HUP0402101A2 - Vajsavszármazékok, előállításuk és alkalmazásuk - Google Patents

Vajsavszármazékok, előállításuk és alkalmazásuk

Info

Publication number
HUP0402101A2
HUP0402101A2 HU0402101A HUP0402101A HUP0402101A2 HU P0402101 A2 HUP0402101 A2 HU P0402101A2 HU 0402101 A HU0402101 A HU 0402101A HU P0402101 A HUP0402101 A HU P0402101A HU P0402101 A2 HUP0402101 A2 HU P0402101A2
Authority
HU
Hungary
Prior art keywords
group
optionally substituted
aryl
heteroaryl
alkyl
Prior art date
Application number
HU0402101A
Other languages
English (en)
Inventor
Didier Roche
Jean-Jacques Zeiller
Francis Contard
Valérie Guyard-Dangremont
Daniel Guerrier
Hervé Dupont
Jean-Jacques Berthelon
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0402101A2 publication Critical patent/HUP0402101A2/hu
Publication of HUP0402101A3 publication Critical patent/HUP0402101A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

Az (I) általános képletű vegyületek - a képletben A jelentésekarboxilcsoport; adott esetben szubsztituált (6-1) szénatomosaril)oxikarbonil- vagy (1-14 szénatomos alkoxi) karbonilcsoport; -CO-NHOH; tetrazolilcsoport; B jelentése adott esetben szubsztituáltetiléncsoport; R1 jelentése hidrogénatom; adott esetben szubsztituált1-14 szénatomos alkil-, 6-18 szénatomos aril-, heteroaril-, (6-18szénatomos aril)-(1-14 szénatomos alkil)- vagy heteroaril-(1-I4szénatomos alkil)-csoport; Z jelentése S vagy Se; n jelentése egészszám, amelynek értéke 0, 1 vagy 2; R2 jelentése adott esetbenszubsztituált 6-18 szénatomos aril-, heteroaril- vagy aromás csoportottartalmazó heterociklusos csoport; és ha R1 jelentése adott esetbenszubsztituált 6-18 szénatomos arilcsoport, akkor R2 jelentése 1-14szénatomos allcilcsoport is lehet; azzal a megkötéssel, hogy ha R1jelentése naftilcsoport vagy 4-metoxifenil-csoport, A jelentésekarboxilcsoport vagy metoxikarbonilcsoport, B jelentése etiléncsoport,n értéke 0, és Z jelentése S vagy Se, akkor R2 jelentésefenilcsoporttól eltérő - valamint gyógyászatilag elfogadható sóik éssztereoizomerjeik diszlipidémia atheroszklerózis és diabéteszkezelésére alkalmazhatók. .A találmány magába foglalja az (I)általános képletű vegyületek előállítását és a vegyületeket tartalmazógyógyászati készítményeket is. Ó
HU0402101A 2001-07-30 2002-07-03 Butyric acid derivatives HUP0402101A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0110198A FR2827859B1 (fr) 2001-07-30 2001-07-30 Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete
PCT/EP2002/007383 WO2003011819A1 (en) 2001-07-30 2002-07-03 Butyric acid derivatives

Publications (2)

Publication Number Publication Date
HUP0402101A2 true HUP0402101A2 (hu) 2005-01-28
HUP0402101A3 HUP0402101A3 (en) 2005-11-28

Family

ID=8866088

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402101A HUP0402101A3 (en) 2001-07-30 2002-07-03 Butyric acid derivatives

Country Status (16)

Country Link
US (1) US7491747B2 (hu)
EP (1) EP1412326B1 (hu)
JP (1) JP4231785B2 (hu)
KR (1) KR20040020951A (hu)
CN (1) CN1555361A (hu)
AU (1) AU2002355631B2 (hu)
BR (1) BR0211519A (hu)
CA (1) CA2455749A1 (hu)
ES (1) ES2391265T3 (hu)
FR (1) FR2827859B1 (hu)
HU (1) HUP0402101A3 (hu)
MX (1) MXPA04000876A (hu)
PL (1) PL367895A1 (hu)
RU (1) RU2293726C2 (hu)
WO (1) WO2003011819A1 (hu)
ZA (1) ZA200401600B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308355A1 (de) 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
FR2873376B1 (fr) * 2004-07-23 2006-11-24 Tetrahedron Sas Nouveaux seleno-hydroxyacides et leurs derives, applications en nutrition, cosmetique et pharmacie
FR2907785B1 (fr) * 2006-10-27 2009-01-16 Tetrahedron Sas Procede de preparation de l'acide 2-hydroxy-4-methylselenobutyrique, seul ou en melange avec son analogue soufre, ainsi que leurs utilisations en nutrition, en particulier en nutrition animale
MX2022016049A (es) 2020-06-25 2023-02-09 Procter & Gamble Aptameros para aplicaciones para el cuidado personal de la salud.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2161991A1 (de) * 1971-12-14 1973-06-20 Degussa Sulfoniumverbindungen s-substituierter 2-hydroxy-4-mercaptobuttersaeuren
JPH02193942A (ja) * 1989-01-19 1990-07-31 Nippon Shinyaku Co Ltd フェノキシ酢酸誘導体
IT1265101B1 (it) * 1993-07-23 1996-10-30 Erba Carlo Spa Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico
JPH09136873A (ja) * 1995-11-15 1997-05-27 Fuji Chem Ind Co Ltd アルキルチオブタン酸誘導体及び腎臓疾患用剤
DK0939628T3 (da) * 1996-07-22 2003-07-07 Monsanto Co Thiolsulfon-metalloproteaseinhibitorer
IT1283782B1 (it) 1996-08-09 1998-04-30 Ct Lab Farm Srl Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo
WO1998039316A1 (en) * 1997-03-04 1998-09-11 Monsanto Company N-hydroxy 4-sulfonyl butanamide compounds
ES2206903T3 (es) 1997-03-04 2004-05-16 Monsanto Company Compuestos sulfonilicos divalentes de acido aril o heteroaril-hidroxamco.
EP1051395B1 (en) * 1998-01-30 2006-11-22 Darwin Discovery Limited N-hydroxyformamide derivatives
JP2000309573A (ja) * 1999-02-24 2000-11-07 Sankyo Co Ltd ２−メルカプトカルボン酸誘導体

Also Published As

Publication number Publication date
RU2004106156A (ru) 2005-07-27
US20050020651A1 (en) 2005-01-27
MXPA04000876A (es) 2004-05-21
KR20040020951A (ko) 2004-03-09
PL367895A1 (en) 2005-03-07
FR2827859B1 (fr) 2005-09-23
US7491747B2 (en) 2009-02-17
RU2293726C2 (ru) 2007-02-20
AU2002355631B2 (en) 2008-03-06
EP1412326B1 (en) 2012-08-22
ZA200401600B (en) 2004-11-17
HUP0402101A3 (en) 2005-11-28
CN1555361A (zh) 2004-12-15
JP2004536883A (ja) 2004-12-09
BR0211519A (pt) 2004-09-14
WO2003011819A1 (en) 2003-02-13
JP4231785B2 (ja) 2009-03-04
EP1412326A1 (en) 2004-04-28
FR2827859A1 (fr) 2003-01-31
CA2455749A1 (en) 2003-02-13
ES2391265T3 (es) 2012-11-22

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