HUE065578T2 - Kinazolin-származékok, mint daganatellenes szerek - Google Patents

Kinazolin-származékok, mint daganatellenes szerek

Info

Publication number
HUE065578T2
HUE065578T2 HUE19862146A HUE19862146A HUE065578T2 HU E065578 T2 HUE065578 T2 HU E065578T2 HU E19862146 A HUE19862146 A HU E19862146A HU E19862146 A HUE19862146 A HU E19862146A HU E065578 T2 HUE065578 T2 HU E065578T2
Authority
HU
Hungary
Prior art keywords
antitumor agents
quinazoline derivatives
quinazoline
derivatives
antitumor
Prior art date
Application number
HUE19862146A
Other languages
English (en)
Hungarian (hu)
Inventor
Ding Zhou
Ziqiang Cheng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HUE065578T2 publication Critical patent/HUE065578T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HUE19862146A 2018-09-18 2019-09-17 Kinazolin-származékok, mint daganatellenes szerek HUE065578T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2018106098 2018-09-18
CN2019091078 2019-06-13

Publications (1)

Publication Number Publication Date
HUE065578T2 true HUE065578T2 (hu) 2024-06-28

Family

ID=69888359

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE19862146A HUE065578T2 (hu) 2018-09-18 2019-09-17 Kinazolin-származékok, mint daganatellenes szerek
HUE23219357A HUE069764T2 (hu) 2018-09-18 2019-09-17 Kinazolin-származékok, mint daganatellenes szerek

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE23219357A HUE069764T2 (hu) 2018-09-18 2019-09-17 Kinazolin-származékok, mint daganatellenes szerek

Country Status (19)

Country Link
US (2) US11723908B2 (OSRAM)
EP (3) EP4360713B1 (OSRAM)
JP (3) JP7546550B2 (OSRAM)
KR (2) KR102889933B1 (OSRAM)
CN (2) CN112654612A (OSRAM)
AU (2) AU2019341273B2 (OSRAM)
CA (1) CA3099776A1 (OSRAM)
DK (2) DK4360713T3 (OSRAM)
ES (2) ES2971927T3 (OSRAM)
FI (2) FI3853220T3 (OSRAM)
HR (2) HRP20240293T1 (OSRAM)
HU (2) HUE065578T2 (OSRAM)
LT (2) LT4360713T (OSRAM)
PL (2) PL4360713T3 (OSRAM)
PT (2) PT4360713T (OSRAM)
RS (2) RS66314B1 (OSRAM)
SI (2) SI3853220T1 (OSRAM)
SM (1) SMT202400524T1 (OSRAM)
WO (1) WO2020057511A1 (OSRAM)

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WO2019196622A1 (zh) * 2018-04-09 2019-10-17 威尚(上海)生物医药有限公司 具有穿过血脑屏障能力的5取代二氟哌啶化合物
CN110357858B (zh) 2018-04-09 2022-02-18 威尚(上海)生物医药有限公司 具有穿过血脑屏障能力的5取代二氟哌啶化合物
HUE065578T2 (hu) * 2018-09-18 2024-06-28 Hoffmann La Roche Kinazolin-származékok, mint daganatellenes szerek
CN111377850B (zh) * 2018-12-31 2022-10-18 艾琪康医药科技(上海)有限公司 一种手性n-取代-3,3-二氟-4-羟基哌啶衍生物及其制备方法
TWI820414B (zh) * 2020-04-17 2023-11-01 大陸商北京賽特明強醫藥科技有限公司 喹唑啉類化合物、製備方法及其應用
CN113527215B (zh) * 2020-04-17 2023-12-05 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、制备方法及其应用
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CN117858872A (zh) * 2021-06-22 2024-04-09 缆图药品公司 用于治疗癌症的杂环egfr抑制剂
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CN115894383B (zh) * 2021-09-30 2025-12-19 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、组合物及其应用
CN115894455B (zh) * 2021-09-30 2024-04-19 北京赛特明强医药科技有限公司 一种喹唑啉类化合物、组合物及其应用
MA66471B1 (fr) * 2021-10-20 2026-02-27 F. Hoffmann-La Roche Ag Formes cristallines de dérivés de quinazoline, leur préparation, leur composition et leur utilisation
WO2023138675A1 (zh) * 2022-01-21 2023-07-27 默达药物(香港)有限公司 喹啉化合物及其用途
US20230293539A1 (en) * 2022-03-14 2023-09-21 Huyabio International, Llc Mll1-wdr5 protein-protein interaction inhibitor compounds and uses thereof
JP2025509995A (ja) * 2022-03-28 2025-04-11 江蘇恒瑞医薬股▲ふん▼有限公司 含窒素複素環系化合物、その調製方法及びその医薬的使用
CN115650977A (zh) * 2022-10-09 2023-01-31 广东润兴生物科技有限公司 一种妥卡替尼的合成方法
TW202446386A (zh) * 2023-04-14 2024-12-01 大陸商迪哲(江蘇)醫藥股份有限公司 喹唑啉ErbB抑制劑的藥物形式
WO2024249642A1 (en) * 2023-06-02 2024-12-05 Acerand Therapeutics (Hong Kong) Limited Egfr inhibitors
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Also Published As

Publication number Publication date
SI4360713T1 (sl) 2025-02-28
HRP20240293T1 (hr) 2024-05-24
FI4360713T3 (fi) 2024-12-27
EP4360713A2 (en) 2024-05-01
RS65413B1 (sr) 2024-05-31
EP4523755A3 (en) 2025-06-11
PL3853220T3 (pl) 2024-09-02
JP2026009898A (ja) 2026-01-21
PL4360713T3 (pl) 2025-06-23
LT4360713T (lt) 2025-01-10
US11723908B2 (en) 2023-08-15
KR20210061329A (ko) 2021-05-27
EP3853220A1 (en) 2021-07-28
DK3853220T3 (da) 2024-03-04
JP7546550B2 (ja) 2024-09-06
JP2024164018A (ja) 2024-11-26
SMT202400524T1 (it) 2025-01-14
CN118255772A (zh) 2024-06-28
US20230293533A1 (en) 2023-09-21
CA3099776A1 (en) 2020-03-26
RS66314B1 (sr) 2025-01-31
AU2019341273A1 (en) 2020-11-19
AU2024204847A1 (en) 2024-08-01
KR20250171398A (ko) 2025-12-08
WO2020057511A1 (en) 2020-03-26
HUE069764T2 (hu) 2025-04-28
ES2971927T3 (es) 2024-06-10
CN112654612A (zh) 2021-04-13
EP4360713B1 (en) 2024-10-30
ES3007082T3 (en) 2025-03-19
SI3853220T1 (sl) 2024-04-30
EP4523755A2 (en) 2025-03-19
FI3853220T3 (fi) 2024-02-22
EP4360713A3 (en) 2024-05-22
DK4360713T3 (da) 2025-01-06
US20210386742A1 (en) 2021-12-16
HRP20241743T1 (hr) 2025-02-28
AU2019341273B2 (en) 2024-09-26
EP3853220B1 (en) 2024-01-03
JP2022501338A (ja) 2022-01-06
KR102889933B1 (ko) 2025-11-24
PT4360713T (pt) 2025-01-07
EP3853220A4 (en) 2022-06-22
PT3853220T (pt) 2024-02-22
LT3853220T (lt) 2024-03-12

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