TR200002860T2 - Bir antiviral benzimidazol terkibin yeni kristal formları. - Google Patents

Bir antiviral benzimidazol terkibin yeni kristal formları.

Info

Publication number
TR200002860T2
TR200002860T2 TR2000/02860T TR200002860T TR200002860T2 TR 200002860 T2 TR200002860 T2 TR 200002860T2 TR 2000/02860 T TR2000/02860 T TR 2000/02860T TR 200002860 T TR200002860 T TR 200002860T TR 200002860 T2 TR200002860 T2 TR 200002860T2
Authority
TR
Turkey
Prior art keywords
crystal forms
new crystal
benzimidazole composition
antiviral
antiviral benzimidazole
Prior art date
Application number
TR2000/02860T
Other languages
English (en)
Inventor
Howard Carter Barry
Neal Glover Bobby
Huang Lian-Feng
William Lancaster Robert
Todd Long Stacey
Catherine Rizzolio Michele
Allen Schmitt Eric
Riddle Sickles Barry
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of TR200002860T2 publication Critical patent/TR200002860T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Bu bulus 5,6-dikloro-2-(izopropilamino)-1-B-L-ribofuranosil-1H- benzimidazol'un fiziksel formlarina, farmasötik bilesimlere ve tibbi terapide kullanimlarina iliskindir.
TR2000/02860T 1998-04-07 1999-04-01 Bir antiviral benzimidazol terkibin yeni kristal formları. TR200002860T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9807354.7A GB9807354D0 (en) 1998-04-07 1998-04-07 Antiviral compound

Publications (1)

Publication Number Publication Date
TR200002860T2 true TR200002860T2 (tr) 2000-12-21

Family

ID=10829932

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02860T TR200002860T2 (tr) 1998-04-07 1999-04-01 Bir antiviral benzimidazol terkibin yeni kristal formları.

Country Status (28)

Country Link
US (9) US6469160B1 (tr)
EP (1) EP1071693B1 (tr)
JP (1) JP2002510703A (tr)
KR (1) KR20010074472A (tr)
CN (1) CN1303390A (tr)
AP (1) AP2000001947A0 (tr)
AT (1) ATE261452T1 (tr)
AU (1) AU752877B2 (tr)
BR (1) BR9909474A (tr)
CA (1) CA2327494C (tr)
DE (1) DE69915461T2 (tr)
EA (1) EA002970B1 (tr)
EE (1) EE04120B1 (tr)
ES (1) ES2216503T3 (tr)
GB (1) GB9807354D0 (tr)
HR (1) HRP20000669A2 (tr)
HU (1) HUP0101669A3 (tr)
ID (1) ID27109A (tr)
IL (1) IL138697A0 (tr)
IS (1) IS5640A (tr)
NO (1) NO20005005L (tr)
NZ (1) NZ507173A (tr)
PL (1) PL343397A1 (tr)
SK (1) SK14832000A3 (tr)
TR (1) TR200002860T2 (tr)
WO (1) WO1999051618A1 (tr)
YU (1) YU60900A (tr)
ZA (1) ZA200005153B (tr)

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GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
NZ536497A (en) 2002-05-16 2006-08-31 Tibotec Pharm Ltd Pseudopolymorphic forms of a HIV protease inhibitor and their use as a medicament
ES2370829T3 (es) * 2004-06-02 2011-12-23 Sandoz Ag Producto intermedio de meropenem en forma cristalina.
US7750153B2 (en) * 2005-07-05 2010-07-06 Hetero Drugs Limited Process for the preparation of didanosine using novel intermediates
WO2007052289A2 (en) * 2005-07-22 2007-05-10 Rubicon Research Pvt Ltd. Novel dispersible tablet composition
EP1928826B1 (en) * 2005-09-21 2013-04-24 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
EA014905B1 (ru) * 2005-10-31 2011-02-28 Янссен Фармацевтика Н.В. Новый способ получения пиперазинильных производных бензамида
MX2008016008A (es) * 2006-06-16 2009-01-16 Lundbeck & Co As H Formas cristalinas de 4-[2-(4-metilfenilsulfonil)-fenil] piperidina con inhibicion combinada de la recaptacion de serotonina y norepinefrina para el tratamiento del dolor neuropatico.
US7919598B2 (en) * 2006-06-28 2011-04-05 Bristol-Myers Squibb Company Crystal structures of SGLT2 inhibitors and processes for preparing same
BRPI0717394A2 (pt) * 2006-10-27 2013-10-15 Signal Pharm Llc Forma cristalina, composição farmacêutica, forma de dosagem unitária única, método para tratar ou prevenir uma doença ou condição, e, processo para preparar um composto
EP2085397A1 (en) * 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) * 2008-04-15 2010-06-09 Basilea Pharmaceutica Ag Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR101043794B1 (ko) * 2009-04-13 2011-06-27 청우산업 주식회사 황토판재로 제공되는 기능성 황토방
KR101713453B1 (ko) 2010-03-12 2017-03-07 오메로스 코포레이션 Pde10 억제제 및 관련 조성물 및 방법
WO2012030957A2 (en) * 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
CN103930419B (zh) * 2011-09-30 2016-06-01 广东东阳光药业有限公司 阿齐沙坦的晶型及其制备方法
NZ716462A (en) * 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
NZ630810A (en) 2014-04-28 2016-03-31 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
AU2016250843A1 (en) 2015-04-24 2017-10-12 Omeros Corporation PDE10 inhibitors and related compositions and methods
JP2018535969A (ja) 2015-11-04 2018-12-06 オメロス コーポレーション Ｐｄｅ１０阻害剤の固体状態形態
CN111303230B (zh) * 2020-03-09 2021-07-13 中国食品药品检定研究院 一种黄体酮共晶物及其制备方法和用途
WO2024081308A1 (en) * 2022-10-12 2024-04-18 Takeda Pharmaceutical Company Limited Method of preparing maribavir

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3399987A (en) * 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) * 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
AU5447094A (en) * 1992-10-21 1994-05-09 Regents Of The University Of Michigan, The Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound

Also Published As

Publication number Publication date
ZA200005153B (en) 2001-09-26
US9163052B2 (en) 2015-10-20
YU60900A (sh) 2003-07-07
HRP20000669A2 (en) 2001-08-31
US20080103186A1 (en) 2008-05-01
EA200000911A1 (ru) 2001-04-23
ES2216503T3 (es) 2004-10-16
IL138697A0 (en) 2001-10-31
NO20005005L (no) 2000-12-06
US20100179101A1 (en) 2010-07-15
US20170002035A1 (en) 2017-01-05
US7714123B2 (en) 2010-05-11
US7297683B2 (en) 2007-11-20
HUP0101669A3 (en) 2003-07-28
NZ507173A (en) 2003-07-25
US6469160B1 (en) 2002-10-22
US20180044366A1 (en) 2018-02-15
DE69915461T2 (de) 2005-03-03
HUP0101669A2 (hu) 2001-10-28
ID27109A (id) 2001-03-01
CA2327494C (en) 2010-10-26
DE69915461D1 (de) 2004-04-15
ATE261452T1 (de) 2004-03-15
IS5640A (is) 2000-09-26
WO1999051618A1 (en) 1999-10-14
AP2000001947A0 (en) 2000-12-31
US20020177703A1 (en) 2002-11-28
US20160030460A1 (en) 2016-02-04
EE04120B1 (et) 2003-08-15
CN1303390A (zh) 2001-07-11
SK14832000A3 (sk) 2001-07-10
PL343397A1 (en) 2001-08-13
EP1071693B1 (en) 2004-03-10
EA002970B1 (ru) 2002-12-26
EP1071693A1 (en) 2001-01-31
BR9909474A (pt) 2000-12-19
US20110118203A1 (en) 2011-05-19
AU3603499A (en) 1999-10-25
GB9807354D0 (en) 1998-06-03
CA2327494A1 (en) 1999-10-14
NO20005005D0 (no) 2000-10-04
AU752877B2 (en) 2002-10-03
KR20010074472A (ko) 2001-08-04
JP2002510703A (ja) 2002-04-09
EE200000584A (et) 2002-04-15
US20130261294A1 (en) 2013-10-03

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