HUE049856T2 - Kinolin-származékok mint TAM RTK inhibitorok - Google Patents
Kinolin-származékok mint TAM RTK inhibitorokInfo
- Publication number
- HUE049856T2 HUE049856T2 HUE16716247A HUE16716247A HUE049856T2 HU E049856 T2 HUE049856 T2 HU E049856T2 HU E16716247 A HUE16716247 A HU E16716247A HU E16716247 A HUE16716247 A HU E16716247A HU E049856 T2 HUE049856 T2 HU E049856T2
- Authority
- HU
- Hungary
- Prior art keywords
- quinoline derivatives
- rtk inhibitors
- tam rtk
- tam
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562147262P | 2015-04-14 | 2015-04-14 | |
US201562147925P | 2015-04-15 | 2015-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE049856T2 true HUE049856T2 (hu) | 2020-10-28 |
Family
ID=55752298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE16716247A HUE049856T2 (hu) | 2015-04-14 | 2016-04-14 | Kinolin-származékok mint TAM RTK inhibitorok |
Country Status (20)
Country | Link |
---|---|
US (1) | US10934274B2 (hu) |
EP (1) | EP3286177B1 (hu) |
JP (2) | JP6654646B2 (hu) |
KR (1) | KR102499359B1 (hu) |
CN (1) | CN107667101B (hu) |
AU (1) | AU2016249860B2 (hu) |
BR (1) | BR112017021929B1 (hu) |
CA (1) | CA2980652C (hu) |
DK (1) | DK3286177T3 (hu) |
ES (1) | ES2807851T3 (hu) |
HK (1) | HK1243707A1 (hu) |
HU (1) | HUE049856T2 (hu) |
IL (1) | IL254898B (hu) |
MX (1) | MX2017013144A (hu) |
MY (1) | MY196078A (hu) |
PH (1) | PH12017501822A1 (hu) |
RU (1) | RU2750727C9 (hu) |
SG (1) | SG11201707638UA (hu) |
WO (1) | WO2016166250A1 (hu) |
ZA (1) | ZA201706380B (hu) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10882841B2 (en) | 2016-03-01 | 2021-01-05 | University Of Maryland, Baltimore | Wnt signaling pathway inhibitors for treatments of disease |
CN110612295B (zh) * | 2017-05-11 | 2023-07-14 | 组合化学工业株式会社 | 吡唑-3-羧酸酰胺衍生物及有害生物防治剂 |
CN109896997A (zh) * | 2017-12-08 | 2019-06-18 | 中国药科大学 | N-酰基苯胺类c-Met激酶抑制剂的制备方法及其用途 |
BR112020012635A2 (pt) | 2017-12-22 | 2020-12-01 | Ravenna Pharmaceuticals, Inc. | derivados de aminopiridina como inibidores de fosfatidilinositol fosfato quinase |
WO2019184918A1 (zh) * | 2018-03-27 | 2019-10-03 | 暨南大学 | 3-氨基吡唑类化合物及其应用 |
AU2019276359A1 (en) * | 2018-05-30 | 2020-10-29 | Qurient Co., Ltd. | Quinoline derivatives as inhibitors of Axl/Mer RTK and CSF1R |
WO2020038460A1 (zh) * | 2018-08-24 | 2020-02-27 | 南京药捷安康生物科技有限公司 | 一种新型的喹啉衍生物抑制剂 |
CN111053771A (zh) * | 2018-10-16 | 2020-04-24 | 正大天晴药业集团股份有限公司 | 用于治疗食道鳞状细胞癌的喹啉类化合物或其药学上可接受的盐 |
CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
WO2023283369A1 (en) * | 2021-07-08 | 2023-01-12 | Vibliome Therapeutics, Llc | Modulators of protein kinases |
TW202333709A (zh) | 2021-12-16 | 2023-09-01 | 美商奇奈特生物製藥公司 | Met激酶抑制劑 |
WO2023183444A1 (en) * | 2022-03-24 | 2023-09-28 | Vibliome Therapeutics, Llc | Modulators of protein kinases |
TW202409014A (zh) * | 2022-08-30 | 2024-03-01 | 大陸商藥捷安康(南京)科技股份有限公司 | 喹啉衍生物抑制劑的晶型及其製備方法及用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
WO2008035209A2 (en) * | 2006-05-30 | 2008-03-27 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
EP2423208A1 (en) * | 2010-08-28 | 2012-02-29 | Lead Discovery Center GmbH | Pharmaceutically active compounds as Axl inhibitors |
EP2680886B1 (en) | 2011-02-28 | 2016-08-10 | Calitor Sciences, LLC | Substituted quinoline compounds |
TWI562989B (en) | 2011-11-14 | 2016-12-21 | Ignyta Inc | Uracil derivatives as axl and c-met kinase inhibitors |
-
2016
- 2016-04-14 SG SG11201707638UA patent/SG11201707638UA/en unknown
- 2016-04-14 RU RU2017139515A patent/RU2750727C9/ru active
- 2016-04-14 HU HUE16716247A patent/HUE049856T2/hu unknown
- 2016-04-14 CA CA2980652A patent/CA2980652C/en active Active
- 2016-04-14 CN CN201680022317.2A patent/CN107667101B/zh active Active
- 2016-04-14 ES ES16716247T patent/ES2807851T3/es active Active
- 2016-04-14 JP JP2017553406A patent/JP6654646B2/ja active Active
- 2016-04-14 EP EP16716247.8A patent/EP3286177B1/en active Active
- 2016-04-14 KR KR1020177032859A patent/KR102499359B1/ko active IP Right Grant
- 2016-04-14 MY MYPI2017703610A patent/MY196078A/en unknown
- 2016-04-14 BR BR112017021929-8A patent/BR112017021929B1/pt active IP Right Grant
- 2016-04-14 MX MX2017013144A patent/MX2017013144A/es unknown
- 2016-04-14 US US15/563,123 patent/US10934274B2/en active Active
- 2016-04-14 AU AU2016249860A patent/AU2016249860B2/en active Active
- 2016-04-14 DK DK16716247.8T patent/DK3286177T3/da active
- 2016-04-14 WO PCT/EP2016/058284 patent/WO2016166250A1/en active Application Filing
-
2017
- 2017-09-21 ZA ZA2017/06380A patent/ZA201706380B/en unknown
- 2017-10-03 IL IL254898A patent/IL254898B/en active IP Right Grant
- 2017-10-04 PH PH12017501822A patent/PH12017501822A1/en unknown
-
2018
- 2018-03-08 HK HK18103281.2A patent/HK1243707A1/zh unknown
-
2019
- 2019-10-25 JP JP2019194258A patent/JP2020012001A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20170135971A (ko) | 2017-12-08 |
JP6654646B2 (ja) | 2020-02-26 |
ES2807851T3 (es) | 2021-02-24 |
EP3286177A1 (en) | 2018-02-28 |
RU2017139515A (ru) | 2019-05-14 |
CA2980652A1 (en) | 2016-10-20 |
AU2016249860A1 (en) | 2017-10-12 |
MY196078A (en) | 2023-03-13 |
US20180093968A1 (en) | 2018-04-05 |
IL254898A0 (en) | 2017-12-31 |
BR112017021929A2 (pt) | 2018-07-03 |
EP3286177B1 (en) | 2020-05-06 |
AU2016249860B2 (en) | 2019-10-10 |
CN107667101A (zh) | 2018-02-06 |
KR102499359B1 (ko) | 2023-02-10 |
RU2750727C2 (ru) | 2021-07-01 |
HK1243707A1 (zh) | 2018-07-20 |
PH12017501822A1 (en) | 2018-04-23 |
SG11201707638UA (en) | 2017-10-30 |
JP2018511624A (ja) | 2018-04-26 |
RU2017139515A3 (hu) | 2019-07-17 |
JP2020012001A (ja) | 2020-01-23 |
ZA201706380B (en) | 2022-03-30 |
US10934274B2 (en) | 2021-03-02 |
CN107667101B (zh) | 2021-07-30 |
RU2750727C9 (ru) | 2021-08-16 |
IL254898B (en) | 2020-11-30 |
CA2980652C (en) | 2021-04-27 |
DK3286177T3 (da) | 2020-06-08 |
BR112017021929B1 (pt) | 2023-05-09 |
WO2016166250A1 (en) | 2016-10-20 |
MX2017013144A (es) | 2018-07-06 |
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