HUP9800550A2 - Benzotiofénszármazékok alkalmazása környezeti ösztrogének inhibiálására szolgáló gyógyszerkészítmények előállítására - Google Patents

Benzotiofénszármazékok alkalmazása környezeti ösztrogének inhibiálására szolgáló gyógyszerkészítmények előállítására

Info

Publication number
HUP9800550A2
HUP9800550A2 HU9800550A HUP9800550A HUP9800550A2 HU P9800550 A2 HUP9800550 A2 HU P9800550A2 HU 9800550 A HU9800550 A HU 9800550A HU P9800550 A HUP9800550 A HU P9800550A HU P9800550 A2 HUP9800550 A2 HU P9800550A2
Authority
HU
Hungary
Prior art keywords
pipe powder
inhibiting
production
estrogens
benzotiophen
Prior art date
Application number
HU9800550A
Other languages
English (en)
Inventor
Henry U. Bryant
Jeffrey A. Dodge
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9800550A2 publication Critical patent/HUP9800550A2/hu
Publication of HUP9800550A3 publication Critical patent/HUP9800550A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány tárgya (I) általánős képletű vegyületek alkalmazásakörnyezeti ösztrőgének hatásának inhibiálására alkalmasgyógyszerkészítmények előállítására. Az (I) általánős képletben R1 ésR3 jelentése egymástól függetlenül metilcsőpőrt, -C(O)-(1-6 szénatőmősalkil)-csőpőrt vagy -C(O)-Ar általánős képletű csőpőrt, ahől Arjelentése kívánt esetben szűbsztitűált fenilcsőpőrt, R2 jelentésepirrőlidinőcsőpőrt, hexametilén-iminő-csőpőrt vagy piperidinőcsőpőrt. ŕ
HU9800550A 1995-01-25 1996-01-22 The use of benzotiophen derivatives for production of pharmaceuticals useful for inhibiting estrogens with environmental origin HUP9800550A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/378,229 US5521214A (en) 1995-01-25 1995-01-25 Methods of inhibiting environmental estrogens

Publications (2)

Publication Number Publication Date
HUP9800550A2 true HUP9800550A2 (hu) 1998-12-28
HUP9800550A3 HUP9800550A3 (en) 1999-10-28

Family

ID=23492278

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800550A HUP9800550A3 (en) 1995-01-25 1996-01-22 The use of benzotiophen derivatives for production of pharmaceuticals useful for inhibiting estrogens with environmental origin

Country Status (13)

Country Link
US (1) US5521214A (hu)
EP (1) EP0806950A4 (hu)
JP (1) JPH10512886A (hu)
KR (1) KR19980701589A (hu)
CN (1) CN1169116A (hu)
AU (1) AU699678B2 (hu)
CA (1) CA2210940A1 (hu)
CZ (1) CZ233797A3 (hu)
EA (1) EA199700136A1 (hu)
FI (1) FI973095A (hu)
HU (1) HUP9800550A3 (hu)
NO (1) NO973367L (hu)
WO (1) WO1996022771A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122025A (en) * 1996-10-30 2003-01-12 Lilly Co Eli Use of raloxifene or pharmaceutically acceptable salts or solvates thereof, in the preparation of a medicament for preventing breast cancer
GB9624800D0 (en) * 1996-11-29 1997-01-15 Lilly Co Eli Methods of preventing breast cancer
US5760030A (en) * 1997-06-30 1998-06-02 Eli Lilly And Company Benzothiophene compounds and methods of use
ES2246234T3 (es) 1999-05-04 2006-02-16 Strakan International Limited Glicosidos de androgenos y actividad androgenica de los mismos.
EP1113007A1 (en) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisoquinoline compounds as estrogen agonists/antagonists
KR100334130B1 (ko) * 2000-02-18 2002-04-26 정명식 에스트로겐 유사물질의 생물학적 분석방법
KR100368936B1 (ko) * 2000-10-04 2003-01-24 주식회사 대웅 우루소데옥시콜린산을 함유한 환경호르몬 독성의 예방 및치료제
US8173114B2 (en) * 2000-11-28 2012-05-08 Mitsubishi Tanabe Pharma Corporation Excretion accelerator for accumulative chlorine compound
US7720727B2 (en) * 2001-03-01 2010-05-18 Fisher-Rosemount Systems, Inc. Economic calculations in process control system
HRP20230080T1 (hr) * 2018-07-12 2023-03-17 Eli Lilly And Company Selektivna sredstva za razgradnju estrogenskog receptora

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5451590A (en) * 1993-12-21 1995-09-19 Eli Lilly & Co. Methods of inhibiting sexual precocity
US5593987A (en) * 1993-12-21 1997-01-14 Eli Lilly And Company Methods of inhibiting breast disorders

Also Published As

Publication number Publication date
JPH10512886A (ja) 1998-12-08
NO973367D0 (no) 1997-07-21
EP0806950A4 (en) 1999-01-07
KR19980701589A (ko) 1998-05-15
CZ233797A3 (cs) 1998-02-18
NO973367L (no) 1997-07-21
WO1996022771A1 (en) 1996-08-01
EP0806950A1 (en) 1997-11-19
AU699678B2 (en) 1998-12-10
FI973095A (fi) 1997-07-24
CN1169116A (zh) 1997-12-31
HUP9800550A3 (en) 1999-10-28
MX9705537A (es) 1997-10-31
AU4764996A (en) 1996-08-14
US5521214A (en) 1996-05-28
CA2210940A1 (en) 1996-08-01
FI973095A0 (fi) 1997-07-23
EA199700136A1 (ru) 1997-12-30

Similar Documents

Publication Publication Date Title
PT1413582E (pt) Pirrolobenzodiazepinas dimericas
AR038431A2 (es) Derivados 2-desoxo-15-alquilo de marcfortina
EA199800141A1 (ru) Гетероциклические соединения
KR100263496B1 (ko) 탁솔 유도체 및 이의 제조방법
NZ278072A (en) Phenylacetic acid oxime derivatives; biocides
HUP9802304A2 (hu) Piridazin-3-on-származékok, intermedierjeik, alkalmazásuk, a vegyületeket hatóanyagként tartalmazó herbicid készítmények
YU35697A (en) Substituted 6,6-hetero-bicyclic derivatives
DK0643705T3 (da) Fremgangsmåde til fremstilling af N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- og N-beta-hydroxyal
TR199800011T1 (xx) Benzo$g] kuinolin t�revleri
ES2066808T3 (es) Derivados de quinoleina, su produccion y uso.
PT918776E (pt) Sintese total de acilfulvenos antitumorais
TR199701728T1 (xx) Sialil-Lewis X ve sialil-Lewis A taklitleri olarak digikosilatlanm�� 1,-2-dioller.
HUP9800550A2 (hu) Benzotiofénszármazékok alkalmazása környezeti ösztrogének inhibiálására szolgáló gyógyszerkészítmények előállítására
ATE171188T1 (de) In 15-stellung substituierte 4-azasteroide
LU92263I2 (fr) Imépitoïne et ses dérivés pharmaceutiquement acceptables (PEXION)
RS49965B (sr) Supstituisani bisindolmaleimidi za inhibiciju ćelijske proliferacije
DE69834271D1 (de) Steroid-3-o-sulfamat-derivate als estronsulfatase-hemmer
HUP9901093A2 (hu) Eljárás benzotiofénszármazékok felhasználása melanóma gátlására alkalmas gyógyszerkészítmények előállítására
DK540585D0 (da) 5-alkyl-1-phenyl-2-piperazinoalkylpyrasolin-3-on-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved, samt farmaceutiske praeparater indeholdende disse forbindelser
HUP9702393A2 (hu) bisz(2-Halogén-etil)-amino-fenil szubsztituált distamycinszármazékok, tumorellenes és vírusellenes hatóanyagok
NZ334030A (en) Synthesis of bisindolylmalimides
TR199802456T2 (xx) Yeni pirol t�revleri.
HUP0001023A2 (hu) 2-(Szubsztituált benzoil)-1-cikloalkánkarbonsav-származékok
HUP9802291A2 (hu) Penicillamin-amid-származékok, és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
FI964278A (fi) Menetelmä 5,6-dihydroksi-2-amino-1,2,3,4-tetrahydronaftaleenin johdannaisten valmistamiseksi