HUP0000090A2 - 1,4-Diszubsztituált piperazinok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk - Google Patents

1,4-Diszubsztituált piperazinok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk

Info

Publication number
HUP0000090A2
HUP0000090A2 HU0000090A HUP0000090A HUP0000090A2 HU P0000090 A2 HUP0000090 A2 HU P0000090A2 HU 0000090 A HU0000090 A HU 0000090A HU P0000090 A HUP0000090 A HU P0000090A HU P0000090 A2 HUP0000090 A2 HU P0000090A2
Authority
HU
Hungary
Prior art keywords
group
atom
pain
independently
diseases
Prior art date
Application number
HU0000090A
Other languages
English (en)
Inventor
Knud Erik Andersen
Rolf Hohlweg
Tine Krogh Jorgensen
Otylie Konigova
Peter Madsen
Zdenek Polivka
Alexandra Silhánková
Vladimir Valenta
Brett Watson
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP0000090A2 publication Critical patent/HUP0000090A2/hu
Publication of HUP0000090A3 publication Critical patent/HUP0000090A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/78—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

A találmány az (I) általános képletű 1,4-diszubsztituált piperazinokravonatkozik, ahol a képletben R1 és R2 jelentése egymástól függetlenül hidrogénatom, halogénatom,trifluor-metil-csoport, hidroxilcsoport, 1-6 szénatomos alkilcsoportvagy 1-6 szénatomos alkoxicsoport; és X jelentése orto-fenilén-csoport, oxigénatom, kénatom, -C(R6R7)-csoport, -CH2CH2-csoport, -CH=CH-CH2-csoport, -CH2-CH=CH-csoport, -CH2-(C=O)-csoport, -(C=O)-CH2-csoport, -CH2CH2CH2-csoport, -CH=CH-csoport, -N(R8)-(C=O)-csoport, -(C=O)-N(R8)-csoport, -O-CH2-csoport, -CH2-O-csoport, -OCH2O-csoport, -S-CH2-csoport, -CH2-S-csoport, -(CH2)N(R8)-csoport, -N(R8)(CH2)-csoport, -N(CH3)SO2-csoport, -SO2N(CH3)-csoport, CH(R10)CH2-csoport, -CH2CH(R10)-csoport, -(C=O)-csoport, -N(R9)-csoport vagy -(S=O)-csoport, ahol R6, R7, R8 és R9jelentése egymástól függetlenül hidrogénatom vagy 1-6 szénatomosalkilcsoport, és ahol R10 jelentése 1-6 szénatomos alkilcsoport vagyfenilcsoport; és Y jelentése N-CH2-csoport, CH-CH2-csoport, C=CH-csoport, CH-O-csoport,ahol csak az aláhúzott atom vesz részt a gyűrűrendszerben; és r jelentése 1, 2 vagy 3; és Z jelentése valamely (a), (b), (c) vagy (d) képletű csoport, ahol M1és M2 jelentése egymástól függetlenül szénatom vagy nitrogénatom. Atalálmány magában foglalja az (I) általános képletű vegyületekgyógyászatilag elfogadható sóit, eljárást a találmány szerintivegyületek előállítására és az azokat tartalmazó gyógyszerkészítményekelőállítására, továbbá azok felhasználását fájdalmak, különösen nagyfájdalmak és/vagy gyulladásos megbetegedések kezelésére, melymegbetegedésekben a C-szálak pathofiziológiás szerepet játszanak aneurogén fájdalmak és/vagy gyulladás kiváltásában. A találmány tárgyatovábbá a fentiek által okozott vagy azzal kapcsolatos indikációkkezelésére történő alkalmazás, mely megbetegedések azinzulinantagonista peptidek cirkulációjával és szekréciójával, példáula nem inzulinfüggő diabetes mellitussal (NIDDM) és az öregedésselösszefüggő obesitással kapcsolatosak. Ó
HU0000090A 1996-10-04 1997-10-02 1,4-disubstituted piperazines, pharmaceutical compositions containing them, process for producing them and their use HUP0000090A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK109096 1996-10-04
PCT/DK1997/000422 WO1998015548A1 (en) 1996-10-04 1997-10-02 1,4-disubstituted piperazines

Publications (2)

Publication Number Publication Date
HUP0000090A2 true HUP0000090A2 (hu) 2001-04-28
HUP0000090A3 HUP0000090A3 (en) 2002-01-28

Family

ID=8100883

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000090A HUP0000090A3 (en) 1996-10-04 1997-10-02 1,4-disubstituted piperazines, pharmaceutical compositions containing them, process for producing them and their use

Country Status (20)

Country Link
US (4) US5916889A (hu)
EP (1) EP0934312B1 (hu)
JP (1) JP2001502307A (hu)
KR (1) KR20000048899A (hu)
CN (1) CN1088459C (hu)
AT (1) ATE234831T1 (hu)
AU (1) AU740662B2 (hu)
BR (1) BR9712196A (hu)
CA (1) CA2267835A1 (hu)
CZ (1) CZ114099A3 (hu)
DE (1) DE69720021T2 (hu)
DK (1) DK0934312T3 (hu)
ES (1) ES2194217T3 (hu)
HU (1) HUP0000090A3 (hu)
IL (1) IL129123A (hu)
NO (1) NO991565L (hu)
PL (1) PL188338B1 (hu)
RU (1) RU2188197C2 (hu)
WO (1) WO1998015548A1 (hu)
ZA (1) ZA978864B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001501629A (ja) * 1996-10-04 2001-02-06 ノボ ノルディスク アクティーゼルスカブ Ｎ―置換アザ複素環式化合物
US6613905B1 (en) * 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7045519B2 (en) * 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
JP4533534B2 (ja) 1998-06-19 2010-09-01 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド グリコーゲンシンターゼキナーゼ３のインヒビター
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US20040038861A1 (en) * 2001-11-26 2004-02-26 Cooper Garth J. S. Methods and compositions for normalizing lipid levels in mammalian tissues
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
AU2005286593A1 (en) * 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyridine compounds, process for their preparation and compositions containing them
FR2885616B1 (fr) * 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2885615B1 (fr) * 2005-05-12 2007-06-22 Servier Lab Nouveaux derives de phenylpyridinylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2009514969A (ja) 2005-11-09 2009-04-09 コンビナトアールエックス インコーポレーティッド 医学的状態を治療するための方法、組成物、およびキット
EP2420239B1 (en) * 2007-04-13 2015-01-14 Southern Research Institute Clomipramine as anti-angiogenic agent
CN103086898B (zh) * 2012-07-11 2015-04-08 山东道可化学有限公司 二苯胺或其环上取代的衍生物的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL102488C (hu) * 1957-07-18
GB1013901A (en) * 1962-01-26 1965-12-22 Kefalas As Dihydroanthracene, dibenzocycloheptadiene and dibenzocycloheptatriene derivatives
FR88751E (hu) * 1963-07-09 1967-06-07
US3435073A (en) * 1966-04-19 1969-03-25 Colgate Palmolive Co 5-(n-benzyl-n-lower alkylaminoalkylene)-5h-dibenzo(a,d)cycloheptenes
GB1347935A (en) * 1971-04-10 1974-02-27 Yoshitomi Pharmaceutical Piperazine derivatives methods for their production and phar maceutical compositions containing them
FR2186249A1 (en) * 1972-05-31 1974-01-11 Synthelabo Phenyl piperazinoalkyl (dihydro)dibenzazepines - antidepressants having low toxicity
HU174126B (hu) * 1977-08-02 1979-11-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija novykh proizvodnykh dibenzo-kvadratnaja skobka-d,g-kvadratnaja skobka zakryta-kvadratnaja skobka-1,3,6-kvadratnaja skobka zakryta-dioksazocina
ES524680A0 (es) * 1983-08-02 1984-12-16 Espanola Farma Therapeut Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina.
AU612437B2 (en) * 1987-12-14 1991-07-11 Kyowa Hakko Kogyo Co. Ltd. Tricyclic compounds
ZA914764B (en) * 1990-06-22 1992-03-25 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene,piperidylidene and piperazine compounds,compositions and methods of use
MY113463A (en) * 1994-01-04 2002-03-30 Novo Nordisk As Novel heterocyclic compounds
UA54385C2 (uk) * 1995-04-07 2003-03-17 Ново Нордіск А/С N-заміщені азагетероциклічні карбонові кислоти та їх ефіри, спосіб їх одержання, фармацевтична композиція та спосіб лікування
EP0851865B1 (en) * 1995-09-19 2002-07-17 Novo Nordisk A/S 12H-Dibenzo[d,g][1,3]dioxocine derivatives

Also Published As

Publication number Publication date
DE69720021D1 (de) 2003-04-24
US5916889A (en) 1999-06-29
DK0934312T3 (da) 2003-07-21
KR20000048899A (ko) 2000-07-25
HUP0000090A3 (en) 2002-01-28
ATE234831T1 (de) 2003-04-15
PL332597A1 (en) 1999-09-27
IL129123A0 (en) 2000-02-17
AU740662B2 (en) 2001-11-08
CN1088459C (zh) 2002-07-31
RU2188197C2 (ru) 2002-08-27
BR9712196A (pt) 1999-08-31
IL129123A (en) 2004-07-25
EP0934312A1 (en) 1999-08-11
US6040302A (en) 2000-03-21
US6004961A (en) 1999-12-21
WO1998015548A1 (en) 1998-04-16
ZA978864B (en) 1998-04-06
CA2267835A1 (en) 1998-04-16
NO991565D0 (no) 1999-03-30
US6133268A (en) 2000-10-17
AU4377297A (en) 1998-05-05
NO991565L (no) 1999-06-04
JP2001502307A (ja) 2001-02-20
PL188338B1 (pl) 2005-01-31
CZ114099A3 (cs) 1999-09-15
CN1234799A (zh) 1999-11-10
EP0934312B1 (en) 2003-03-19
ES2194217T3 (es) 2003-11-16
DE69720021T2 (de) 2004-02-05

Similar Documents

Publication Publication Date Title
CA1137978A (en) 1-phenyl-2-aminoethanol derivatives
HUP0000090A2 (hu) 1,4-Diszubsztituált piperazinok, e vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és alkalmazásuk
US4177290A (en) Acetamide derivatives
EP0393457B1 (en) Proteinase inhibitor
FI73984C (fi) Nya morfolinofoereningar.
HUP0204147A2 (hu) [(RR,SS)-3-(2-dimetilaminoetil-1-hidroxiciklohexil)fenil]-2-hidroxibenzoátból származtatott új észterek, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
SE9702799D0 (sv) New compounds
HUP0100702A2 (hu) Gyulladásgátló oxadiazolil-adenozin származékok, eljárás előállításukra és köztitermékeik
HU9401323D0 (en) New aminoacid derivates, process for producing the same and pharmaceutical compositions containing these compounds
HUP0400992A2 (hu) Karbonsavval helyettesített oxazol-származékok, eljárás előállításukra és PPAR-alfa- és -gamma-aktivátorként való alkalmazásuk diabétesz kezelésére felhasználható gyógyszerek készítésére
MXPA05007496A (es) Tienopirimidindionas y su uso en la modulacion de enfermedades autoinmunes.
HUP0203700A2 (hu) N-szubsztituált cianopirrolidinek és cukorbetegség-ellenes szerként való alkalmazásuk és az ezeket tartalmazó gyógyászati készítmények
KR940005553A (ko) N- 벤조일아미노산 유도체, 이를 함유하는 약제학적 조성물 및 이의 제조방법
ATE19878T1 (de) Benzimidazol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
JPH01160992A (ja) 新規化合物、その製法及びそれを含む医薬組成物
PH23607A (en) Amide derivatives and pharmaceutical composition containing said compounds
HUP0500201A2 (hu) Policiklusos vegyületek, mint potenciális alfa2-adrenoceptor antagonisták és ezeket tartalmazó gyógyszerkészítmények
HUP0401235A2 (hu) 5-HT6 receptor affinitással rendelkező arilszulfonil-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
KR950029242A (ko) 2환-방향족 화합물, 이를 함유하는 제약 및 화장품 조성물 및 이의 용도
MY111702A (en) 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
HUP0203471A2 (hu) Trombózisellenes hatású vegyületek, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0003577A2 (hu) Tetrahidro-gamma-karbolinok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
ATE142213T1 (de) Cephalosporinverbindungen und verfahren zu ihrer herstellung
IL112432A0 (en) Fatty acid derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
CA2364900A1 (en) Polycyclic 2-amino-thiazole systems, method for the production thereof and medicament containing said compounds

Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees