HUP0500350A2 - Pszichiátriai és neurológiai rendellenességek kezelésére alkalmas 3-indol-származékok - Google Patents
Pszichiátriai és neurológiai rendellenességek kezelésére alkalmas 3-indol-származékokInfo
- Publication number
- HUP0500350A2 HUP0500350A2 HU0500350A HUP0500350A HUP0500350A2 HU P0500350 A2 HUP0500350 A2 HU P0500350A2 HU 0500350 A HU0500350 A HU 0500350A HU P0500350 A HUP0500350 A HU P0500350A HU P0500350 A2 HUP0500350 A2 HU P0500350A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- atom
- cycloalkylalkyl
- alkynyl
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title abstract 2
- 208000020016 psychiatric disease Diseases 0.000 title abstract 2
- -1 perhydroazepinyl group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 2
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 abstract 1
- 102000003962 Dopamine D4 receptors Human genes 0.000 abstract 1
- 108090000357 Dopamine D4 receptors Proteins 0.000 abstract 1
- 101150104779 HTR2A gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000003441 thioacyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
A találmány új, a dopamin D4 receptorok vonatkozásában affinitástmutató 3-indolin-származékokra vonatkozik. A találmány szerintivegyületek felhasználhatók bizonyos pszichiátriai és neurológiairendellenességek, különösen különböző pszichózisok kezelésére. Atalálmány szerinti vegyületek továbbá affinitást mutatnak az 5-HT2Areceptorok vonatkozásában is. A találmány szerinti vegyületek (I)általános képletében R1 jelentése acil-, tioacil- vagytrifluormetilszulfonilcsoport vagy R12SO2-, R12OCOvagy R12SCO-általános képletű csoport - ezekben a képletekben R12 jelentésealkil-, alkenil-, alkinil-, cikloalkil-, cikloalkilalkil- vagyarilcsoport - vagy R13R14NCO vagy R13R14NCS- általános képletűcsoport, és az utóbbi két képletben R13 és R14 egymástól függetlenülhidrogénatomot vagy alkil-, alkenil-, alkinil-, cikloalkil-,cikloalkilalkil- vagy arilcsoportot jelent vagy R13 és R14 együttpirrolidinil-, piperidinil- vagy perhidroazepinilcsoportot alkotnakazzal a nitrogénatommal, amelyhez kapcsolódnak; n értéke 1 és 6közötti egész szám; X jelentése szén- vagy nitrogénatom vagymetincsoport, és az X helyettesítőből kiinduló szaggatott vonal kémiaikötést jelent, ha X jelentése szénatom, illetve nem jelent kötést, haX jelentése nitrogénatom vagy metincsoport; R', R< és R2 egymástólfüggetlenül hidrogénatomot vagy halogénatommal adott esetbenszubsztituált alkilcsoportot jelent; és R3-R11 egymástól függetlenülhidrogén- vagy halogénatomot vagy ciano-, nitro-, alkil-, alkenil-,alkinil-, cikloalkil-, cikloalkilalkil-, amino-, alkilamino-,dialkilamino-, alkilkarbonil-, aminokarbonil-, alkilaminokarbonil-,dialkilaminokarbonil-, alkoxi-, alkiltio-, alkilszulfonil-, hidroxi-,trifluormetil- vagy trifluormetilszulfonilcsoportot jeIent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001931 | 2000-12-22 | ||
| PCT/DK2001/000835 WO2002051833A1 (en) | 2000-12-22 | 2001-12-18 | 3-indoline derivatives useful in the treatment of psychiatric and neurologic disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0500350A2 true HUP0500350A2 (hu) | 2005-08-29 |
Family
ID=8159925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500350A HUP0500350A2 (hu) | 2000-12-22 | 2001-12-18 | Pszichiátriai és neurológiai rendellenességek kezelésére alkalmas 3-indol-származékok |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20040044007A1 (hu) |
| EP (1) | EP1345921A1 (hu) |
| JP (1) | JP2004516321A (hu) |
| KR (1) | KR20030063455A (hu) |
| CN (1) | CN1491223A (hu) |
| AR (1) | AR035521A1 (hu) |
| BG (1) | BG107982A (hu) |
| BR (1) | BR0116365A (hu) |
| CA (1) | CA2432473A1 (hu) |
| CZ (1) | CZ20032004A3 (hu) |
| EA (1) | EA200300718A1 (hu) |
| HU (1) | HUP0500350A2 (hu) |
| IL (1) | IL156340A0 (hu) |
| IS (1) | IS6837A (hu) |
| MX (1) | MXPA03005555A (hu) |
| NO (1) | NO20032636D0 (hu) |
| PL (1) | PL362133A1 (hu) |
| SK (1) | SK9342003A3 (hu) |
| WO (1) | WO2002051833A1 (hu) |
| ZA (1) | ZA200304643B (hu) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20012060A1 (it) * | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| US7884096B2 (en) | 2003-12-02 | 2011-02-08 | Pharmaneuroboost N.V. | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| US8304431B2 (en) | 2003-12-02 | 2012-11-06 | Pharmaneuroboost N.V. | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| US7855195B2 (en) | 2003-12-02 | 2010-12-21 | Pharmaneuroboost N.V. | Method of treating mental disorders using D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| US7812176B2 (en) | 2004-03-23 | 2010-10-12 | Arena Pharmaceuticals, Inc. | Processes for preparing substituted N-aryl-N′-[3-(1H-pyrazol-5-YL) phenyl] ureas and intermediates thereof |
| PT1751138E (pt) * | 2004-05-11 | 2008-02-25 | Egis Gyogyszergyar Nyrt | Derivados de indol-2-ona para o tratamento de desordens nervosas centrais, desordens gastrointestinais e desordens cardiovasculares. |
| CA2565061A1 (en) * | 2004-05-11 | 2005-11-17 | Balazs Volk | Pyridine derivatives of alkyl oxindoles as 5-ht7 receptor active agents |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| PE20061130A1 (es) | 2004-11-19 | 2007-01-05 | Arena Pharm Inc | Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a |
| USRE45337E1 (en) | 2006-05-18 | 2015-01-13 | Arena Pharmaceuticals, Inc. | Ethers, secondary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| MX2008014622A (es) | 2006-05-18 | 2008-11-28 | Arena Pharm Inc | Formas cristalinas y procesos para la preparacion de fenil-pirazoles utiles como moduladores del receptor de serotonina 5-ht2a. |
| US8148417B2 (en) | 2006-05-18 | 2012-04-03 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| KR100868353B1 (ko) * | 2007-03-08 | 2008-11-12 | 한국화학연구원 | 도파민 ｄ4 수용체 길항제인 신규 피페라지닐프로필피라졸유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| JP5393677B2 (ja) | 2007-08-15 | 2014-01-22 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ＨＴ２Ａセロトニン受容体に関連した障害の治療のための５−ＨＴ２Ａセロトニン受容体のモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン誘導体 |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| KR101062376B1 (ko) | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
| HUE036506T2 (hu) | 2008-10-28 | 2018-07-30 | Arena Pharm Inc | 5-HT2A szerotonin receptor modulátort tartalmazó készítmények az ilyen receptor modulátorokkal kapcsolatos rendellenességek kezelésére |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| WO2011075596A1 (en) | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| WO2016192657A1 (en) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
| MX2017016413A (es) | 2015-06-12 | 2018-08-01 | Axovant Sciences Gmbh | Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamineto de un trastorno conductual del sueño rem. |
| JP2018520187A (ja) | 2015-07-15 | 2018-07-26 | アクソヴァント サイエンシーズ ゲゼルシャフト ミット ベシュレンクテル ハフツングAxovant Sciences GmbH | 神経変性疾患と関連する幻覚の予防および処置のために有用な５−ｈｔ２ａセロトニン受容体のモジュレーターとしてのジアリールおよびアリールヘテロアリール尿素誘導体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3751417A (en) * | 1971-08-12 | 1973-08-07 | American Cyanamid Co | 1-acyl-3-(2-(4-phenyl-1-piperazinyl)ethyl)indolines |
| US3900563A (en) * | 1973-06-18 | 1975-08-19 | American Cyanamid Co | Method of using 3-(2-(4-phenyl-1-piperazinyl)ethyl)-indolines |
| US4302589A (en) * | 1980-05-08 | 1981-11-24 | American Cyanamid Company | Cis-mono and disubstituted-2-methyl-3-[(piperazinyl) and (piperidino)ethyl]indolines, intermediates for their preparation and methods of preparation |
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| DE4101686A1 (de) * | 1991-01-22 | 1992-07-23 | Merck Patent Gmbh | Indolderivate |
| NZ243065A (en) * | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| GB9305623D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
| DE19512639A1 (de) * | 1995-04-05 | 1996-10-10 | Merck Patent Gmbh | Benzonitrile und -fluoride |
| ITMI20012060A1 (it) * | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
-
2001
- 2001-12-17 AR ARP010105843A patent/AR035521A1/es not_active Application Discontinuation
- 2001-12-18 ZA ZA200304643A patent/ZA200304643B/en unknown
- 2001-12-18 KR KR10-2003-7008437A patent/KR20030063455A/ko not_active Application Discontinuation
- 2001-12-18 CZ CZ20032004A patent/CZ20032004A3/cs unknown
- 2001-12-18 SK SK934-2003A patent/SK9342003A3/sk unknown
- 2001-12-18 IL IL15634001A patent/IL156340A0/xx unknown
- 2001-12-18 CN CNA018227481A patent/CN1491223A/zh active Pending
- 2001-12-18 CA CA002432473A patent/CA2432473A1/en not_active Abandoned
- 2001-12-18 EP EP01271969A patent/EP1345921A1/en not_active Withdrawn
- 2001-12-18 MX MXPA03005555A patent/MXPA03005555A/es unknown
- 2001-12-18 EA EA200300718A patent/EA200300718A1/ru unknown
- 2001-12-18 PL PL36213301A patent/PL362133A1/xx unknown
- 2001-12-18 BR BR0116365-5A patent/BR0116365A/pt not_active Application Discontinuation
- 2001-12-18 WO PCT/DK2001/000835 patent/WO2002051833A1/en not_active Application Discontinuation
- 2001-12-18 HU HU0500350A patent/HUP0500350A2/hu unknown
- 2001-12-18 JP JP2002552928A patent/JP2004516321A/ja not_active Withdrawn
-
2003
- 2003-06-05 IS IS6837A patent/IS6837A/is unknown
- 2003-06-11 NO NO20032636A patent/NO20032636D0/no not_active Application Discontinuation
- 2003-06-17 US US10/601,347 patent/US20040044007A1/en not_active Abandoned
- 2003-07-08 BG BG107982A patent/BG107982A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20040044007A1 (en) | 2004-03-04 |
| CN1491223A (zh) | 2004-04-21 |
| PL362133A1 (en) | 2004-10-18 |
| JP2004516321A (ja) | 2004-06-03 |
| NO20032636L (no) | 2003-06-11 |
| IL156340A0 (en) | 2004-01-04 |
| CA2432473A1 (en) | 2002-07-04 |
| BR0116365A (pt) | 2004-07-06 |
| MXPA03005555A (es) | 2004-03-26 |
| SK9342003A3 (en) | 2003-10-07 |
| AR035521A1 (es) | 2004-06-02 |
| EP1345921A1 (en) | 2003-09-24 |
| EA200300718A1 (ru) | 2003-10-30 |
| BG107982A (bg) | 2004-08-31 |
| ZA200304643B (en) | 2004-07-19 |
| IS6837A (is) | 2003-06-05 |
| NO20032636D0 (no) | 2003-06-11 |
| WO2002051833A1 (en) | 2002-07-04 |
| CZ20032004A3 (cs) | 2003-10-15 |
| KR20030063455A (ko) | 2003-07-28 |
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