HUP0302012A2 - Injekcióval adagolható nyújtott hatóanyag-leadású mikrogömbök és eljárás elżállításukra - Google Patents

Injekcióval adagolható nyújtott hatóanyag-leadású mikrogömbök és eljárás elżállításukra

Info

Publication number
HUP0302012A2
HUP0302012A2 HU0302012A HUP0302012A HUP0302012A2 HU P0302012 A2 HUP0302012 A2 HU P0302012A2 HU 0302012 A HU0302012 A HU 0302012A HU P0302012 A HUP0302012 A HU P0302012A HU P0302012 A2 HUP0302012 A2 HU P0302012A2
Authority
HU
Hungary
Prior art keywords
active ingredient
preparation
prolonged release
microspheres
injection delivery
Prior art date
Application number
HU0302012A
Other languages
English (en)
Inventor
Jean-Pierre Benoit
Claire Dulieu
Joël Richard
Original Assignee
Ethypharm
Mainelab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm, Mainelab filed Critical Ethypharm
Publication of HUP0302012A2 publication Critical patent/HUP0302012A2/hu
Publication of HUP0302012A3 publication Critical patent/HUP0302012A3/hu
Publication of HU228702B1 publication Critical patent/HU228702B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A találmány tárgya szubkután vagy intramuszkuláris injekcióvaladagolható mikrogömbök, amelyek tartalmaznak egy fehérjejellegűhatóanyagot és egy hatóanyagot bevonó szert, amely a hatóanyagfelszabadulását megnyújtja, és amelyekre jellemző, hogy - teljesenmentesek szerves oldószer nyomoktól, - olyan bevonó eljárással lehetezeket előállítani, amely tartalmazza a hatóanyag és a bevonószer szuperkritikusfluidumban keverés mellett történő érintkeztetését, ahol a bevonóanyag oldható a szuperkritikus fluidumban és - a fehérje jellegűhatóanyag nincs denaturálva. A találmány a mikrogömbök előállításáraszolgáló eljárást is magában foglalja. Ó
HU0302012A 2000-05-23 2001-05-22 Prolonged release microspheres for injection delivery and preparation method HU228702B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0006587A FR2809309B1 (fr) 2000-05-23 2000-05-23 Microspheres a liberation prolongee pour administration injectable
PCT/FR2001/001575 WO2001089481A1 (fr) 2000-05-23 2001-05-22 Microspheres a liberation prolongee pour administration injectable et procede de preparation

Publications (3)

Publication Number Publication Date
HUP0302012A2 true HUP0302012A2 (hu) 2003-09-29
HUP0302012A3 HUP0302012A3 (en) 2005-11-28
HU228702B1 HU228702B1 (en) 2013-05-28

Family

ID=8850528

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302012A HU228702B1 (en) 2000-05-23 2001-05-22 Prolonged release microspheres for injection delivery and preparation method

Country Status (18)

Country Link
US (1) US20040043076A1 (hu)
EP (1) EP1303259B1 (hu)
JP (1) JP2003534267A (hu)
KR (1) KR100787669B1 (hu)
CN (1) CN1438877A (hu)
AR (1) AR029667A1 (hu)
AU (2) AU6399601A (hu)
BR (1) BR0111054A (hu)
CA (1) CA2410219A1 (hu)
ES (1) ES2413406T3 (hu)
FR (1) FR2809309B1 (hu)
HU (1) HU228702B1 (hu)
IL (2) IL153046A0 (hu)
MX (1) MXPA02011560A (hu)
NO (1) NO333742B1 (hu)
TW (1) TWI264310B (hu)
WO (1) WO2001089481A1 (hu)
ZA (1) ZA200209553B (hu)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
EP1197513B1 (en) 2000-10-10 2005-03-30 Kao Corporation Process for preparing composite particles
EP1335661B1 (en) 2000-10-27 2009-05-06 Baxter Healthcare S.A. Production of microspheres
EP1418890B1 (en) * 2001-08-16 2008-05-14 Baxter International Inc. Propellant-based microparticle formulations
US20080026068A1 (en) * 2001-08-16 2008-01-31 Baxter Healthcare S.A. Pulmonary delivery of spherical insulin microparticles
GB0205868D0 (en) * 2002-03-13 2002-04-24 Univ Nottingham Polymer composite with internally distributed deposition matter
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
KR101137785B1 (ko) * 2003-07-18 2012-04-25 백스터 인터내셔널 인코포레이티드 제어된 상 분리에 의해 제조된 작은 구형 입자의 제조방법, 이용 방법 및 조성물
EP1646354A4 (en) * 2003-07-22 2010-03-17 Baxter Int SMALL SPHERICAL PARTICLES OF LOW MOLECULAR WEIGHT MOLECULES AND PROCESSES FOR THEIR PREPARATION AND USE
CN1838968A (zh) 2003-08-08 2006-09-27 艾伯吉尼斯公司 针对甲状旁腺激素(pth)之抗体和其用途
US7318925B2 (en) * 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
KR100603974B1 (ko) * 2003-12-05 2006-07-25 김갑식 고체상 지질을 용매로 이용한 나노수준의 또는 비결정질입자의 제조 방법
FR2868704B1 (fr) * 2004-04-07 2007-09-14 Ethypharm Sa Utilisation de lipides pour ameliorer la biodisponibilite de principes actifs proteiques en formulations injectables sous cutanees ou intra-musculaires
DK1765294T3 (da) 2004-05-12 2008-11-10 Baxter Int Nukleinsyremikrokugler samt deres fremstilling og afgivelse
US8728525B2 (en) * 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
JP2007537288A (ja) * 2004-05-12 2007-12-20 バクスター インターナショナル インコーポレイテッド オリゴヌクレオチド含有マイクロスフェア、１型糖尿病を処置する医薬の製造のための、その使用
CN103393601A (zh) * 2004-05-12 2013-11-20 巴克斯特国际公司 含有蛋白并在高浓度蛋白下显示可注射性的微球体
US7390097B2 (en) * 2004-08-23 2008-06-24 3M Innovative Properties Company Multiple channel illumination system
FR2874836B1 (fr) * 2004-09-09 2007-04-27 Pierre Fabre Medicament Sa Procede d'enrobage de poudres
CN100556531C (zh) * 2004-11-29 2009-11-04 独立行政法人科学技术振兴机构 复合微粒的制造方法
CN101188996B (zh) * 2005-04-27 2013-03-27 巴克斯特国际公司 表面改性的微粒及其形成和使用方法
CA2615378C (en) * 2005-07-15 2015-02-17 Map Pharmaceuticals, Inc. Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof
EP1904219A4 (en) * 2005-07-15 2011-07-27 Map Pharmaceuticals Inc METHOD FOR FORMING PARTICLES
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
JP5118139B2 (ja) * 2006-08-04 2013-01-16 バクスター・インターナショナル・インコーポレイテッド 新規発症自己免疫性糖尿病を予防および／または逆転させるためのマイクロスフィアに基づく組成物
US20080248122A1 (en) * 2006-10-06 2008-10-09 Baxter International Inc. Microencapsules Containing Surface-Modified Microparticles And Methods Of Forming And Using The Same
AU2008242842B2 (en) * 2007-04-17 2014-06-05 Baxter Healthcare Sa Nucleic acid microparticles for pulmonary delivery
EP2170283B1 (en) 2007-06-22 2019-01-09 Board of Regents, The University of Texas System Formation of stable submicron peptide or protein particles by thin film freezing
GB0812742D0 (en) * 2008-07-11 2008-08-20 Critical Pharmaceuticals Ltd Process
US8323685B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US20100047292A1 (en) * 2008-08-20 2010-02-25 Baxter International Inc. Methods of processing microparticles and compositions produced thereby
US8323615B2 (en) * 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
US8367427B2 (en) * 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
CA2743789C (en) * 2008-11-16 2017-10-31 Board Of Regents, The Univesity Of Texas System Low viscosity highly concentrated suspensions
US20100291221A1 (en) * 2009-05-15 2010-11-18 Robert Owen Cook Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation
EP2353588B1 (en) * 2010-01-21 2015-04-15 Agricultural Technology Research Institute A sustained release preparation of factor IX
KR101156094B1 (ko) * 2010-02-22 2012-06-20 경상대학교산학협력단 약물송달을 위한 양친성 ＰＨＡ－ｍＰＥＧ 공중합 나노 컨테이너
PL2790681T5 (pl) 2011-11-18 2024-02-05 Regeneron Pharmaceuticals, Inc. Sposób otrzymywania farmaceutycznej postaci użytkowej o przedłużonym uwalnianiu zawierającej mikrocząstki białkowe powlekane polimerem z wykorzystaniem suszenia rozpyłowego
CN102552169B (zh) * 2012-02-17 2015-07-29 深圳市健元医药科技有限公司 一种醋酸阿肽地尔缓释微球制剂及其制备方法
KR101421343B1 (ko) * 2012-08-21 2014-07-18 경상대학교산학협력단 폴리(4-하이드록시부티레이트)-ｂ-모노메톡시(폴리에틸렌글리콜) 공중합체 나노입자, 이의 제조방법 및 이를 유효성분으로 함유하는 뇌질환 치료용 약학적 조성물
WO2014051251A1 (en) * 2012-09-28 2014-04-03 Industrial Cooperation Foundation Chonbuk National University Pvax copolymer and pvax microparticles comprising the same
CN102921011B (zh) * 2012-11-09 2014-10-15 东华大学 一种仿血细胞形貌温敏聚合物微球及其制备方法
GB201317756D0 (en) * 2013-10-08 2013-11-20 Critical Pharmaceuticals Ltd New process
RU2684611C2 (ru) * 2013-12-31 2019-04-10 ПБ энд Б СА Композиции контролируемого высвобождения жирных кислот для применения при реконструкции и коррекции фигуры
CN104474533A (zh) * 2014-11-24 2015-04-01 华南理工大学 一种可用于创面修复的复合微球的制备方法
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9375478B1 (en) 2015-01-30 2016-06-28 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
CN108042793B (zh) * 2017-11-13 2020-07-07 中国人民解放军第四军医大学 包埋gdnf的多核-单壳微球缓释系统的制备方法
EP3842069A4 (en) * 2018-08-20 2022-06-01 Institute Of Process Engineering Chinese Acadamy Of Sciences MICROCAPSULE BASED VACCINE
CN110585055B (zh) * 2019-08-26 2023-06-13 武汉贝缇安卡医疗健康投资有限公司 AcSDKP在增加成纤维细胞分泌Ⅲ型胶原蛋白含量的应用
CN114209887B (zh) * 2021-08-24 2023-03-03 杭州协合医疗用品有限公司 一种含可控降解聚酯微球的注射用凝胶

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3777721D1 (de) * 1986-08-11 1992-04-30 American Cyanamid Co Zusammensetzungen zur parenteralen verabreichung und deren verwendung.
EP0706821A1 (en) * 1994-10-06 1996-04-17 Centre De Microencapsulation Method of coating particles
AU5004196A (en) * 1995-03-10 1996-10-02 Boehringer Mannheim Gmbh Polypeptide-containing pharmaceutical forms of administration in the form of microparticles and method for the preparation thereof
FR2753639B1 (fr) * 1996-09-25 1998-12-11 Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede
US5766637A (en) * 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
ATE287257T1 (de) * 1997-01-16 2005-02-15 Massachusetts Inst Technology Zubereitung von partikelhaltigen arzneimitteln zur inhalation
WO2000004916A1 (en) * 1998-07-23 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Encapsulation of water soluble peptides
WO2000010541A1 (en) * 1998-08-25 2000-03-02 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
FR2797398B1 (fr) * 1999-08-11 2002-10-18 Mainelab Microparticules pour administration pulmonaire
AU2729101A (en) * 1999-12-21 2001-07-03 Rxkinetix, Inc. Particulate drug-containing products and method of manufacture
DE60141680D1 (de) * 2000-01-14 2010-05-12 Univ Brown Res Found Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln
CA2382133C (en) * 2000-05-10 2010-11-23 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery

Also Published As

Publication number Publication date
NO333742B1 (no) 2013-09-02
FR2809309B1 (fr) 2004-06-11
WO2001089481A1 (fr) 2001-11-29
EP1303259A1 (fr) 2003-04-23
AU2001263996B2 (en) 2006-01-19
CA2410219A1 (fr) 2001-11-29
US20040043076A1 (en) 2004-03-04
ZA200209553B (en) 2003-08-26
IL153046A0 (en) 2003-06-24
BR0111054A (pt) 2003-04-15
IL153046A (en) 2013-12-31
TWI264310B (en) 2006-10-21
JP2003534267A (ja) 2003-11-18
KR20030011858A (ko) 2003-02-11
KR100787669B1 (ko) 2007-12-21
EP1303259B1 (fr) 2013-03-20
NO20025552D0 (no) 2002-11-19
NO20025552L (no) 2003-01-20
CN1438877A (zh) 2003-08-27
FR2809309A1 (fr) 2001-11-30
AR029667A1 (es) 2003-07-10
ES2413406T3 (es) 2013-07-16
MXPA02011560A (es) 2004-09-10
AU6399601A (en) 2001-12-03
HUP0302012A3 (en) 2005-11-28
HU228702B1 (en) 2013-05-28

Similar Documents

Publication Publication Date Title
HUP0302012A2 (hu) Injekcióval adagolható nyújtott hatóanyag-leadású mikrogömbök és eljárás elżállításukra
WO2004000389A3 (en) Rapidly dissolving micro-perforator for drug delivery and other applications
DE60237170D1 (de) Verfahren zur messung der wirkstärke von glatirameracetat
DK1161452T3 (da) Kovalent forbundne insulindimerer
EP0887075A3 (en) Adhesive mixture for transdermal delivery of highly plasticizing drugs
GEP20074123B (en) Amino acids with affinity for the alpha−2−delta−protein
CA2449244A1 (en) Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug
DE60321351D1 (de) Verfahren zur herstellung von oral verzehrbaren darreichungsformen
HUP0203623A2 (hu) Tramadol-szacharinátot tartalmazó, késleltetett hatású adagolási forma és alkalmazása
HUP0400782A2 (hu) Antikolinergikumokon és PDE-IV inhibitorokon alapuló új gyógyszerkészítmények
DE60212475D1 (de) Pharmazeutische Tablette und eine Verfahren zu deren Herstellung
ATE375729T1 (de) Verfahren zur herstellung eines pharmazeutischen kaugummis
DE60139462D1 (de) Arzneimittel zur gesteuerten freisetzung von paracetamol
HUP9801227A2 (hu) Monoamin-oxidáz B inhibitorokból álló gyógyászati készítmények és alkalmazásuk
MXPA04000317A (es) Un copolimero de bloque amfifilico cargado positivamente como un vehiculo de medicamento y complejo del mismo con un medicamento cargado negativamente.
FR2782455B3 (fr) Composition pharmaceutique injectable a base d'un sel pharmaceutiquement acceptable du clopidogrel ou de ticlopidine
DE602005012522D1 (de) Flüssige allergie-impfstoffformulierung zur oromukosalen verabreichung
HUP0202729A2 (hu) Ösztramusztin-foszfátot és aminosavakat tartalmazó, parenteralis felhasználásra szolgáló készítmények
HUP0400262A2 (hu) Glikopeptidek, előállításuk és alkalmazásuk szklerózis multiplex kezelésében
HUP0402298A2 (hu) Dezoxipeganin alkalmazása klinikai depresszió kezelésére
NO20024363L (no) Nye LHRH-antagonister, produksjon og anvendelse av disse som medikamant
DE602004016170D1 (de) Verfahren zur herstellung von finasterid form i
HUP0203057A2 (hu) Módosított ciliáris nerotróf faktor, ennek előállítási és használati módszere
ATE477235T1 (de) Verfahren zur hydrierung von aromatischen verbindungen
Wilson Milestones for Kubota.

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees