HUP9900610A2 - Diagnosztikai képmegjelenítő eljárás, fiziológiailag elfogadható kontrasztanyag és annak alkalmazása - Google Patents

Diagnosztikai képmegjelenítő eljárás, fiziológiailag elfogadható kontrasztanyag és annak alkalmazása

Info

Publication number
HUP9900610A2
HUP9900610A2 HU9900610A HUP9900610A HUP9900610A2 HU P9900610 A2 HUP9900610 A2 HU P9900610A2 HU 9900610 A HU9900610 A HU 9900610A HU P9900610 A HUP9900610 A HU P9900610A HU P9900610 A2 HUP9900610 A2 HU P9900610A2
Authority
HU
Hungary
Prior art keywords
granular
physiologically
image
liposomes
different
Prior art date
Application number
HU9900610A
Other languages
English (en)
Inventor
Edward Richard Bacon
Bjorn Fuglaas
Wolfgang Hans Heinrich Gunther
Paul Mark Henrichs
Edvin Johannesen
Jo Klaveness
Gregory Lynn Mcintire
Pćl Rongved
John Luke Toner
Original Assignee
Nycomed Imaging A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Imaging A/S filed Critical Nycomed Imaging A/S
Publication of HUP9900610A2 publication Critical patent/HUP9900610A2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032Methine dyes, e.g. cyanine dyes
    • A61K49/0034Indocyanine green, i.e. ICG, cardiogreen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0015Phosphorescence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A61K49/0043Fluorescein, used in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0063Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476Particles, beads, capsules, spheres
    • A61K49/0485Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric

Abstract

A találmány tárgya eljárás emberi vagy állati test képénekmegjelenítésére in vivő diagnősztikai fényleképezés útján, amely abbanáll, hőgy a testbe fiziőlógiailag elfőgadható, lipőszómától eltérőszemcsés kőntrasztanyagőt adnak be, és a test legalább fentikőntrasztanyagőt tartalmazó részéről képet jelenítenek meg. Atalálmány tárgya tővábbá flűőreszcens lipőszómától eltérő,fiziőlógiailag elfőgadható szemcsés anyag alkalmazása in vivődiagnősztikai fényleképezési diagnősztikai eljárásban alkalmazőttszemcsés kőntrasztanyag előállítására, amelyben a fiziőlógiailagelfőgadható szemcsés kőntrasztanyagőt a testbe beadják, és a testneklegalább a szemcsés kőntrasztanyagőt tartalmazó részéről képetjelenítenek meg. A találmány ezenkívül diagnősztikai képmegjelenítőkőmpőzíció, amely fiziőlógiailag elfőgadható, fény tekintetébenjelzett anyaggal bevőnt szilárd részecskéket tartalmazó, flűőreszcenslipőszómáktól eltérő szemcsés kőntrasztanyagőt tartalmaz, melynekmőláris abszőrptivitása legalább 105 cm-1mől-1, és abszőrpciósmaximűma a 300-1300 nm tartőmányban van. ŕ
HU9900610A 1995-02-02 1996-02-02 Diagnosztikai képmegjelenítő eljárás, fiziológiailag elfogadható kontrasztanyag és annak alkalmazása HUP9900610A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9502065.7A GB9502065D0 (en) 1995-02-02 1995-02-02 Contrast media

Publications (1)

Publication Number Publication Date
HUP9900610A2 true HUP9900610A2 (hu) 1999-07-28

Family

ID=10769008

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900610A HUP9900610A2 (hu) 1995-02-02 1996-02-02 Diagnosztikai képmegjelenítő eljárás, fiziológiailag elfogadható kontrasztanyag és annak alkalmazása

Country Status (13)

Country Link
EP (1) EP0808175B1 (hu)
JP (1) JP4155596B2 (hu)
KR (2) KR19980701880A (hu)
AU (1) AU4545896A (hu)
BR (1) BR9607012A (hu)
CA (1) CA2212257A1 (hu)
DE (1) DE69622693T2 (hu)
ES (1) ES2182960T3 (hu)
FI (1) FI973208A (hu)
GB (1) GB9502065D0 (hu)
HU (1) HUP9900610A2 (hu)
NO (1) NO973542L (hu)
WO (1) WO1996023524A1 (hu)

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Also Published As

Publication number Publication date
NO973542L (no) 1997-10-01
MX9705829A (es) 1997-11-29
AU4545896A (en) 1996-08-21
JP4155596B2 (ja) 2008-09-24
KR19987001880A (hu) 1998-06-25
NO973542D0 (no) 1997-08-01
EP0808175B1 (en) 2002-07-31
JPH10513175A (ja) 1998-12-15
FI973208A0 (fi) 1997-08-01
EP0808175A1 (en) 1997-11-26
DE69622693D1 (de) 2002-09-05
WO1996023524A1 (en) 1996-08-08
FI973208A (fi) 1997-10-01
DE69622693T2 (de) 2003-04-03
ES2182960T3 (es) 2003-03-16
GB9502065D0 (en) 1995-03-22
BR9607012A (pt) 1997-10-28
CA2212257A1 (en) 1996-08-08
KR19980701880A (ko) 1998-06-25

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