TR200003543T2 - Yeni 3-aril-2-hidroksipropiyonik asit türevi III. - Google Patents

Yeni 3-aril-2-hidroksipropiyonik asit türevi III.

Info

Publication number
TR200003543T2
TR200003543T2 TR2000/03543T TR200003543T TR200003543T2 TR 200003543 T2 TR200003543 T2 TR 200003543T2 TR 2000/03543 T TR2000/03543 T TR 2000/03543T TR 200003543 T TR200003543 T TR 200003543T TR 200003543 T2 TR200003543 T2 TR 200003543T2
Authority
TR
Turkey
Prior art keywords
new
aryl
acid derivative
hydroxypropionic acid
derivative iii
Prior art date
Application number
TR2000/03543T
Other languages
English (en)
Inventor
Andersson Kjell
Lindstedt Alstermark Eva-Lotte
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TR200003543T2 publication Critical patent/TR200003543T2/tr

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/29—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07C233/75—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
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    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
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    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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  • Organic Chemistry (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Formül (I) ve bunun farmasötik açidan kabul gören tuzlarina, solvatlarina ve kristalli formlarina sahip yeni bir 3-{4-[2-(4-tert-butoksikarbonilaminofenil) etoksi]fenil}-(S)-2-etoksi propanoik asit bilesigi, bunun imalatina yönelik bir islem ve ara baglar, bunu ihtiva eden farmasötik preparasyonlar ve bilesigin, insülin direncine bagli klinik durumlarda kullanilmasi (Formül).
TR2000/03543T 1998-06-04 1999-05-31 Yeni 3-aril-2-hidroksipropiyonik asit türevi III. TR200003543T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9801990A SE9801990D0 (sv) 1998-06-04 1998-06-04 New 3-aryl propionic acid derivatives and analogs

Publications (1)

Publication Number Publication Date
TR200003543T2 true TR200003543T2 (tr) 2001-04-20

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Family Applications (1)

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TR2000/03543T TR200003543T2 (tr) 1998-06-04 1999-05-31 Yeni 3-aril-2-hidroksipropiyonik asit türevi III.

Country Status (28)

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US (1) US6362360B1 (tr)
EP (1) EP1084101B1 (tr)
JP (2) JP3568897B2 (tr)
KR (1) KR20010052522A (tr)
CN (1) CN1311769A (tr)
AR (1) AR019853A1 (tr)
AT (1) ATE261429T1 (tr)
AU (1) AU4667099A (tr)
BR (1) BR9910913A (tr)
CA (1) CA2334107A1 (tr)
DE (1) DE69915470T2 (tr)
DK (1) DK1084101T3 (tr)
EE (1) EE200000717A (tr)
ES (1) ES2216527T3 (tr)
ID (1) ID28164A (tr)
IL (1) IL139942A0 (tr)
IS (1) IS5735A (tr)
MA (1) MA26637A1 (tr)
NO (1) NO20006114L (tr)
PL (1) PL344682A1 (tr)
PT (1) PT1084101E (tr)
SE (1) SE9801990D0 (tr)
SK (1) SK17672000A3 (tr)
TN (1) TNSN99107A1 (tr)
TR (1) TR200003543T2 (tr)
TW (1) TW446694B (tr)
WO (1) WO1999062870A1 (tr)
ZA (2) ZA200006773B (tr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1280574A (zh) * 1997-10-27 2001-01-17 雷迪研究基金会 新的杂环化合物及其在医药中的应用、它们的制备方法和含有它们的药物组合物
SE9801992D0 (sv) * 1998-06-04 1998-06-04 Astra Ab New 3-aryl-2-hydroxypropionic acid derivative I
MA26634A1 (fr) 1998-06-04 2004-12-20 Astra Ab Nouveaux derives de l'acide 3-aryl propionique et analogues
WO2001040165A1 (en) * 1999-12-03 2001-06-07 Astrazeneca Ab Crystalline form of 3-{4-[2-(4-tert-butoxycarbonylaminophenyl)ethoxy]phenyl}-(s)-2-ethoxy propanoic acid
RU2268880C2 (ru) * 1999-12-03 2006-01-27 Астразенека Аб Кристаллическая форма (s)-2-этокси-3-[4-(2-{4-метансульфонилоксифенил}этокси)фенил]пропановой кислоты
TW574193B (en) * 1999-12-03 2004-02-01 Astrazeneca Ab Novel phenalkyloxy-phenyl derivatives, pharmaceutical composition containing the same and their uses
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ZA200006771B (en) 2002-05-20
IL139942A0 (en) 2002-02-10
SE9801990D0 (sv) 1998-06-04
TNSN99107A1 (fr) 2005-11-10
EP1084101A1 (en) 2001-03-21
DE69915470T2 (de) 2005-02-24
JP3568897B2 (ja) 2004-09-22
JP2004256548A (ja) 2004-09-16
JP2002516898A (ja) 2002-06-11
IS5735A (is) 2000-11-28
BR9910913A (pt) 2001-03-06
AR019853A1 (es) 2002-03-20
TW446694B (en) 2001-07-21
NO20006114L (no) 2001-02-02
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ES2216527T3 (es) 2004-10-16
MA26637A1 (fr) 2004-12-20
NO20006114D0 (no) 2000-12-01
PL344682A1 (en) 2001-11-19
DE69915470D1 (en) 2004-04-15
ATE261429T1 (de) 2004-03-15
PT1084101E (pt) 2004-07-30
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AU4667099A (en) 1999-12-20
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CN1311769A (zh) 2001-09-05
EE200000717A (et) 2001-08-15

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