HUP0101669A2 - Egy vírusellenes hatású benzimidazol vegyület új kristályos formái - Google Patents

Egy vírusellenes hatású benzimidazol vegyület új kristályos formái

Info

Publication number
HUP0101669A2
HUP0101669A2 HU0101669A HUP0101669A HUP0101669A2 HU P0101669 A2 HUP0101669 A2 HU P0101669A2 HU 0101669 A HU0101669 A HU 0101669A HU P0101669 A HUP0101669 A HU P0101669A HU P0101669 A2 HUP0101669 A2 HU P0101669A2
Authority
HU
Hungary
Prior art keywords
crystalline forms
novel crystalline
benzimidazole compound
antiviral
antiviral benzimidazole
Prior art date
Application number
HU0101669A
Other languages
English (en)
Inventor
Barry Howard Carter
Bobby Neal Glover
Lian-Feng Huang
Robert William Lancaster
Stacey Todd Long
Michele Catherine Rizzolio
Eric Allen Schmitt
Barry Ridle Sickles
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HUP0101669A2 publication Critical patent/HUP0101669A2/hu
Publication of HUP0101669A3 publication Critical patent/HUP0101669A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A találmány Az 5,6-diklór-2-(izopropilamino)-1-(b-L-ribofuranozil)-1H-benzimidazol I, II, IV, V, VI jelű kristályos formáira, valamintkristályos etanolátja formáira, valamint ezek előállítási eljárásáravonatkozik. A találmány szerinti vegyületek különösen jó víruselleneshatásúak. A találmány oltalmi körébe tartozik továbbá ezen kristályosformákat vagy ezek bármilyen keverékét tartalmazó gyógyszerkészítményis. Ó
HU0101669A 1998-04-07 1999-04-01 Novel crystalline forms of an antiviral benzimidazole compound HUP0101669A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9807354.7A GB9807354D0 (en) 1998-04-07 1998-04-07 Antiviral compound
PCT/EP1999/002214 WO1999051618A1 (en) 1998-04-07 1999-04-01 Novel crystalline forms of an antiviral benzimidazole compound

Publications (2)

Publication Number Publication Date
HUP0101669A2 true HUP0101669A2 (hu) 2001-10-28
HUP0101669A3 HUP0101669A3 (en) 2003-07-28

Family

ID=10829932

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101669A HUP0101669A3 (en) 1998-04-07 1999-04-01 Novel crystalline forms of an antiviral benzimidazole compound

Country Status (28)

Country Link
US (9) US6469160B1 (hu)
EP (1) EP1071693B1 (hu)
JP (1) JP2002510703A (hu)
KR (1) KR20010074472A (hu)
CN (1) CN1303390A (hu)
AP (1) AP2000001947A0 (hu)
AT (1) ATE261452T1 (hu)
AU (1) AU752877B2 (hu)
BR (1) BR9909474A (hu)
CA (1) CA2327494C (hu)
DE (1) DE69915461T2 (hu)
EA (1) EA002970B1 (hu)
EE (1) EE04120B1 (hu)
ES (1) ES2216503T3 (hu)
GB (1) GB9807354D0 (hu)
HR (1) HRP20000669A2 (hu)
HU (1) HUP0101669A3 (hu)
ID (1) ID27109A (hu)
IL (1) IL138697A0 (hu)
IS (1) IS5640A (hu)
NO (1) NO20005005L (hu)
NZ (1) NZ507173A (hu)
PL (1) PL343397A1 (hu)
SK (1) SK14832000A3 (hu)
TR (1) TR200002860T2 (hu)
WO (1) WO1999051618A1 (hu)
YU (1) YU60900A (hu)
ZA (1) ZA200005153B (hu)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB0008939D0 (en) * 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
DK2767539T3 (en) 2002-05-16 2017-09-11 Janssen Sciences Ireland Uc Pseudopolymorphic forms of an HIV protease inhibitor
WO2005118586A1 (en) * 2004-06-02 2005-12-15 Sandoz Ag Meropenem intermediate in crystalline form
EP1910393A2 (en) * 2005-07-05 2008-04-16 Hetero Drugs Limited A novel process for the preparation of didanosine using novel intermediates
US9198862B2 (en) * 2005-07-22 2015-12-01 Rubicon Research Private Limited Dispersible tablet composition
US8188138B2 (en) * 2005-09-21 2012-05-29 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
BRPI0617947A2 (pt) * 2005-10-31 2011-08-09 Janssen Pharmaceutica Nv processos para a preparação de derivados de piperazinil e diazapanil benzamida
CA2656057C (en) * 2006-06-16 2012-10-02 H. Lundbeck A/S Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain
US7919598B2 (en) * 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
CN101568544B (zh) * 2006-10-27 2016-10-26 西格诺药品有限公司 包含4‑[9‑(四氢‑呋喃‑3‑基)‑8‑(2,4,6‑三氟‑苯氨基)‑9h‑嘌呤‑2‑基氨基]‑环己烷‑1‑醇的固体形式，其组合物，及其用途
EP2085397A1 (en) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR101043794B1 (ko) * 2009-04-13 2011-06-27 청우산업 주식회사 황토판재로 제공되는 기능성 황토방
PT2544679T (pt) 2010-03-12 2019-07-11 Omeros Corp Inibidores de pde-10 e composições e métodos relacionados
CN103189360A (zh) * 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
US8546344B2 (en) * 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
CN103930419B (zh) * 2011-09-30 2016-06-01 广东东阳光药业有限公司 阿齐沙坦的晶型及其制备方法
NZ716494A (en) 2014-04-28 2017-07-28 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
NZ716462A (en) 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
US9879002B2 (en) 2015-04-24 2018-01-30 Omeros Corporation PDE10 inhibitors and related compositions and methods
JP2018535969A (ja) 2015-11-04 2018-12-06 オメロス コーポレーション Ｐｄｅ１０阻害剤の固体状態形態
CN111303230B (zh) * 2020-03-09 2021-07-13 中国食品药品检定研究院 一种黄体酮共晶物及其制备方法和用途
AU2023361470A1 (en) * 2022-10-12 2024-09-19 Takeda Pharmaceutical Company Limited Method of preparing maribavir

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) * 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) * 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1994008456A1 (en) * 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound

Also Published As

Publication number Publication date
CN1303390A (zh) 2001-07-11
HRP20000669A2 (en) 2001-08-31
US20020177703A1 (en) 2002-11-28
US20170002035A1 (en) 2017-01-05
IS5640A (is) 2000-09-26
IL138697A0 (en) 2001-10-31
US20160030460A1 (en) 2016-02-04
US7297683B2 (en) 2007-11-20
GB9807354D0 (en) 1998-06-03
US20110118203A1 (en) 2011-05-19
EA200000911A1 (ru) 2001-04-23
NO20005005L (no) 2000-12-06
PL343397A1 (en) 2001-08-13
SK14832000A3 (sk) 2001-07-10
WO1999051618A1 (en) 1999-10-14
DE69915461T2 (de) 2005-03-03
DE69915461D1 (de) 2004-04-15
CA2327494C (en) 2010-10-26
EP1071693A1 (en) 2001-01-31
US20080103186A1 (en) 2008-05-01
US6469160B1 (en) 2002-10-22
BR9909474A (pt) 2000-12-19
EA002970B1 (ru) 2002-12-26
AP2000001947A0 (en) 2000-12-31
NZ507173A (en) 2003-07-25
KR20010074472A (ko) 2001-08-04
US20180044366A1 (en) 2018-02-15
ATE261452T1 (de) 2004-03-15
TR200002860T2 (tr) 2000-12-21
AU752877B2 (en) 2002-10-03
NO20005005D0 (no) 2000-10-04
ID27109A (id) 2001-03-01
ES2216503T3 (es) 2004-10-16
US20100179101A1 (en) 2010-07-15
US20130261294A1 (en) 2013-10-03
YU60900A (sh) 2003-07-07
JP2002510703A (ja) 2002-04-09
EE200000584A (et) 2002-04-15
ZA200005153B (en) 2001-09-26
CA2327494A1 (en) 1999-10-14
US9163052B2 (en) 2015-10-20
HUP0101669A3 (en) 2003-07-28
US7714123B2 (en) 2010-05-11
EE04120B1 (et) 2003-08-15
AU3603499A (en) 1999-10-25
EP1071693B1 (en) 2004-03-10

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