HUP0001264A2 - Izoxazolin-tioészterek lipázzal katalizált, dinamikus rezolválása izoxazolinkarbonsavakká - Google Patents

Izoxazolin-tioészterek lipázzal katalizált, dinamikus rezolválása izoxazolinkarbonsavakká

Info

Publication number
HUP0001264A2
HUP0001264A2 HU0001264A HUP0001264A HUP0001264A2 HU P0001264 A2 HUP0001264 A2 HU P0001264A2 HU 0001264 A HU0001264 A HU 0001264A HU P0001264 A HUP0001264 A HU P0001264A HU P0001264 A2 HUP0001264 A2 HU P0001264A2
Authority
HU
Hungary
Prior art keywords
isoxazoline
stereoisomers
thioesters
ester
carboxylic acids
Prior art date
Application number
HU0001264A
Other languages
English (en)
Inventor
Luigi Anzalone
Jaan A. Pesti
Jianguo Yin
Lin-Hua Zhang
Original Assignee
Du Pont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharmaceuticals Company filed Critical Du Pont Pharmaceuticals Company
Publication of HUP0001264A2 publication Critical patent/HUP0001264A2/hu
Publication of HUP0001264A3 publication Critical patent/HUP0001264A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány általában nagy őptikai tisztaságú, szűbsztitűáltizőxazőlin-5-il-ecetsavak új előállítási eljárására vőnatkőzikészterezett, szűbsztitűált izőxazől-5-il-acetátők sztereőizőmerkeverékéből. Ezek a termékek különösen trőmbózisős betegségekbenalkalmazható gyógyszerek, valamint mezőgazdasági hatóanyagőkszintézisében közbenső termékként használhatók. A találmány szerintieljárás lényege, hőgy szűbsztitűált izőxazőlin-5-il-ecetsav-észtersztereőizőmer keverékéből indűlnak ki, amelyet az egyik sztereőizőmerkeverékéből indűlnak ki, amelyet az egyik sztereőizőmer észtertszelektíven hidrőlizáló lipáz enzimmel kezelnek, s így az egyiksztereőizőmer savat 51%-nál nagyőbb hőzammal és 80%-nál nagyőbbőptikai tisztasággal kapják. szter minőségében előnyös egy tiőészterfelhasználása, amely az alkilésztereknél győrsabban és kedvezőbbenhidrőlizál. ŕ
HU0001264A 1997-03-26 1998-03-26 Lipase catalyzed dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids HUP0001264A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4210997P 1997-03-26 1997-03-26

Publications (2)

Publication Number Publication Date
HUP0001264A2 true HUP0001264A2 (hu) 2000-08-28
HUP0001264A3 HUP0001264A3 (en) 2002-02-28

Family

ID=21920103

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001264A HUP0001264A3 (en) 1997-03-26 1998-03-26 Lipase catalyzed dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids

Country Status (20)

Country Link
US (1) US6022977A (hu)
EP (1) EP0971906A1 (hu)
JP (1) JP2001520672A (hu)
KR (1) KR20010005493A (hu)
CN (1) CN1251095A (hu)
AU (1) AU741040B2 (hu)
BR (1) BR9811255A (hu)
CA (1) CA2283234A1 (hu)
EA (1) EA001970B1 (hu)
EE (1) EE9900434A (hu)
HU (1) HUP0001264A3 (hu)
IL (1) IL132004A0 (hu)
LT (1) LT4674B (hu)
LV (1) LV12431B (hu)
NO (1) NO994480L (hu)
NZ (1) NZ500388A (hu)
PL (1) PL336008A1 (hu)
SI (1) SI20027A (hu)
SK (1) SK131599A3 (hu)
WO (1) WO1998042687A1 (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2803513B1 (fr) * 2000-01-12 2003-12-19 Oreal Utilisation de la dhea et/ou de ses precurseurs ou derives pour ameliorer l'aspect papyrace de la peau
US6624311B2 (en) 2000-10-27 2003-09-23 Bristol-Myers Squibb Pharma Company Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester
GB0306267D0 (en) * 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
CN101643757B (zh) * 2009-09-07 2011-10-19 浙江大学 光学纯n-取代-吗啉-3-酮-2-乙酸的制备方法
DK3484528T3 (da) 2016-07-18 2021-02-15 Janssen Pharmaceutica Nv Tau-pet-billeddannelsesligander

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256898A (en) * 1978-05-15 1981-03-17 The Upjohn Company α(substituted) Amino-3-substituted-2-isoxazoline-5-acetic acids (esters)
US4970297A (en) * 1987-03-13 1990-11-13 Syntex (U.S.A.) Inc. Transglutaminase inhibitors
US4952700A (en) * 1988-04-25 1990-08-28 W.R. Grace & Co.-Conn. Preparation of isoxazolines and isoxazoles
US4933464A (en) * 1988-04-25 1990-06-12 W. R. Grace & Co.-Conn. Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles
US5108916A (en) * 1989-06-05 1992-04-28 Rhone-Poulenc Rorer, S.A. Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa
CA2023856A1 (en) * 1989-09-26 1991-03-27 Jeffrey M. Howell Enzymatic resolution process
AT398081B (de) * 1991-04-29 1994-09-26 Chemie Linz Gmbh Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates
GB9304351D0 (en) * 1993-03-03 1993-04-21 Chiros Ltd Arylalkanoic acid resolution and microorganisms for use therein
US5489562A (en) * 1993-08-30 1996-02-06 Rohm And Haas Company Herbicide comprising acivicin and α-methyl derivatives thereof
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
BR9408137A (pt) * 1993-11-24 1997-08-12 Du Pont Merck Pharma Composto éster de prodroga método de tratamento composição farmacêutica e método de inibição
US5446056A (en) * 1993-11-24 1995-08-29 The Du Pont Merck Pharmaceutical Company Isoxazoline compounds useful as fibrinogen receptor antagonists
DE69422061T2 (de) * 1993-11-26 2000-03-30 Pfizer 3-phenyl-2-isoxazoline derivate als entzündugshemmende mittel
US5716967A (en) * 1993-11-26 1998-02-10 Pfizer Inc. Isoxazoline compounds as antiinflammatory agents
KR100200449B1 (ko) * 1994-03-09 1999-06-15 디. 제이. 우드, 스피겔 알렌 제이 Tnf 방출 억제제로서의 이소옥사졸린 화합물

Also Published As

Publication number Publication date
PL336008A1 (en) 2000-06-05
NZ500388A (en) 2001-06-29
SK131599A3 (en) 2001-05-10
EA199900874A1 (ru) 2000-04-24
LV12431A (lv) 2000-02-20
EA001970B1 (ru) 2001-10-22
NO994480D0 (no) 1999-09-16
LV12431B (en) 2000-07-20
JP2001520672A (ja) 2001-10-30
WO1998042687A1 (en) 1998-10-01
EE9900434A (et) 2000-04-17
IL132004A0 (en) 2001-03-19
SI20027A (sl) 2000-02-29
NO994480L (no) 1999-09-16
LT4674B (lt) 2000-07-25
CA2283234A1 (en) 1998-10-01
LT99112A (en) 2000-02-25
AU741040B2 (en) 2001-11-22
BR9811255A (pt) 2000-07-18
US6022977A (en) 2000-02-08
EP0971906A1 (en) 2000-01-19
AU6941498A (en) 1998-10-20
CN1251095A (zh) 2000-04-19
HUP0001264A3 (en) 2002-02-28
KR20010005493A (ko) 2001-01-15

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