HUP0400718A2 - PDE7 és PDE4 kettős inhibitorok alkalmazása leukocita aktivitással társult betegségek kezelésére szolgáló gyógyszerkészítmények előállítására - Google Patents
PDE7 és PDE4 kettős inhibitorok alkalmazása leukocita aktivitással társult betegségek kezelésére szolgáló gyógyszerkészítmények előállításáraInfo
- Publication number
- HUP0400718A2 HUP0400718A2 HU0400718A HUP0400718A HUP0400718A2 HU P0400718 A2 HUP0400718 A2 HU P0400718A2 HU 0400718 A HU0400718 A HU 0400718A HU P0400718 A HUP0400718 A HU P0400718A HU P0400718 A2 HUP0400718 A2 HU P0400718A2
- Authority
- HU
- Hungary
- Prior art keywords
- pde
- preparation
- leukocyte activation
- pharmaceutical compositions
- associated disorders
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 2
- 230000009977 dual effect Effects 0.000 title abstract 2
- 210000000265 leukocyte Anatomy 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 101100296719 Caenorhabditis elegans pde-4 gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 101100407335 Dictyostelium discoideum pde7 gene Proteins 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 abstract 1
- 229940123304 Phosphodiesterase 7 inhibitor Drugs 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 abstract 1
- 239000002606 phosphodiesterase VII inhibitor Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- Animal Behavior & Ethology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgyát kettős PDE7 és PDE4 inhibitorok alkalmazása képezileukocita aktiválással társult rendellenességek, különösentranszplantátum-kilökődés, reumatoid artritisz, gyulladásosbélbetegség, pszoriázis, asztma, krónikus elzáródásos tüdőbetegség,bőrfarkas és szklerózis multiplex kezelésére szolgálógyógyszerkészítmények előállítására. Ó
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28796401P | 2001-05-01 | 2001-05-01 | |
US29928701P | 2001-06-19 | 2001-06-19 | |
US36875202P | 2002-03-29 | 2002-03-29 | |
PCT/US2002/013742 WO2002088080A2 (en) | 2001-05-01 | 2002-04-30 | Dual inhibitors of pde 7 and pde 4 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0400718A2 true HUP0400718A2 (hu) | 2004-07-28 |
Family
ID=27403765
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400718A HUP0400718A2 (hu) | 2001-05-01 | 2002-04-30 | PDE7 és PDE4 kettős inhibitorok alkalmazása leukocita aktivitással társult betegségek kezelésére szolgáló gyógyszerkészítmények előállítására |
HU0400828A HUP0400828A2 (hu) | 2001-05-01 | 2002-05-01 | Kondenzált heterociklikus aminopirimidinek, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0400828A HUP0400828A2 (hu) | 2001-05-01 | 2002-05-01 | Kondenzált heterociklikus aminopirimidinek, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények |
Country Status (6)
Country | Link |
---|---|
US (2) | US20030104974A1 (hu) |
EP (2) | EP1383743A4 (hu) |
JP (2) | JP2004532233A (hu) |
CA (2) | CA2444436A1 (hu) |
HU (2) | HUP0400718A2 (hu) |
WO (3) | WO2002088079A2 (hu) |
Families Citing this family (123)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2404603A1 (en) * | 2000-10-23 | 2012-01-11 | Glaxosmithkline LLC | Novel trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds for the treatment of CSBP/p38 kinase mediated diseases |
US7241890B2 (en) | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
JPWO2003104230A1 (ja) | 2002-06-07 | 2005-10-06 | 協和醗酵工業株式会社 | 二環性ピリミジン誘導体 |
EP1599600A2 (en) * | 2002-11-13 | 2005-11-30 | Bayer HealthCare AG | DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 7A2 (PDE7a2) |
EP1571146A4 (en) * | 2002-12-10 | 2010-09-01 | Ono Pharmaceutical Co | NITROGENIC HETEROCYCLIC COMPOUNDS AND THEIR MEDICAL USE |
JP2006219373A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するピリジニルピラゾロピリミジノン誘導体 |
JP2006219374A (ja) | 2003-06-13 | 2006-08-24 | Daiichi Asubio Pharma Co Ltd | Pde7阻害作用を有するイミダゾトリアジノン誘導体 |
AU2004272437A1 (en) * | 2003-09-09 | 2005-03-24 | Ono Pharmaceutical Co., Ltd. | CRF antagonists and heterobicyclic compounds |
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2002
- 2002-04-29 WO PCT/US2002/013628 patent/WO2002088079A2/en not_active Application Discontinuation
- 2002-04-30 EP EP02725882A patent/EP1383743A4/en not_active Withdrawn
- 2002-04-30 CA CA002444436A patent/CA2444436A1/en not_active Abandoned
- 2002-04-30 HU HU0400718A patent/HUP0400718A2/hu unknown
- 2002-04-30 US US10/135,998 patent/US20030104974A1/en not_active Abandoned
- 2002-04-30 JP JP2002585382A patent/JP2004532233A/ja active Pending
- 2002-04-30 WO PCT/US2002/013742 patent/WO2002088080A2/en not_active Application Discontinuation
- 2002-05-01 WO PCT/US2002/014049 patent/WO2002087513A2/en not_active Application Discontinuation
- 2002-05-01 JP JP2002584865A patent/JP2005506304A/ja active Pending
- 2002-05-01 HU HU0400828A patent/HUP0400828A2/hu unknown
- 2002-05-01 EP EP02731650A patent/EP1383506A4/en not_active Withdrawn
- 2002-05-01 CA CA002443835A patent/CA2443835A1/en not_active Abandoned
- 2002-05-01 US US10/137,508 patent/US20030092908A1/en not_active Abandoned
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WO2002087513A2 (en) | 2002-11-07 |
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US20030104974A1 (en) | 2003-06-05 |
WO2002088080A2 (en) | 2002-11-07 |
EP1383743A2 (en) | 2004-01-28 |
US20030092908A1 (en) | 2003-05-15 |
CA2443835A1 (en) | 2002-11-07 |
WO2002088079A3 (en) | 2003-01-30 |
WO2002087513A3 (en) | 2003-03-13 |
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