HUP0103147A2 - GLP1-et tartalmazó gyógyszerkészítmény és alkalmazása funkcionális diszpepszia és/vagy irritábilis colonszindróma kezelésére - Google Patents
GLP1-et tartalmazó gyógyszerkészítmény és alkalmazása funkcionális diszpepszia és/vagy irritábilis colonszindróma kezeléséreInfo
- Publication number
- HUP0103147A2 HUP0103147A2 HU0103147A HUP0103147A HUP0103147A2 HU P0103147 A2 HUP0103147 A2 HU P0103147A2 HU 0103147 A HU0103147 A HU 0103147A HU P0103147 A HUP0103147 A HU P0103147A HU P0103147 A2 HUP0103147 A2 HU P0103147A2
- Authority
- HU
- Hungary
- Prior art keywords
- bowel syndrome
- irritable bowel
- functional dyspepsia
- derivatives
- treatment
- Prior art date
Links
- 201000006549 dyspepsia Diseases 0.000 title abstract 3
- 208000002551 irritable bowel syndrome Diseases 0.000 title abstract 3
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 239000003626 gastrointestinal polypeptide Substances 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- -1 GLP-1 compound Chemical class 0.000 abstract 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
- 101800000224 Glucagon-like peptide 1 Proteins 0.000 abstract 1
- 102100040918 Pro-glucagon Human genes 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 210000005095 gastrointestinal system Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
A találmány glukagonszerű peptid-1 (GLP-1) és származékainak osztálybatartozó, a gasztrointesztinális rendszerben szekréciógátló és simaizom relaxáns hatással rendelkező, gasztrointesztinális peptidhormononok új alkalmazására vonatkozik, funkcionális diszpepszia és azirritábilis colon szindroma kezelésére alkalmas gyógyszerkészítményelőállítására. A találmány egy gyógyszerkészítményre is vonatkozik,amelyik legalább egyet tartalmaz az említett osztályba tartozó GLP-1vegyületek és származékaik közül kombinációban egy vagy több másgasztrointesztinális peptid hormonnal vagy azok származékaival,farmakológiai szempontból elfogadható adalékanyagokkal együtt,valamint egy módszerre funkcionális diszpepszia vagy irritábilis colonszindróma vagy mindkettő kezelésére legalább egy, az említettosztályba tartozó, fent említett hatásokkal és tulajdonságokkalrendelkező GLP-1 vegyület és származékai hatásos mennyiségénekbeadásával. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9802080A SE9802080D0 (sv) | 1998-06-11 | 1998-06-11 | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
PCT/SE1999/000997 WO1999064060A1 (en) | 1998-06-11 | 1999-06-08 | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0103147A2 true HUP0103147A2 (hu) | 2002-01-28 |
HUP0103147A3 HUP0103147A3 (en) | 2002-02-28 |
Family
ID=20411665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0103147A HUP0103147A3 (en) | 1998-06-11 | 1999-06-08 | Pharmaceutical composition comprising glp1 and their use for the treatment of functional dyspepsia and/or irritable bowel syndrome |
Country Status (19)
Country | Link |
---|---|
US (1) | US6348447B1 (hu) |
EP (2) | EP1405642A1 (hu) |
JP (2) | JP2002517468A (hu) |
AT (1) | ATE252912T1 (hu) |
AU (1) | AU738994B2 (hu) |
CA (1) | CA2321700C (hu) |
CZ (1) | CZ300873B6 (hu) |
DE (1) | DE69912434T2 (hu) |
DK (1) | DK1094834T3 (hu) |
ES (1) | ES2205845T3 (hu) |
HU (1) | HUP0103147A3 (hu) |
NO (1) | NO327738B1 (hu) |
NZ (1) | NZ506163A (hu) |
PL (1) | PL198802B1 (hu) |
PT (1) | PT1094834E (hu) |
RU (1) | RU2226402C2 (hu) |
SE (1) | SE9802080D0 (hu) |
WO (1) | WO1999064060A1 (hu) |
ZA (1) | ZA200004080B (hu) |
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CN104371019B (zh) | 2013-08-13 | 2019-09-10 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
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MY147327A (en) * | 1995-06-29 | 2012-11-30 | Novartis Ag | Somatostatin peptides |
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1998
- 1998-06-11 SE SE9802080A patent/SE9802080D0/xx unknown
-
1999
- 1999-06-08 JP JP2000553128A patent/JP2002517468A/ja not_active Ceased
- 1999-06-08 DE DE69912434T patent/DE69912434T2/de not_active Expired - Lifetime
- 1999-06-08 PT PT99930089T patent/PT1094834E/pt unknown
- 1999-06-08 NZ NZ506163A patent/NZ506163A/en unknown
- 1999-06-08 DK DK99930089T patent/DK1094834T3/da active
- 1999-06-08 AT AT99930089T patent/ATE252912T1/de not_active IP Right Cessation
- 1999-06-08 WO PCT/SE1999/000997 patent/WO1999064060A1/en active IP Right Grant
- 1999-06-08 CA CA2321700A patent/CA2321700C/en not_active Expired - Fee Related
- 1999-06-08 PL PL343104A patent/PL198802B1/pl not_active IP Right Cessation
- 1999-06-08 HU HU0103147A patent/HUP0103147A3/hu unknown
- 1999-06-08 US US09/445,571 patent/US6348447B1/en not_active Expired - Lifetime
- 1999-06-08 EP EP20030024624 patent/EP1405642A1/en not_active Withdrawn
- 1999-06-08 EP EP99930089A patent/EP1094834B1/en not_active Expired - Lifetime
- 1999-06-08 AU AU46697/99A patent/AU738994B2/en not_active Ceased
- 1999-06-08 CZ CZ20004491A patent/CZ300873B6/cs not_active IP Right Cessation
- 1999-06-08 RU RU2000133249/14A patent/RU2226402C2/ru not_active IP Right Cessation
- 1999-06-08 ES ES99930089T patent/ES2205845T3/es not_active Expired - Lifetime
-
2000
- 2000-08-10 ZA ZA200004080A patent/ZA200004080B/xx unknown
- 2000-12-06 NO NO20006194A patent/NO327738B1/no not_active IP Right Cessation
-
2010
- 2010-07-01 JP JP2010151403A patent/JP2010270125A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2321700A1 (en) | 1999-12-16 |
CZ20004491A3 (en) | 2001-05-16 |
JP2010270125A (ja) | 2010-12-02 |
ES2205845T3 (es) | 2004-05-01 |
ZA200004080B (en) | 2001-12-24 |
AU738994B2 (en) | 2001-10-04 |
EP1405642A1 (en) | 2004-04-07 |
JP2002517468A (ja) | 2002-06-18 |
HUP0103147A3 (en) | 2002-02-28 |
DE69912434D1 (de) | 2003-12-04 |
ATE252912T1 (de) | 2003-11-15 |
US6348447B1 (en) | 2002-02-19 |
PL198802B1 (pl) | 2008-07-31 |
PL343104A1 (en) | 2001-07-30 |
RU2226402C2 (ru) | 2004-04-10 |
NZ506163A (en) | 2004-10-29 |
NO20006194D0 (no) | 2000-12-06 |
DE69912434T2 (de) | 2004-05-06 |
NO327738B1 (no) | 2009-09-14 |
WO1999064060A1 (en) | 1999-12-16 |
DK1094834T3 (da) | 2004-01-05 |
CA2321700C (en) | 2011-05-03 |
PT1094834E (pt) | 2004-03-31 |
SE9802080D0 (sv) | 1998-06-11 |
EP1094834A1 (en) | 2001-05-02 |
NO20006194L (no) | 2001-01-25 |
CZ300873B6 (cs) | 2009-09-02 |
EP1094834B1 (en) | 2003-10-29 |
AU4669799A (en) | 1999-12-30 |
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