HUP0201632A3 - Process for the synthesis of (r)-1-(3,5-bis(trifluormethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation - Google Patents

Process for the synthesis of (r)-1-(3,5-bis(trifluormethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation

Info

Publication number
HUP0201632A3
HUP0201632A3 HU0201632A HUP0201632A HUP0201632A3 HU P0201632 A3 HUP0201632 A3 HU P0201632A3 HU 0201632 A HU0201632 A HU 0201632A HU P0201632 A HUP0201632 A HU P0201632A HU P0201632 A3 HUP0201632 A3 HU P0201632A3
Authority
HU
Hungary
Prior art keywords
trifluormethyl
ethan
bis
phenyl
synthesis
Prior art date
Application number
HU0201632A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of HUP0201632A2 publication Critical patent/HUP0201632A2/hu
Publication of HUP0201632A3 publication Critical patent/HUP0201632A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
    • C07C29/88—Separation; Purification; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification of at least one compound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0073—Rhodium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU0201632A 1999-07-01 2000-06-27 Process for the synthesis of (r)-1-(3,5-bis(trifluormethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation HUP0201632A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14198899P 1999-07-01 1999-07-01
US16195799P 1999-10-28 1999-10-28

Publications (2)

Publication Number Publication Date
HUP0201632A2 HUP0201632A2 (en) 2002-08-28
HUP0201632A3 true HUP0201632A3 (en) 2005-11-28

Family

ID=26839640

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201632A HUP0201632A3 (en) 1999-07-01 2000-06-27 Process for the synthesis of (r)-1-(3,5-bis(trifluormethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation

Country Status (20)

Country Link
US (2) US6504066B1 (hu)
EP (1) EP1196364A1 (hu)
JP (1) JP2003503468A (hu)
KR (1) KR20020025092A (hu)
CN (1) CN1358163A (hu)
AR (1) AR031366A1 (hu)
AU (1) AU5768400A (hu)
BR (1) BR0012016A (hu)
CA (1) CA2376598A1 (hu)
CZ (1) CZ20014663A3 (hu)
EA (1) EA200200112A1 (hu)
HR (1) HRP20010968A2 (hu)
HU (1) HUP0201632A3 (hu)
IL (1) IL146633A0 (hu)
MX (1) MXPA02000056A (hu)
PL (1) PL352182A1 (hu)
SK (1) SK19372001A3 (hu)
UA (1) UA71630C2 (hu)
WO (1) WO2001002326A1 (hu)
YU (1) YU88001A (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0201632A3 (en) * 1999-07-01 2005-11-28 Merck & Co Inc Process for the synthesis of (r)-1-(3,5-bis(trifluormethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation
EP1345878A4 (en) 2000-12-20 2005-12-14 Merck & Co Inc SYNTHESIS OF 1- (3,5-BIS (TRIFLUOROMETHYL) -PHENYL) THAN-1-ONE
AU2002365968A1 (en) * 2001-11-19 2003-06-10 Merck And Co., Inc. Process for the synthesis of (r)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol and esters thereof by dynamic kinetic resolution
WO2007147897A1 (de) * 2006-06-23 2007-12-27 Basf Se Verfahren zur herstellung von optisch aktiven 2-halogen-1-phenylethanol-derivaten und folgeprodukten davon
CN103232324B (zh) * 2013-04-12 2016-03-16 广西新晶科技有限公司 一种(r)-3，5-双(三氟甲基)苯乙醇的制备方法
CN105085189A (zh) * 2014-05-12 2015-11-25 中山奕安泰医药科技有限公司 不对称氢化法制备（r）- 3,5-双三氟甲基苯乙醇的方法
CN107641072B (zh) * 2016-07-22 2020-07-21 江苏威凯尔医药科技有限公司 一种制备(s)-2-氯-1-(3,4-二氟苯基)乙醇的方法
CN107602357B (zh) * 2017-09-28 2020-06-02 万华化学集团股份有限公司 一种制备薄荷酮的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3008671A1 (de) * 1979-03-08 1980-09-11 Montedison Spa Verfahren zur katalytischen umwandlung von carbonylverbindungen bzw. hydroxylverbindungen
US5763688A (en) * 1994-12-07 1998-06-09 Research Development Corporation Of Japan Method for producing an alcohol
US6184381B1 (en) * 1995-12-06 2001-02-06 Japan Science & Technology Corp. Process for preparing optically active compounds
GB9706321D0 (en) * 1997-03-26 1997-05-14 Zeneca Ltd Catalytic hydrogenation
JPH11124350A (ja) * 1997-10-21 1999-05-11 Mitsubishi Chemical Corp 光学活性アルコールの製造方法
HUP0201632A3 (en) * 1999-07-01 2005-11-28 Merck & Co Inc Process for the synthesis of (r)-1-(3,5-bis(trifluormethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation

Also Published As

Publication number Publication date
WO2001002326A1 (en) 2001-01-11
US6777580B2 (en) 2004-08-17
MXPA02000056A (es) 2002-07-02
YU88001A (sh) 2004-09-03
CA2376598A1 (en) 2001-01-11
CZ20014663A3 (cs) 2002-05-15
JP2003503468A (ja) 2003-01-28
CN1358163A (zh) 2002-07-10
AR031366A1 (es) 2003-09-24
BR0012016A (pt) 2002-03-26
SK19372001A3 (sk) 2002-04-04
UA71630C2 (uk) 2004-12-15
EA200200112A1 (ru) 2002-06-27
EP1196364A1 (en) 2002-04-17
US6504066B1 (en) 2003-01-07
HUP0201632A2 (en) 2002-08-28
KR20020025092A (ko) 2002-04-03
PL352182A1 (en) 2003-08-11
HRP20010968A2 (en) 2003-06-30
AU5768400A (en) 2001-01-22
IL146633A0 (en) 2002-07-25
US20030153760A1 (en) 2003-08-14

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished