HUP0302221A3 - 4-amino-quinazolines - Google Patents
4-amino-quinazolinesInfo
- Publication number
- HUP0302221A3 HUP0302221A3 HU0302221A HUP0302221A HUP0302221A3 HU P0302221 A3 HUP0302221 A3 HU P0302221A3 HU 0302221 A HU0302221 A HU 0302221A HU P0302221 A HUP0302221 A HU P0302221A HU P0302221 A3 HUP0302221 A3 HU P0302221A3
- Authority
- HU
- Hungary
- Prior art keywords
- quinazolines
- amino
- Prior art date
Links
- DRYRBWIFRVMRPV-UHFFFAOYSA-N quinazolin-4-amine Chemical class C1=CC=C2C(N)=NC=NC2=C1 DRYRBWIFRVMRPV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66690800A | 2000-09-20 | 2000-09-20 | |
| PCT/EP2001/010705 WO2002024667A1 (en) | 2000-09-20 | 2001-09-17 | 4-amino-quinazolines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0302221A2 HUP0302221A2 (hu) | 2003-10-28 |
| HUP0302221A3 true HUP0302221A3 (en) | 2004-01-28 |
Family
ID=24676013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0302221A HUP0302221A3 (en) | 2000-09-20 | 2001-09-17 | 4-amino-quinazolines |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7547702B2 (hu) |
| EP (1) | EP1318984A1 (hu) |
| JP (1) | JP2004509876A (hu) |
| CN (1) | CN1474815A (hu) |
| AU (1) | AU2001293817A1 (hu) |
| BR (1) | BR0114020A (hu) |
| CA (1) | CA2422488A1 (hu) |
| HU (1) | HUP0302221A3 (hu) |
| MX (1) | MXPA03002410A (hu) |
| NO (1) | NO20031268D0 (hu) |
| PL (1) | PL359920A1 (hu) |
| WO (1) | WO2002024667A1 (hu) |
| ZA (1) | ZA200303062B (hu) |
Families Citing this family (52)
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|---|---|---|---|---|
| EP1317448B2 (en) | 2000-09-15 | 2011-05-04 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| JP2004509876A (ja) | 2000-09-20 | 2004-04-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ４−アミノ−キナゾリン |
| JP4160395B2 (ja) | 2000-12-21 | 2008-10-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用なピラゾール化合物 |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
| US20030199526A1 (en) * | 2001-12-07 | 2003-10-23 | Deborah Choquette | Pyrimidine-based compounds useful as GSK-3 inhibitors |
| DE60320933D1 (de) | 2002-01-10 | 2008-06-26 | Bayer Healthcare Ag | Rho-kinase inhibitoren |
| US6924290B2 (en) | 2002-01-23 | 2005-08-02 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
| JP4423043B2 (ja) | 2002-01-23 | 2010-03-03 | バイエル ファーマセチカル コーポレーション | Ｒｈｏ−キナーゼ阻害剤 |
| US7645878B2 (en) * | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
| EP1532145B1 (en) | 2002-08-02 | 2006-09-13 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of gsk-3 |
| US7312239B2 (en) * | 2002-09-04 | 2007-12-25 | Mitsubishi Pharma Corporation | Medicament for prevention and/or therapy of arterial wall disorder |
| US7713983B2 (en) | 2003-03-03 | 2010-05-11 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| WO2004103270A2 (en) | 2003-04-02 | 2004-12-02 | Suntory Pharmaceutical Research Laboratories Llc | Compounds and methods for treatment of thrombosis |
| CA2520323C (en) * | 2003-04-09 | 2013-07-09 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| WO2005007672A2 (en) * | 2003-06-20 | 2005-01-27 | Coley Pharmaceutical Gmbh | Small molecule toll-like receptor (tlr) antagonists |
| JP2009513502A (ja) | 2003-07-02 | 2009-04-02 | エフ．ホフマン−ラ ロシュ アーゲー | アリールアミン置換キナゾリノン化合物 |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| US8283354B2 (en) | 2004-09-02 | 2012-10-09 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7928107B2 (en) | 2004-09-02 | 2011-04-19 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7718658B2 (en) | 2004-09-02 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| RU2007122485A (ru) | 2004-11-17 | 2008-12-27 | Мийкана Терапьютикс | Ингибиторы киназы |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| KR20140025610A (ko) | 2005-09-30 | 2014-03-04 | 미카나 테라퓨틱스, 인크. | 치환된 피라졸 화합물 |
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| GEP20146134B (en) | 2009-03-27 | 2014-08-11 | Merck Sharp & Dohme | Inhibitors of hepatitis c virus replication |
| US20190127365A1 (en) | 2017-11-01 | 2019-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus replication |
| CA2760205A1 (en) | 2009-05-12 | 2010-11-18 | Schering Corporation | Fused tricyclic aryl compounds useful for the treatment of viral diseases |
| JP2012528194A (ja) | 2009-05-29 | 2012-11-12 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃ型肝炎などの疾患を処置するための３つの整列型アリール部分で構成された抗菌性化合物 |
| AU2010253791A1 (en) | 2009-05-29 | 2011-11-24 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked Aryl moieties to treat diseases such as Hepatitis C |
| SI3575288T1 (sl) | 2009-09-03 | 2022-01-31 | Bristol-Myers Squibb Company | Kinazolini kot ionski kanalni inhibitorji kalija |
| CN102574817A (zh) | 2009-09-24 | 2012-07-11 | 巴斯夫欧洲公司 | 用于抵抗无脊椎动物害虫的氨基喹唑啉化合物 |
| US20130156731A1 (en) | 2009-12-22 | 2013-06-20 | Kevin X. Chen | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas |
| US8732671B2 (en) * | 2010-02-26 | 2014-05-20 | Red Hat, Inc. | Generating stack traces of call stacks that lack frame pointers |
| ES2558554T3 (es) * | 2010-03-09 | 2016-02-05 | Merck Sharp & Dohme Corp. | Compuestos de sililo tricíclicos condensados y métodos de uso de los mismos para el tratamiento de enfermedades víricas |
| EP2621279B1 (en) | 2010-09-29 | 2018-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| WO2012122716A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
| CA2895129C (en) | 2012-12-20 | 2022-07-05 | Sanford-Burnham Medical Research Institute | Quinazoline neurotensin receptor 1 agonists and uses thereof |
| WO2014110687A1 (en) | 2013-01-16 | 2014-07-24 | Merck Sharp & Dohme Corp. | Thiazolyl-substitued tetracyclic compounds and methods of use thereof for treatment of viral diseases |
| CA2952732C (en) | 2014-06-25 | 2024-01-02 | Sanford-Burnham Medical Research Institute | Small molecule agonists of neurotensin receptor 1 |
| CN104496915B (zh) * | 2014-12-19 | 2017-05-03 | 华侨大学 | 一种喹唑啉酮芳香化合物的合成方法 |
| AU2015371257B2 (en) | 2014-12-24 | 2018-09-06 | Gilead Sciences, Inc. | Isoquinoline compounds for the treatment of HIV |
| EP3237414B1 (en) | 2014-12-24 | 2019-05-08 | Gilead Sciences, Inc. | Fused pyrimidine compounds for the tratment of hiv |
| TWI699355B (zh) | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
| WO2018107200A1 (en) * | 2016-12-13 | 2018-06-21 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| JP2022544700A (ja) * | 2019-08-22 | 2022-10-20 | バイオヘイブン・セラピューティクス・リミテッド | 筋萎縮性側索硬化症および関連障害の治療のためにｔｄｐ－４３に結合する分子 |
| WO2022241186A1 (en) * | 2021-05-13 | 2022-11-17 | Duke University | Compositions for and methods of treating and/or preventing pain |
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| US3669968A (en) * | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
| US4642347A (en) * | 1985-05-21 | 1987-02-10 | American Home Products Corporation | 3(2-quinolinylalkoxy)phenols |
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| JP2004509876A (ja) | 2000-09-20 | 2004-04-02 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ４−アミノ−キナゾリン |
| AU9684601A (en) | 2000-10-12 | 2002-04-22 | Univ Rochester | Compositions that inhibit proliferation of cancer cells |
| WO2002053143A2 (en) | 2001-01-05 | 2002-07-11 | The Medical College Of Georgia Research Institute, Inc. | Treatment of erectile dysfunction with rho-kinase inhibitors |
-
2001
- 2001-09-17 JP JP2002529077A patent/JP2004509876A/ja active Pending
- 2001-09-17 WO PCT/EP2001/010705 patent/WO2002024667A1/en active Application Filing
- 2001-09-17 HU HU0302221A patent/HUP0302221A3/hu unknown
- 2001-09-17 CA CA002422488A patent/CA2422488A1/en not_active Abandoned
- 2001-09-17 CN CNA018190766A patent/CN1474815A/zh active Pending
- 2001-09-17 US US10/380,908 patent/US7547702B2/en not_active Expired - Lifetime
- 2001-09-17 EP EP01974258A patent/EP1318984A1/en not_active Withdrawn
- 2001-09-17 BR BR0114020-5A patent/BR0114020A/pt not_active Application Discontinuation
- 2001-09-17 MX MXPA03002410A patent/MXPA03002410A/es unknown
- 2001-09-17 PL PL01359920A patent/PL359920A1/xx unknown
- 2001-09-17 AU AU2001293817A patent/AU2001293817A1/en not_active Abandoned
-
2003
- 2003-03-19 NO NO20031268A patent/NO20031268D0/no unknown
- 2003-04-17 ZA ZA200303062A patent/ZA200303062B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1474815A (zh) | 2004-02-11 |
| BR0114020A (pt) | 2003-07-22 |
| JP2004509876A (ja) | 2004-04-02 |
| HUP0302221A2 (hu) | 2003-10-28 |
| PL359920A1 (en) | 2004-09-06 |
| MXPA03002410A (es) | 2003-06-19 |
| US20060019974A1 (en) | 2006-01-26 |
| WO2002024667A1 (en) | 2002-03-28 |
| NO20031268D0 (no) | 2003-03-19 |
| CA2422488A1 (en) | 2002-03-28 |
| AU2001293817A1 (en) | 2002-04-02 |
| US7547702B2 (en) | 2009-06-16 |
| EP1318984A1 (en) | 2003-06-18 |
| ZA200303062B (en) | 2004-07-19 |
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