HUP0300371A2 - Jelöléskönyvtár vegyületek, készítmények, kittek és használatuk módja - Google Patents

Jelöléskönyvtár vegyületek, készítmények, kittek és használatuk módja

Info

Publication number
HUP0300371A2
HUP0300371A2 HU0300371A HUP0300371A HUP0300371A2 HU P0300371 A2 HUP0300371 A2 HU P0300371A2 HU 0300371 A HU0300371 A HU 0300371A HU P0300371 A HUP0300371 A HU P0300371A HU P0300371 A2 HUP0300371 A2 HU P0300371A2
Authority
HU
Hungary
Prior art keywords
etag
reporter
reporters
compounds
kits
Prior art date
Application number
HU0300371A
Other languages
English (en)
Inventor
Tracy Matray
Hussein Salinmimoosavi
Sharat Singh
Original Assignee
Aclara Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/561,579 external-priority patent/US6682887B1/en
Application filed by Aclara Biosciences, Inc. filed Critical Aclara Biosciences, Inc.
Publication of HUP0300371A2 publication Critical patent/HUP0300371A2/hu
Publication of HUP0300371A3 publication Critical patent/HUP0300371A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/08—Direct analysis of the library members per se by physical methods, e.g. spectroscopy
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Structural Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgyát olyan vegyületcsaládok képezik, amiket jelöléskéntlehet használni (ezekre eTag riporterekként hivatkoznak), polimervegyületekhez kapcsolva, majd vizsgálni lehet őket az eTagriportereknek a polimer vegyületről való felszabadulása, majdelválasztása és kimutatása alapján. Az oligonukleotidokhoz az eTagriportereket az oligonukleotidok végére szintetizálják, foszfit- vagyfoszfát-kémia alkalmazásával, és a tömeget módosító régiókat, töltéstmódosító régiókat és a kimutatható régiókat egymás után adják amolekulákhoz, ezzel eTag-gel jelzett riportermolekulákat állítva elő.Kis építőköveket használva és kombinációjukat variálva könnyennagyszámú különböző eTag riporter állítható elő, az érdekesoligonukleotidhoz kapcsolva, azonosítás céljából. Olyan protokollokathasználnak, amik felszabadítják az eTag riportert, ha a megcélzottszekvencia jelen van a mintában. Ó
HU0300371A 2000-04-28 2000-10-27 Tag library compounds, compositions, kits and methods of use HUP0300371A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/561,579 US6682887B1 (en) 1999-04-30 2000-04-28 Detection using degradation of a tagged sequence
US09/602,586 US6514700B1 (en) 1999-04-30 2000-06-21 Nucleic acid detection using degradation of a tagged sequence
PCT/US2000/029724 WO2001083502A1 (en) 2000-04-28 2000-10-27 Tag library compounds, compositions, kits and methods of use

Publications (2)

Publication Number Publication Date
HUP0300371A2 true HUP0300371A2 (hu) 2003-06-28
HUP0300371A3 HUP0300371A3 (en) 2005-09-28

Family

ID=27072683

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300371A HUP0300371A3 (en) 2000-04-28 2000-10-27 Tag library compounds, compositions, kits and methods of use

Country Status (13)

Country Link
US (3) US6514700B1 (hu)
EP (1) EP1278760B1 (hu)
JP (2) JP3566255B2 (hu)
KR (1) KR100495242B1 (hu)
AT (1) ATE398135T1 (hu)
AU (2) AU1240201A (hu)
CA (1) CA2403326C (hu)
DE (1) DE60039196D1 (hu)
DK (1) DK1278760T3 (hu)
ES (1) ES2308999T3 (hu)
HU (1) HUP0300371A3 (hu)
PL (1) PL364923A1 (hu)
WO (1) WO2001083502A1 (hu)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613523B2 (en) * 2001-06-29 2003-09-02 Agilent Technologies, Inc. Method of DNA sequencing using cleavable tags
WO2003104814A2 (en) * 2002-01-01 2003-12-18 Phynexus, Inc. Biomolecule open channel solid phase extraction systems and methods
AU2003222253A1 (en) * 2002-03-05 2003-09-22 Monogram Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
NZ537660A (en) 2002-07-15 2008-12-24 Genentech Inc Methods for identifying tumors that are responsive to treatment with anti-ErbB2 antibodies
WO2004011128A1 (en) * 2002-07-26 2004-02-05 Aclara Biosciences, Inc. Methods and compositions for screening cell binding molecules
US20040053263A1 (en) * 2002-08-30 2004-03-18 Abreu Maria T. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
FR2846331B1 (fr) * 2002-10-29 2006-11-17 Synth Innove Lab Phtaleines de purete elevee et leur procede de preparation
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
EP1599492A4 (en) * 2003-01-17 2008-09-24 Virologic Inc RECIPIENTS DORPHANIZATION BY USING MARKED MOLECULAR LIBRARIES
EP1606419A1 (en) 2003-03-18 2005-12-21 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
CA2521106A1 (en) * 2003-04-01 2004-10-14 Monogram Biosciences, Inc. Intracellular complexes as biomarkers
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
EP1673399B1 (en) * 2003-08-11 2017-04-05 Monogram BioSciences, Inc. Detecting and profiling molecular complexes
US20050106602A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Simplified methods for isolating nucleic acids from cellular materials
US20050106576A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Methods of using cleavable solid phases for isolating nucleic acids
US20050106589A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Compositions and methods for releasing nucleic acids from solid phase binding materials
US20050136477A1 (en) * 2003-11-17 2005-06-23 Hashem Akhavan-Tafti Methods for isolating nucleic acids from biological and cellular materials
JP2007525217A (ja) 2004-02-19 2007-09-06 ザ ガバナーズ オブ ザ ユニバーシティー オブ アルバータ レプチンプロモーター多型及びその使用
US20050191687A1 (en) * 2004-02-27 2005-09-01 Tianxin Wang Method for multiplexed analyte detection
EP1766061B1 (en) * 2004-05-20 2013-07-17 Quest Diagnostics Investments Incorporated Single label comparative hybridization
US20080042805A1 (en) * 2005-05-17 2008-02-21 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials
US20070008115A1 (en) * 2005-05-17 2007-01-11 Morhard Robert C System, method and devices for detecting, monitoring, tracking and identifying explosive materials using RFID tags
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US20070268135A1 (en) * 2006-05-17 2007-11-22 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using visibility devices
MX2007014378A (es) * 2005-05-17 2008-02-06 Explo Track Llc Sistema y metodo para detectar, monitorear, rastrear e identificar materiales explosivos.
US20080312092A1 (en) * 2005-07-08 2008-12-18 The University Of Denver Photoinduced Signal Amplification Through Externally Sensitized Photofragmentation in Masked Photosensitizers
US20090247420A1 (en) * 2005-12-12 2009-10-01 Kutateladze Andrei G Method for encoding and screening combinatorial libraries
JP2008111709A (ja) * 2006-10-30 2008-05-15 Japan Science & Technology Agency 標識剤及び標的物質の測定方法
US7902345B2 (en) * 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US8133701B2 (en) * 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US7507539B2 (en) * 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
US8735167B2 (en) * 2007-08-20 2014-05-27 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
US8741858B2 (en) 2007-09-21 2014-06-03 Zhongxu Ren Oligomer-nucleoside phosphate conjugates
WO2009070772A1 (en) 2007-11-27 2009-06-04 Monogram Biosciences, Inc. Enhanced method for detecting and/or quantifying an analyte in a sample
CA2711843C (en) * 2007-12-20 2018-11-13 Laboratory Corporation Of America Holdings Her-2 diagnostic methods
WO2010065568A2 (en) * 2008-12-01 2010-06-10 Laboratory Corporation Of America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
US20100233732A1 (en) * 2009-01-15 2010-09-16 Laboratory Corporation Of America Holdings Methods of Determining Patient Response By Measurement of HER-2 Expression
KR20110120891A (ko) 2009-01-15 2011-11-04 래버러토리 코포레이션 오브 아메리카 홀딩스 Ｈｅｒ-３의 측정에 의한 환자 반응의 결정 방법
WO2010107946A2 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
JP6120449B2 (ja) * 2011-05-06 2017-04-26 キアゲン ゲーエムベーハー リンカーを介して結合した標識を含むオリゴヌクレオチド
WO2014053479A1 (en) 2012-10-02 2014-04-10 Roche Diagnostics Gmbh Methods of specifically releasing a sub-group of objects
US9540699B2 (en) 2013-03-13 2017-01-10 William Beaumont Hospital Methods of diagnosing increased risk of developing MRSA
US9765220B2 (en) 2013-08-22 2017-09-19 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
EP3050886A1 (en) * 2015-02-02 2016-08-03 Bürkert Werke GmbH Fluorescent dyes and dye precursors
US11084932B2 (en) 2015-02-26 2021-08-10 Sony Group Corporation Phenylethynylnaphthalene dyes and methods for their use
EP3262055A4 (en) * 2015-02-26 2018-09-05 Sony Corporation Water soluble fluorescent or colored dyes comprising conjugating groups
KR20180005650A (ko) 2015-05-11 2018-01-16 소니 주식회사 초휘도 이량체성 또는 중합체성 염료
CN105510420B (zh) * 2015-12-20 2017-12-12 青岛科技大学 一种基于磁珠分离和dna标记金纳米粒子探针检测atp含量的方法
WO2017161030A1 (en) 2016-03-15 2017-09-21 Laboratory Corporation Of America Holdings Methods of assessing protein interactions between cells
CN109415574B (zh) 2016-04-01 2021-05-28 索尼公司 具有刚性间隔基团的超亮二聚体或聚合物染料
RU2762328C2 (ru) 2016-04-01 2021-12-17 Сони Корпорейшн Ультраяркие димерные или полимерные красители
JP7069033B2 (ja) 2016-04-06 2022-05-17 ソニーグループ株式会社 スペーシングリンカー基を有する超明色ダイマーまたはポリマー染料
WO2017196954A1 (en) 2016-05-10 2017-11-16 Sony Corporation Ultra bright polymeric dyes with peptide backbones
JP7068192B2 (ja) 2016-05-10 2022-05-16 ソニーグループ株式会社 ポリマー染料およびシクロデキストリンを含む組成物、ならびにその使用
EP3455300A1 (en) 2016-05-11 2019-03-20 Sony Corporation Ultra bright dimeric or polymeric dyes
US11377563B2 (en) 2016-06-06 2022-07-05 Sony Corporation Ionic polymers comprising fluorescent or colored reporter groups
WO2018022925A1 (en) 2016-07-29 2018-02-01 Sony Corporation Ultra bright dimeric or polymeric dyes and methods for preparation of the same
EP3691690A1 (en) 2017-10-05 2020-08-12 Sony Corporation Programmable polymeric drugs
CN111836645A (zh) 2017-11-16 2020-10-27 索尼公司 可编程的聚合药物
JP2021510698A (ja) * 2018-01-12 2021-04-30 ソニー株式会社 生物学的に活性な化合物を含むホスホアルキルリボースポリマー
CN112041680A (zh) 2018-03-19 2020-12-04 索尼公司 二价金属用于增强荧光信号的应用
JP2021518410A (ja) 2018-03-21 2021-08-02 ソニーグループ株式会社 リンカー基を有するポリマータンデム色素
US12006438B2 (en) 2018-06-27 2024-06-11 Sony Group Corporation Polymeric dyes with linker groups comprising deoxyribose
WO2021062176A2 (en) 2019-09-26 2021-04-01 Sony Corporation Polymeric tandem dyes with linker groups

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331590A (en) * 1978-03-13 1982-05-25 Miles Laboratories, Inc. β-Galactosyl-umbelliferone-labeled protein and polypeptide conjugates
FR2431581A1 (fr) 1978-07-18 1980-02-15 Soum Rene Systeme d'assemblage de planchers
US4650750A (en) * 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5516931A (en) * 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
GB8407736D0 (en) * 1984-03-26 1984-05-02 Univ London Detecting specific polynucleotide sequences
US4767699A (en) * 1985-05-02 1988-08-30 Allied Corporation Diagnostic reagent, kit and method employing polynucleotide displacement, separation, enzymatic cleavage and adenosine phosphate detection
US4675300A (en) 1985-09-18 1987-06-23 The Board Of Trustees Of The Leland Stanford Junior University Laser-excitation fluorescence detection electrokinetic separation
US4876187A (en) * 1985-12-05 1989-10-24 Meiogenics, Inc. Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences
US4780421A (en) * 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
US5494793A (en) * 1986-12-15 1996-02-27 British Technology Group Usa Inc. Monomeric phthalocyanine reagents
US5403711A (en) * 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
CA2118806A1 (en) * 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
DE69322266T2 (de) 1992-04-03 1999-06-02 Perkin Elmer Corp Proben zusammensetzung und verfahren
US5470705A (en) 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
US5958202A (en) * 1992-09-14 1999-09-28 Perseptive Biosystems, Inc. Capillary electrophoresis enzyme immunoassay
US5721099A (en) 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5614402A (en) * 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US5719028A (en) * 1992-12-07 1998-02-17 Third Wave Technologies Inc. Cleavase fragment length polymorphism
US5888780A (en) * 1992-12-07 1999-03-30 Third Wave Technologies, Inc. Rapid detection and identification of nucleic acid variants
US5324401A (en) 1993-02-05 1994-06-28 Iowa State University Research Foundation, Inc. Multiplexed fluorescence detector system for capillary electrophoresis
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
CN1154640C (zh) * 1993-10-01 2004-06-23 纽约市哥伦比亚大学理事 用标示物编码的多元组合化学库
AU1254295A (en) 1993-12-17 1995-07-03 Perkin-Elmer Corporation, The Uncharged polymers for separation of biomolecules by capillary electrophoresis
US6045995A (en) 1994-08-24 2000-04-04 Isis Pharmaceuticals, Inc. Capillary electrophoretic detection of nucleic acids
US5843666A (en) * 1994-09-02 1998-12-01 Lumigen, Inc. Chemiluminescent detection methods using dual enzyer-labeled binding partners
EP0842294B1 (en) * 1994-12-23 2002-10-23 Dade Behring Inc. Detection of nucleic acids by nuclease-catalyzed product formation
US5560811A (en) 1995-03-21 1996-10-01 Seurat Analytical Systems Incorporated Capillary electrophoresis apparatus and method
WO1996031263A1 (en) * 1995-04-06 1996-10-10 Arqule, Inc. Method for rapid purification, analysis and characterization of collections of chemical compounds
US5843655A (en) * 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5846839A (en) * 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US6312893B1 (en) * 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
DE19627032C2 (de) * 1996-07-04 1999-04-15 Deutsches Krebsforsch Verfahren zum Abbau von potentiell veränderten Nukleinsäuren
US6045676A (en) 1996-08-26 2000-04-04 The Board Of Regents Of The University Of California Electrochemical detector integrated on microfabricated capilliary electrophoresis chips
US5952654A (en) * 1997-10-29 1999-09-14 Northeastern University Field-release mass spectrometry
US6562567B2 (en) * 1998-01-27 2003-05-13 California Institute Of Technology Method of detecting a nucleic acid
EP1078265A1 (en) * 1998-02-18 2001-02-28 Dade Behring Inc. Chemiluminescent compositions for use in detection of multiple analytes
US6335201B1 (en) * 1998-03-06 2002-01-01 The Regents Of The University Of California Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility
AU775179B2 (en) 1999-03-15 2004-07-22 Applied Biosystems, Llc Probe/mobility modifier complexes for multiplex nucleic acid detection
AU3519900A (en) * 1999-03-19 2000-10-09 Aclara Biosciences, Inc. Methods for single nucleotide polymorphism detection
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6331530B1 (en) * 1999-07-13 2001-12-18 The Trustees Of Columbia University In The City Of New York Hydrophilic carrier for photosensitizers that cleaves when they catalyze the formation of singlet oxygen
DE60137722D1 (de) * 2000-06-13 2009-04-02 Univ Boston Verwendung von mass-matched nukleotide in der analyse von oligonukleotidmischungen sowie in der hoch-multiplexen nukleinsäuresequenzierung

Also Published As

Publication number Publication date
JP3566255B2 (ja) 2004-09-15
HUP0300371A3 (en) 2005-09-28
WO2001083502A1 (en) 2001-11-08
DE60039196D1 (de) 2008-07-24
CA2403326C (en) 2010-03-30
ATE398135T1 (de) 2008-07-15
CA2403326A1 (en) 2001-11-08
EP1278760B1 (en) 2008-06-11
KR20030032939A (ko) 2003-04-26
AU1240201A (en) 2001-11-12
US20030175747A1 (en) 2003-09-18
ES2308999T3 (es) 2008-12-16
AU2001212402B2 (en) 2004-11-04
US6514700B1 (en) 2003-02-04
PL364923A1 (en) 2004-12-27
JP2003532092A (ja) 2003-10-28
KR100495242B1 (ko) 2005-06-14
DK1278760T3 (da) 2008-10-13
EP1278760A1 (en) 2003-01-29
JP2004117376A (ja) 2004-04-15
US20040029139A1 (en) 2004-02-12

Similar Documents

Publication Publication Date Title
HUP0300371A2 (hu) Jelöléskönyvtár vegyületek, készítmények, kittek és használatuk módja
US11479805B2 (en) Combinatorial single molecule analysis of chromatin
JP2022028662A (ja) ゲノムアセンブリ、ハプロタイプフェージング、および標的に依存しない核酸検出のための方法
ES2875998T3 (es) Procedimientos de perfilado de complejos moleculares mediante el uso de códigos de barras dependientes de la proximidad
WO2006039537A3 (en) A system and method for inhibiting the decryption of a nucleic acid probe sequence used for the detection of a specific nucleic acid
BR9707056B1 (pt) processos e composições para determinar a seqüência de moléculas de ácido nucleico.
Wen et al. Single cell epigenome sequencing technologies
AU2014362322B2 (en) Methods for labeling DNA fragments to recontruct physical linkage and phase
US20160281154A1 (en) Methods for assessing cancer
DE102008025656A1 (de) Verfahren zur quantitativen Analyse von Nikleinsäuren, Marker dafür und deren Verwendung
CN109863250A (zh) 可用于纳米孔检测的标记的核苷酸
US20050112620A1 (en) Nucleic acid mapping using linear analysis
JP2013509863A (ja) 定量的ヌクレアーゼ保護シークエンシング（ｑＮＰＳ）
WO2003008642A3 (en) Amplification of nucleic acid fragments using nicking agents
WO2004099434A3 (en) Homogeneous multiplex screening assays and kits
EP1251136A3 (en) Method and reagents for analyzing the nucleotide sequence of nucleic acids
CN110730822B (zh) 鉴定化合物的方法
ATE553216T1 (de) Sonden, bibliotheken und kits zur analyse von nukleinsäuregemischen und verfahren zu deren konstruktion
Rana Crime investigation through DNA methylation analysis: methods and applications in forensics
JP2022184895A (ja) クロマチン相互作用のゲノムワイドな同定
Park et al. Comparison of library construction kits for mRNA sequencing in the Illumina platform
Watanabe et al. Development of a Real‐Time PCR‐Based Method for Analyzing Semen‐Specific Unmethylated DNA Regions and Methylation Status in Aged Body Fluid Stains
WO2005054516A3 (en) Peptide nucleic acid probes for analysis of certain staphylococcus species
Tommasi et al. A versatile assay for detection of aberrant DNA methylation in bladder cancer
WO2005017488A3 (en) Method and system for identifying biological entities in biological and environmental samples