HUP0402659A3 - Chromosome-based platforms - Google Patents

Chromosome-based platforms

Info

Publication number
HUP0402659A3
HUP0402659A3 HU0402659A HUP0402659A HUP0402659A3 HU P0402659 A3 HUP0402659 A3 HU P0402659A3 HU 0402659 A HU0402659 A HU 0402659A HU P0402659 A HUP0402659 A HU P0402659A HU P0402659 A3 HUP0402659 A3 HU P0402659A3
Authority
HU
Hungary
Prior art keywords
chromosome
based platforms
platforms
Prior art date
Application number
HU0402659A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of HUP0402659A2 publication Critical patent/HUP0402659A2/hu
Publication of HUP0402659A3 publication Critical patent/HUP0402659A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases RNAses, DNAses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/10011Details dsDNA Bacteriophages
    • C12N2795/10311Siphoviridae
    • C12N2795/10322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/108Plasmid DNA episomal vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/20Pseudochromosomes, minichrosomosomes
    • C12N2800/208Pseudochromosomes, minichrosomosomes of mammalian origin, e.g. minichromosome
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/15Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/40Vector systems having a special element relevant for transcription being an insulator
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/60Vector systems having a special element relevant for transcription from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/80Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85Vector systems having a special element relevant for transcription from vertebrates mammalian
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells
HU0402659A 2001-05-30 2002-05-30 Chromosome-based platforms HUP0402659A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29475801P 2001-05-30 2001-05-30
US36689102P 2002-03-21 2002-03-21
PCT/US2002/017452 WO2002097059A2 (en) 2001-05-30 2002-05-30 Chromosome-based platforms

Publications (2)

Publication Number Publication Date
HUP0402659A2 HUP0402659A2 (en) 2007-07-30
HUP0402659A3 true HUP0402659A3 (en) 2008-07-28

Family

ID=26968714

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402659A HUP0402659A3 (en) 2001-05-30 2002-05-30 Chromosome-based platforms

Country Status (11)

Country Link
US (5) US20030119104A1 (hu)
EP (1) EP1390384A4 (hu)
JP (2) JP4489424B2 (hu)
AU (1) AU2002310275B2 (hu)
BR (1) BR0209989A (hu)
CA (1) CA2441937A1 (hu)
HU (1) HUP0402659A3 (hu)
IL (1) IL157746A0 (hu)
MX (1) MXPA03010626A (hu)
NZ (2) NZ545697A (hu)
WO (1) WO2002097059A2 (hu)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160970A1 (en) * 1996-04-10 2002-10-31 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20030033617A1 (en) * 1996-04-10 2003-02-13 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6936469B2 (en) * 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US7294511B2 (en) * 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
IL157746A0 (en) 2001-05-30 2004-03-28 Chromos Molecular Systems Inc Chromosome-based platforms
JP4771656B2 (ja) * 2001-05-30 2011-09-14 カリックス・バイオ−ベンチャーズ・インコーポレイテッド 植物人工染色体、その使用及び植物人工染色体の製造方法
ITMI20012110A1 (it) * 2001-10-12 2003-04-12 Keryos Spa Vettori multi-cistronici utilizzabili in protocolli di trsferimento genico
AU2002350039A1 (en) 2001-10-29 2003-05-12 Renovis, Inc. Method for isolating cell-type specific mrnas
EP1470148B1 (en) 2002-02-01 2012-07-18 Life Technologies Corporation Double-stranded oligonucleotides
US20030166282A1 (en) * 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
AU2003304425A1 (en) * 2002-06-04 2005-03-07 Michele Calos Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same
US20100075423A1 (en) * 2002-06-12 2010-03-25 Life Technologies Corporation Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
EP1532271A4 (en) * 2002-06-12 2006-10-18 Ambion Inc METHODS AND COMPOSITIONS RELATED TO POLYPEPTIDES WITH RNASE III DOMAINS THAT TRANSFER RNA INTERFERENCE
WO2004022741A1 (ja) * 2002-09-03 2004-03-18 Japan Science And Technology Agency 哺乳類人工染色体
JP2006503583A (ja) * 2002-10-24 2006-02-02 バイオジェン・アイデック・エムエイ・インコーポレイテッド フェリチン重鎖遺伝子座に基づいた高発現遺伝子座ベクター
US20060277610A1 (en) * 2002-10-29 2006-12-07 Shunsuke Ishi Construction of knockdown animal by transferring double-stranded rna expression vector
WO2005028615A2 (en) * 2003-06-26 2005-03-31 Invitrogen Corporation Methods and compositions for detecting promoter activity and expressing fusion proteins
US7330851B2 (en) * 2003-08-18 2008-02-12 Eaglehawk, Limited Data security through dissembly of data elements or connections between elements
AU2004282558A1 (en) * 2003-10-14 2005-04-28 Biogen Idec Ma Inc. FLP-mediated recombination
AU2005210493B2 (en) 2004-02-02 2009-06-04 Pioneer Hi-Bred International, Inc. AP2 domain transcription factor ODP2 (ovule development protein 2) and methods of use
US20060174364A1 (en) * 2004-03-01 2006-08-03 Avigenics, Inc. Artificial chromosomes and transchromosomic avians
ES2679282T3 (es) 2004-10-22 2018-08-23 Revivicor Inc. Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena
WO2006055931A2 (en) * 2004-11-18 2006-05-26 Stratatech Corporation Vectors for stable gene expression
US20060142228A1 (en) * 2004-12-23 2006-06-29 Ambion, Inc. Methods and compositions concerning siRNA's as mediators of RNA interference
US8315816B2 (en) * 2005-02-16 2012-11-20 Genetic Technologies Limited Methods of genetic analysis involving the amplification of complementary duplicons
US20070031390A1 (en) * 2005-05-18 2007-02-08 Daniel Weeks Methods and compositions for site-specific genomic expression of nucleic acid sequences
JP4895100B2 (ja) * 2006-05-01 2012-03-14 国立大学法人鳥取大学 内在遺伝子を含まないヒト人工染色体ベクター
CA2652598A1 (en) * 2006-05-17 2007-11-29 Pioneer Hi-Bred International, Inc. Artificial plant minichromosomes
US20090165176A1 (en) * 2006-05-17 2009-06-25 Pioneer Hi-Bred International, Inc. Artificial Plant Minichromosomes
US20090100550A1 (en) * 2006-05-17 2009-04-16 Pioneer Hi-Bred International, Inc. Artificial Plant Minichromosomes
NZ574140A (en) 2006-07-05 2012-02-24 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
US20090191542A1 (en) * 2006-08-23 2009-07-30 Xcellerex, Inc. Multi-variant cell indication technique
AR070141A1 (es) * 2008-01-23 2010-03-17 Glenmark Pharmaceuticals Sa Anticuerpos humanizados especificos para el factor von willebrand
EP2265730B1 (en) 2008-03-12 2018-06-06 The Rockefeller University Methods and compositions for translational profiling and molecular phenotyping
EP2348827B1 (en) 2008-10-27 2015-07-01 Revivicor, Inc. Immunocompromised ungulates
EP3372687B1 (en) * 2008-11-28 2022-01-12 Anton Bauer Artificial chromosome vector
AU2010221135A1 (en) * 2009-03-05 2011-09-29 Metabolix, Inc. Propagation of transgenic plants
WO2010102293A1 (en) 2009-03-06 2010-09-10 Metabolix, Inc. Method of positive plant selection using sorbitol dehydrogenase
US8778890B2 (en) * 2009-03-31 2014-07-15 Temple University—Of the Commonwealth System of Higher Education Leptin antagonist and methods of use
US9181559B2 (en) 2009-09-15 2015-11-10 Metabolix, Inc. Generation of high polyhydroxybutyrate producing oilseeds
US20110167516A1 (en) 2009-12-30 2011-07-07 Pioneer Hi-Bred International, Inc. Methods and compositions for the introduction and regulated expression of genes in plants
WO2011082310A2 (en) 2009-12-30 2011-07-07 Pioneer Hi-Bred International, Inc. Methods and compositions for targeted polynucleotide modification
SG183929A1 (en) * 2010-03-29 2012-10-30 Univ Pennsylvania Pharmacologically induced transgene ablation system
WO2013006861A1 (en) 2011-07-07 2013-01-10 University Of Georgia Research Foundation, Inc. Sorghum grain shattering gene and uses thereof in altering seed dispersal
WO2013184768A1 (en) 2012-06-05 2013-12-12 University Of Georgia Research Foundation, Inc. Compositions and methods of gene silencing in plants
CA2881787A1 (en) 2012-08-13 2014-02-20 University Of Georgia Research Foundation, Inc. Compositions and methods for increasing pest resistance in plants
HU230368B1 (hu) 2012-11-16 2016-03-29 Magyar Tudományos Akadémia Szegedi Biológiai Kutatóközpont Új módszer az emlős mesterséges kromoszóma több génnel való feltöltésére
AU2013361456A1 (en) 2012-12-18 2015-07-02 Metabolix, Inc. Transcriptional regulation for improved plant productivity
GB201414130D0 (en) * 2014-08-08 2014-09-24 Agency Science Tech & Res Mutants of the bacteriophage lambda integrase
JP6734283B2 (ja) * 2015-01-21 2020-08-05 フレッド ハッチンソン キャンサー リサーチ センター 遺伝子治療用ポイントオブケア及び/又はポータブルプラットフォーム
EP3256582A4 (en) 2015-02-09 2018-06-20 Edward Perkins Compositions and methods for monitoring in real-time construction and bioengineering of mammalian synthetic chromosomes
US11174467B2 (en) 2015-04-08 2021-11-16 Yield10 Bioscience, Inc. Plants with enhanced yield and methods of construction
ES2959326T3 (es) 2015-11-24 2024-02-23 Glaxosmithkline Ip Dev Ltd Líneas celulares estables para producción retroviral
US10450574B2 (en) 2015-11-24 2019-10-22 Glaxosmithkline Intellectual Property Development Limited Transient transfection method for retroviral production
AU2017250265B2 (en) * 2016-04-12 2023-08-17 CarryGenes Bioengineering Methods for creating synthetic chromosomes having gene regulatory systems and uses thereof
CN109328232A (zh) 2016-04-12 2019-02-12 辛普洛德生物技术有限责任公司 用于产生表达生物合成通路的合成染色体的方法及其用途
CA3020965A1 (en) 2016-04-12 2017-10-19 Synploid Biotek, Llc Sequential loadings of multiple delivery vectors using a single selectable marker
BR112018074094A2 (pt) 2016-05-27 2019-03-06 Univ Illinois plantas transgênicas com aumento da eficiência e do crescimento da fotossíntese
AU2017377068B2 (en) 2016-12-15 2022-12-08 CarryGenes Bioengineering Methods of cell renewal
EP3583121A1 (en) * 2017-02-17 2019-12-25 Lonza Ltd Multi-site specific integration cells for difficult to express proteins
WO2018169892A1 (en) * 2017-03-15 2018-09-20 Synploid Biotek, Llc Compositions and methods of chromosomal silencing
GB201706121D0 (en) 2017-04-18 2017-05-31 Glaxosmithkline Ip Dev Ltd Stable cell lines for retroviral production
CA3073321A1 (en) 2017-09-05 2019-03-14 Synploid Biotek, Llc Lineage reporter synthetic chromosomes and methods of use
WO2019088257A1 (ja) * 2017-11-02 2019-05-09 国立大学法人鳥取大学 哺乳類人工染色体ベクターを利用するタンパク質の高生産方法
JP6823791B2 (ja) * 2018-09-25 2021-02-03 国立研究開発法人産業技術総合研究所 人工染色体ベクター及び形質転換哺乳類細胞
GB201816919D0 (en) 2018-10-17 2018-11-28 Glaxosmithkline Ip Dev Ltd Adeno-associated viral vector producer cell lines
EP4363595A1 (en) * 2021-06-28 2024-05-08 Inpamac Biotech Canada Inc. Compositions, constructs, cells and methods for increased recombinant protein expression by site-specific integration
WO2023215399A1 (en) * 2022-05-03 2023-11-09 University Of Southern California Assembling synthetic dna constructs from natural dna
JP7212982B1 (ja) * 2022-10-05 2023-01-26 株式会社Logomix 細胞ライブラリおよびその製造方法
WO2024075756A1 (ja) * 2022-10-05 2024-04-11 株式会社Logomix 細胞ライブラリおよびその製造方法

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US187936A (en) * 1877-02-27 Improvement in detecters of counterfeit coin
US5393A (en) * 1847-12-11 Apparatus for clubfeet
US107572A (en) * 1870-09-20 Improvement in shoe-fastenings
US109351A (en) * 1870-11-15 Improvement in sawing-machines
US11155A (en) * 1854-06-27 Improvement in grass-harvesters
US224930A (en) * 1880-02-24 Harness pipe-loop attachment for wax-thread sewing-machines
US4673640A (en) * 1984-04-30 1987-06-16 Biotechnica International, Inc. Regulated protein production using site-specific recombination
CA1293460C (en) * 1985-10-07 1991-12-24 Brian Lee Sauer Site-specific recombination of dna in yeast
US4775630A (en) * 1986-08-15 1988-10-04 Vanderbilt University Transcriptional control element adapted for regulation of gene expression in animal cells
US4801540A (en) * 1986-10-17 1989-01-31 Calgene, Inc. PG gene and its use in plants
US4920211A (en) * 1988-01-04 1990-04-24 Vanderbilt University Mutated adenovirus E1A gene for E1A promoter stimulation
US5270201A (en) 1988-03-24 1993-12-14 The General Hospital Corporation Artificial chromosome vector
GB8900483D0 (en) * 1989-01-10 1989-03-08 Celltech Ltd Recombinant dna method
US5190871A (en) * 1989-06-12 1993-03-02 Eli Lilly And Company Use of the site-specific integrating function of phage φC31
US5501967A (en) * 1989-07-26 1996-03-26 Mogen International, N.V./Rijksuniversiteit Te Leiden Process for the site-directed integration of DNA into the genome of plants
US5272071A (en) * 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5658772A (en) * 1989-12-22 1997-08-19 E. I. Du Pont De Nemours And Company Site-specific recombination of DNA in plant cells
CA2042093C (en) * 1990-05-09 2002-12-24 Gyula Hadlaczky Cell line carrying an excess of mammalian centromeres
US5288625A (en) * 1991-09-13 1994-02-22 Biologic Research Center Of The Hungarian Academy Of Sciences Mammalian artificial chromosomes
JP3314241B2 (ja) * 1992-04-06 2002-08-12 ヤマハ発動機株式会社 自動二輪車用エンジンの排気浄化装置
JPH07508410A (ja) * 1992-06-18 1995-09-21 ジェンファーム インターナショナル インコーポレイテッド 酵母人工染色体を有するトランスジェニック非ヒト動物の製造方法
US5527695A (en) * 1993-01-29 1996-06-18 Purdue Research Foundation Controlled modification of eukaryotic genomes
WO1994023049A2 (en) * 1993-04-02 1994-10-13 The Johns Hopkins University The introduction and expression of large genomic sequences in transgenic animals
IT1261847B (it) * 1993-09-01 1996-06-03 San Romanello Centro Fond Metodo per marcare cellule eucariote.
US5804177A (en) * 1993-11-15 1998-09-08 Humphries; R. Keith Method of using CD24 as a cell marker
US5641694A (en) * 1994-12-22 1997-06-24 International Business Machines Corporation Method of fabricating vertical epitaxial SOI transistor
FR2731014B1 (fr) * 1995-02-23 1997-03-28 Rhone Poulenc Rorer Sa Molecules d'adn, preparation et utilisation en therapie genique
US5691140A (en) * 1995-05-18 1997-11-25 New England Biolabs, Inc. Bidirectional in vitro transcription vectors utilizing a single RNA polymerase for both directions
DK0937098T3 (da) * 1995-06-07 2002-12-02 Invitrogen Corp Rekombinatorisk kloning under anvendelse af gensplejsede rekombinationssites
US5695967A (en) * 1995-06-07 1997-12-09 Case Western Reserve University Method for stably cloning large repeating units of DNA
US5869294A (en) * 1995-06-07 1999-02-09 Case Western Reserve University Method for stably cloning large repeating DNA sequences
US6133503A (en) * 1995-10-31 2000-10-17 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
US5721118A (en) * 1995-10-31 1998-02-24 The Regents Of The University Of California, San Diego Mammalian artificial chromosomes and methods of using same
AUPN903196A0 (en) 1996-03-29 1996-04-26 Australian National University, The Single-step excision means
US6025155A (en) * 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20020160970A1 (en) * 1996-04-10 2002-10-31 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US20030033617A1 (en) * 1996-04-10 2003-02-13 Gyula Hadlaczky Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) * 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6297029B1 (en) 1996-08-26 2001-10-02 Tsuneko Okazaki Mammalian artificial chromosomes
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
JP3151657B2 (ja) * 1997-03-26 2001-04-03 農林水産省農業生物資源研究所長 遺伝子導入法
US6365373B2 (en) * 1997-04-25 2002-04-02 Genentech, Inc. Nucleic acids encoding NGF variants
JP3544098B2 (ja) * 1997-05-19 2004-07-21 日本電産株式会社 動圧流体軸受装置
WO1998055637A1 (en) 1997-06-03 1998-12-10 Arch Development Corporation Plant artificial chromosome (plac) compositions and methods
US6114600A (en) * 1997-10-31 2000-09-05 The United States Of America As Represented By The Secretary Of Agriculture Resolution of complex integration patterns to obtain single copy transgenes
EP1574573B9 (en) 1997-11-18 2009-03-04 Pioneer Hi-Bred International, Inc. Compositions and methods for genetic modification of plants
CA2306188C (en) * 1997-11-18 2008-08-05 Pioneer Hi-Bred International, Inc. A novel method for the integration of foreign dna into eukaryotic genomes
CA2311282A1 (en) * 1997-11-28 1999-06-10 Medical Research Council Yac vectors
US6100092A (en) * 1998-06-15 2000-08-08 Board Of Trustees, Rutgers The State University Of New Jersey Materials and methods for amplifying polynucleotides in plants
KR20010083061A (ko) * 1998-06-23 2001-08-31 클라우디오 쿼르타 천연 생산물 생산 능력을 적합한 생산 숙주로 전달하는 방법
EP2348118A1 (en) 1998-07-21 2011-07-27 Millipore Corporation A polynucleotide comprising a ubiquitous chromatin opening element (ucoe)
US6171821B1 (en) * 1998-07-24 2001-01-09 Apoptogen, Inc. XIAP IRES and uses thereof
WO2000011155A1 (en) * 1998-08-19 2000-03-02 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for genomic modification
TWI255853B (en) * 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
EP1165792A2 (en) 1999-03-18 2002-01-02 The University of Chicago Plant centromeres
CA2367396A1 (en) 1999-04-06 2000-10-12 Oklahoma Medical Research Foundation Method for selecting recombinase variants with altered specificity
US6746870B1 (en) * 1999-07-23 2004-06-08 The Regents Of The University Of California DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
CA2379115C (en) * 1999-07-23 2011-04-26 The Regents Of The University Of California Dna recombination in eukaryotic cells by the bacteriophage phic31 recombination system
AU6511000A (en) 1999-08-02 2001-02-19 Baylor College Of Medicine Novel vectors and system for selectable targeted integration of transgenes into a chromosome without antibiotic resistance markers
US7247768B1 (en) * 1999-08-05 2007-07-24 Icon Genetics, Inc. Method of making plant artificial chromosomes
DE60027570T2 (de) 1999-08-05 2007-02-15 Icon Genetics, Inc. Verfahren zur herstellung künstlicher pflanzenchromosomen
DE19941186A1 (de) * 1999-08-30 2001-03-01 Peter Droege Sequenz-spezifische DNA-Rekombination in eukaryotischen Zellen
US7220567B2 (en) 2000-05-17 2007-05-22 Schering Corporation Isolation of Micromonospora carbonacea var africana pMLP1 integrase and use of integrating function for site-specific integration into Micromonospora halophitica and Micromonospora carbonacea chromosome
CN1455817A (zh) 2000-07-21 2003-11-12 (由农业部部长代表的)美利坚合众国 用于在真核基因组中置换、转移和富积dna的方法
EP1430124B1 (en) 2000-09-20 2013-11-06 EMD Millipore Corporation Artificial ubiquitous chromatin opening elements (ucoe)
US6376192B1 (en) * 2000-11-28 2002-04-23 Baylor College Of Medicine Method for screening of DNA libraries and generation of recombinant DNA constructs
US7294511B2 (en) * 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20030186390A1 (en) * 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
US6936469B2 (en) 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
WO2002076508A1 (en) 2001-03-22 2002-10-03 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
IL157746A0 (en) * 2001-05-30 2004-03-28 Chromos Molecular Systems Inc Chromosome-based platforms
JP4771656B2 (ja) * 2001-05-30 2011-09-14 カリックス・バイオ−ベンチャーズ・インコーポレイテッド 植物人工染色体、その使用及び植物人工染色体の製造方法
AU2003220642C1 (en) 2002-03-29 2009-01-29 Syngenta Participations Ag Lambda integrase mediated recombination in plants
CA2495787A1 (en) * 2002-05-01 2003-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
WO2010037208A1 (en) * 2008-10-03 2010-04-08 Dow Agrosciences Llc Production of products of pharmaceutical interest in plant cell cultures
NZ591972A (en) * 2008-10-03 2013-04-26 Agrisoma Biosciences Inc Production of modified fatty acids in plants

Also Published As

Publication number Publication date
US20050181506A1 (en) 2005-08-18
JP2005503778A (ja) 2005-02-10
US20030119104A1 (en) 2003-06-26
AU2002310275B2 (en) 2006-08-31
WO2002097059A9 (en) 2003-09-25
US7521240B2 (en) 2009-04-21
WO2002097059A2 (en) 2002-12-05
WO2002097059A3 (en) 2003-05-30
EP1390384A4 (en) 2005-08-17
JP4489424B2 (ja) 2010-06-23
BR0209989A (pt) 2005-04-12
EP1390384A2 (en) 2004-02-25
IL157746A0 (en) 2004-03-28
WO2002097059B1 (en) 2003-12-31
NZ545697A (en) 2008-06-30
MXPA03010626A (es) 2004-12-06
NZ528003A (en) 2006-09-29
CA2441937A1 (en) 2002-12-05
US20060246586A1 (en) 2006-11-02
HUP0402659A2 (en) 2007-07-30
JP2009017884A (ja) 2009-01-29
US20060024820A1 (en) 2006-02-02
US20120064578A1 (en) 2012-03-15

Similar Documents

Publication Publication Date Title
IL157746A0 (en) Chromosome-based platforms
DE60228850D1 (en) Thermoplastisches transparentes acrylnitril-butadien-styrol-harz (abs-harz)
AU2002360430A8 (en) 14-methyl-epothilones
AU2002313943A8 (en) Electromobile
GB0006193D0 (en) Platforms
GB0102393D0 (en) Cup-carrier
AU2001100134A4 (en) Enviro-trap
TW493677U (en) Doorstopper structure
TW574995U (en) Structure for mini-bicycle
GB0117479D0 (en) Jetters
CA92420S (en) Cleat
CA92421S (en) Cleat
CA92665S (en) Bedboard
CA93126S (en) Titlt-latch
CA93125S (en) Tilt-latch
CA93075S (en) Travelbag
CA92978S (en) Photo-changer
CA91502S (en) Bedboard
AU2479P (en) Crackerjack xTriticosecale
AU2288P (en) Prime322 xTriticosecale
GB0118992D0 (en) Platform
GB0114220D0 (en) Faster connection leads
GB0106455D0 (en) Boccia ramp
TW481424U (en) Case structure
AU143674S (en) An aquafoil

Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: GLAXO GROUP LIMITED, GB

Free format text: FORMER OWNER(S): CHROMOS MOLECULAR SYSTEMS, INC., CA

HC9A Change of name, address

Owner name: GLAXO GROUP LIMITED, GB

Free format text: FORMER OWNER(S): CHROMOS MOLECULAR SYSTEMS, INC., CA; GLAXO GROUP LIMITED, GB

FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished