HUP0103460A3 - Indole derivatives with antiviral activity and pharmaceutical compositions containing them - Google Patents

Indole derivatives with antiviral activity and pharmaceutical compositions containing them

Info

Publication number
HUP0103460A3
HUP0103460A3 HU0103460A HUP0103460A HUP0103460A3 HU P0103460 A3 HUP0103460 A3 HU P0103460A3 HU 0103460 A HU0103460 A HU 0103460A HU P0103460 A HUP0103460 A HU P0103460A HU P0103460 A3 HUP0103460 A3 HU P0103460A3
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
compositions containing
antiviral activity
indole derivatives
indole
Prior art date
Application number
HU0103460A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of HUP0103460A2 publication Critical patent/HUP0103460A2/hu
Publication of HUP0103460A3 publication Critical patent/HUP0103460A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0103460A 1998-03-26 1999-03-26 Indole derivatives with antiviral activity and pharmaceutical compositions containing them HUP0103460A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7820398 1998-03-26
PCT/JP1999/001547 WO1999050245A1 (en) 1998-03-26 1999-03-26 Indole derivatives with antiviral activity

Publications (2)

Publication Number Publication Date
HUP0103460A2 HUP0103460A2 (hu) 2002-01-28
HUP0103460A3 true HUP0103460A3 (en) 2002-11-28

Family

ID=13655476

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103460A HUP0103460A3 (en) 1998-03-26 1999-03-26 Indole derivatives with antiviral activity and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (3) US6333323B1 (de)
EP (1) EP1069111A4 (de)
JP (1) JP3794469B2 (de)
KR (1) KR20010041705A (de)
CN (1) CN1142909C (de)
AU (1) AU752005B2 (de)
BR (1) BR9909146A (de)
CA (1) CA2326166A1 (de)
HU (1) HUP0103460A3 (de)
ID (1) ID26031A (de)
IL (1) IL137974A0 (de)
NO (1) NO317423B1 (de)
NZ (1) NZ506435A (de)
PL (1) PL343249A1 (de)
RU (1) RU2217421C2 (de)
WO (1) WO1999050245A1 (de)
ZA (1) ZA200004047B (de)

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AU752005B2 (en) * 1998-03-26 2002-09-05 Shionogi & Co., Ltd. Indole derivatives with antiviral activity
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AU4225499A (en) * 1998-06-03 1999-12-20 Merck & Co., Inc. Hiv integrase inhibitors
WO2000039086A1 (en) 1998-12-25 2000-07-06 Shionogi & Co., Ltd. Aromatic heterocycle compounds having hiv integrase inhibiting activities
US7294481B1 (en) * 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
EP1186599A4 (de) * 1999-06-02 2003-02-26 Shionogi & Co Neuartiger prozess zur herstellung substituierter propenon-derivate
WO2001000578A1 (en) * 1999-06-25 2001-01-04 Merck & Co., Inc. 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
EP1219607B1 (de) * 1999-09-02 2011-04-06 Shionogi & Co., Ltd. Derivate von aromatische heterocyclen enthaltende integraseinhibitoren
CZ20023940A3 (cs) * 2000-06-13 2003-05-14 Shionogi & Co., Ltd. Lékařské směsi zahrnující propenonové deriváty
WO2001095905A1 (fr) * 2000-06-14 2001-12-20 Shionogi & Co., Ltd. Inhibiteur d'enzymes possedant deux ions metal divalents en tant que centres actifs
AU2002243228B2 (en) * 2000-11-16 2007-08-02 The Regents Of The University Of California Marine actinomycete taxon for drug and fermentation product discovery
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
US7067539B2 (en) 2001-02-08 2006-06-27 Schering Corporation Cannabinoid receptor ligands
PL365027A1 (en) 2001-03-01 2004-12-27 Shionogi & Co, Ltd. Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
WO2003016275A1 (fr) 2001-08-10 2003-02-27 Shionogi & Co., Ltd. Agent antiviral
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
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NZ532291A (en) 2001-11-14 2005-11-25 Schering Corp Cannabinoid receptor ligands
EP1463741A4 (de) * 2001-12-07 2006-07-05 Us Gov Health & Human Serv Verbindungen zur behandlung von hiv-infektion und aids
US20030236277A1 (en) * 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
CA2487346A1 (en) 2002-06-19 2003-12-31 Schering Corporation Cannabinoid receptor agonists
US7176232B2 (en) 2002-06-24 2007-02-13 The Regents Of The University Of California Salinosporamides and methods for use thereof
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US7919497B2 (en) 2002-08-02 2011-04-05 Nereus Pharmaceuticals, Inc. Analogs of dehydrophenylahistins and their therapeutic use
US7935704B2 (en) * 2003-08-01 2011-05-03 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
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CN1316968C (zh) * 2005-09-30 2007-05-23 青岛大学 吲哚－2,3－二酮在制备抗病毒或免疫增强剂药物中的应用
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7855225B2 (en) * 2006-03-02 2010-12-21 Astellas Pharma Inc. 17βHSD type 5 inhibitor
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JP2019511565A (ja) 2016-02-08 2019-04-25 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド ツカレゾールまたはそのアナログを含む組成物
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JP2020503363A (ja) 2017-01-06 2020-01-30 ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド チューブリン結合化合物およびその治療的使用
CN110381938A (zh) 2017-02-01 2019-10-25 大连万春布林医药有限公司 减少中性粒细胞缺乏症的方法
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Also Published As

Publication number Publication date
CN1294580A (zh) 2001-05-09
RU2217421C2 (ru) 2003-11-27
NO20004787D0 (no) 2000-09-25
WO1999050245A1 (en) 1999-10-07
AU752005B2 (en) 2002-09-05
NO20004787L (no) 2000-11-27
IL137974A0 (en) 2001-10-31
CN1142909C (zh) 2004-03-24
CA2326166A1 (en) 1999-10-07
KR20010041705A (ko) 2001-05-25
US20020019434A1 (en) 2002-02-14
ZA200004047B (en) 2001-04-25
JP3794469B2 (ja) 2006-07-05
US6506787B2 (en) 2003-01-14
US20030181499A1 (en) 2003-09-25
EP1069111A4 (de) 2001-06-06
AU2958199A (en) 1999-10-18
NZ506435A (en) 2002-08-28
PL343249A1 (en) 2001-07-30
ID26031A (id) 2000-11-16
EP1069111A1 (de) 2001-01-17
NO317423B1 (no) 2004-10-25
BR9909146A (pt) 2000-12-05
US6716605B2 (en) 2004-04-06
US6333323B1 (en) 2001-12-25
HUP0103460A2 (hu) 2002-01-28

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