HUP9800085A2 - Eljárás karbonilvegyületek redukálására és alfa-amino-alkohol-származékok előállítására - Google Patents
Eljárás karbonilvegyületek redukálására és alfa-amino-alkohol-származékok előállításáraInfo
- Publication number
- HUP9800085A2 HUP9800085A2 HU9800085A HUP9800085A HUP9800085A2 HU P9800085 A2 HUP9800085 A2 HU P9800085A2 HU 9800085 A HU9800085 A HU 9800085A HU P9800085 A HUP9800085 A HU P9800085A HU P9800085 A2 HUP9800085 A2 HU P9800085A2
- Authority
- HU
- Hungary
- Prior art keywords
- tube powder
- alkyl
- aralkyl
- reduction
- amino
- Prior art date
Links
- 150000001728 carbonyl compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000843 powder Substances 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- -1 aluminum compound Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- 238000011916 stereoselective reduction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B41/00—Formation or introduction of functional groups containing oxygen
- C07B41/02—Formation or introduction of functional groups containing oxygen of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya egy könnyű és egyszerű eljárás karbőnilvegyületekhidrőxilvegyületekké történő redűkálására, elsősőrban a-aminő-halőgén-ketőn-származékők sztereőszelektív redűkálására, amelynek sőrán egy(1) általánős képletű karbőnilvegyületet egy (4) általánős képletűszerves alűmíniűmvegyülettel reagáltatnak, és így a megfelelő (5)általánős képletű alkőhőlvegyületet kapják.A képletekbenR1 és R2 jelentése egymástól függetlenül alkilcsőpőrt, aralkilcsőpőrt,arilcsőpőrt, cianőcsőpőrt, hidrőgénatőm, (2) általánős képletűcsőpőrt, ahől X jelentése halőgénatőm ésn értéke 0-2,vagy (3) általánős képletű csőpőrt, ahőlY jelentése alkőxicsőpőrt, aralkil-őxi-csőpőrt, adőtt esetbenszűbsztitűált aminőcsőpőrt, vagy alkiltiőcsőpőrt,R3 és R4 jelentése egymástól függetlenül alkilcsőpőrt, aralkilcsőpőrtvagy arilcsőpőrt,R5 jelentése primer vagy szekűnder alkilcsőpőrt vagy primer vagyszekűnder aralkilcsőpőrt.(1) (2) (3) (4) (5)ŕ
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3563296 | 1996-01-29 | ||
| JP3725696 | 1996-01-30 | ||
| JP11031796 | 1996-04-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9800085A2 true HUP9800085A2 (hu) | 1998-05-28 |
| HUP9800085A3 HUP9800085A3 (en) | 1998-06-29 |
Family
ID=27288817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9800085A HUP9800085A3 (en) | 1996-01-29 | 1997-01-29 | Processes for the reduction of carbonyl compounds and producing alfa-amino-alcohol derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6150567A (hu) |
| EP (1) | EP0827943B1 (hu) |
| JP (1) | JP4545830B2 (hu) |
| KR (1) | KR19980703369A (hu) |
| AT (1) | ATE240918T1 (hu) |
| CA (1) | CA2216537A1 (hu) |
| DE (1) | DE69722111T2 (hu) |
| HU (1) | HUP9800085A3 (hu) |
| WO (1) | WO1997028105A1 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3863230B2 (ja) * | 1996-08-16 | 2006-12-27 | 株式会社カネカ | β−アミノ−α−ヒドロキシ酸誘導体の製造方法 |
| RU2169138C2 (ru) * | 1996-09-13 | 2001-06-20 | Ниппон Каяку Кабусики Кайся | Способ получения оптически активных эфиров эритро-3-амино-2-оксимасляных кислот и соответствующих исходных кислот |
| IN184319B (hu) * | 1997-06-03 | 2000-08-05 | Kaneka Corp | |
| CA2273643A1 (en) * | 1998-06-09 | 1999-12-09 | F. Hoffmann-La Roche Ag | Stereoselective reduction of carbonyl compounds |
| WO2000053575A1 (fr) | 1999-03-10 | 2000-09-14 | Kaneka Corporation | SYNTHESE DE α-AMINO-α',α'-DIHALOCETONES ET PROCEDE DE PREPARATION DE DERIVES D'ACIDES AMINES β PAR UTILISATION DE CES DERNIERS |
| EP1346979A4 (en) * | 2000-11-30 | 2005-11-09 | Ajinomoto Kk | PROCESS FOR THE PREPARATION OF N-PROTECTED AMINO ALCOHOLS AND N-PROTECTED AMINOEPOXIDES |
| US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| EP1511729A4 (en) * | 2002-05-22 | 2006-09-06 | Errant Gene Therapeutics Llc | HISTONDEACETYLASEINHIBITORS BASED ON ALPHACHALCOGEN METHYL CARBONYL COMPOUNDS |
| EP1511477A4 (en) | 2002-05-22 | 2008-04-09 | Errant Gene Therapeutics Llc | HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS |
| EP1846350A2 (en) * | 2005-01-27 | 2007-10-24 | University of Nottingham | Improved method for the preparation of enantiomerically enriched secondary alcohols by the addition of organoaluminium reagents to carbonyl compounds |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| KR20160129109A (ko) | 2008-05-23 | 2016-11-08 | 아미라 파마슈티칼스 인코포레이티드 | 5-리폭시게나아제 활성화 단백질 억제제 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54154739A (en) * | 1978-05-26 | 1979-12-06 | Ono Pharmaceut Co Ltd | Reducing agents |
| US4745204A (en) * | 1986-06-05 | 1988-05-17 | International Business Machines Corporation | Process for producing aluminum alkoxide or aluminum aryloxide |
| JPS632935A (ja) * | 1986-06-20 | 1988-01-07 | Sumitomo Chem Co Ltd | 光学活性アルコ−ル類の製造方法 |
| JPH0723332B2 (ja) * | 1987-05-29 | 1995-03-15 | 旭化成工業株式会社 | １，３−ジクロル−２−プロパノ−ルの製造法 |
| US5434265A (en) * | 1992-12-22 | 1995-07-18 | Eli Lilly And Company | Inhibitors of HIV protease |
| US5523463A (en) * | 1994-09-23 | 1996-06-04 | Hoffmann-La Roche Inc. | Method of producing halogenated and alpha-aminoalchohols |
| US5591885A (en) * | 1994-09-23 | 1997-01-07 | Hoffman-La Roche Inc. | Process for the preparation of halogenated α-aminoketone compounds |
-
1997
- 1997-01-29 AT AT97901761T patent/ATE240918T1/de not_active IP Right Cessation
- 1997-01-29 US US08/930,011 patent/US6150567A/en not_active Expired - Fee Related
- 1997-01-29 DE DE69722111T patent/DE69722111T2/de not_active Expired - Fee Related
- 1997-01-29 WO PCT/JP1997/000189 patent/WO1997028105A1/ja not_active Application Discontinuation
- 1997-01-29 CA CA002216537A patent/CA2216537A1/en not_active Abandoned
- 1997-01-29 HU HU9800085A patent/HUP9800085A3/hu unknown
- 1997-01-29 EP EP97901761A patent/EP0827943B1/en not_active Expired - Lifetime
- 1997-01-29 KR KR1019970706774A patent/KR19980703369A/ko not_active Application Discontinuation
- 1997-01-29 JP JP52748397A patent/JP4545830B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69722111D1 (de) | 2003-06-26 |
| JP4545830B2 (ja) | 2010-09-15 |
| HUP9800085A3 (en) | 1998-06-29 |
| CA2216537A1 (en) | 1997-08-07 |
| ATE240918T1 (de) | 2003-06-15 |
| WO1997028105A1 (en) | 1997-08-07 |
| EP0827943A4 (en) | 2000-07-26 |
| DE69722111T2 (de) | 2004-02-19 |
| US6150567A (en) | 2000-11-21 |
| EP0827943B1 (en) | 2003-05-21 |
| KR19980703369A (ko) | 1998-10-15 |
| EP0827943A1 (en) | 1998-03-11 |
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