HUP0104204A2 - COX-2 inhibítor hatású pirazolo-piridin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
COX-2 inhibítor hatású pirazolo-piridin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0104204A2 HUP0104204A2 HU0104204A HUP0104204A HUP0104204A2 HU P0104204 A2 HUP0104204 A2 HU P0104204A2 HU 0104204 A HU0104204 A HU 0104204A HU P0104204 A HUP0104204 A HU P0104204A HU P0104204 A2 HUP0104204 A2 HU P0104204A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- carbon atom
- cox
- inhibitors
- fluorine atoms
- Prior art date
Links
- 229940111134 coxibs Drugs 0.000 title abstract 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000005229 pyrazolopyridines Chemical class 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- AMFYRKOUWBAGHV-UHFFFAOYSA-N 1h-pyrazolo[4,3-b]pyridine Chemical group C1=CN=C2C=NNC2=C1 AMFYRKOUWBAGHV-UHFFFAOYSA-N 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 abstract 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- -1 formyl- Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002075 main ingredient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A tal lm ny t rgya COX-2 inhibitor hat sú pirazolo-piridin-szrmazékok. A tal lm ny (I) ltal nos képletű vegyületekre és gyógyszatilag elfogadható sz rmazékaira vonatkozik - ahol R0 és R1 egymstól függetlenül jelenthet hidrogén- vagy halogénatomot, 1-6szénatomos alkil- vagy alkoxicsoportot vagy egy vagy t"bb fluoratommalszubsztitu lt 1-6 szénatomos alkoxicsoportot; R2 jelentésehidrogénatom, 1-6 szénatomos alkilcsoport, egy vagy t"bb fluoratommalszubsztitu lt 1-6 szénatomos alkilcsoport, 1-6 szénatomos alkoxi-, 1-6szénatomos hidroxi-alkil-, S-1-6 szénatomos alkil-, formil-, 1-6szénatomos alkil-karbonil-, 1-6 szénatomos alkil-szulfonil- vagy egyvagy t"bb fluoratommal szubsztitu lt 1-6 szénatomos alkoxicsoport; ésR3 jelentése 1-6 szénatomos alkil- vagy aminocsoport. Az (I) ltal nosképletű vegyületek hat sos és szelektív COX-2 inhibitorok és f jdalom,l z, kül"nb"ző llapotokban és betegségekben előforduló gyullad sokkezelésére haszn lhatók. A tal lm ny t rgy hoz tartozik elj r s afenti vegyületek elő llít s ra és a vegyületeket tartalmazógyógyszerkészítmények. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9824062.5A GB9824062D0 (en) | 1998-11-03 | 1998-11-03 | Chemical compounds |
GBGB9920909.0A GB9920909D0 (en) | 1999-09-03 | 1999-09-03 | Chemical compounds |
PCT/EP1999/008186 WO2000026216A1 (en) | 1998-11-03 | 1999-11-01 | Pyrazolopyridine derivatives as selective cox-2 inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0104204A2 true HUP0104204A2 (hu) | 2002-04-29 |
HUP0104204A3 HUP0104204A3 (en) | 2002-06-28 |
Family
ID=26314603
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0104204A HUP0104204A3 (en) | 1998-11-03 | 1999-11-01 | Pyrazolopyridine derivatives as cox-2 inhibitors, process for their preparation and pharmaceutical compositions thereof |
Country Status (24)
Country | Link |
---|---|
US (1) | US7223772B1 (hu) |
EP (1) | EP1127058B1 (hu) |
JP (1) | JP3420751B2 (hu) |
KR (1) | KR20010075673A (hu) |
CN (1) | CN1263755C (hu) |
AR (1) | AR021055A1 (hu) |
AT (1) | ATE275148T1 (hu) |
AU (1) | AU767464B2 (hu) |
BR (1) | BR9915011A (hu) |
CA (1) | CA2349567A1 (hu) |
CO (1) | CO5150164A1 (hu) |
CZ (1) | CZ20011556A3 (hu) |
DE (1) | DE69919887T2 (hu) |
ES (1) | ES2228127T3 (hu) |
GC (1) | GC0000112A (hu) |
HU (1) | HUP0104204A3 (hu) |
MY (1) | MY119689A (hu) |
NO (1) | NO318884B1 (hu) |
NZ (1) | NZ511349A (hu) |
PE (1) | PE20001305A1 (hu) |
PL (1) | PL348208A1 (hu) |
TR (1) | TR200101208T2 (hu) |
TW (1) | TW542836B (hu) |
WO (1) | WO2000026216A1 (hu) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5190664A1 (es) | 1999-06-30 | 2002-08-29 | Pfizer Prod Inc | Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2 |
GB0002312D0 (en) * | 2000-02-01 | 2000-03-22 | Glaxo Group Ltd | Medicaments |
PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
ATE300541T1 (de) | 2000-12-15 | 2005-08-15 | Glaxo Group Ltd | Pyrazolopyridinderivate |
WO2002048147A2 (en) | 2000-12-15 | 2002-06-20 | Glaxo Group Limited | Pyrazolopyridines |
DE60201074T2 (de) | 2001-03-08 | 2005-09-15 | Smithkline Beecham Corp. | Pyrazolopyridinderivate |
WO2002078700A1 (en) | 2001-03-30 | 2002-10-10 | Smithkline Beecham Corporation | Pyralopyridines, process for their preparation and use as therapteutic compounds |
DE60212949T2 (de) | 2001-04-10 | 2007-01-04 | Smithkline Beecham Corp. | Antivirale pyrazolopyridin verbindungen |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
US6962914B2 (en) | 2001-04-27 | 2005-11-08 | Smithkline Beecham Corporation | Pyrazolopyridinyl pyridine and pyrimidine therapeutic compounds |
ATE337316T1 (de) | 2001-06-21 | 2006-09-15 | Smithkline Beecham Corp | Imidazo 1,2-aöpyridin-derivate zur prophylaxe und behandlung von herpes-infektionen |
DE60220525T2 (de) * | 2001-09-07 | 2008-02-07 | Smithkline Beecham Corp. | Pyrazolo-pyridine für die behandlung von herpes-ansteckungen |
DE60211539T2 (de) | 2001-10-05 | 2006-09-21 | Smithkline Beecham Corp. | Imidazopyridinderivate zur verwendung bei der behandlung von herpes-vireninfektion |
GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124934D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124939D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124941D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
US7199120B2 (en) | 2001-12-11 | 2007-04-03 | Smithkline Beecham Corporation | Pyrazolo-pyridine derivatives as antiherpes agents |
PT1474395E (pt) | 2002-02-12 | 2008-01-02 | Smithkline Beecham Corp | Derivados de nicotinamida úteis como inibidores de p38 |
AU2003258630A1 (en) | 2002-08-19 | 2004-03-11 | Glaxo Group Limited | Pyrimidine derivatives as selective cox-2 inhibitors |
UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
UA80296C2 (en) * | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
US7153863B2 (en) | 2002-10-03 | 2006-12-26 | Smithkline Beecham Corporation | Therapeutic compounds based on pyrazolopyridline derivatives |
PL378296A1 (pl) | 2003-02-27 | 2006-03-20 | Palau Pharma S.A. | Pochodne pirazolopirydyny |
GB0308186D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308185D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308201D0 (en) | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
ATE342722T1 (de) | 2003-05-07 | 2006-11-15 | Osteologix As | Behandlung von knorpel/knochen-erkrankungen mit wasserlöslichen strontiumsalzen |
GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
WO2006066968A1 (en) | 2004-12-23 | 2006-06-29 | Glaxo Group Limited | Pyridine compounds for the treatment of prostaglandin mediated diseases |
DE102005024012A1 (de) * | 2005-05-20 | 2006-11-23 | Grünenthal GmbH | Verwendung von 2,5-disubstituierten Thiazol-4-on-Derivaten in Arzneimitteln |
BRPI0712381A2 (pt) * | 2006-06-06 | 2012-07-10 | Avigen Inc | compostos de pirazolo[1,5-a]piridina substituìda e seus métodos de uso |
CA2676413A1 (en) * | 2007-01-19 | 2008-07-31 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
GB0704407D0 (en) | 2007-03-07 | 2007-04-18 | Glaxo Group Ltd | Compounds |
US7943658B2 (en) | 2007-07-23 | 2011-05-17 | Bristol-Myers Squibb Company | Indole indane amide compounds useful as CB2 agonists and method |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
GB0813144D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
WO2011012622A1 (en) | 2009-07-30 | 2011-02-03 | Glaxo Group Limited | Benzoxazinone derivatives for the treatment of glytl mediated disorders |
WO2011023753A1 (en) | 2009-08-27 | 2011-03-03 | Glaxo Group Limited | Benzoxazine derivatives as glycine transport inhibitors |
GB201000685D0 (en) | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
GB201007791D0 (en) | 2010-05-10 | 2010-06-23 | Glaxo Group Ltd | Novel compounds |
GB201007789D0 (en) | 2010-05-10 | 2010-06-23 | Glaxo Group Ltd | Novel Compound |
WO2012004604A1 (en) | 2010-07-09 | 2012-01-12 | Convergence Pharmaceuticals Limited | Tetrazole compounds as calcium channel blockers |
JP6058556B2 (ja) | 2011-01-19 | 2017-01-11 | クオンベルゲンセ プハルマセウトイカルス リミテッド | CaV2.2カルシウムチャンネルブロッカーとしてのピペラジン誘導体 |
GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
GB201417500D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
GB201417497D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
GB201417499D0 (en) | 2014-10-03 | 2014-11-19 | Convergence Pharmaceuticals | Novel use |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925849A (en) | 1987-06-15 | 1990-05-15 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutically useful pyrazolopyridines |
US5155114A (en) | 1989-01-23 | 1992-10-13 | Fujisawa Pharmaceutical Company, Ltd. | Method of treatment using pyrazolopyridine compound |
GB8901423D0 (en) | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
AU6355190A (en) | 1989-06-13 | 1991-01-17 | Smithkline Beecham Corporation | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages |
AU622330B2 (en) | 1989-06-23 | 1992-04-02 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides |
EP0533837A4 (en) | 1990-06-12 | 1994-11-17 | Smithkline Beecham Corp | Inhibition of 5-lipoxygenase and cyclooxygenase pathway mediated diseases |
GB9015764D0 (en) | 1990-07-18 | 1990-09-05 | Fujisawa Pharmaceutical Co | Pyrazolopyridine compound and processes for preparation thereof |
US5300478A (en) | 1993-01-28 | 1994-04-05 | Zeneca Limited | Substituted fused pyrazolo compounds |
US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
US5552422A (en) | 1995-01-11 | 1996-09-03 | Merck Frosst Canada, Inc. | Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents |
CA2216809A1 (en) | 1995-04-04 | 1996-10-10 | Alan Naylor | Imidazo[1,2-a]pyridine derivatives |
US5700816A (en) | 1995-06-12 | 1997-12-23 | Isakson; Peter C. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor |
US6342510B1 (en) | 1995-06-12 | 2002-01-29 | G. D. Searle & Co. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist |
EP0833622B8 (en) | 1995-06-12 | 2005-10-12 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor |
YU11900A (sh) | 1997-09-05 | 2002-11-15 | Glaxo Group Limited | Derivati 2,3-diaril-pirazolo (1,5-b) piridazina, njihovo dobijanje i njihova upotreba kao inhibitora ciklooksigenaze 2(cox-2) |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
US6711762B2 (en) | 2002-01-30 | 2004-03-30 | Ktk Services, Inc. | Method of using a truck cab bridge bed |
-
1999
- 1999-11-01 ES ES99955897T patent/ES2228127T3/es not_active Expired - Lifetime
- 1999-11-01 WO PCT/EP1999/008186 patent/WO2000026216A1/en not_active Application Discontinuation
- 1999-11-01 CN CNB99815234XA patent/CN1263755C/zh not_active Expired - Fee Related
- 1999-11-01 CZ CZ20011556A patent/CZ20011556A3/cs unknown
- 1999-11-01 BR BR9915011-5A patent/BR9915011A/pt not_active IP Right Cessation
- 1999-11-01 EP EP99955897A patent/EP1127058B1/en not_active Expired - Lifetime
- 1999-11-01 AR ARP990105525A patent/AR021055A1/es unknown
- 1999-11-01 DE DE69919887T patent/DE69919887T2/de not_active Expired - Fee Related
- 1999-11-01 PL PL99348208A patent/PL348208A1/xx not_active Application Discontinuation
- 1999-11-01 TR TR2001/01208T patent/TR200101208T2/xx unknown
- 1999-11-01 KR KR1020017005495A patent/KR20010075673A/ko not_active Application Discontinuation
- 1999-11-01 AU AU12667/00A patent/AU767464B2/en not_active Ceased
- 1999-11-01 CA CA002349567A patent/CA2349567A1/en not_active Abandoned
- 1999-11-01 HU HU0104204A patent/HUP0104204A3/hu unknown
- 1999-11-01 US US09/830,836 patent/US7223772B1/en not_active Expired - Fee Related
- 1999-11-01 AT AT99955897T patent/ATE275148T1/de not_active IP Right Cessation
- 1999-11-01 JP JP2000579604A patent/JP3420751B2/ja not_active Expired - Fee Related
- 1999-11-01 NZ NZ511349A patent/NZ511349A/en unknown
- 1999-11-02 GC GCP1999355 patent/GC0000112A/xx active
- 1999-11-02 TW TW088119040A patent/TW542836B/zh not_active IP Right Cessation
- 1999-11-02 CO CO99068974A patent/CO5150164A1/es unknown
- 1999-11-02 MY MYPI99004739A patent/MY119689A/en unknown
- 1999-11-03 PE PE1999001103A patent/PE20001305A1/es not_active Application Discontinuation
-
2001
- 2001-05-02 NO NO20012156A patent/NO318884B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
HUP0104204A3 (en) | 2002-06-28 |
WO2000026216A1 (en) | 2000-05-11 |
TR200101208T2 (tr) | 2001-10-22 |
AU767464B2 (en) | 2003-11-13 |
CN1263755C (zh) | 2006-07-12 |
NZ511349A (en) | 2003-10-31 |
JP2002528547A (ja) | 2002-09-03 |
CN1332741A (zh) | 2002-01-23 |
NO20012156D0 (no) | 2001-05-02 |
EP1127058A1 (en) | 2001-08-29 |
DE69919887T2 (de) | 2005-09-15 |
PL348208A1 (en) | 2002-05-06 |
EP1127058B1 (en) | 2004-09-01 |
CO5150164A1 (es) | 2002-04-29 |
DE69919887D1 (de) | 2004-10-07 |
GC0000112A (en) | 2005-06-29 |
ES2228127T3 (es) | 2005-04-01 |
ATE275148T1 (de) | 2004-09-15 |
NO318884B1 (no) | 2005-05-18 |
PE20001305A1 (es) | 2000-12-06 |
CZ20011556A3 (cs) | 2001-11-14 |
AR021055A1 (es) | 2002-06-12 |
JP3420751B2 (ja) | 2003-06-30 |
AU1266700A (en) | 2000-05-22 |
CA2349567A1 (en) | 2000-05-11 |
MY119689A (en) | 2005-06-30 |
TW542836B (en) | 2003-07-21 |
BR9915011A (pt) | 2001-08-07 |
KR20010075673A (ko) | 2001-08-09 |
US7223772B1 (en) | 2007-05-29 |
NO20012156L (no) | 2001-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0104204A2 (hu) | COX-2 inhibítor hatású pirazolo-piridin-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
HUP0203376A2 (hu) | Ciklooxigenáz-2 inhibitor hatású 5-aril-1h-1,2,4-triazol-származékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
HUP0003644A2 (hu) | 2,3-Diaril-pirazolo[1,5-b]piridazin-származékok, ezeket tartalmazó gyógyászati készítmények ciklooxigenáz 2(COX-2) gátlására, valamint eljárás a vegyületek előállítására | |
HUP0401307A2 (hu) | 5-HT6 hatással rendelkező új indolszármazékok, eljárás az előállításukra, és ezeket tartalmazó gyógyszerkészítmények | |
HUP0301344A2 (hu) | Nem szteroid gyulladásgátlók, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
HUP0001555A2 (hu) | Tetrahidro-imidazo-naftiridin származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
AU2661400A (en) | Pyrazolopyridines | |
HUP0101146A2 (hu) | Foszfolipáz enzim inhibitor hatású indolszármazékok, valamint a vegyületeket tartalmazó gyógyászati készítmények | |
HUP0100156A2 (hu) | Foszfolipáz-A2 inhibitor hatású indolszármazékok és alkalmazásuk gyógyászati készítmények előállítására | |
HUP0301120A2 (hu) | Szubsztituált fenilamino-kinazolin-származékok, alkalmazásuk rendellenes sejtnövekedés kezelésére és azokat tartalmazó gyógyszerkészítmények | |
HUP0301562A2 (hu) | Új oxazolidinonszármazékok és eljárás ezek előállítására, ezeket tartalmazó gyógyszerkészítmények | |
HUP0002960A2 (hu) | Aril-oxi-szulfonil-amino-hidroxámsav-származékok | |
HUP0002517A2 (hu) | Acil-piperazinilpirimidin-származékok, eljárás előállításukra, a vegyületeket tartalmazó gyógyászati készítmények és gyógyszerként való alkalmazásuk | |
HUP0203184A2 (hu) | Izoxazolkarboxamid-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
HUP0400370A2 (hu) | Antibakteriális hatású oxazolidinonszármazékok, előállításukra szolgáló eljárás, azokat hatóanyagként tartalmazó gyógyászati készítmények, alkalmazásuk és intermedierek | |
IL149586A0 (en) | Pyrimidine derivatives as selective inhibitors of cox-2 | |
HUP9902405A2 (hu) | Szerotonin agonistát tartalmazó gyógyászati készítmények nátha és szénanátha kezelésére | |
SE9701304D0 (sv) | Compounds | |
HUP0103004A2 (hu) | Szelektív COX-2-gátló hatású, szubsztituált imidazo[1,2a]azinok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
HUP0201910A2 (hu) | Új aminobenzofenonszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
HUP0004780A2 (hu) | Prosztaglandin agonisták felhasználása merevedési rendellenességek vagy impotencia kezelésében | |
HUP0104520A2 (hu) | Szubsztituált benzo[de]izokinolin-1,3-dion-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyászati készítmények | |
ES2175405T3 (es) | Derivados de adenosina. | |
HUP0104963A2 (hu) | Bőrbetegségek kezelésére szolgáló készítmények | |
TR200103550T2 (tr) | Faktör VIIa inhibitörler. |