HUP0300965A2 - Új aril-etén-szulfonamidok pirimidinszármazékai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Új aril-etén-szulfonamidok pirimidinszármazékai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0300965A2 HUP0300965A2 HU0300965A HUP0300965A HUP0300965A2 HU P0300965 A2 HUP0300965 A2 HU P0300965A2 HU 0300965 A HU0300965 A HU 0300965A HU P0300965 A HUP0300965 A HU P0300965A HU P0300965 A2 HUP0300965 A2 HU P0300965A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- heterocyclyl
- amino
- group
- aryl
- Prior art date
Links
- 229940124530 sulfonamide Drugs 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- -1 tri-substituted phenyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
- 125000005149 cycloalkylsulfinyl group Chemical group 0.000 abstract 1
- 125000005366 cycloalkylthio group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000005367 heteroarylalkylthio group Chemical group 0.000 abstract 1
- 125000005241 heteroarylamino group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 abstract 1
- 125000005368 heteroarylthio group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000005844 heterocyclyloxy group Chemical group 0.000 abstract 1
- 125000004468 heterocyclylthio group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000005191 hydroxyalkylamino group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány (I) általános képletű aril-etén-szulfonamidokra és azokgyógyászatilag alkalmazható sóira vonatkozik - a képletben R1 és R2egymástól függetlenül aril- vagy heteroaril-csoportot jelent; R3jelentése fenilcsoport, mono-, di- vagy triszubsztituált fenilcsoport,arilcsoport vagy heteroaril-csoport; R4 jelentése hidrogénatom,halogénatom vagy trifluor-metil-alkil-, alkil-amino-, alkoxi-, alkil-szulfono-, alkil-szulfinil-, alkil-tio-, alkil-tio-alkil-, hidroxi-alkil-, alkoxi-alkil-, hidroxi-alkoxi-alkil-, hidroxi-alkil-amino-,alkil-amino-alkil-, amino-, di-alkil-amino-,[N-(hidroxi-alkil)-N-alkil]-amino-, aril-, aril-amino-, aril-alkil-amino-, aril-tio-, aril-alkil-tio-, aril-oxi-, aril-alkil-oxi-, aril-alkil-, aril-szulfinil-,heteroaril-, heteroaril-oxi-, heteroaril-alkil-oxi-, heteroaril-amino-, heteroaril-alkil-amino-, heteroaril-tio-, heteroaril-alkil-tio-, heteroaril-alkil-, heteroaril-szulfinil-, heterociklil-,heterociklil-alkil-oxi-, heterociklil-oxi-, heterociklil-amino-,heterociklil-alkil-amino-, heterociklil-tio-, heterociklil-alkil-tio-,heterociklil-alkil-, heterociklil-szulfinil-, cikloalkil-, cikloalkil-oxi-, cikloalkil-alkil-oxi-, cikloalkil-amino-, cikloalkil-alkil-amino-, cikloalkil-tio-, cikloalkil-alkil-tio-, cikloalkil-alkil- vagycikloalkil-szulfinil-csoport; R5 és R6 egymástól függetlenülhidrogénatomot vagy alkilcsoportot jelent; X vegyértékkötést vagy -O-,-S-, -NH- vagy -CH2- csoportot jelent; Y -O-, -S- vagy -NH- csoportotjelent; Z vegyértékkötést vagy -O-, -S- vagy -NH- csoportot jelent; ésQ jelentése -(CH2)n-, -CH2-ciklopropilén-CH2- vagy -(CH2)m-C<C-(CH2)p- csoport. A találmány kiterjed a vegyületeket tartalmazógyógyszerkészítményekre és a vegyületek alkalmazásáragyógyszerkészítmények előállítására. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP0007006 | 2000-07-21 | ||
PCT/EP2001/007922 WO2002008200A2 (en) | 2000-07-21 | 2001-07-10 | Arylethene-sulfonamides, their preparation and their use as endothelin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0300965A2 true HUP0300965A2 (hu) | 2003-10-28 |
HUP0300965A3 HUP0300965A3 (en) | 2004-01-28 |
Family
ID=8164031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300965A HUP0300965A3 (en) | 2000-07-21 | 2001-07-10 | Novel pyrimidin derivatives of arylethene sulfonamides, pharmaceutical compositions containing them and their use |
Country Status (21)
Country | Link |
---|---|
US (1) | US6951856B2 (hu) |
EP (1) | EP1309564B1 (hu) |
JP (1) | JP4832706B2 (hu) |
KR (1) | KR100826332B1 (hu) |
CN (1) | CN100562518C (hu) |
AR (1) | AR030247A1 (hu) |
AT (1) | ATE329908T1 (hu) |
AU (2) | AU2001281970B2 (hu) |
BR (1) | BR0112614A (hu) |
CA (1) | CA2416785C (hu) |
DE (1) | DE60120711T2 (hu) |
ES (1) | ES2266233T3 (hu) |
HU (1) | HUP0300965A3 (hu) |
IL (2) | IL153471A0 (hu) |
MX (1) | MXPA03000430A (hu) |
MY (1) | MY140724A (hu) |
NO (1) | NO324771B1 (hu) |
NZ (1) | NZ523304A (hu) |
TW (1) | TWI289553B (hu) |
WO (1) | WO2002008200A2 (hu) |
ZA (1) | ZA200300137B (hu) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0508461B8 (pt) | 2004-03-05 | 2021-05-25 | Hoffmann La Roche | diaminopirimidinas, seus usos, e composição farmacêutica |
EP1924564B1 (en) | 2005-09-01 | 2016-11-09 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
EP1924566B1 (en) | 2005-09-01 | 2016-01-13 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
KR101025381B1 (ko) | 2005-09-01 | 2011-03-28 | 에프. 호프만-라 로슈 아게 | P2x3 및 p2x2/3 조정자로서의 다이아미노피리미딘 |
TWI331523B (en) * | 2005-12-08 | 2010-10-11 | Nat Health Research Institutes | Vinylsulfonate compounds |
WO2009020579A1 (en) * | 2007-08-07 | 2009-02-12 | Schering Corporation | Gamma secretase modulators |
WO2009104152A1 (en) * | 2008-02-20 | 2009-08-27 | Actelion Pharmaceuticals Ltd | Combination treatment for ovarian cancer |
IT1393136B1 (it) * | 2009-03-11 | 2012-04-11 | Sifa Vitor S R L | Procedimento per la preparazione del bosentan |
US20100256371A1 (en) * | 2009-04-02 | 2010-10-07 | Glenmark | Processes for the preparation of bosentan and its intermediates thereof |
AU2018332634A1 (en) * | 2017-09-12 | 2020-04-30 | Agency For Science, Technology And Research | Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase |
CN110885328B (zh) * | 2018-09-10 | 2022-08-12 | 成都康弘药业集团股份有限公司 | 作为钠通道阻滞剂的磺酰胺类化合物及其用途 |
TWI833430B (zh) | 2021-11-08 | 2024-02-21 | 大陸商正大天晴藥業集團股份有限公司 | 氮雜聯苯類化合物及其應用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
TW287160B (hu) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
TW394761B (en) | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
JP2790065B2 (ja) * | 1993-12-17 | 1998-08-27 | 田辺製薬株式会社 | ベンゼンスルホンアミド誘導体及びその製法 |
IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
US5739333A (en) | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
CN1102580C (zh) * | 1995-12-20 | 2003-03-05 | 山之内制药株式会社 | 芳基乙烯基磺酰胺衍生物及其医药组合物 |
TWI284642B (en) | 1999-01-18 | 2007-08-01 | Hoffmann La Roche | Novel heterocyclic sulfonamides |
US6417360B1 (en) | 1999-03-03 | 2002-07-09 | Hoffmann-La Roche Inc. | Heterocyclic sulfonamides |
-
2001
- 2001-07-09 MY MYPI20013244A patent/MY140724A/en unknown
- 2001-07-10 AU AU2001281970A patent/AU2001281970B2/en not_active Ceased
- 2001-07-10 CN CNB018126693A patent/CN100562518C/zh not_active Expired - Fee Related
- 2001-07-10 AT AT01960485T patent/ATE329908T1/de active
- 2001-07-10 JP JP2002514106A patent/JP4832706B2/ja not_active Expired - Fee Related
- 2001-07-10 WO PCT/EP2001/007922 patent/WO2002008200A2/en active IP Right Grant
- 2001-07-10 ES ES01960485T patent/ES2266233T3/es not_active Expired - Lifetime
- 2001-07-10 CA CA002416785A patent/CA2416785C/en not_active Expired - Fee Related
- 2001-07-10 MX MXPA03000430A patent/MXPA03000430A/es active IP Right Grant
- 2001-07-10 HU HU0300965A patent/HUP0300965A3/hu unknown
- 2001-07-10 IL IL15347101A patent/IL153471A0/xx active IP Right Grant
- 2001-07-10 EP EP01960485A patent/EP1309564B1/en not_active Expired - Lifetime
- 2001-07-10 DE DE60120711T patent/DE60120711T2/de not_active Expired - Lifetime
- 2001-07-10 US US10/332,247 patent/US6951856B2/en not_active Expired - Fee Related
- 2001-07-10 BR BR0112614-8A patent/BR0112614A/pt not_active Application Discontinuation
- 2001-07-10 AU AU8197001A patent/AU8197001A/xx active Pending
- 2001-07-10 NZ NZ523304A patent/NZ523304A/en unknown
- 2001-07-10 KR KR1020037000256A patent/KR100826332B1/ko not_active IP Right Cessation
- 2001-07-16 AR ARP010103391A patent/AR030247A1/es active IP Right Grant
- 2001-07-23 TW TW090117915A patent/TWI289553B/zh not_active IP Right Cessation
-
2002
- 2002-12-16 IL IL153471A patent/IL153471A/en not_active IP Right Cessation
-
2003
- 2003-01-06 ZA ZA200300137A patent/ZA200300137B/en unknown
- 2003-01-20 NO NO20030274A patent/NO324771B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20030220359A1 (en) | 2003-11-27 |
US6951856B2 (en) | 2005-10-04 |
KR100826332B1 (ko) | 2008-05-02 |
DE60120711T2 (de) | 2007-06-06 |
IL153471A0 (en) | 2003-07-06 |
NO20030274D0 (no) | 2003-01-20 |
HUP0300965A3 (en) | 2004-01-28 |
AU2001281970B2 (en) | 2006-03-16 |
CA2416785A1 (en) | 2002-01-31 |
CN1441788A (zh) | 2003-09-10 |
TWI289553B (en) | 2007-11-11 |
CA2416785C (en) | 2009-11-10 |
IL153471A (en) | 2007-09-20 |
ZA200300137B (en) | 2004-04-06 |
ES2266233T3 (es) | 2007-03-01 |
KR20030016382A (ko) | 2003-02-26 |
BR0112614A (pt) | 2003-06-10 |
WO2002008200A3 (en) | 2002-05-10 |
ATE329908T1 (de) | 2006-07-15 |
EP1309564B1 (en) | 2006-06-14 |
EP1309564A2 (en) | 2003-05-14 |
AU8197001A (en) | 2002-02-05 |
AR030247A1 (es) | 2003-08-13 |
JP4832706B2 (ja) | 2011-12-07 |
JP2004504385A (ja) | 2004-02-12 |
MY140724A (en) | 2010-01-15 |
WO2002008200A2 (en) | 2002-01-31 |
MXPA03000430A (es) | 2003-06-24 |
NO20030274L (no) | 2003-01-20 |
DE60120711D1 (de) | 2006-07-27 |
NZ523304A (en) | 2005-02-25 |
CN100562518C (zh) | 2009-11-25 |
NO324771B1 (no) | 2007-12-10 |
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