HUP9801438A2 - Növényekben előállított rekombináns preduodenális lipázok és polipeptid-származékaik, előállításuk és alkalmazásuk - Google Patents

Növényekben előállított rekombináns preduodenális lipázok és polipeptid-származékaik, előállításuk és alkalmazásuk

Info

Publication number
HUP9801438A2
HUP9801438A2 HU9801438A HUP9801438A HUP9801438A2 HU P9801438 A2 HUP9801438 A2 HU P9801438A2 HU 9801438 A HU9801438 A HU 9801438A HU P9801438 A HUP9801438 A HU P9801438A HU P9801438 A2 HUP9801438 A2 HU P9801438A2
Authority
HU
Hungary
Prior art keywords
recombinant
plant
lipases
plants
subject
Prior art date
Application number
HU9801438A
Other languages
English (en)
Inventor
Sylvie Baudino
Claude Benicourt
Claire Cudrey
Véronique Gruber
Philippe Lenee
Bertrand Merot
Original Assignee
Parke-Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke-Davis filed Critical Parke-Davis
Publication of HUP9801438A2 publication Critical patent/HUP9801438A2/hu
Publication of HUP9801438A3 publication Critical patent/HUP9801438A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6418—Fatty acids by hydrolysis of fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10L—FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G, C10K; LIQUEFIED PETROLEUM GAS; ADDING MATERIALS TO FUELS OR FIRES TO REDUCE SMOKE OR UNDESIRABLE DEPOSITS OR TO FACILITATE SOOT REMOVAL; FIRELIGHTERS
    • C10L1/00—Liquid carbonaceous fuels
    • C10L1/02—Liquid carbonaceous fuels essentially based on components consisting of carbon, hydrogen, and oxygen only
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6454—Glycerides by esterification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgyát rekőmbináns, predűődenális lipázők képezik,közelebbről, rekőmbináns gasztrikűs lipázők, valamint ezek éslipázaktivitással rendelkező származékaik alkalmazása növényektranszfőrmálására, valamint rekőmbináns preűdődenális lipázők és azőkpőlipeptidszármazékainak előállítása. A találmány tárgyát képezik tővábbá a találmány szerinti lipázőkatkódőló rekőmbináns nűkleőtidszekvenciák; a nűkleőtidszekvenciákattartalmazó vektőrők; a vektőrőkkal transzfőrmált gazdasejtek; anűkleőtidszekvenciákkal genetikailag transzfőrmált növények, növényirészek és növényi sejtek; az előbbiekből nyert, enzimatikűs aktivitásúnövényi extraktűmők; a rekőmbináns pőlipeptideket vagy enzimatikűsaktivitású extraktűmőkat tartalmazó gyógyászati készítmények. Szintén a találmány tárgyát képezi a találmány szerinti növények,növényi részek, növényi sejtek, enzimatikűs aktivitású növényiextraktűmők, rekőmbináns predűődenális lipázők és származékaikalkalmazása, a találmány pőlipeptideket fűnkciőnális főrmábantartalmazó élelmiszerek, gyógyászati készítmények és agrő-alimentáris(azaz mezőgazdasági-élelmezési) vagy ipari felhasználás céljáraalkalmas enzimatikűs készítmények előállítására. ŕ
HU9801438A 1995-04-20 1996-04-19 Recombinant preduodenal lipases and polypeptide derivatives produced by plants, processes for obtaining them and their uses HUP9801438A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9504754A FR2733249B1 (fr) 1995-04-20 1995-04-20 Lipase gastrique de chien recombinante et polypeptides derives produits par les plantes, leurs procedes d'obtention et leurs utilisations

Publications (2)

Publication Number Publication Date
HUP9801438A2 true HUP9801438A2 (hu) 1998-10-28
HUP9801438A3 HUP9801438A3 (en) 2000-11-28

Family

ID=9478306

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801438A HUP9801438A3 (en) 1995-04-20 1996-04-19 Recombinant preduodenal lipases and polypeptide derivatives produced by plants, processes for obtaining them and their uses

Country Status (26)

Country Link
US (2) US6573431B1 (hu)
EP (1) EP0822988B1 (hu)
JP (2) JP4077875B2 (hu)
KR (1) KR19990007901A (hu)
CN (1) CN1185178A (hu)
AR (1) AR004482A1 (hu)
AT (1) ATE313632T1 (hu)
AU (1) AU718905B2 (hu)
BG (1) BG64320B1 (hu)
BR (1) BR9608011A (hu)
CA (1) CA2218418A1 (hu)
CZ (1) CZ330997A3 (hu)
DE (1) DE69635611T2 (hu)
ES (1) ES2256858T3 (hu)
FR (1) FR2733249B1 (hu)
HU (1) HUP9801438A3 (hu)
IL (1) IL117955A0 (hu)
MX (1) MX9707973A (hu)
NZ (1) NZ307579A (hu)
PL (1) PL186586B1 (hu)
RU (1) RU2235129C2 (hu)
SK (1) SK140197A3 (hu)
TR (1) TR199701207T1 (hu)
UA (1) UA73267C2 (hu)
WO (1) WO1996033277A2 (hu)
ZA (1) ZA963146B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2759857B1 (fr) * 1997-02-27 1999-04-30 Biocem Nouvelles utilisations de la sterilite male chez les plantes
FR2774379B1 (fr) * 1998-01-30 2002-03-29 Groupe Limagrain Holding Procede de production, par des cellules vegetales, d'alpha 1-antitrypsine et de ses variantes, et produits contenant l'alpha-antitrypsine ainsi obtenue
FR2777155B1 (fr) 1998-04-09 2000-06-23 Meristem Therapeutics Semences et plantes dont le pouvoir germinatif est detruit par l'absence totale ou partielle d'au moins une reserve energetique indispensable a la germination
FR2810667B1 (fr) * 2000-06-23 2004-09-03 Warner Lambert Co Procede d'isolement et de purification d'une proteine, et proteine obtenue
US7288124B2 (en) 2004-09-08 2007-10-30 L'oreal S.A. Heteroaromatic binuclear black direct dyes
WO2007010533A2 (en) 2005-07-18 2007-01-25 Protalix Ltd. Mucosal or enteral administration of biologically active macromolecules
FR3036119B1 (fr) * 2015-05-15 2019-04-19 Universite De Picardie Jules Verne Procede de production de proteines d'interet a partir d'une structure vegetale
CN112480233B (zh) * 2020-12-14 2022-05-27 上海交通大学 一种生物活性肽iahpklgkrir及其制备方法和应用
CN115669542B (zh) * 2022-11-04 2023-08-25 西北农林科技大学 一种植物组织培养脱毒方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3150988A1 (de) * 1980-12-30 1982-08-05 Institut Français du Pétrole, 92502 Rueil-Malmaison, Hauts-de-Seine Brennbare kompositionen, die alkohole und fettsaeureester enthalten und insbesondere als dieseltreibstoffe brauchbar sind
US5538868A (en) * 1984-02-08 1996-07-23 Cetus Oncology Corporation Recombinant ricin toxin fragments
GB8421210D0 (en) * 1984-08-21 1984-09-26 Celltech Ltd Polypeptide and polypeptide composition
GB2188057B (en) * 1986-02-04 1990-03-07 Inst Penyelidikan Minyak Kelap Transesterification of fats and oils
FR2603804B1 (fr) * 1986-09-17 1989-10-27 Jouveinal Sa Lipases et extraits lipasiques, leur procede de preparation et leur application en therapeutique
WO1991006661A1 (en) * 1989-11-03 1991-05-16 Opta Food Ingredients, Inc. Lipase-catalyzed in situ generation of mono- and di-glycerides
IL97645A (en) * 1990-03-23 1997-03-18 Gist Brocades Nv Production of enzymes in seeds and their use
DK162790D0 (da) * 1990-07-06 1990-07-06 Novo Nordisk As Plantecelle
CA2114636C (en) * 1991-08-01 2006-11-28 Jon Donson Recombinant plant viral nucleic acids
FR2683549B1 (fr) * 1991-11-13 1994-11-18 Jouveinal Inst Rech Acides nucleiques codant pour la lipase gastrique de lapin et derives polypeptidiques, leur utilisation pour la production de ces polypeptides, et compositions pharmaceutiques a base de ces derniers.
FR2699179B1 (fr) * 1992-12-16 1995-01-06 Jouveinal Inst Rech Acides nucléiques codant pour la lipase gastrique de chien et dérivés polypeptidiques, leur utilisation pour la production de ces polypeptides, et compositions pharmaceutiques à base de ces derniers.
IS4130A (is) * 1993-03-01 1994-09-02 Ab Astra Ný fjölpeptíð
FR2722798B1 (fr) * 1994-07-25 1996-09-13 Toulouse Inst Nat Polytech 1procede de production d'acides gras2plantes oleagineuses

Also Published As

Publication number Publication date
NZ307579A (en) 1999-11-29
EP0822988B1 (fr) 2005-12-21
US6573431B1 (en) 2003-06-03
JP4077875B2 (ja) 2008-04-23
KR19990007901A (ko) 1999-01-25
JP2007325590A (ja) 2007-12-20
EP0822988A2 (fr) 1998-02-11
WO1996033277A3 (fr) 1996-11-28
CA2218418A1 (fr) 1996-10-24
SK140197A3 (en) 1998-07-08
DE69635611T2 (de) 2006-09-14
ZA963146B (en) 1997-01-22
IL117955A0 (en) 1996-08-04
HUP9801438A3 (en) 2000-11-28
MX9707973A (es) 1998-08-30
ES2256858T3 (es) 2006-07-16
BG101959A (en) 1998-07-31
BG64320B1 (bg) 2004-09-30
WO1996033277A2 (fr) 1996-10-24
RU2235129C2 (ru) 2004-08-27
FR2733249B1 (fr) 1997-06-06
UA73267C2 (en) 2005-07-15
BR9608011A (pt) 1999-01-05
ATE313632T1 (de) 2006-01-15
DE69635611D1 (de) 2006-01-26
CN1185178A (zh) 1998-06-17
US20040072317A1 (en) 2004-04-15
AU5696796A (en) 1996-11-07
PL186586B1 (pl) 2004-01-30
AR004482A1 (es) 1998-12-16
CZ330997A3 (cs) 1998-03-18
JPH11504207A (ja) 1999-04-20
PL322874A1 (en) 1998-03-02
AU718905B2 (en) 2000-04-20
FR2733249A1 (fr) 1996-10-25
TR199701207T1 (xx) 1998-02-21

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