HUP9700699A2 - Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására - Google Patents

Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására

Info

Publication number
HUP9700699A2
HUP9700699A2 HU9700699A HUP9700699A HUP9700699A2 HU P9700699 A2 HUP9700699 A2 HU P9700699A2 HU 9700699 A HU9700699 A HU 9700699A HU P9700699 A HUP9700699 A HU P9700699A HU P9700699 A2 HUP9700699 A2 HU P9700699A2
Authority
HU
Hungary
Prior art keywords
general formula
amino
carboxamide oxime
salt
reacted
Prior art date
Application number
HU9700699A
Other languages
English (en)
Inventor
László Ürögdi
Mihály Barabás
Ede Márványos
Zita Csákai
Magdolna Török
Original Assignee
BIOREX Kutató és Fejlesztő Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to HU9700699A priority Critical patent/HU220971B1/hu
Application filed by BIOREX Kutató és Fejlesztő Rt. filed Critical BIOREX Kutató és Fejlesztő Rt.
Publication of HU9700699D0 publication Critical patent/HU9700699D0/hu
Priority to PCT/HU1997/000082 priority patent/WO1998043948A1/en
Priority to PL97336072A priority patent/PL336072A1/xx
Priority to NZ500020A priority patent/NZ500020A/en
Priority to EEP199900438A priority patent/EE03868B1/xx
Priority to KR1019997009020A priority patent/KR20010005943A/ko
Priority to EP97947819A priority patent/EP0975585A1/en
Priority to CN97182087A priority patent/CN1251574A/zh
Priority to US09/402,267 priority patent/US6180787B1/en
Priority to AU54055/98A priority patent/AU737994B2/en
Priority to SK1348-99A priority patent/SK134899A3/sk
Priority to EA199900899A priority patent/EA199900899A1/ru
Priority to JP54132298A priority patent/JP2001521498A/ja
Priority to BR9714717-6A priority patent/BR9714717A/pt
Priority to TR1999/02207T priority patent/TR199902207T2/xx
Priority to APAP/P/1999/001646A priority patent/AP9901646A0/en
Priority to CA002285360A priority patent/CA2285360A1/en
Priority to YU49499A priority patent/YU49499A/sh
Priority to MA25016A priority patent/MA26143A1/fr
Priority to EG36098A priority patent/EG22104A/xx
Priority to ZA982755A priority patent/ZA982755B/xx
Priority to PE1998000247A priority patent/PE83299A1/es
Priority to TNTNSN98046A priority patent/TNSN98046A1/fr
Priority to ARP980101495A priority patent/AR012308A1/es
Priority to UY24945A priority patent/UY24945A1/es
Priority to CO98018891A priority patent/CO4940491A1/es
Priority to HRP9700699A priority patent/HRP980175A2/hr
Priority to IDP980507A priority patent/ID20016A/id
Priority to TW087105087A priority patent/TW455573B/zh
Publication of HUP9700699A2 publication Critical patent/HUP9700699A2/hu
Publication of HUP9700699A3 publication Critical patent/HUP9700699A3/hu
Priority to IS5174A priority patent/IS5174A/is
Priority to IL13204899A priority patent/IL132048A0/xx
Priority to NO19994628A priority patent/NO312027B1/no
Priority to BG103847A priority patent/BG63116B1/bg
Publication of HU220971B1 publication Critical patent/HU220971B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/12—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reactions not involving the formation of oxyimino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/02—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

A találmány tárgya javítőtt eljárás (I) általánős képletű O-(3-aminő-2-hidrőxi- prőpil)-hidrőximsav-halőgenidek, ezek savaddíciós sóinak,valamint őptikailag aktív alakjainak előállítására. E képletben R1adőtt esetben helyettesített fenilcsőpőrt, vagy piridil- vagytienilcsőpőrt, X halőgénatőm, R2 és R3 egyenes vagy elágazó láncúalkilcsőpőrt, vagy együttesen, a közrezárt nitrőgénatőmmal 5-7 tagútelített heterőciklűsős csőpőrtőt képeznek, mely adőtt esetben tővábbiheterőatőmőt tartalmazhat, és adőtt esetben szűbsztitűált lehet. Az eljárás sőrán egy (II) általánős képletű karbőxamid-őximőt reaktív3-aminő-2- hidrőxi-prőpán-származékkal reagáltatnak, a kapőtt O-szűbsztitűált karbőxamid-őximőt halőgénhidrőgéansav jelenlétébennátriűm-nitrittel diazőtálják, a diazóniűmsót elbőntják, a kapőttterméket elkülönítik. A találmány lényege, hőgy a (II) általánős képletű karbőxamid-őximőtegy (III) általánős képletű 3-hidrőxi-azetidinűmsóval reagáltatják,ahől R2 és R3 a fenti és Y' sóképző katiőn, alkálihidrőxiddalmeglúgősítőtt, adőtt esetben vizet is tartalmazó rövid szénláncúalkőhőlős, előnyösen etanőlős reakcióelegyben, és a reakció sőránképződő intermedier O-szűbsztitűált karbőxamid-őxim diazőtálása előtta reakcióelegyet semlegesítik, és eltávőlítják belőle a szervesőldószert. ŕ
HU9700699A 1997-04-03 1997-04-03 Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására HU220971B1 (hu)

Priority Applications (33)

Application Number Priority Date Filing Date Title
HU9700699A HU220971B1 (hu) 1997-04-03 1997-04-03 Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
CA002285360A CA2285360A1 (en) 1997-04-03 1997-12-05 Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
EP97947819A EP0975585A1 (en) 1997-04-03 1997-12-05 Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
US09/402,267 US6180787B1 (en) 1997-04-03 1997-12-05 Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
NZ500020A NZ500020A (en) 1997-04-03 1997-12-05 Process for preparing O-(3-amino-2-hydroxy-propyl)-hydroximic acid halides
EEP199900438A EE03868B1 (et) 1997-04-03 1997-12-05 Protsess O-(3-amino-2-hüdroksüpropüül) hüdroksüümhappehalogeniidide valmistamiseks
KR1019997009020A KR20010005943A (ko) 1997-04-03 1997-12-05 0-(3-아미노-2-히드록시-프로필)-히드록심산할라이드의 제조방법
PCT/HU1997/000082 WO1998043948A1 (en) 1997-04-03 1997-12-05 Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
CN97182087A CN1251574A (zh) 1997-04-03 1997-12-05 O－(3－氨基－2－羟基－丙基)－肟酰卤类的制备方法
PL97336072A PL336072A1 (en) 1997-04-03 1997-12-05 Method of obtaining halides of 0-(3-amino-2-hydroxypropyl)hydroximic acid
AU54055/98A AU737994B2 (en) 1997-04-03 1997-12-05 Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
SK1348-99A SK134899A3 (en) 1997-04-03 1997-12-05 Process for preparing o-(3-amino-2-hydroxy-propyl)hydroxymic acid halides
EA199900899A EA199900899A1 (ru) 1997-04-03 1997-12-05 Способ получения галогенангидридов о-(3-амино-2-гидрокси-пропил)-гидроксамовых кислот
JP54132298A JP2001521498A (ja) 1997-04-03 1997-12-05 Ｏ−（３−アミノ−２−ヒドロキシ−プロピル）−ヒドロキシミック酸ハロゲン化物の製造方法
BR9714717-6A BR9714717A (pt) 1997-04-03 1997-12-05 Processo para preparação de halogenetos do ácido o-(3-amino-2-hidroxipropil)-hidroxìmico
TR1999/02207T TR199902207T2 (xx) 1997-04-03 1997-12-05 0-(3-Amino-2-Hidroksi-Propil)-hidroksimik asit halidler haz�rlama prosesi.
APAP/P/1999/001646A AP9901646A0 (en) 1997-04-03 1997-12-05 Process for preparing 0-(3-Amino-2-hydroxy-propyl)-hydroxymic and halides.
YU49499A YU49499A (sh) 1997-04-03 1997-12-15 Postupak za dobijanje halogenida o-(3-amino-2-hidroksi- propil)-hidroksimske kiseline
MA25016A MA26143A1 (fr) 1997-04-03 1998-03-30 Procede pour la preparation d'0-(3-amino-2-hydroxy-propyl) acide haloide hydroxymic
EG36098A EG22104A (en) 1997-04-03 1998-03-31 Process for preparing 0-(3-amino-2-hydroxy-propyl) hydroxymic acid halides
ZA982755A ZA982755B (en) 1997-04-03 1998-04-01 Process for preparing 0-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
PE1998000247A PE83299A1 (es) 1997-04-03 1998-04-02 Proceso para preparar haluros de acido o-(3-amino-2-hidroxi-propil)-hidroximico
TNTNSN98046A TNSN98046A1 (fr) 1997-04-03 1998-04-02 Un procede pour la production des chlorures de l'acide o-(amino -3hydroxy-propyle).
ARP980101495A AR012308A1 (es) 1997-04-03 1998-04-02 Proceso para preparar haluros de acido o-(3-amino-2-hidroxi-propil)- hidroximico
UY24945A UY24945A1 (es) 1997-04-03 1998-04-02 Proceso para preparar haluros de acido o-(3-amino-2-hidroxi- propil)-hidroximico
IDP980507A ID20016A (id) 1997-04-03 1998-04-03 Proses pembuatan halida-halida asam o-(3-mino-2-hidroksi-propil)-hidroksimat
HRP9700699A HRP980175A2 (en) 1997-04-03 1998-04-03 Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
CO98018891A CO4940491A1 (es) 1997-04-03 1998-04-03 Proceso para preparar haluros de acido o-(3-amino-2-hidroxi- propil)-hidroximico
TW087105087A TW455573B (en) 1997-04-03 1998-04-07 Process for preparing 0-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
IS5174A IS5174A (is) 1997-04-03 1999-09-10 Aðferð til framleiðslu á O-(3-amínó-2-hýdroxý-própýl)-hýdroxýmsýru halíð
IL13204899A IL132048A0 (en) 1997-04-03 1999-09-23 Process for preparing o-(3-amino-2-hydroxy-propyl)-hydroxymic acid halides
NO19994628A NO312027B1 (no) 1997-04-03 1999-09-23 Fremgangsmåte for fremstilling av O-(3-amino-2- hydroksypropyl)-hydroksiminsyrehalogenider
BG103847A BG63116B1 (bg) 1997-04-03 1999-11-02 Метод за получаване на о-(3-амино-2-хидрокси-пропил)- хидроксимови ацилхалогениди

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9700699A HU220971B1 (hu) 1997-04-03 1997-04-03 Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására

Publications (4)

Publication Number Publication Date
HU9700699D0 HU9700699D0 (en) 1997-05-28
HUP9700699A2 true HUP9700699A2 (hu) 1999-01-28
HUP9700699A3 HUP9700699A3 (en) 1999-04-28
HU220971B1 HU220971B1 (hu) 2002-07-29

Family

ID=89994956

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9700699A HU220971B1 (hu) 1997-04-03 1997-04-03 Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására

Country Status (33)

Country Link
US (1) US6180787B1 (hu)
EP (1) EP0975585A1 (hu)
JP (1) JP2001521498A (hu)
KR (1) KR20010005943A (hu)
CN (1) CN1251574A (hu)
AP (1) AP9901646A0 (hu)
AR (1) AR012308A1 (hu)
AU (1) AU737994B2 (hu)
BG (1) BG63116B1 (hu)
BR (1) BR9714717A (hu)
CA (1) CA2285360A1 (hu)
CO (1) CO4940491A1 (hu)
EA (1) EA199900899A1 (hu)
EE (1) EE03868B1 (hu)
EG (1) EG22104A (hu)
HR (1) HRP980175A2 (hu)
HU (1) HU220971B1 (hu)
ID (1) ID20016A (hu)
IL (1) IL132048A0 (hu)
IS (1) IS5174A (hu)
MA (1) MA26143A1 (hu)
NO (1) NO312027B1 (hu)
NZ (1) NZ500020A (hu)
PE (1) PE83299A1 (hu)
PL (1) PL336072A1 (hu)
SK (1) SK134899A3 (hu)
TN (1) TNSN98046A1 (hu)
TR (1) TR199902207T2 (hu)
TW (1) TW455573B (hu)
UY (1) UY24945A1 (hu)
WO (1) WO1998043948A1 (hu)
YU (1) YU49499A (hu)
ZA (1) ZA982755B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
NZ533795A (en) 2002-01-11 2006-03-31 Biorex Kutato Fejlesztoe Kft Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
BR112014014822A2 (pt) * 2011-12-23 2017-06-13 Akzo Nobel Chemicals Int Bv composto; método para produção de um composto; uso de um composto; composição; processo para fabricação de papel ou papelão; e papel ou papelão
EP2861413B1 (en) * 2012-06-14 2019-05-01 Novartis AG Azetidinium-containing copolymers and uses thereof
CN103804309B (zh) * 2012-11-09 2019-08-02 广州喜鹊医药有限公司 一种氯肟类化合物及其制备方法和在制药中的应用
JP2024500632A (ja) 2020-11-19 2024-01-10 ゼブラ デンマーク エー／エス アリモクロモルクエン酸塩及びその中間体の調製プロセス

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207305B (en) * 1988-03-23 1993-03-29 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoxime derivatives
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HUT54347A (en) * 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes

Also Published As

Publication number Publication date
EE03868B1 (et) 2002-10-15
BR9714717A (pt) 2000-06-20
WO1998043948A1 (en) 1998-10-08
EG22104A (en) 2002-07-31
PL336072A1 (en) 2000-06-05
NO994628D0 (no) 1999-09-23
NZ500020A (en) 2001-09-28
ID20016A (id) 1998-09-10
TR199902207T2 (xx) 2000-02-21
CN1251574A (zh) 2000-04-26
SK134899A3 (en) 2000-06-12
IS5174A (is) 1999-09-10
HRP980175A2 (en) 1999-06-30
EA199900899A1 (ru) 2000-04-24
UY24945A1 (es) 1998-09-28
BG103847A (en) 2000-07-31
AU5405598A (en) 1998-10-22
HU220971B1 (hu) 2002-07-29
TNSN98046A1 (fr) 2005-03-15
US6180787B1 (en) 2001-01-30
PE83299A1 (es) 1999-09-01
AP9901646A0 (en) 1999-09-30
KR20010005943A (ko) 2001-01-15
CA2285360A1 (en) 1998-10-08
HU9700699D0 (en) 1997-05-28
ZA982755B (en) 1998-10-01
CO4940491A1 (es) 2000-07-24
AR012308A1 (es) 2000-10-18
IL132048A0 (en) 2001-03-19
TW455573B (en) 2001-09-21
HUP9700699A3 (en) 1999-04-28
JP2001521498A (ja) 2001-11-06
EE9900438A (et) 2000-04-17
MA26143A1 (fr) 2004-07-01
EP0975585A1 (en) 2000-02-02
NO312027B1 (no) 2002-03-04
NO994628L (no) 1999-09-23
AU737994B2 (en) 2001-09-06
BG63116B1 (bg) 2001-04-30
YU49499A (sh) 2001-09-28

Similar Documents

Publication Publication Date Title
ATE1242T1 (de) Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure.
ES8702793A1 (es) Un procedimiento para desinfectar un substrato
HUP9802517A2 (hu) Foszfonsavval helyettesített benzazepinon-N-ecetsav-származékok, eljárás ezek előállítására és az e vegyületeket tartalmazó gyógyászati készítmények
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
HUP9700699A2 (hu) Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására
ZA825123B (en) New theophylline derivatives and process for their production
SE7909754L (sv) Forfarande for framstellning av endolderivat
KR960017689A (ko) 포스포노메틸화 키토산
IE45090L (en) N-phosphonomethylene - aminoalkane phosphonic acids.
ES502018A0 (es) Un procedimiento para preparar una composicion detergente granular
DE3479804D1 (en) Phosphonates
WO1999035133A3 (en) 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid derivatives as chelating agents
JPS5268193A (en) Synthesis of novel cephalosporin derivatives
SI1051393T1 (en) New derivatives of sulfonic, phosphonic and phosphinic aminoalkane acids, their production and their use as medicaments
GB1091447A (en) 1,2,3,4,4a,9b-hexahydro-5h-indeno[1,2-c]pyridin-(5)-ol derivatives and their preparation
MY109517A (en) Carboxylic acid derivatives
JPS5455565A (en) Novel thiazolidine derivative
JPS54128591A (en) Cephalosporin analog
GEP20033119B (en) Novel Octahydro-6, 10-Dioxo-6H-Pyridazino {1,2-a}{1 Carboxylic Acid Derivatives, Method for Preparation and Use Thereof
JPS5212109A (en) Process for preparation of alkylglycerylether
GB929099A (en) Thiolo- and thiolothiono-phosphoric, phosphonic and phosphinic acid esters
AU8785691A (en) Process for the preparation of ureidoperoxycarboxylic acids
AU6118680A (en) Oxo-pyrido(1,2-a) thienopyrimidine compounds
JPS55129299A (en) 1-beta-d-arabinofuranosyl-cytosine-5'-phosphoric alkyl ester
JPS5572191A (en) Antibiotic n-desacetyl ps-5

Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee