HUP0301461A2 - 17 alfa-fluoralkil szteroidok alkalmazása a tumorsejtek növekedési faktor függésének gátlására szolgáló gyógyszerkészítmény előállítására - Google Patents

17 alfa-fluoralkil szteroidok alkalmazása a tumorsejtek növekedési faktor függésének gátlására szolgáló gyógyszerkészítmény előállítására

Info

Publication number
HUP0301461A2
HUP0301461A2 HU0301461A HUP0301461A HUP0301461A2 HU P0301461 A2 HUP0301461 A2 HU P0301461A2 HU 0301461 A HU0301461 A HU 0301461A HU P0301461 A HUP0301461 A HU P0301461A HU P0301461 A2 HUP0301461 A2 HU P0301461A2
Authority
HU
Hungary
Prior art keywords
growth factor
inhibition
alpha
pharmaceutical compositions
tumor cells
Prior art date
Application number
HU0301461A
Other languages
English (en)
Inventor
Ulrike Fuhrmann
Rosemarie Lichtner
Original Assignee
Schering Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10051609A external-priority patent/DE10051609A1/de
Application filed by Schering Ag. filed Critical Schering Ag.
Publication of HUP0301461A2 publication Critical patent/HUP0301461A2/hu
Publication of HUP0301461A3 publication Critical patent/HUP0301461A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány a progeszteron receptor inhibitoroknak a tumorsejteknövekedési faktor függő gátlására szolgáló gyógyszerkészítményekelőállítására, különösen a 17a-fluoralkil szteroidok alkalmazásáravonatkozik. Ó
HU0301461A 2000-10-18 2001-10-17 Use of 17 alpha-fluoroalkyl steroids for producing pharmaceutical compositions for inhibition of the growth factor dependency of tumor cells HUP0301461A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24101000P 2000-10-18 2000-10-18
DE10051609A DE10051609A1 (de) 2000-10-18 2000-10-18 Hemmung der Wachstumsfaktorabhängigkeit von Tumorzellen
PCT/EP2001/012004 WO2002032429A2 (en) 2000-10-18 2001-10-17 Use of inhibitors of progesterone receptor for treating cancer

Publications (2)

Publication Number Publication Date
HUP0301461A2 true HUP0301461A2 (hu) 2003-10-28
HUP0301461A3 HUP0301461A3 (en) 2010-01-28

Family

ID=26007397

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301461A HUP0301461A3 (en) 2000-10-18 2001-10-17 Use of 17 alpha-fluoroalkyl steroids for producing pharmaceutical compositions for inhibition of the growth factor dependency of tumor cells

Country Status (26)

Country Link
EP (1) EP1414465B1 (hu)
JP (1) JP4335525B2 (hu)
KR (1) KR20030044006A (hu)
CN (1) CN1311833C (hu)
AT (1) ATE339208T1 (hu)
AU (2) AU2002215958B2 (hu)
BG (1) BG107745A (hu)
BR (1) BR0114677A (hu)
CA (1) CA2423013A1 (hu)
CY (1) CY1106289T1 (hu)
CZ (1) CZ299945B6 (hu)
DE (1) DE60123138T2 (hu)
DK (1) DK1414465T3 (hu)
EA (1) EA005945B1 (hu)
EE (1) EE200300156A (hu)
ES (1) ES2272561T3 (hu)
HK (1) HK1071697A1 (hu)
HR (1) HRP20030386A2 (hu)
HU (1) HUP0301461A3 (hu)
IL (2) IL154974A0 (hu)
MX (1) MXPA03002953A (hu)
NO (1) NO20031745L (hu)
NZ (1) NZ545965A (hu)
PL (1) PL366415A1 (hu)
SK (1) SK4752003A3 (hu)
WO (1) WO2002032429A2 (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006054535A1 (de) * 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
DE102009034367A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034362A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034366A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034368A1 (de) 2009-07-20 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102009034526A1 (de) 2009-07-21 2011-02-10 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten
DE102009034525A1 (de) 2009-07-21 2011-01-27 Bayer Schering Pharma Aktiengesellschaft 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten
DE102010007722A1 (de) 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten
DE102010007719A1 (de) * 2010-02-10 2011-08-11 Bayer Schering Pharma Aktiengesellschaft, 13353 Progesteronrezeptorantagonisten

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466315A3 (en) * 1990-05-30 1992-07-01 Larrian Gillespie Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation
US5238950A (en) * 1991-12-17 1993-08-24 Schering Corporation Inhibitors of platelet-derived growth factor
DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette
PE20000129A1 (es) * 1997-12-23 2000-03-11 Schering Ag 11 beta-halogeno-estratrienos sustituidos en 7 alfa, asi como el procedimiento para elaborar preparados farmaceuticos que contienen tales 11 beta-halogeno-estratrienos sustituidos en 7 alfa
FR2789393B1 (fr) * 1999-02-05 2001-10-12 Centre Nat Rech Scient Lactol steroidique

Also Published As

Publication number Publication date
SK4752003A3 (en) 2003-10-07
AU2002215958B2 (en) 2006-08-17
HRP20030386A2 (en) 2005-04-30
NO20031745D0 (no) 2003-04-15
JP2004513094A (ja) 2004-04-30
CY1106289T1 (el) 2011-10-12
EE200300156A (et) 2003-08-15
MXPA03002953A (es) 2003-08-07
KR20030044006A (ko) 2003-06-02
NZ545965A (en) 2007-09-28
AU1595802A (en) 2002-04-29
NO20031745L (no) 2003-04-15
DE60123138D1 (de) 2006-10-26
EP1414465A2 (en) 2004-05-06
CN1551772A (zh) 2004-12-01
AU2002215958C1 (en) 2002-04-29
WO2002032429A2 (en) 2002-04-25
ATE339208T1 (de) 2006-10-15
DE60123138T2 (de) 2007-09-13
PL366415A1 (en) 2005-01-24
IL154974A (en) 2007-05-15
EA200300468A1 (ru) 2003-10-30
IL154974A0 (en) 2003-10-31
EA005945B1 (ru) 2005-08-25
EP1414465B1 (en) 2006-09-13
JP4335525B2 (ja) 2009-09-30
HUP0301461A3 (en) 2010-01-28
BR0114677A (pt) 2003-10-07
HK1071697A1 (en) 2005-07-29
ES2272561T3 (es) 2007-05-01
CN1311833C (zh) 2007-04-25
CZ299945B6 (cs) 2008-12-29
DK1414465T3 (da) 2007-01-29
CA2423013A1 (en) 2002-04-25
BG107745A (bg) 2004-01-30
WO2002032429A3 (en) 2004-02-19

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees