HUP0001264A2 - Izoxazolin-tioészterek lipázzal katalizált, dinamikus rezolválása izoxazolinkarbonsavakká - Google Patents
Izoxazolin-tioészterek lipázzal katalizált, dinamikus rezolválása izoxazolinkarbonsavakkáInfo
- Publication number
- HUP0001264A2 HUP0001264A2 HU0001264A HUP0001264A HUP0001264A2 HU P0001264 A2 HUP0001264 A2 HU P0001264A2 HU 0001264 A HU0001264 A HU 0001264A HU P0001264 A HUP0001264 A HU P0001264A HU P0001264 A2 HUP0001264 A2 HU P0001264A2
- Authority
- HU
- Hungary
- Prior art keywords
- isoxazoline
- stereoisomers
- thioesters
- ester
- carboxylic acids
- Prior art date
Links
- 102000004882 Lipase Human genes 0.000 title abstract 2
- 108090001060 Lipase Proteins 0.000 title abstract 2
- ZYDBNGULYNHMSF-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole-3-carboxylic acid Chemical class OC(=O)C1=NOCC1 ZYDBNGULYNHMSF-UHFFFAOYSA-N 0.000 title 1
- 239000004367 Lipase Substances 0.000 title 1
- -1 isoxazoline thioesters Chemical class 0.000 title 1
- 235000019421 lipase Nutrition 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- OPENOQVDUQHOLB-UHFFFAOYSA-N 2-(4,5-dihydro-1,2-oxazol-5-yl)acetic acid Chemical class OC(=O)CC1CC=NO1 OPENOQVDUQHOLB-UHFFFAOYSA-N 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány általában nagy őptikai tisztaságú, szűbsztitűáltizőxazőlin-5-il-ecetsavak új előállítási eljárására vőnatkőzikészterezett, szűbsztitűált izőxazől-5-il-acetátők sztereőizőmerkeverékéből. Ezek a termékek különösen trőmbózisős betegségekbenalkalmazható gyógyszerek, valamint mezőgazdasági hatóanyagőkszintézisében közbenső termékként használhatók. A találmány szerintieljárás lényege, hőgy szűbsztitűált izőxazőlin-5-il-ecetsav-észtersztereőizőmer keverékéből indűlnak ki, amelyet az egyik sztereőizőmerkeverékéből indűlnak ki, amelyet az egyik sztereőizőmer észtertszelektíven hidrőlizáló lipáz enzimmel kezelnek, s így az egyiksztereőizőmer savat 51%-nál nagyőbb hőzammal és 80%-nál nagyőbbőptikai tisztasággal kapják. szter minőségében előnyös egy tiőészterfelhasználása, amely az alkilésztereknél győrsabban és kedvezőbbenhidrőlizál. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4210997P | 1997-03-26 | 1997-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0001264A2 true HUP0001264A2 (hu) | 2000-08-28 |
HUP0001264A3 HUP0001264A3 (en) | 2002-02-28 |
Family
ID=21920103
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001264A HUP0001264A3 (en) | 1997-03-26 | 1998-03-26 | Lipase catalyzed dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids |
Country Status (20)
Country | Link |
---|---|
US (1) | US6022977A (hu) |
EP (1) | EP0971906A1 (hu) |
JP (1) | JP2001520672A (hu) |
KR (1) | KR20010005493A (hu) |
CN (1) | CN1251095A (hu) |
AU (1) | AU741040B2 (hu) |
BR (1) | BR9811255A (hu) |
CA (1) | CA2283234A1 (hu) |
EA (1) | EA001970B1 (hu) |
EE (1) | EE9900434A (hu) |
HU (1) | HUP0001264A3 (hu) |
IL (1) | IL132004A0 (hu) |
LT (1) | LT4674B (hu) |
LV (1) | LV12431B (hu) |
NO (1) | NO994480D0 (hu) |
NZ (1) | NZ500388A (hu) |
PL (1) | PL336008A1 (hu) |
SI (1) | SI20027A (hu) |
SK (1) | SK131599A3 (hu) |
WO (1) | WO1998042687A1 (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2803513B1 (fr) * | 2000-01-12 | 2003-12-19 | Oreal | Utilisation de la dhea et/ou de ses precurseurs ou derives pour ameliorer l'aspect papyrace de la peau |
US6624311B2 (en) | 2000-10-27 | 2003-09-23 | Bristol-Myers Squibb Pharma Company | Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester |
GB0306267D0 (en) | 2003-03-19 | 2003-04-23 | Ineos Fluor Ltd | Process |
CN101643757B (zh) * | 2009-09-07 | 2011-10-19 | 浙江大学 | 光学纯n-取代-吗啉-3-酮-2-乙酸的制备方法 |
DK3484528T3 (da) | 2016-07-18 | 2021-02-15 | Janssen Pharmaceutica Nv | Tau-pet-billeddannelsesligander |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4256898A (en) * | 1978-05-15 | 1981-03-17 | The Upjohn Company | α(substituted) Amino-3-substituted-2-isoxazoline-5-acetic acids (esters) |
US4970297A (en) * | 1987-03-13 | 1990-11-13 | Syntex (U.S.A.) Inc. | Transglutaminase inhibitors |
US4952700A (en) * | 1988-04-25 | 1990-08-28 | W.R. Grace & Co.-Conn. | Preparation of isoxazolines and isoxazoles |
US4933464A (en) * | 1988-04-25 | 1990-06-12 | W. R. Grace & Co.-Conn. | Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles |
US5108916A (en) * | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
CA2023856A1 (en) * | 1989-09-26 | 1991-03-27 | Jeffrey M. Howell | Enzymatic resolution process |
AT398081B (de) * | 1991-04-29 | 1994-09-26 | Chemie Linz Gmbh | Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates |
GB9304351D0 (en) * | 1993-03-03 | 1993-04-21 | Chiros Ltd | Arylalkanoic acid resolution and microorganisms for use therein |
US5489562A (en) * | 1993-08-30 | 1996-02-06 | Rohm And Haas Company | Herbicide comprising acivicin and α-methyl derivatives thereof |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
HUT74690A (en) * | 1993-11-24 | 1997-01-28 | Du Pont Merck Pharma | Novel isoxazoline and isoxazole fibrinogen receptor antagonists process for producing them and pharmaceutical compositions containing them |
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
WO1995014680A1 (en) * | 1993-11-26 | 1995-06-01 | Pfizer Inc. | 3-aryl-2-isoxazolines as antiinflammatory agents |
DK0730588T3 (da) * | 1993-11-26 | 1997-12-08 | Pfizer | Isoxazolinforbindelser som antiinflammatoriske midler |
JPH09505082A (ja) * | 1994-03-09 | 1997-05-20 | ファイザー・インコーポレーテッド | Tnf放出の阻害剤としてのイソオキサゾリン |
-
1998
- 1998-03-25 US US09/047,555 patent/US6022977A/en not_active Expired - Fee Related
- 1998-03-26 SI SI9820028A patent/SI20027A/sl unknown
- 1998-03-26 PL PL98336008A patent/PL336008A1/xx unknown
- 1998-03-26 CN CN98803597A patent/CN1251095A/zh active Pending
- 1998-03-26 EE EEP199900434A patent/EE9900434A/xx unknown
- 1998-03-26 EA EA199900874A patent/EA001970B1/ru not_active IP Right Cessation
- 1998-03-26 EP EP98915165A patent/EP0971906A1/en not_active Withdrawn
- 1998-03-26 JP JP54596498A patent/JP2001520672A/ja active Pending
- 1998-03-26 IL IL13200498A patent/IL132004A0/xx unknown
- 1998-03-26 HU HU0001264A patent/HUP0001264A3/hu unknown
- 1998-03-26 BR BR9811255-4A patent/BR9811255A/pt not_active IP Right Cessation
- 1998-03-26 WO PCT/US1998/005903 patent/WO1998042687A1/en not_active Application Discontinuation
- 1998-03-26 AU AU69414/98A patent/AU741040B2/en not_active Ceased
- 1998-03-26 SK SK1315-99A patent/SK131599A3/sk unknown
- 1998-03-26 CA CA002283234A patent/CA2283234A1/en not_active Abandoned
- 1998-03-26 KR KR1019997008550A patent/KR20010005493A/ko not_active Application Discontinuation
- 1998-03-26 NZ NZ500388A patent/NZ500388A/en unknown
-
1999
- 1999-09-10 LT LT99-112A patent/LT4674B/lt not_active IP Right Cessation
- 1999-09-14 LV LVP-99-132A patent/LV12431B/en unknown
- 1999-09-16 NO NO994480A patent/NO994480D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA001970B1 (ru) | 2001-10-22 |
BR9811255A (pt) | 2000-07-18 |
LT99112A (en) | 2000-02-25 |
WO1998042687A1 (en) | 1998-10-01 |
KR20010005493A (ko) | 2001-01-15 |
IL132004A0 (en) | 2001-03-19 |
AU741040B2 (en) | 2001-11-22 |
CN1251095A (zh) | 2000-04-19 |
EP0971906A1 (en) | 2000-01-19 |
SI20027A (sl) | 2000-02-29 |
LV12431A (lv) | 2000-02-20 |
CA2283234A1 (en) | 1998-10-01 |
AU6941498A (en) | 1998-10-20 |
JP2001520672A (ja) | 2001-10-30 |
PL336008A1 (en) | 2000-06-05 |
NZ500388A (en) | 2001-06-29 |
SK131599A3 (en) | 2001-05-10 |
LT4674B (lt) | 2000-07-25 |
EA199900874A1 (ru) | 2000-04-24 |
US6022977A (en) | 2000-02-08 |
NO994480L (no) | 1999-09-16 |
HUP0001264A3 (en) | 2002-02-28 |
NO994480D0 (no) | 1999-09-16 |
EE9900434A (et) | 2000-04-17 |
LV12431B (en) | 2000-07-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS61181390A (ja) | 酵素によるグリセライドの製造法 | |
DE69213033D1 (de) | Enzymkatalysiertes Verfahren zur Herstellung von optisch aktiven Karbonsäuren | |
DE68925002D1 (de) | Verfahren zur Herstellung von optisch-aktiven alpha-substituierten organischen Säuren und Mikroorganismen und Enzyme, die dafür verwendet werden. | |
SG46729A1 (en) | Novel microorganisms their use and process for the production of l-amimo acids | |
DE69123595D1 (de) | Verfahren zur herstellung von polyolpolyestern | |
HUP0001264A2 (hu) | Izoxazolin-tioészterek lipázzal katalizált, dinamikus rezolválása izoxazolinkarbonsavakká | |
HUP0202526A2 (hu) | Zsírsav-deszaturáz gén növényekből | |
EP1035211A4 (en) | PROCESS FOR THE PREPARATION OF ARACHIDONIC ACID-CONTAINING LIPID AND DI-HOMO-GAMMA-LINOLIC ACID-CONTAINING LIPID. | |
DE69728481D1 (de) | Verfahren zur Herstellung von omega-9 hochungesättigten Fettsäuren und diese enthaltendes Lipid | |
DK0872540T3 (da) | Aromastof | |
JPH0860181A (ja) | 高度不飽和脂肪酸含有油脂 | |
JPH11263750A (ja) | 長鎖不飽和脂肪酸メントールエステルおよび酵素法によるその製造方法 | |
FI935712A (fi) | Menetelmä optisesti aktiivisten transglysidihappoestereiden entsyaattiseksi valmistamiseksi | |
JP2002088392A (ja) | 油脂類のエステル交換方法 | |
ATE150488T1 (de) | Verfahren zur herstellung von alkyglycoside estern. | |
JP2707642B2 (ja) | リゾリン脂質の製造法 | |
JPS6258992A (ja) | エステル合成法 | |
JPS6222597A (ja) | 糖グリセロ−ルおよび脂肪酸の製造法 | |
JPS6012992A (ja) | 光学活性カルボン酸の製造法 | |
ATE115536T1 (de) | Verfahren zur racematspaltung von 2,2- dimethylcyclopropancarbonsäure. | |
AU699638B2 (en) | Process for the preparation of optically active 2-halopropionic acids | |
DE69005317D1 (de) | Verfahren und Zwischenprodukte zur Herstellung von Isopropylestern von 3S-amino-2R-hydroxyalkansäuren. | |
JPH0264197A (ja) | 油脂の加水分解方法 | |
JPH0889263A (ja) | 酵素によるプロピレングリコールモノ脂肪酸エステルの製造方法 |