DE60000978D1 - 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose - Google Patents

22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose

Info

Publication number
DE60000978D1
DE60000978D1 DE60000978T DE60000978T DE60000978D1 DE 60000978 D1 DE60000978 D1 DE 60000978D1 DE 60000978 T DE60000978 T DE 60000978T DE 60000978 T DE60000978 T DE 60000978T DE 60000978 D1 DE60000978 D1 DE 60000978D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
hydroxycholesta
meiose
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60000978T
Other languages
English (en)
Other versions
DE60000978T2 (de
Inventor
Dirk Leysen
Van Der Jaap Louw
Gerard Hanssen
Anja Wiersma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE60000978D1 publication Critical patent/DE60000978D1/de
Publication of DE60000978T2 publication Critical patent/DE60000978T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60000978T 1999-03-09 2000-03-03 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose Expired - Fee Related DE60000978T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99200680 1999-03-09
PCT/EP2000/001780 WO2000053618A1 (en) 1999-03-09 2000-03-03 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis

Publications (2)

Publication Number Publication Date
DE60000978D1 true DE60000978D1 (de) 2003-01-23
DE60000978T2 DE60000978T2 (de) 2003-07-17

Family

ID=8239958

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60000978T Expired - Fee Related DE60000978T2 (de) 1999-03-09 2000-03-03 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose

Country Status (9)

Country Link
US (1) US6518262B1 (de)
EP (1) EP1163258B1 (de)
JP (1) JP2002539134A (de)
AT (1) ATE229538T1 (de)
AU (1) AU3285000A (de)
DE (1) DE60000978T2 (de)
DK (1) DK1163258T3 (de)
ES (1) ES2188515T3 (de)
WO (1) WO2000053618A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059920A2 (en) * 1999-04-06 2000-10-12 Akzo Nobel N.V. Orally active 7.alpha.-alkyl androgens
GB9930533D0 (en) * 1999-12-23 2000-02-16 Mitsubishi Tokyo Pharm Inc Nucleic acid delivery
WO2001076360A2 (en) * 2000-04-06 2001-10-18 Novo Nordisk A/S Synchronization of the cytoplasmatic and the nuclear maturation of oocytes in vitro
WO2005020928A2 (en) 2003-08-29 2005-03-10 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
WO2007098281A2 (en) 2006-02-27 2007-08-30 Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
US9526737B2 (en) 2007-12-03 2016-12-27 The Regents Of The University Of California Oxysterols for activation of hedgehog signaling, osteoinduction, antiadipogenesis, and Wnt signaling
EP2847206A4 (de) 2012-05-07 2016-01-20 Univ California Oxysterol-analogon oxy133 zur induktion von osteogenese und hedgehog-signalisierung sowie zur adipogenesehemmung
CA2911205A1 (en) 2013-05-02 2014-11-06 The Regents Of The University Of California Bone-selective osteogenic oxysterol-bone targeting agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2837414A1 (de) * 1977-08-29 1979-03-08 Searle & Co 25-alkylcholesterin-derivate
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols
HUP9800731A3 (en) * 1995-03-06 2000-03-28 Novo Nordisk As Stimulation of meiosis
CA2275683A1 (en) 1996-12-20 1998-07-02 Frederik Christian Gronvald Meiosis regulating compounds

Also Published As

Publication number Publication date
ATE229538T1 (de) 2002-12-15
US6518262B1 (en) 2003-02-11
DK1163258T3 (da) 2003-03-31
EP1163258A1 (de) 2001-12-19
ES2188515T3 (es) 2003-07-01
WO2000053618A1 (en) 2000-09-14
JP2002539134A (ja) 2002-11-19
DE60000978T2 (de) 2003-07-17
EP1163258B1 (de) 2002-12-11
AU3285000A (en) 2000-09-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: N.V. ORGANON, OSS, NL

8339 Ceased/non-payment of the annual fee