ES2196090T3 - Derivados pirimidinicos. - Google Patents

Derivados pirimidinicos.

Info

Publication number
ES2196090T3
ES2196090T3 ES95940471T ES95940471T ES2196090T3 ES 2196090 T3 ES2196090 T3 ES 2196090T3 ES 95940471 T ES95940471 T ES 95940471T ES 95940471 T ES95940471 T ES 95940471T ES 2196090 T3 ES2196090 T3 ES 2196090T3
Authority
ES
Spain
Prior art keywords
alkyl
derivative
salt
pyrimidinic
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95940471T
Other languages
English (en)
Inventor
Mitsuteru Hirata
Takeo Deushi
Yoshio Takahashi
Masahiro Tamura
Takeshi Ohshima
Toshiaki Oda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kowa Co Ltd
Original Assignee
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co Ltd filed Critical Kowa Co Ltd
Application granted granted Critical
Publication of ES2196090T3 publication Critical patent/ES2196090T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Abstract

LA PRESENTE INVENCION SE REFIERE A UN DERIVADO DE PIRIMIDINA DE LA FORMULA SIGUIENTE (1) O A UNA SAL DEL DERIVADO: [DONDE R{SUP,1} REPRESENTA UN GRUPO ALQUILO DE BAJO PESO MOLECULAR; CADA UNO DE R{SUP,2} Y R{SUP,3} REPRESENTA H, ALQUILO O ALCOXI; CADA UNO DE R{SUP,4} Y R{SUP,5} REPRESENTA H O ALQUILO; R{SUP,6} REPRESENTA ALQUILO, - OR{SUP,7}, O - NR{SUP,8}R{SUP,9}; Y N ES UN NUMERO ENTRE 0 Y 3 INCLUSIVE (DONDE CADA UNO DE R{SUP,7}, R{SUP,8} Y R{SUP,9} REPRESENTA H, ALQUILO, ARILO, ARALQUILO, AMINO, UN ANILLO HETEROCICLICO, ETC.)], ASI COMO A UN MEDICAMENTO QUE CONTIENE EL DERIVADO O LA SAL COMO PRINCIPIO ACTIVO. ESTOS COMPUESTOS PRESENTAN UNA INTENSA ACTIVIDAD INHIBIDORA DE LA UNION FRENTE A LA ENDOTELINA Y EFECTOS VASOCONSTRICTOR Y DE PROLIFERACION CELULAR POTENTES. POR CONSIGUIENTE, LOS COMPUESTOS SON EFICACES COMO REMEDIOS PARA DISTINTAS ENFERMEDADES INCLUIDAS LAS DEL SISTEMA CIRCULATORIO.
ES95940471T 1994-12-28 1995-12-19 Derivados pirimidinicos. Expired - Lifetime ES2196090T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP32732994 1994-12-28
JP16945495 1995-07-05

Publications (1)

Publication Number Publication Date
ES2196090T3 true ES2196090T3 (es) 2003-12-16

Family

ID=26492784

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95940471T Expired - Lifetime ES2196090T3 (es) 1994-12-28 1995-12-19 Derivados pirimidinicos.

Country Status (12)

Country Link
US (2) US6008224A (es)
EP (1) EP0801062B1 (es)
CN (1) CN1171785A (es)
AT (1) ATE238285T1 (es)
CA (1) CA2207100C (es)
DE (1) DE69530516T2 (es)
ES (1) ES2196090T3 (es)
FI (1) FI972795A0 (es)
HU (1) HUT77534A (es)
NO (1) NO973001L (es)
PT (1) PT801062E (es)
WO (1) WO1996020177A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9903526A3 (en) * 1995-09-06 2000-07-28 Kowa Co Pyrimidine derivatives and pharmaceutical compositions containing the same
US7566452B1 (en) * 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
CA2315614C (en) * 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
KR100495550B1 (ko) * 2000-01-25 2005-06-16 에프. 호프만-라 로슈 아게 설폰아미드의 제조 방법
US6387915B2 (en) 2000-05-31 2002-05-14 Pfizer Inc. Isoxazole-sulfonamide endothelin antagonists
US6670362B2 (en) 2000-09-20 2003-12-30 Pfizer Inc. Pyridazine endothelin antagonists
US11446303B2 (en) * 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2086544C1 (ru) * 1991-06-13 1997-08-10 Хоффманн-Ля Рош АГ Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
TW394761B (en) * 1993-06-28 2000-06-21 Hoffmann La Roche Novel Sulfonylamino Pyrimidines
IL111959A (en) * 1993-12-17 2000-07-16 Tanabe Seiyaku Co N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them
HUP9903526A3 (en) 1995-09-06 2000-07-28 Kowa Co Pyrimidine derivatives and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
AU696216B2 (en) 1998-09-03
DE69530516D1 (de) 2003-05-28
CA2207100A1 (en) 1996-07-04
FI972795A (fi) 1997-06-27
EP0801062B1 (en) 2003-04-23
NO973001L (no) 1997-08-27
US6008224A (en) 1999-12-28
AU4190096A (en) 1996-07-19
EP0801062A1 (en) 1997-10-15
EP0801062A4 (en) 1998-04-29
HUT77534A (hu) 1998-05-28
US6337334B1 (en) 2002-01-08
CA2207100C (en) 2008-02-19
DE69530516T2 (de) 2003-12-24
NO973001D0 (no) 1997-06-27
PT801062E (pt) 2003-08-29
CN1171785A (zh) 1998-01-28
WO1996020177A1 (fr) 1996-07-04
FI972795A0 (fi) 1997-06-27
ATE238285T1 (de) 2003-05-15

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