HUP0003497A2 - Eljárás szubsztituált 2-nitro-guanidin-származékok és intermedierjeik előállítására - Google Patents
Eljárás szubsztituált 2-nitro-guanidin-származékok és intermedierjeik előállításáraInfo
- Publication number
- HUP0003497A2 HUP0003497A2 HU0003497A HUP0003497A HUP0003497A2 HU P0003497 A2 HUP0003497 A2 HU P0003497A2 HU 0003497 A HU0003497 A HU 0003497A HU P0003497 A HUP0003497 A HU P0003497A HU P0003497 A2 HUP0003497 A2 HU P0003497A2
- Authority
- HU
- Hungary
- Prior art keywords
- general formula
- iia
- iib
- compound
- intermediates
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- -1 substituted-2-nitroguanidine Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000962 organic group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical group 0.000 abstract 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/08—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgya eljárás (I) általános képletű vegyületek - amelyekképletében R1 hidrogénatom vagy alkilcsoport; R2 hidrogénatom, alkil-, cikloalkil- vagy -CH2B csoport; Het adott esetben szubsztituált heterociklusos csoport; és B jelentése adott esetben szubsztituált fenil-, 3-piridil- vagytiazolilcsoport - és ahol lehetséges a vegyületek E/Z<>-izomereinek,E/Z-izomerkeverékeinek és/vagy tautomereinek szabad formában vagy sóformában történő előállítására, amelynek során egy (IIa) általánosképletű vegyületet Q-A-Q (IIa) vagy egy (IIb) általános képletűvegyületet - ahol az általános képletekben A kémiai kötés vagy szerves csoport, U szerves csoport, és Q jelentése általános képletű csoport, amelyben R1, R2 és Hetjelentése az (I) általános képletnél meghatározott - és adott esetbena (IIa) vagy (IIb) általános képletű vegyület E/Z<> izomereit, E/Zizomerkeverékeit és/vagy tautomereit szabad formában vagy só formábanhidrolizálják. A találmány tárgyát képezi továbbá a (IIa), (IIb),(IIIa) és (IIIb) általános képletű intermedierek előállítási eljárása. ezekben a képletekben A és U jelentése az előzőkben megadott, és Tjelentése amelyben R2 jelentése az előzőkben megadott. Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH193497 | 1997-08-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0003497A2 true HUP0003497A2 (hu) | 2001-02-28 |
| HUP0003497A3 HUP0003497A3 (en) | 2002-11-28 |
Family
ID=4222018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0003497A HUP0003497A3 (en) | 1997-08-18 | 1998-08-14 | Method for producing substituted-2-nitroguanidine derivatives and their intermediates |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6462043B1 (hu) |
| EP (1) | EP1005455A1 (hu) |
| JP (1) | JP2001515065A (hu) |
| KR (1) | KR20010022974A (hu) |
| CN (1) | CN1271345A (hu) |
| AU (1) | AU738428B2 (hu) |
| BR (1) | BR9811912A (hu) |
| CA (1) | CA2300808A1 (hu) |
| HU (1) | HUP0003497A3 (hu) |
| ID (1) | ID23446A (hu) |
| IL (1) | IL134549A0 (hu) |
| PL (1) | PL338645A1 (hu) |
| RU (1) | RU2202544C2 (hu) |
| UA (1) | UA69387C2 (hu) |
| WO (1) | WO1999009008A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6507398B2 (ja) * | 2015-06-03 | 2019-05-08 | 日本曹達株式会社 | グアニジン化合物および殺菌剤 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW198724B (hu) * | 1990-10-24 | 1993-01-21 | Ciba Geigy Ag |
-
1998
- 1998-08-14 CA CA002300808A patent/CA2300808A1/en not_active Abandoned
- 1998-08-14 IL IL13454998A patent/IL134549A0/xx unknown
- 1998-08-14 EP EP98946337A patent/EP1005455A1/de not_active Withdrawn
- 1998-08-14 PL PL98338645A patent/PL338645A1/xx unknown
- 1998-08-14 KR KR1020007001582A patent/KR20010022974A/ko not_active Application Discontinuation
- 1998-08-14 RU RU2000106433/04A patent/RU2202544C2/ru not_active IP Right Cessation
- 1998-08-14 HU HU0003497A patent/HUP0003497A3/hu not_active Application Discontinuation
- 1998-08-14 ID IDW20000317A patent/ID23446A/id unknown
- 1998-08-14 AU AU93423/98A patent/AU738428B2/en not_active Ceased
- 1998-08-14 BR BR9811912-5A patent/BR9811912A/pt not_active Application Discontinuation
- 1998-08-14 US US09/485,873 patent/US6462043B1/en not_active Expired - Fee Related
- 1998-08-14 JP JP2000509692A patent/JP2001515065A/ja active Pending
- 1998-08-14 WO PCT/EP1998/005166 patent/WO1999009008A1/de not_active Application Discontinuation
- 1998-08-14 UA UA2000020845A patent/UA69387C2/uk unknown
- 1998-08-14 CN CN98809327A patent/CN1271345A/zh active Pending
-
2002
- 2002-08-22 US US10/226,181 patent/US20030130520A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1005455A1 (de) | 2000-06-07 |
| BR9811912A (pt) | 2000-08-15 |
| IL134549A0 (en) | 2001-04-30 |
| UA69387C2 (uk) | 2004-09-15 |
| PL338645A1 (en) | 2000-11-06 |
| CN1271345A (zh) | 2000-10-25 |
| HUP0003497A3 (en) | 2002-11-28 |
| KR20010022974A (ko) | 2001-03-26 |
| CA2300808A1 (en) | 1999-02-25 |
| RU2202544C2 (ru) | 2003-04-20 |
| ID23446A (id) | 2000-04-20 |
| WO1999009008A1 (de) | 1999-02-25 |
| JP2001515065A (ja) | 2001-09-18 |
| US6462043B1 (en) | 2002-10-08 |
| US20030130520A1 (en) | 2003-07-10 |
| AU738428B2 (en) | 2001-09-20 |
| AU9342398A (en) | 1999-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC4A | Lapse of provisional application due to refusal |