HUP0001758A3 - Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus, pharmaceutical compositions comprising thereof and their use - Google Patents
Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus, pharmaceutical compositions comprising thereof and their useInfo
- Publication number
- HUP0001758A3 HUP0001758A3 HU0001758A HUP0001758A HUP0001758A3 HU P0001758 A3 HUP0001758 A3 HU P0001758A3 HU 0001758 A HU0001758 A HU 0001758A HU P0001758 A HUP0001758 A HU P0001758A HU P0001758 A3 HUP0001758 A3 HU P0001758A3
- Authority
- HU
- Hungary
- Prior art keywords
- dolastatin
- terminus
- carbonyl
- derivatives
- pharmaceutical compositions
- Prior art date
Links
- LQKSHSFQQRCAFW-CCVNJFHASA-N [(2s)-1-[(2s)-2-benzyl-3-methoxy-5-oxo-2h-pyrrol-1-yl]-3-methyl-1-oxobutan-2-yl] (2s)-1-[(2s)-1-[(2s)-2-[[(2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxyl Chemical class C([C@@H]1N(C(=O)C=C1OC)C(=O)[C@@H](OC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C)C(C)C)C1=CC=CC=C1 LQKSHSFQQRCAFW-CCVNJFHASA-N 0.000 title 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 title 1
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/814,577 US5965537A (en) | 1997-03-10 | 1997-03-10 | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
| PCT/US1998/004317 WO1998040400A1 (fr) | 1997-03-10 | 1998-03-05 | Derives de dolastatine 15 dotes de fonctionnalites carbonyle et heterocyclique au niveau d'une terminaison carboxyle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001758A2 HUP0001758A2 (hu) | 2001-05-28 |
| HUP0001758A3 true HUP0001758A3 (en) | 2001-12-28 |
Family
ID=25215470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001758A HUP0001758A3 (en) | 1997-03-10 | 1998-03-05 | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus, pharmaceutical compositions comprising thereof and their use |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5965537A (fr) |
| EP (1) | EP0981539A1 (fr) |
| JP (1) | JP2001518084A (fr) |
| KR (1) | KR20000076099A (fr) |
| CN (1) | CN1252806A (fr) |
| AR (1) | AR011957A1 (fr) |
| AU (1) | AU744511B2 (fr) |
| BR (1) | BR9808017A (fr) |
| CA (1) | CA2297164A1 (fr) |
| CO (1) | CO4950525A1 (fr) |
| HR (1) | HRP980124A2 (fr) |
| HU (1) | HUP0001758A3 (fr) |
| IL (1) | IL131596A0 (fr) |
| NO (1) | NO994364L (fr) |
| TW (1) | TW505657B (fr) |
| WO (1) | WO1998040400A1 (fr) |
| ZA (1) | ZA981957B (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| CN101307046B (zh) | 2000-10-30 | 2012-08-15 | 詹森药业有限公司 | 三肽酶抑制剂 |
| US7256257B2 (en) * | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US6884869B2 (en) * | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| PT1545613E (pt) * | 2002-07-31 | 2011-09-27 | Seattle Genetics Inc | Conjugados de auristatina e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infecciosa |
| DE10240818A1 (de) * | 2002-08-30 | 2004-05-13 | Grünenthal GmbH | Substituierte 2-Pyrrolidin-2-yl-[1,3,4]-oxadiazol-Derivate |
| FR2856685B1 (fr) * | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| SG10201701737XA (en) | 2003-11-06 | 2017-04-27 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
| JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Ｂｉｒドメイン結合化合物 |
| EP2024362A4 (fr) | 2006-05-16 | 2012-01-25 | Pharmascience Inc | Composés de liaison au domaine iap bir |
| SG183023A1 (en) | 2007-07-16 | 2012-08-30 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
| MX341687B (es) | 2010-02-10 | 2016-08-30 | Immunogen Inc | "anticuerpos cd20 y su utilización". |
| US9284350B2 (en) | 2010-02-12 | 2016-03-15 | Pharmascience Inc. | IAP BIR domain binding compounds |
| CA2891280C (fr) | 2012-11-24 | 2018-03-20 | Hangzhou Dac Biotech Co., Ltd. | Lieurs hydrophiles et leurs utilisations pour la conjugaison de medicaments a des molecules se liant aux cellules |
| PT3122757T (pt) | 2014-02-28 | 2023-11-03 | Hangzhou Dac Biotech Co Ltd | Ligantes carregados e as suas utilizações em conjugação |
| WO2016086357A1 (fr) * | 2014-12-02 | 2016-06-09 | Merck Sharp & Dohme Corp. | Méthyl oxazoles antagonistes du récepteur d'orexine |
| US9987255B2 (en) | 2014-12-19 | 2018-06-05 | Merck Sharp & Dohme Corp. | 5,5-bicyclic oxazole orexin receptor antagonists |
| CN104952808A (zh) * | 2015-06-12 | 2015-09-30 | 广州先艺电子科技有限公司 | 一种预置金锡盖板及其制造方法 |
| EP3319936A4 (fr) | 2015-07-12 | 2019-02-06 | Suzhou M-conj Biotech Co., Ltd. | Lieux de pontage pour la conjugaison des molécules de liaison cellulaire |
| US9839687B2 (en) | 2015-07-15 | 2017-12-12 | Suzhou M-Conj Biotech Co., Ltd. | Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule |
| JP7138350B2 (ja) | 2016-11-14 | 2022-09-16 | ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ． | 共役連結体、該連結体を含有する細胞結合分子－薬物共役体、並びに該共役体及び連結体の使用及び製造方法 |
| CN109776342A (zh) * | 2019-02-26 | 2019-05-21 | 北京大学深圳研究生院 | 顺式β-氨基酸及其衍生物的合成方法 |
| US20240132487A1 (en) * | 2019-10-17 | 2024-04-25 | Givaudan Sa | Substituted azacyles as trmp8 modulators |
| JPWO2023033129A1 (fr) | 2021-09-03 | 2023-03-09 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US4879278A (en) * | 1989-05-16 | 1989-11-07 | Arizona Board Of Regents | Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15 |
| US5091368A (en) * | 1990-08-08 | 1992-02-25 | Harbor Branch Oceanographic Institution, Inc. | Biologically active compounds from blue-green algae |
| EP0598129B1 (fr) * | 1991-08-09 | 2000-03-22 | Teikoku Hormone Mfg. Co., Ltd. | Nouveau derive de tetrapeptide |
| CZ292612B6 (cs) * | 1992-05-20 | 2003-11-12 | Abbott Gmbh & Co. Kg | Peptid s protirakovinnou aktivitou, jeho použití a farmaceutický prostředek s obsahem takového peptidu |
| US5831002A (en) * | 1992-05-20 | 1998-11-03 | Basf Aktiengesellschaft | Antitumor peptides |
| AU679479B2 (en) * | 1992-12-16 | 1997-07-03 | Basf Aktiengesellschaft | Dolostatin analog |
| US5530097A (en) * | 1994-08-01 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory peptide amides |
| US5504191A (en) * | 1994-08-01 | 1996-04-02 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Human cancer inhibitory pentapeptide methyl esters |
| US5554725A (en) * | 1994-09-14 | 1996-09-10 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Synthesis of dolastatin 15 |
| US5807984A (en) * | 1995-11-09 | 1998-09-15 | Basf Aktienegesellschaft | Oligopeptides, the preparation and use thereof |
-
1997
- 1997-03-10 US US08/814,577 patent/US5965537A/en not_active Expired - Fee Related
-
1998
- 1998-03-05 CN CN98803903A patent/CN1252806A/zh active Pending
- 1998-03-05 WO PCT/US1998/004317 patent/WO1998040400A1/fr not_active Application Discontinuation
- 1998-03-05 AU AU64482/98A patent/AU744511B2/en not_active Ceased
- 1998-03-05 BR BR9808017-2A patent/BR9808017A/pt not_active IP Right Cessation
- 1998-03-05 IL IL13159698A patent/IL131596A0/xx unknown
- 1998-03-05 CA CA002297164A patent/CA2297164A1/fr not_active Abandoned
- 1998-03-05 HU HU0001758A patent/HUP0001758A3/hu unknown
- 1998-03-05 JP JP53963098A patent/JP2001518084A/ja active Pending
- 1998-03-05 EP EP98910182A patent/EP0981539A1/fr not_active Withdrawn
- 1998-03-05 KR KR1019997008187A patent/KR20000076099A/ko not_active Application Discontinuation
- 1998-03-09 ZA ZA9801957A patent/ZA981957B/xx unknown
- 1998-03-09 CO CO98012757A patent/CO4950525A1/es unknown
- 1998-03-10 AR ARP980101061A patent/AR011957A1/es unknown
- 1998-03-10 TW TW087103515A patent/TW505657B/zh active
- 1998-03-10 HR HR08/814,577A patent/HRP980124A2/hr not_active Application Discontinuation
-
1999
- 1999-09-09 NO NO994364A patent/NO994364L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW505657B (en) | 2002-10-11 |
| BR9808017A (pt) | 2000-03-08 |
| NO994364D0 (no) | 1999-09-09 |
| AU744511B2 (en) | 2002-02-28 |
| AU6448298A (en) | 1998-09-29 |
| ZA981957B (en) | 1999-09-09 |
| HRP980124A2 (en) | 1998-12-31 |
| HUP0001758A2 (hu) | 2001-05-28 |
| CN1252806A (zh) | 2000-05-10 |
| CA2297164A1 (fr) | 1998-09-17 |
| NO994364L (no) | 1999-11-09 |
| AR011957A1 (es) | 2000-09-13 |
| IL131596A0 (en) | 2001-01-28 |
| JP2001518084A (ja) | 2001-10-09 |
| US5965537A (en) | 1999-10-12 |
| CO4950525A1 (es) | 2000-09-01 |
| WO1998040400A1 (fr) | 1998-09-17 |
| KR20000076099A (ko) | 2000-12-26 |
| EP0981539A1 (fr) | 2000-03-01 |
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