HUP9801621A2 - Új eszteráz és eljárás optikailag aktív chromanvegyületek előállítására - Google Patents

Új eszteráz és eljárás optikailag aktív chromanvegyületek előállítására

Info

Publication number
HUP9801621A2
HUP9801621A2 HU9801621A HUP9801621A HUP9801621A2 HU P9801621 A2 HUP9801621 A2 HU P9801621A2 HU 9801621 A HU9801621 A HU 9801621A HU P9801621 A HUP9801621 A HU P9801621A HU P9801621 A2 HUP9801621 A2 HU P9801621A2
Authority
HU
Hungary
Prior art keywords
esterase
optically active
production
acetic acid
methods
Prior art date
Application number
HU9801621A
Other languages
English (en)
Inventor
Nobuhiro Fukumara
Yasuko Matsuba
Toshihiro Oikawa
Original Assignee
Mitsui Chemicals, Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Chemicals, Incorporated filed Critical Mitsui Chemicals, Incorporated
Publication of HU9801621D0 publication Critical patent/HU9801621D0/hu
Publication of HUP9801621A2 publication Critical patent/HUP9801621A2/hu
Publication of HUP9801621A3 publication Critical patent/HUP9801621A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány szerinti eljárással őptikailag aktív krőmán-3-ecetsavat ésőptikailag aktív krőmán-3-ecetsav-észtereket lehet előállítani úgy,hőgy ha az (I) általánős képletű (3R)- és (3S)-krőmán-3-ecetsav-észterek keverékét - a képletben R1 jelentése 1-5 szénatőmős, egyenes vagy elágazó láncú alkilcsőpőrt,az R2 jelentése hidrőgénatőm vagy szűbsztitűált vagy szűbsztitűálatlanaminőcsőpőrt - őptikailag szelektív hidrőlízisaktivitással rendelkezőészter-hidrőlázzal, vagy az észterázt tartalmazó mikrőőrganizműsőkkal,vagy az abból készült enzimpreparátűmmal kezelik. szterázkéntelőnyösen Pseűdőnőcardia nemzetséghez tartőzó baktériűmból származó,új észterázt alkalmaznak. A találmány tárgyát képezi a fent említettúj észteráz és előállítására vőnatkőzó eljárás. ŕ
HU9801621A 1997-07-18 1998-07-17 Novel esterase and methods for the production of optically active chroman compounds HUP9801621A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP19394997 1997-07-18
JP21975897 1997-08-01
JP31999597 1997-11-20

Publications (3)

Publication Number Publication Date
HU9801621D0 HU9801621D0 (en) 1998-09-28
HUP9801621A2 true HUP9801621A2 (hu) 1999-08-30
HUP9801621A3 HUP9801621A3 (en) 2001-08-28

Family

ID=27326840

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801621A HUP9801621A3 (en) 1997-07-18 1998-07-17 Novel esterase and methods for the production of optically active chroman compounds

Country Status (6)

Country Link
US (2) US6060290A (hu)
EP (1) EP0892044B1 (hu)
KR (1) KR100300443B1 (hu)
CN (1) CN1218110A (hu)
DE (1) DE69828338T2 (hu)
HU (1) HUP9801621A3 (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0892044B1 (en) * 1997-07-18 2004-12-29 Mitsui Chemicals, Inc. Esterase and its use for the production of optically active chroman compounds
KR20030012964A (ko) * 2001-08-06 2003-02-14 주식회사 제노포커스 광학활성 α-치환 헤테로시클릭카르복실산 에스테르의제조방법
WO2008000738A1 (de) 2006-06-27 2008-01-03 Basf Se Proteine mit esterase-aktivität
NO2171061T3 (hu) * 2007-07-04 2018-02-24
US8206969B2 (en) 2007-12-20 2012-06-26 Basf Se CALB muteins and their use
CN101979528B (zh) * 2010-10-21 2012-05-30 北京农业生物技术研究中心 一种酯酶及其编码基因与应用
EP3572523A1 (en) * 2018-05-25 2019-11-27 Bayer Aktiengesellschaft Novel carboxyesterhydrolases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4430089A1 (de) * 1994-08-25 1996-02-29 Bayer Ag Verfahren zur enzymatischen Herstellung von enantiomerenreinen Chroman-2-carbonsäuren und deren Derivaten
US5658796A (en) * 1995-06-07 1997-08-19 Seprachem, Inc. Optical resolution of alkyl chroman-2-carboxylates
TW363051B (en) * 1995-08-31 1999-07-01 Mitsui Toatsu Chemicals Substituted amidine derivatives and platelet aggregation inhibitor containing the same
EP0892044B1 (en) * 1997-07-18 2004-12-29 Mitsui Chemicals, Inc. Esterase and its use for the production of optically active chroman compounds

Also Published As

Publication number Publication date
CN1218110A (zh) 1999-06-02
KR19990013989A (ko) 1999-02-25
EP0892044A3 (en) 2001-05-02
EP0892044A2 (en) 1999-01-20
DE69828338T2 (de) 2005-06-02
HU9801621D0 (en) 1998-09-28
US6303349B1 (en) 2001-10-16
KR100300443B1 (ko) 2001-09-06
EP0892044B1 (en) 2004-12-29
HUP9801621A3 (en) 2001-08-28
DE69828338D1 (de) 2005-02-03
US6060290A (en) 2000-05-09

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