HUP0201910A2 - Új aminobenzofenonszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Új aminobenzofenonszármazékok és ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0201910A2 HUP0201910A2 HU0201910A HUP0201910A HUP0201910A2 HU P0201910 A2 HUP0201910 A2 HU P0201910A2 HU 0201910 A HU0201910 A HU 0201910A HU P0201910 A HUP0201910 A HU P0201910A HU P0201910 A2 HUP0201910 A2 HU P0201910A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- hydroxyl
- compounds
- alkylthio
- Prior art date
Links
- MAOBFOXLCJIFLV-UHFFFAOYSA-N (2-aminophenyl)-phenylmethanone Chemical class NC1=CC=CC=C1C(=O)C1=CC=CC=C1 MAOBFOXLCJIFLV-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 hydroxyl- Chemical group 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A találmány (I) általános képletű új vegyületekre, farmakológiailagelfogadható savakkal alkotott sóikra, hidrátjaikra és szolvátjaikra,valamint ezek alkalmazására vonatkozik, a képletben R1 jelentése egyvagy több, azonos vagy különböző hidroxilcsoport, halogénatom, alkil-,alkoxi-, alkiltio- vagy cianocsoport, R3 jelentése egy vagy több,azonos vagy különböző halogénatom, hidroxil-, merkapto-,trifluormetil-, alkil-, alkoxi-, alkiltio- vagy cianocsoport, és R6jelentése hidrogénatom vagy metilcsoport. A találmány továbbá (II)általános képletű vegyületek és farmakológiailag elfogadható,nemtoxikus savakkal alkotott sóik alkalmazására vonatkozik, aképletben R1 és R2 jelentése egymástól függetlenül egy vagy többazonos vagy különböző hidrogén-, halogénatom, hidroxil-, merkapto-,trifluormetil-, amino-, alkil-, alkoxi-, alkiltio-, alkilamino-,alkoxikarbonil-, ciano-, karbamoil-, fenil- és nitrocsoport, R2továbbá jelenthet karboxilcsoportot, R3 jelentése hidrogén-,halogénatom, hidroxil-, merkapto-, trifluormetil-, amino-, alkil-,alkoxi-, alkiltio-, alkilamino-, alkoxikarbonil-, fenil-, ciano-,karboxil- vagy karbamoilcsoport, R4, R5 és R6 jelentése egymástólfüggetlenül hidrogénatom, trifluormetil-, alkil-, karbamoil-,alkoxikarbonil- vagy alkaloilcsoport, X jelentése oxigénatom, N-OHvagy N-O-alkil képletű csoport, dialkoxi-, ciklusos dialkoxi-,dialkiltio- vagy ciklusos dialkiltiocsoport. A vegyületek humán- ésállatgyógyászatban alkalmazhatók. A találmány kiterjed a vegyületekettartalmazó gyógyszerkészítményekre is. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14406599P | 1999-07-16 | 1999-07-16 | |
| PCT/DK2000/000384 WO2001005744A1 (en) | 1999-07-16 | 2000-07-11 | Novel aminobenzophenones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0201910A2 true HUP0201910A2 (hu) | 2002-12-28 |
| HUP0201910A3 HUP0201910A3 (en) | 2006-03-28 |
Family
ID=22506899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0201910A HUP0201910A3 (en) | 1999-07-16 | 2000-07-11 | Novel aminobenzophenones, pharmaceutical compositions containing them and their use |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6624199B1 (hu) |
| EP (1) | EP1202954B1 (hu) |
| JP (1) | JP2003505359A (hu) |
| KR (1) | KR20020013961A (hu) |
| CN (1) | CN1231459C (hu) |
| AT (1) | ATE251117T1 (hu) |
| AU (1) | AU768473B2 (hu) |
| CA (1) | CA2379316A1 (hu) |
| DE (1) | DE60005689T2 (hu) |
| DK (1) | DK1202954T3 (hu) |
| ES (1) | ES2204639T3 (hu) |
| HK (1) | HK1048304B (hu) |
| HU (1) | HUP0201910A3 (hu) |
| NZ (1) | NZ516824A (hu) |
| PL (1) | PL353645A1 (hu) |
| PT (1) | PT1202954E (hu) |
| RU (1) | RU2243964C2 (hu) |
| WO (1) | WO2001005744A1 (hu) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541670B2 (en) * | 1999-12-06 | 2003-04-01 | Leo Pharmaceutical Products Ltd. A/S | Aminobenzophenones as inhibitors of IL 1β and TNF-α |
| CA2408727A1 (en) | 2000-05-22 | 2001-11-29 | Leo Pharma A/S | Benzophenones as inhibitors of il-1.beta. and tnf-.alpha. |
| GB0107368D0 (en) * | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
| AU2002333193A1 (en) * | 2001-08-15 | 2003-03-03 | Leo Pharma A/S | A pharmaceutical composition for dermal application |
| EP1423356A2 (en) | 2001-08-28 | 2004-06-02 | Leo Pharma A/S | Novel aminobenzoephenones |
| US20030225089A1 (en) * | 2002-04-10 | 2003-12-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors |
| EP1707205A2 (en) | 2002-07-09 | 2006-10-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| ZA200510137B (en) * | 2003-07-24 | 2007-04-25 | Leo Pharma As | Novel aminobenzophenone compounds |
| JP2007538024A (ja) | 2004-05-19 | 2007-12-27 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミロイドベータペプチドのレベル変化に関連する疾患及び状態の治療方法及び新規エノールカルボキサミド化合物 |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PT1828148E (pt) | 2004-12-13 | 2010-05-04 | Leo Pharma As | Compostos de amino benzofenona substituídos por triazol |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| FR2894821B1 (fr) * | 2005-12-15 | 2008-02-29 | Galderma Res & Dev | Compositions comprenant au moins un compose retinoide et au moins un compose anti-irritant et leurs utilisations |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| EP2206534A1 (de) | 2008-10-09 | 2010-07-14 | c-a-i-r biosciences GmbH | Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9701453D0 (en) * | 1997-01-24 | 1997-03-12 | Leo Pharm Prod Ltd | Aminobenzophenones |
-
2000
- 2000-07-11 DE DE60005689T patent/DE60005689T2/de not_active Expired - Fee Related
- 2000-07-11 CA CA002379316A patent/CA2379316A1/en not_active Abandoned
- 2000-07-11 NZ NZ516824A patent/NZ516824A/en unknown
- 2000-07-11 AU AU58067/00A patent/AU768473B2/en not_active Ceased
- 2000-07-11 DK DK00943698T patent/DK1202954T3/da active
- 2000-07-11 WO PCT/DK2000/000384 patent/WO2001005744A1/en not_active Application Discontinuation
- 2000-07-11 PL PL00353645A patent/PL353645A1/xx not_active Application Discontinuation
- 2000-07-11 RU RU2002103862/04A patent/RU2243964C2/ru not_active IP Right Cessation
- 2000-07-11 AT AT00943698T patent/ATE251117T1/de not_active IP Right Cessation
- 2000-07-11 PT PT00943698T patent/PT1202954E/pt unknown
- 2000-07-11 JP JP2001511405A patent/JP2003505359A/ja active Pending
- 2000-07-11 CN CNB008115028A patent/CN1231459C/zh not_active Expired - Fee Related
- 2000-07-11 ES ES00943698T patent/ES2204639T3/es not_active Expired - Lifetime
- 2000-07-11 EP EP00943698A patent/EP1202954B1/en not_active Expired - Lifetime
- 2000-07-11 HU HU0201910A patent/HUP0201910A3/hu unknown
- 2000-07-11 KR KR1020027000669A patent/KR20020013961A/ko not_active Application Discontinuation
- 2000-07-11 US US10/030,965 patent/US6624199B1/en not_active Expired - Fee Related
-
2003
- 2003-01-23 HK HK03100579.6A patent/HK1048304B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2243964C2 (ru) | 2005-01-10 |
| EP1202954A1 (en) | 2002-05-08 |
| ES2204639T3 (es) | 2004-05-01 |
| HUP0201910A3 (en) | 2006-03-28 |
| NZ516824A (en) | 2004-03-26 |
| HK1048304B (zh) | 2006-04-21 |
| CN1231459C (zh) | 2005-12-14 |
| WO2001005744A1 (en) | 2001-01-25 |
| JP2003505359A (ja) | 2003-02-12 |
| PL353645A1 (en) | 2003-12-01 |
| PT1202954E (pt) | 2004-02-27 |
| DE60005689T2 (de) | 2004-08-05 |
| ATE251117T1 (de) | 2003-10-15 |
| DE60005689D1 (de) | 2003-11-06 |
| HK1048304A1 (en) | 2003-03-28 |
| KR20020013961A (ko) | 2002-02-21 |
| EP1202954B1 (en) | 2003-10-01 |
| US6624199B1 (en) | 2003-09-23 |
| CA2379316A1 (en) | 2001-01-25 |
| CN1368950A (zh) | 2002-09-11 |
| DK1202954T3 (da) | 2004-02-09 |
| AU5806700A (en) | 2001-02-05 |
| AU768473B2 (en) | 2003-12-11 |
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