HUP0500095A3 - Enzymatic cycling assays for homocysteine and cystathionine - Google Patents
Enzymatic cycling assays for homocysteine and cystathionineInfo
- Publication number
- HUP0500095A3 HUP0500095A3 HU0500095A HUP0500095A HUP0500095A3 HU P0500095 A3 HUP0500095 A3 HU P0500095A3 HU 0500095 A HU0500095 A HU 0500095A HU P0500095 A HUP0500095 A HU P0500095A HU P0500095 A3 HUP0500095 A3 HU P0500095A3
- Authority
- HU
- Hungary
- Prior art keywords
- cystathionine
- homocysteine
- enzymatic cycling
- cycling assays
- assays
- Prior art date
Links
- YPWSLBHSMIKTPR-UHFFFAOYSA-N Cystathionine Natural products OC(=O)C(N)CCSSCC(N)C(O)=O YPWSLBHSMIKTPR-UHFFFAOYSA-N 0.000 title 1
- ILRYLPWNYFXEMH-UHFFFAOYSA-N D-cystathionine Natural products OC(=O)C(N)CCSCC(N)C(O)=O ILRYLPWNYFXEMH-UHFFFAOYSA-N 0.000 title 1
- ILRYLPWNYFXEMH-WHFBIAKZSA-N L-cystathionine Chemical compound [O-]C(=O)[C@@H]([NH3+])CCSC[C@H]([NH3+])C([O-])=O ILRYLPWNYFXEMH-WHFBIAKZSA-N 0.000 title 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 230000001351 cycling effect Effects 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/012,762 US6635438B2 (en) | 1999-11-02 | 2001-11-06 | Enzymatic cycling assays for homocysteine and cystathionine |
| PCT/US2002/035777 WO2003040694A2 (en) | 2001-11-06 | 2002-11-06 | Enzymatic cycling assays for homocysteine and cystathionine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0500095A2 HUP0500095A2 (hu) | 2005-05-30 |
| HUP0500095A3 true HUP0500095A3 (en) | 2010-03-29 |
| HU228343B1 HU228343B1 (en) | 2013-03-28 |
Family
ID=21756556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500095A HU228343B1 (en) | 2001-11-06 | 2002-11-06 | Enzymatic cycling assays for homocysteine and cystathionine |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6635438B2 (hu) |
| EP (1) | EP1470242B1 (hu) |
| CN (1) | CN1612937B (hu) |
| AU (1) | AU2002352538A1 (hu) |
| BR (1) | BRPI0213936B8 (hu) |
| DK (1) | DK1470242T3 (hu) |
| HU (1) | HU228343B1 (hu) |
| NO (1) | NO20042144L (hu) |
| RU (1) | RU2344176C2 (hu) |
| SK (1) | SK288189B6 (hu) |
| WO (1) | WO2003040694A2 (hu) |
| ZA (1) | ZA200403395B (hu) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635438B2 (en) * | 1999-11-02 | 2003-10-21 | Catch, Inc. | Enzymatic cycling assays for homocysteine and cystathionine |
| GB0008784D0 (en) * | 2000-04-10 | 2000-05-31 | Axis Shield Plc | Assay |
| GB0311804D0 (en) * | 2003-05-22 | 2003-06-25 | Univ Glasgow | Improved homocysteine assay |
| US7097968B2 (en) * | 2003-07-10 | 2006-08-29 | General Atomics | Methods and compositions for assaying homocysteine |
| US8476034B2 (en) * | 2003-07-10 | 2013-07-02 | General Atomics | Methods and compositions for assaying homocysteine |
| DE10342264C5 (de) | 2003-09-12 | 2012-10-31 | Leica Biosystems Nussloch Gmbh | System zum eindeutigen Zuordnen von histologischen Kassetten und Objektträgern |
| GB0428130D0 (en) * | 2004-12-22 | 2005-01-26 | Oxford Biosensors Ltd | Selective HDL cholesterol assay |
| CA2618699C (en) * | 2005-08-11 | 2012-10-02 | J. Craig Venter Institute, Inc. | In vitro recombination method |
| EP1976876A4 (en) * | 2005-12-22 | 2010-01-13 | Conjuchem Biotechnologies Inc | PROCESS FOR PRODUCING PREFORMED ALBUMIN CONJUGATES AND THERAPEUTIC AGENT |
| WO2009039298A2 (en) | 2007-09-18 | 2009-03-26 | University Of Florida Research Foundation, Inc. | Sensors using aigan/gan high electron mobility transistors |
| WO2009091581A2 (en) * | 2008-01-18 | 2009-07-23 | Vatrix Medical, Inc. | Diagnostic biomarkers for vascular aneurysm |
| WO2010054159A2 (en) * | 2008-11-06 | 2010-05-14 | University Of Florida Research Foundation, Inc. | Materials and methods for detecting toxins, pathogens and other biological materials |
| RU2012132313A (ru) * | 2009-12-30 | 2014-02-10 | Зэ Стейт Оф Орегон Эктинг Бай Энд Сру Зэ Стейт Боард Оф Хайе Эдьюкейшн Он Бехалф Оф Портланд Стейт Юниверсити | Обнаружение тиола |
| US9216209B1 (en) | 2011-06-06 | 2015-12-22 | Kilmer S. McCully | Compositions and method for utilization of thioretinamide in therapy of degenerative diseases of aging |
| RU2471181C1 (ru) * | 2011-06-20 | 2012-12-27 | Открытое акционерное общество Научно-производственное объединение "Химавтоматика" | Способ определения суммарного содержания антиоксидантов и суммарного содержания антоцианов в пищевых продуктах и напитках |
| US9034318B2 (en) * | 2011-08-30 | 2015-05-19 | The Regents Of The University Of Colorado, A Body Corporate | Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria |
| JP5914019B2 (ja) * | 2012-02-03 | 2016-05-11 | 旭化成ファーマ株式会社 | 酵素サイクリング反応によるメバロン酸の測定方法およびその校正試料 |
| CN104755926B (zh) | 2012-08-24 | 2017-12-01 | 卡斯西部储备大学 | 用于检测α‑甲酰基‑CoA消旋酶(AMACR)和前列腺癌的系统和方法 |
| CN103674873B (zh) * | 2013-11-22 | 2015-05-20 | 杭州利安生物科技有限公司 | 一种定量检测丝氨酸的方法 |
| CN104111338B (zh) * | 2014-05-07 | 2016-03-02 | 山东博科生物产业有限公司 | 一种抗干扰性强的同型半胱氨酸检测试剂盒 |
| US11009479B2 (en) | 2014-05-27 | 2021-05-18 | Case Western Reserve University | Systems and methods for the detection of HbA1c |
| US10465229B2 (en) | 2014-05-27 | 2019-11-05 | Case Western Reserve University | System and method for detecting neural injury |
| US10883956B2 (en) | 2014-05-27 | 2021-01-05 | Case Western Reserve University | Electrochemical sensor for analyte detection |
| CN104198726B (zh) * | 2014-08-14 | 2016-07-06 | 上海睿康生物科技有限公司 | 一种稳定的同型半胱氨酸检测试剂盒 |
| CN105039368A (zh) * | 2015-07-08 | 2015-11-11 | 北京嘉万生物技术有限公司 | 一种重组酵母胱硫醚beta合酶催化中心的表达及放大生产 |
| CN105181970B (zh) * | 2015-08-28 | 2017-05-03 | 宁波瑞源生物科技有限公司 | 一种稳定的同型半胱氨酸检测试剂盒 |
| CN106970230B (zh) * | 2017-03-29 | 2019-06-11 | 广州市伊川生物科技有限公司 | 一种同型半胱氨酸测定试剂盒 |
| CN110346572A (zh) * | 2018-04-04 | 2019-10-18 | 浙江力耐得传动科技有限公司 | 偶联丙酮酸氧化酶测定同型半胱氨酸（Hcy）的方法及测定试剂盒 |
| CN108802125B (zh) * | 2018-08-28 | 2023-09-15 | 长沙理工大学 | 基于七(6-巯基-6-去氧)-β-环糊精的L-半胱氨酸的检测方法及传感器 |
| CN109975279B (zh) * | 2019-03-07 | 2021-05-28 | 广州悦蜂生物防治科技有限公司 | 一种检测脂肪酶活性的方法、试剂盒及速测卡 |
| US11697807B2 (en) | 2019-09-30 | 2023-07-11 | Case Western Reserve University | Electrochemical biosensor |
| CN110954581A (zh) * | 2019-12-19 | 2020-04-03 | 湖南海源医疗科技股份有限公司 | 一种快速检测同型半胱氨酸的电化学方法 |
| CN114689415A (zh) * | 2020-12-31 | 2022-07-01 | 桂林优利特医疗电子有限公司 | 一种稳定性好的同型半胱氨酸检测试剂盒及制备方法 |
| CN114277021B (zh) * | 2021-11-19 | 2022-09-20 | 武汉瀚海新酶生物科技有限公司 | 胱硫醚-β-裂解酶及其制备方法和应用 |
| CN114807199A (zh) * | 2022-02-22 | 2022-07-29 | 三诺生物传感股份有限公司 | 重组胱硫醚β-裂解酶的制备方法及其应用 |
| CN115725556B (zh) * | 2022-09-20 | 2024-05-03 | 青岛硕景生物科技有限公司 | 一种稳定性提高的突变胱硫醚β裂解酶及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6063581A (en) | 1992-01-22 | 2000-05-16 | Axis-Shield Asa | Immunoassay for homocysteine |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US5563036A (en) | 1994-04-29 | 1996-10-08 | Tularik, Inc. | Transcription factor-DNA binding assay |
| US5627645A (en) | 1994-09-30 | 1997-05-06 | New Oji Paper Co., Ltd. | Method of and apparatus for measuring retardation of composite layer |
| US5635375A (en) | 1995-01-09 | 1997-06-03 | Regents Of The University Of Colorado | Method of increasing the yield and heme saturation of cystathione β-synthase |
| GB9617683D0 (en) * | 1996-08-23 | 1996-10-02 | Univ Glasgow | Homocysteine desulphurase |
| US5985540A (en) | 1997-07-24 | 1999-11-16 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
| US6066467A (en) * | 1997-07-24 | 2000-05-23 | Anticancer, Inc. | High specificity homocysteine assays for biological samples |
| US5885767A (en) | 1998-05-22 | 1999-03-23 | Biocatalytics, Inc. | Methods and compositions for quantitating L-homocysteine and/or l-methionine in a solution |
| US6174696B1 (en) * | 1999-11-12 | 2001-01-16 | Genzyme Corporation | Method for the determination of homocysteine |
| AU777349B2 (en) | 1998-11-12 | 2004-10-14 | Axis-Shield Diagnostics, Ltd. | A method for the determination of homocysteine |
| US6046017A (en) | 1999-06-14 | 2000-04-04 | Virginia Commonwealth University | Rapid and sensitive assay for homocysteine |
| US6664073B1 (en) * | 1999-11-02 | 2003-12-16 | Catch Inc. | Enzymatic cycling assays for homocysteine and cystathionine |
| US6635438B2 (en) * | 1999-11-02 | 2003-10-21 | Catch, Inc. | Enzymatic cycling assays for homocysteine and cystathionine |
| US6305597B1 (en) | 2000-07-20 | 2001-10-23 | Impac Group, Inc. | One-piece folding carton with integrally formed sliding display hang tab |
-
2001
- 2001-11-06 US US10/012,762 patent/US6635438B2/en not_active Expired - Lifetime
-
2002
- 2002-11-06 CN CN028268083A patent/CN1612937B/zh not_active Ceased
- 2002-11-06 BR BRPI0213936A patent/BRPI0213936B8/pt not_active IP Right Cessation
- 2002-11-06 RU RU2004117087/13A patent/RU2344176C2/ru active
- 2002-11-06 AU AU2002352538A patent/AU2002352538A1/en not_active Abandoned
- 2002-11-06 EP EP02789500.2A patent/EP1470242B1/en not_active Expired - Lifetime
- 2002-11-06 ZA ZA200403395A patent/ZA200403395B/xx unknown
- 2002-11-06 DK DK02789500.2T patent/DK1470242T3/da active
- 2002-11-06 SK SK204-2004A patent/SK288189B6/sk not_active IP Right Cessation
- 2002-11-06 HU HU0500095A patent/HU228343B1/hu unknown
- 2002-11-06 WO PCT/US2002/035777 patent/WO2003040694A2/en not_active Application Discontinuation
-
2003
- 2003-08-28 US US10/651,183 patent/US6867014B2/en not_active Expired - Lifetime
-
2004
- 2004-05-25 NO NO20042144A patent/NO20042144L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002352538A1 (en) | 2003-05-19 |
| US6867014B2 (en) | 2005-03-15 |
| HU228343B1 (en) | 2013-03-28 |
| BRPI0213936B8 (pt) | 2021-07-27 |
| ZA200403395B (en) | 2006-06-28 |
| RU2004117087A (ru) | 2005-04-27 |
| HUP0500095A2 (hu) | 2005-05-30 |
| WO2003040694A3 (en) | 2004-08-19 |
| BRPI0213936B1 (pt) | 2015-08-25 |
| CN1612937B (zh) | 2010-05-05 |
| RU2344176C2 (ru) | 2009-01-20 |
| SK2042004A3 (en) | 2004-10-05 |
| US6635438B2 (en) | 2003-10-21 |
| WO2003040694A2 (en) | 2003-05-15 |
| BR0213936A (pt) | 2004-08-31 |
| EP1470242A2 (en) | 2004-10-27 |
| US20030138872A1 (en) | 2003-07-24 |
| US20040096929A1 (en) | 2004-05-20 |
| NO20042144L (no) | 2004-08-06 |
| EP1470242B1 (en) | 2013-08-14 |
| SK288189B6 (sk) | 2014-05-06 |
| CN1612937A (zh) | 2005-05-04 |
| DK1470242T3 (da) | 2013-11-11 |
| EP1470242A4 (en) | 2007-01-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB9A | Succession in title |
Owner name: AXIS-SHIELD DIAGNOSTICS, LTD., GB Free format text: FORMER OWNER(S): CATCH, INC., US |