HUP0400964A2 - (S)-2-Etoxi-3-[4-[2-[4-(metánszulfonil-oxi)-fenil]-etoxi]-fenil]-propánsavat vagy 3-[4-[2-[4-(terc-butoxi-karbonil-amino)-fenil]-etoxi]-fenil]-(S)-2-etoxi-propánsavat és inzulint tartalmazó gyógyszer-kombináció - Google Patents
(S)-2-Etoxi-3-[4-[2-[4-(metánszulfonil-oxi)-fenil]-etoxi]-fenil]-propánsavat vagy 3-[4-[2-[4-(terc-butoxi-karbonil-amino)-fenil]-etoxi]-fenil]-(S)-2-etoxi-propánsavat és inzulint tartalmazó gyógyszer-kombinációInfo
- Publication number
- HUP0400964A2 HUP0400964A2 HU0400964A HUP0400964A HUP0400964A2 HU P0400964 A2 HUP0400964 A2 HU P0400964A2 HU 0400964 A HU0400964 A HU 0400964A HU P0400964 A HUP0400964 A HU P0400964A HU P0400964 A2 HUP0400964 A2 HU P0400964A2
- Authority
- HU
- Hungary
- Prior art keywords
- ethoxy
- phenyl
- propanoic acid
- insulin
- tert
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- QNDFBOXBUCDYNZ-NRFANRHFSA-N (2s)-2-ethoxy-3-[4-[2-[4-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]ethoxy]phenyl]propanoic acid Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(NC(=O)OC(C)(C)C)C=C1 QNDFBOXBUCDYNZ-NRFANRHFSA-N 0.000 title abstract 2
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 title 1
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 235000019260 propionic acid Nutrition 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 239000000890 drug combination Substances 0.000 abstract 1
- CXGTZJYQWSUFET-IBGZPJMESA-N tesaglitazar Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(OS(C)(=O)=O)C=C1 CXGTZJYQWSUFET-IBGZPJMESA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány tárgya gyógyszerkombináció, ami (S)-2-etoxi-3-[4-[2-[4-(metánszulfonil-oxi)-fenil]-etoxi]-fenil]-propánsavat vagygyógyászatilag alkalmazható sóját vagy a vegyület vagy a sószolvátját, vagy 3-[4-[2-[4-(terc-butoxi-karbonil-amino)-fenil]-etoxi]-fenil]-(S)-2-etoxi-propánsavat vagy gyógyászatilag alkalmazhatósóját vagy a vegyület vagy a só szolvátját tartalmazza, inzulinnalegyütt. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0101981A SE0101981D0 (sv) | 2001-06-01 | 2001-06-01 | Pharmaceutical combination |
PCT/SE2002/001037 WO2002096453A1 (en) | 2001-06-01 | 2002-05-30 | A pharmaceutical combination comprising either (s)-2-ethoxy-3 [4-(2- {4-methane sulfonyl oxyphenyl} ethoxy)phenyl] propanoic acid or 3-{4-[2- (4-tert-butoxy carbonylamino phenyl) ethoxy] phenyl}-(s)-2-ethoxy propanoic acid and insulin |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0400964A2 true HUP0400964A2 (hu) | 2004-08-30 |
HUP0400964A3 HUP0400964A3 (en) | 2007-11-28 |
Family
ID=20284363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400964A HUP0400964A3 (en) | 2001-06-01 | 2002-05-30 | A pharmaceutical combination comprising either (s)-2-ethoxy-3 [4-(2-{4-methane sulfonyl oxyphenyl]ethoxy))phenyl]propanoic acid or 3-{4-[2-(4-tert-butoxy carbonylamino phenyl)ethoxy]phenyl}-(s)-2-ethoxy propanoic acid and insulin |
Country Status (22)
Country | Link |
---|---|
US (1) | US20040147600A1 (hu) |
EP (1) | EP1401485A1 (hu) |
JP (1) | JP2004532873A (hu) |
KR (1) | KR20040072027A (hu) |
CN (1) | CN1535155A (hu) |
BR (1) | BR0210129A (hu) |
CA (1) | CA2448637A1 (hu) |
CO (1) | CO5540383A2 (hu) |
CZ (1) | CZ20033233A3 (hu) |
EE (1) | EE200300577A (hu) |
HU (1) | HUP0400964A3 (hu) |
IL (1) | IL159034A0 (hu) |
IS (1) | IS7056A (hu) |
MX (1) | MXPA03011012A (hu) |
NO (1) | NO20035236D0 (hu) |
NZ (1) | NZ529812A (hu) |
PL (1) | PL367704A1 (hu) |
RU (1) | RU2003136156A (hu) |
SE (1) | SE0101981D0 (hu) |
SK (1) | SK14712003A3 (hu) |
WO (1) | WO2002096453A1 (hu) |
ZA (1) | ZA200309261B (hu) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60308390T2 (de) * | 2003-11-28 | 2007-09-06 | Merck Santé | Behandlung von Hyperurikämie |
AR052888A1 (es) * | 2005-01-28 | 2007-04-11 | Lilly Co Eli | Uso del agonista alfa de ppar para preparar una formulacion farmaceutica, paquete y dosis unitaria de dicha formulacion |
CN102036559A (zh) * | 2008-05-19 | 2011-04-27 | 雀巢产品技术援助有限公司 | 降低动物脂质吸收的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
SE9801990D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl propionic acid derivatives and analogs |
EP1145717B1 (en) * | 2000-04-13 | 2004-05-12 | Pfizer Products Inc. | Synergistic effect of glyburide and milrinone |
-
2001
- 2001-06-01 SE SE0101981A patent/SE0101981D0/xx unknown
-
2002
- 2002-05-30 KR KR10-2003-7015636A patent/KR20040072027A/ko not_active Application Discontinuation
- 2002-05-30 EE EEP200300577A patent/EE200300577A/xx unknown
- 2002-05-30 RU RU2003136156/15A patent/RU2003136156A/ru not_active Application Discontinuation
- 2002-05-30 PL PL02367704A patent/PL367704A1/xx not_active Application Discontinuation
- 2002-05-30 IL IL15903402A patent/IL159034A0/xx unknown
- 2002-05-30 CN CNA028149645A patent/CN1535155A/zh active Pending
- 2002-05-30 JP JP2002592962A patent/JP2004532873A/ja not_active Withdrawn
- 2002-05-30 MX MXPA03011012A patent/MXPA03011012A/es unknown
- 2002-05-30 NZ NZ529812A patent/NZ529812A/xx unknown
- 2002-05-30 US US10/479,707 patent/US20040147600A1/en not_active Abandoned
- 2002-05-30 SK SK1471-2003A patent/SK14712003A3/sk not_active Application Discontinuation
- 2002-05-30 CA CA002448637A patent/CA2448637A1/en not_active Abandoned
- 2002-05-30 HU HU0400964A patent/HUP0400964A3/hu unknown
- 2002-05-30 CZ CZ20033233A patent/CZ20033233A3/cs unknown
- 2002-05-30 WO PCT/SE2002/001037 patent/WO2002096453A1/en not_active Application Discontinuation
- 2002-05-30 EP EP02736371A patent/EP1401485A1/en not_active Withdrawn
- 2002-05-30 BR BR0210129-7A patent/BR0210129A/pt not_active IP Right Cessation
-
2003
- 2003-11-25 NO NO20035236A patent/NO20035236D0/no not_active Application Discontinuation
- 2003-11-27 ZA ZA200309261A patent/ZA200309261B/en unknown
- 2003-11-28 IS IS7056A patent/IS7056A/is unknown
- 2003-12-23 CO CO03112112A patent/CO5540383A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ529812A (en) | 2006-03-31 |
CO5540383A2 (es) | 2005-07-29 |
IL159034A0 (en) | 2004-05-12 |
PL367704A1 (en) | 2005-03-07 |
EE200300577A (et) | 2004-02-16 |
SE0101981D0 (sv) | 2001-06-01 |
MXPA03011012A (es) | 2004-02-27 |
EP1401485A1 (en) | 2004-03-31 |
KR20040072027A (ko) | 2004-08-16 |
BR0210129A (pt) | 2004-06-08 |
NO20035236D0 (no) | 2003-11-25 |
IS7056A (is) | 2003-11-28 |
CZ20033233A3 (cs) | 2004-12-15 |
HUP0400964A3 (en) | 2007-11-28 |
US20040147600A1 (en) | 2004-07-29 |
RU2003136156A (ru) | 2005-05-20 |
ZA200309261B (en) | 2005-02-28 |
CN1535155A (zh) | 2004-10-06 |
CA2448637A1 (en) | 2002-12-05 |
SK14712003A3 (sk) | 2004-08-03 |
JP2004532873A (ja) | 2004-10-28 |
WO2002096453A1 (en) | 2002-12-05 |
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Legal Events
Date | Code | Title | Description |
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FD9A | Lapse of provisional protection due to non-payment of fees |