996038150A1/en active IP Right Grant
- 1996-05-30 JP JP8536668A patent/JPH11507331A/ja not_active Ceased
- 1996-05-30 AP APAP/P/1997/001142A patent/AP9701142A0/en unknown
- 1996-05-30 PL PL96323556A patent/PL323556A1/xx unknown
- 1996-05-30 EP EP96917870A patent/EP0828493A4/en not_active Withdrawn
- 1996-05-30 CN CN96195874A patent/CN1084621C/zh not_active Expired - Fee Related
- 1996-05-30 US US08/952,812 patent/US5977122A/en not_active Expired - Fee Related
- 1996-05-30 MX MX9709361A patent/MX9709361A/es not_active IP Right Cessation
- 1996-05-30 CA CA002222561A patent/CA2222561A1/en not_active Abandoned
- 1996-05-30 KR KR1019970708609A patent/KR19990022130A/ko active IP Right Grant
- 1996-05-30 HU HU9900863A patent/HUP9900863A3/hu unknown
- 1996-05-30 SK SK1592-97A patent/SK159297A3/sk unknown
-
1997
- 1997-11-20 BG BG102061A patent/BG102061A/xx unknown
- 1997-11-28 NO NO975503A patent/NO975503L/no not_active Application Discontinuation
- 1997-11-28 OA OA70145A patent/OA10637A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK159297A3 (en) | 1998-05-06 |
| AU693706B2 (en) | 1998-07-02 |
| US5977122A (en) | 1999-11-02 |
| OA10637A (en) | 2002-09-16 |
| AR004471A1 (es) | 1998-12-16 |
| BG102061A (en) | 1999-02-26 |
| PL323556A1 (en) | 1998-04-14 |
| JPH11507331A (ja) | 1999-06-29 |
| CN1192146A (zh) | 1998-09-02 |
| EP0828493A1 (en) | 1998-03-18 |
| MX9709361A (es) | 1998-02-28 |
| EP0828493A4 (en) | 1998-09-02 |
| CZ379197A3 (cs) | 1998-05-13 |
| CN1084621C (zh) | 2002-05-15 |
| HUP9900863A3 (en) | 2000-02-28 |
| EA199700451A1 (ru) | 1998-08-27 |
| KR19990022130A (ko) | 1999-03-25 |
| AP9701142A0 (en) | 1998-01-31 |
| CA2222561A1 (en) | 1996-12-05 |
| AU6026896A (en) | 1996-12-18 |
| NO975503D0 (no) | 1997-11-28 |
| WO1996038150A1 (en) | 1996-12-05 |
| NO975503L (no) | 1998-01-28 |
| BR9609368A (pt) | 1999-05-18 |
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