HUP0203697A2 - Új alfaVbéta3-integrin-inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Új alfaVbéta3-integrin-inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0203697A2 HUP0203697A2 HU0203697A HUP0203697A HUP0203697A2 HU P0203697 A2 HUP0203697 A2 HU P0203697A2 HU 0203697 A HU0203697 A HU 0203697A HU P0203697 A HUP0203697 A HU P0203697A HU P0203697 A2 HUP0203697 A2 HU P0203697A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- substituted
- unsubstituted
- formula
- cona2
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052794 bromium Inorganic materials 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 239000000460 chlorine Chemical group 0.000 abstract 4
- 229910052731 fluorine Inorganic materials 0.000 abstract 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 3
- 239000011737 fluorine Substances 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- -1 -CO-A Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A találmány új (I) általános képletű vegyületekre, fiziológiailagelviselhető sóikra és szolvátjaira vonatkozik, amelyek az avb3-integrin ligandumaiként biológiai hatást fejtenek ki. A képletben X,Y, Z, R1, R4 és R5 jelentései az alábbiak: X jelentése H2N-C(=NH)-,H2N-C(=NH)-NH-, A-C(=NH)-NH-, Hetl- vagy Het1-NH- képletű csoport,amelyekben a primer aminocsoportok hagyományos aminovédőcsoportot ishordozhatnak, Y jelentése (a) vagy (b) képletű csoport, ahol l, 2, 3vagy 4 metiléncsoport N-, O- és/vagy S-atommal lehet lecserélve, Zjelentése kémiai kötés, -O-, -NH-, -NA , -CH(OH)-, -CH(OA)-, -CHA-, -CA2- vagy -S-, R1 jelentése szubsztituálatlan vagy egyszeresen,kétszeresen vagy háromszorosan fluor-, klór-, brómatommal, A-, -OA, -OCF3 vagy -CN csoporttal szubsztituált feniléncsoport, R2 jelentése -N-CHvagy -CAképletű csoport, R3 jelentése H, F, Cl, Br, A, OA vagy -OCF3, R4 jelentése fluor-, klór-, brómatommal, A, Aril, OA, SA, CO-A,CN, -COOA, -CONH2 , -CONHA, -CONA2 vagy NO2 csoporttal szubsztituáltfenil-, naftil vagy Het2-csoport, R5 jelentése -OH, -OA, -NH2, -NHAvagy -NA2 csoport, Het1 jelentése egy- vagy kétgyűrűs, 1-4nitrogématomot tartalmazó heterociklusos csoport, amelyszubsztituálatlan vagy egyszeresen vagy kétszeresen aminocsoporttalszubsztituált, Het2 jelentése egy- vagy kétgyűrűs aromás, 1-3nitrogén-, oxigén- és/vagy kénatomot tartalmazó heterociklusoscsoport, amely szubsztituálatlan vagy fluor-, klór-, brómatommal, -A,-OA, -SA, -OCF3, -CO-A, -CN, -COOA, -CONH2, -CONHA, -CONA2 vagy NO2csoporttal egyszeresen vagy kétszeresen szubsztituált, Aril jelentéseszubsztituálatlan vagy halogénatommal, -A, -OA, -OH, -CO-A -CN, -COOA,-COOH, -CONH2, -CONHA, -CONA2 vagy NO2 csoporttal egyszeresen vagytöbbszörösen szubsztituált fenil- vagy naftilcsoport, A jelentése 1-12szénatomos alkilcsoport, n értéke 1, 2, 3, 4, 5 vagy 6, m, o értékeegvmástól függetlenül 0, 1, 2, 3, 4, 5 vagy 6. A találmány kiterjed avegyületeket tartalmazó gyógyszerkészítményekre és azok alkalmazásárais. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19939981A DE19939981A1 (de) | 1999-08-24 | 1999-08-24 | Neue Inhibitoren des Integrins alphavß3 |
| PCT/EP2000/007591 WO2001014338A1 (de) | 1999-08-24 | 2000-08-04 | NEUE INHIBITOREN DES INTEGRINS αVβ¿3? |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0203697A2 true HUP0203697A2 (hu) | 2003-03-28 |
| HUP0203697A3 HUP0203697A3 (en) | 2004-04-28 |
Family
ID=7919343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0203697A HUP0203697A3 (en) | 1999-08-24 | 2000-08-04 | Novel integrin alphavbetha3 inhibitors, pharmaceutical compositions containing them and their use |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1206454A1 (hu) |
| JP (1) | JP2003507458A (hu) |
| KR (1) | KR20020016651A (hu) |
| CN (1) | CN1370147A (hu) |
| AU (1) | AU6570500A (hu) |
| BR (1) | BR0013504A (hu) |
| CA (1) | CA2382850A1 (hu) |
| CZ (1) | CZ2002523A3 (hu) |
| DE (1) | DE19939981A1 (hu) |
| HK (1) | HK1049666A1 (hu) |
| HU (1) | HUP0203697A3 (hu) |
| MX (1) | MXPA02001861A (hu) |
| NO (1) | NO20020886L (hu) |
| PL (1) | PL352989A1 (hu) |
| SK (1) | SK2282002A3 (hu) |
| WO (1) | WO2001014338A1 (hu) |
| ZA (1) | ZA200202287B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY26780A1 (es) | 2000-06-15 | 2002-01-31 | Pharmacia Corp | Cicloalquil avb3 antagonistas |
| US6531494B1 (en) | 2001-08-29 | 2003-03-11 | Pharmacia Corporation | Gem-substituted αvβ3 antagonists |
| BRPI0417250A (pt) * | 2003-12-03 | 2007-03-06 | Scripps Research Inst | peptìdios e polinucleotìdio isolados e purificados, anticorpos, vetor, célula hospedeira, métodos de inibição de agregação plaquetária, da ligação do fibrinogênio a plaquetas, de uso de polinucleotìdio para a produção de proteìna e de tratamento de pessoa e composições farmacêuticas |
| BRPI0419110A (pt) * | 2004-10-14 | 2007-12-11 | Pharmacia Corp | antagonistas de bifenil integrina |
| PT3538528T (pt) * | 2016-11-08 | 2021-02-16 | Bristol Myers Squibb Co | Pirrol amidas como inibidores de integrina v |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08325264A (ja) * | 1995-05-31 | 1996-12-10 | Sumitomo Metal Ind Ltd | 新規２−芳香環置換−３−フェニルプロピオン酸またはアクリル酸誘導体 |
| EP0946164A4 (en) * | 1996-10-30 | 2000-08-23 | Merck & Co Inc | INTEGRIN ANTAGONISTS |
| EP1061921A4 (en) * | 1998-03-10 | 2005-03-30 | Smithkline Beecham Corp | VITRONECTIN RECEPTOR ANTAGONIST |
-
1999
- 1999-08-24 DE DE19939981A patent/DE19939981A1/de not_active Withdrawn
-
2000
- 2000-08-04 CZ CZ2002523A patent/CZ2002523A3/cs unknown
- 2000-08-04 AU AU65705/00A patent/AU6570500A/en not_active Abandoned
- 2000-08-04 WO PCT/EP2000/007591 patent/WO2001014338A1/de not_active Application Discontinuation
- 2000-08-04 JP JP2001518427A patent/JP2003507458A/ja active Pending
- 2000-08-04 CA CA002382850A patent/CA2382850A1/en not_active Abandoned
- 2000-08-04 HU HU0203697A patent/HUP0203697A3/hu unknown
- 2000-08-04 EP EP00953158A patent/EP1206454A1/de not_active Withdrawn
- 2000-08-04 KR KR1020027001419A patent/KR20020016651A/ko not_active Application Discontinuation
- 2000-08-04 SK SK228-2002A patent/SK2282002A3/sk unknown
- 2000-08-04 MX MXPA02001861A patent/MXPA02001861A/es unknown
- 2000-08-04 PL PL00352989A patent/PL352989A1/xx unknown
- 2000-08-04 BR BR0013504-6A patent/BR0013504A/pt not_active IP Right Cessation
- 2000-08-04 CN CN00811950A patent/CN1370147A/zh active Pending
-
2002
- 2002-02-22 NO NO20020886A patent/NO20020886L/no not_active Application Discontinuation
- 2002-03-20 ZA ZA200202287A patent/ZA200202287B/en unknown
-
2003
- 2003-03-12 HK HK03101785.4A patent/HK1049666A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1206454A1 (de) | 2002-05-22 |
| HK1049666A1 (zh) | 2003-05-23 |
| CN1370147A (zh) | 2002-09-18 |
| WO2001014338A1 (de) | 2001-03-01 |
| MXPA02001861A (es) | 2004-09-06 |
| KR20020016651A (ko) | 2002-03-04 |
| DE19939981A1 (de) | 2001-03-01 |
| ZA200202287B (en) | 2003-08-27 |
| NO20020886D0 (no) | 2002-02-22 |
| CZ2002523A3 (cs) | 2002-05-15 |
| SK2282002A3 (en) | 2002-06-04 |
| JP2003507458A (ja) | 2003-02-25 |
| HUP0203697A3 (en) | 2004-04-28 |
| CA2382850A1 (en) | 2001-03-01 |
| NO20020886L (no) | 2002-02-22 |
| BR0013504A (pt) | 2002-05-07 |
| PL352989A1 (en) | 2003-09-22 |
| AU6570500A (en) | 2001-03-19 |
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