HUE048356T2 - Diftéria-toxin-interleukin-3 konjugátumokon alapuló eljárások és készítmények - Google Patents
Diftéria-toxin-interleukin-3 konjugátumokon alapuló eljárások és készítményekInfo
- Publication number
- HUE048356T2 HUE048356T2 HUE17151480A HUE17151480A HUE048356T2 HU E048356 T2 HUE048356 T2 HU E048356T2 HU E17151480 A HUE17151480 A HU E17151480A HU E17151480 A HUE17151480 A HU E17151480A HU E048356 T2 HUE048356 T2 HU E048356T2
- Authority
- HU
- Hungary
- Prior art keywords
- conjugates
- interleukin
- methods
- diphtheria toxin
- compositions based
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/202—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84347106P | 2006-09-07 | 2006-09-07 | |
| US93277207P | 2007-06-01 | 2007-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE048356T2 true HUE048356T2 (hu) | 2020-07-28 |
Family
ID=39157851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE17151480A HUE048356T2 (hu) | 2006-09-07 | 2007-09-07 | Diftéria-toxin-interleukin-3 konjugátumokon alapuló eljárások és készítmények |
| HUS2100013C HUS2100013I1 (hu) | 2006-09-07 | 2021-04-22 | Diftéria-toxin-interleukin-3 konjugátumokon alapuló eljárások és készítmények |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUS2100013C HUS2100013I1 (hu) | 2006-09-07 | 2021-04-22 | Diftéria-toxin-interleukin-3 konjugátumokon alapuló eljárások és készítmények |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US7763242B2 (hu) |
| EP (3) | EP3520806B1 (hu) |
| JP (6) | JP5550905B2 (hu) |
| AU (1) | AU2007293047B2 (hu) |
| CA (5) | CA3153438C (hu) |
| CY (2) | CY1119654T1 (hu) |
| DK (2) | DK2063907T3 (hu) |
| ES (2) | ES2781402T7 (hu) |
| FR (1) | FR21C1017I2 (hu) |
| HU (2) | HUE048356T2 (hu) |
| LT (2) | LT3207941T (hu) |
| LU (1) | LUC00206I2 (hu) |
| NL (1) | NL301103I2 (hu) |
| PL (2) | PL2063907T3 (hu) |
| PT (1) | PT3207941T (hu) |
| SI (1) | SI3207941T1 (hu) |
| WO (1) | WO2008030539A2 (hu) |
Families Citing this family (33)
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| EP1692113B1 (en) | 2003-11-14 | 2017-09-27 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| EP3520806B1 (en) | 2006-09-07 | 2024-03-20 | Scott & White Memorial Hospital | Methods and compositions based on diphtheria toxin-interleukin-3 conjugates |
| WO2010027802A2 (en) | 2008-08-25 | 2010-03-11 | New York University | Methods for treating diabetic wounds |
| US20110171219A1 (en) * | 2008-09-19 | 2011-07-14 | Fahar Merchant | Treating cancer stem cells using targeted cargo proteins |
| CA2789810C (en) * | 2010-02-17 | 2020-12-01 | Csl Limited | Compositions and methods for targeting type 1 interferon-producing cells |
| CA2805412C (en) | 2010-06-17 | 2021-04-27 | New York University | Therapeutic and cosmetic uses and applications of calreticulin |
| WO2012019061A2 (en) | 2010-08-05 | 2012-02-09 | Stem Centrx, Inc. | Novel effectors and methods of use |
| SG187965A1 (en) | 2010-08-27 | 2013-04-30 | Stem Centrx Inc | Notum protein modulators and methods of use |
| CA2810016A1 (en) | 2010-09-03 | 2012-03-08 | Stem Centrx, Inc. | Novel modulators and methods of use |
| RU2016123839A (ru) | 2010-12-08 | 2018-11-30 | АббВай Стемсентркс ЭлЭлСи | Новые модуляторы и способы их применения |
| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| CA2840989A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Immunogenic combination compositions and uses thereof |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| PE20190658A1 (es) | 2012-02-24 | 2019-05-08 | Abbvie Stemcentrx Llc | Moduladores y metodos de empleo novedosos |
| JP6401060B2 (ja) | 2012-02-24 | 2018-10-03 | アッヴィ・ステムセントルクス・エル・エル・シー | 抗ｓｅｚ６抗体及び使用方法 |
| JP6462591B2 (ja) | 2013-02-22 | 2019-01-30 | アッヴィ・ステムセントルクス・エル・エル・シー | 新規抗体コンジュゲートおよびその使用 |
| JP2016538318A (ja) | 2013-08-28 | 2016-12-08 | ステムセントリックス， インコーポレイテッド | 新規ｓｅｚ６モジュレーターおよび使用方法 |
| BR112016004242A8 (pt) | 2013-08-28 | 2018-06-12 | Stemcentrx Inc | Métodos para conjugação sítio-específica de anticorpos e composições |
| US20150104392A1 (en) | 2013-10-04 | 2015-04-16 | Aptose Biosciences Inc. | Compositions, biomarkers and their use in the treatment of cancer |
| KR20160070191A (ko) | 2013-11-06 | 2016-06-17 | 스템센트알엑스 인코포레이티드 | 신규한 항-클라우딘 항체 및 사용 방법 |
| BR112016013048A2 (pt) | 2013-12-12 | 2017-09-26 | Stemcentrx Inc | anticorpos anti-dpep3 e métodos de uso |
| US10308721B2 (en) | 2014-02-21 | 2019-06-04 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
| AU2015253422B2 (en) | 2014-04-30 | 2020-09-03 | Abbvie Stemcentrx Llc | Anti-PTK7 antibody-drug conjugates |
| TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗ｍｆｉ２抗體及使用方法 |
| US10934359B2 (en) | 2016-04-21 | 2021-03-02 | Abbvie Stemcentrx Llc | Anti-BMPR1B antibodies and methods of use |
| CN107793481A (zh) * | 2016-08-31 | 2018-03-13 | 南京传奇生物科技有限公司 | 一种靶向人cd123的嵌合受体配体及其应用 |
| WO2019089511A1 (en) | 2017-10-30 | 2019-05-09 | Aptose Biosciences Inc. | Aryl imidazoles for the treatment of cancer |
| WO2019210179A1 (en) | 2018-04-27 | 2019-10-31 | Stemline Therapeutics, Inc. | Methods of treating an autoimmune disease with a human interleukin-3 (il-3)-diphtheria toxin conjugate (dt-il3) |
| US20210148923A1 (en) * | 2018-05-30 | 2021-05-20 | The Governing Council Of The University Of Toronto | Methods and kits for identifying a protein associated with receptor-ligand interactions |
| EP3873476A1 (en) | 2018-10-31 | 2021-09-08 | Stemline Therapeutics, Inc. | Combination therapy method of treating myeloproliferative neoplasms with a diphtheria toxin-human interleukin-3 conjugate in combination with other agents |
| WO2020112642A1 (en) | 2018-11-30 | 2020-06-04 | Stemline Therapeutics, Inc. | Improved methods of treating myeloproliferative neoplasms with a diphtheria toxin-human interleukin-3 conjugate |
| WO2021099573A1 (en) * | 2019-11-21 | 2021-05-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for diagnosing and treating chronic myelomonocytic leukemia (cmml) |
| EP4259103A1 (en) | 2020-12-10 | 2023-10-18 | Stemline Therapeutics Inc. | Improved lyophilized formulation |
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| IT1203672B (it) | 1982-05-12 | 1989-02-15 | Harvard College | Proteina ibrida comprendente frammenti proteici collegati da legami peptidici e relativo gene di fusione composizione contenente tale proteina |
| US5080898A (en) | 1982-05-12 | 1992-01-14 | The University Hospital | Enzymatically active toxin coupled to a cell-specific ligand |
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| CA2071867A1 (en) | 1989-11-06 | 1991-05-07 | Edith Mathiowitz | Method for producing protein microspheres |
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| DE4140121C2 (de) | 1991-12-05 | 1994-06-30 | Manfred Mueller | Verfahren zum Herstellen von gefaßten, gegossenen Schmuckstücken |
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| US7361336B1 (en) | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
| US6004528A (en) | 1997-09-18 | 1999-12-21 | Bergstein; Ivan | Methods of cancer diagnosis and therapy targeted against the cancer stemline |
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| SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
| US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| WO2001040308A1 (en) | 1999-12-03 | 2001-06-07 | The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland | Dendritic cell-specific antibodies |
| AU5003001A (en) | 2000-03-06 | 2001-09-17 | Univ Kentucky Res Found | Methods to impair hematologic cancer progenitor cells and compounds related thereto |
| CA2439852A1 (en) | 2001-03-02 | 2002-09-12 | Christine Dingivan | Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists |
| US20030068320A1 (en) | 2001-03-02 | 2003-04-10 | Christine Dingivan | Methods of administering/dosing CD2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders |
| JP4764818B2 (ja) | 2003-04-11 | 2011-09-07 | メディミューン，エルエルシー | 組換えｉｌ−９抗体およびその使用 |
| EP3520806B1 (en) | 2006-09-07 | 2024-03-20 | Scott & White Memorial Hospital | Methods and compositions based on diphtheria toxin-interleukin-3 conjugates |
| AU2014201901B2 (en) | 2006-09-07 | 2016-05-05 | Scott & White Healthcare | Methods and compositions based on diphtheria toxin-interleukin-3 conjugates |
| US8163279B2 (en) | 2007-04-13 | 2012-04-24 | Stemline Therapeutics, Inc. | IL3Rα antibody conjugates and uses thereof |
| WO2013130917A1 (en) | 2012-02-29 | 2013-09-06 | Ambrx, Inc. | Interleukin-3 polypeptide conjugates their uses |
-
2007
- 2007-09-07 EP EP19159793.9A patent/EP3520806B1/en active Active
- 2007-09-07 EP EP07837840.3A patent/EP2063907B1/en active Active
- 2007-09-07 CA CA3153438A patent/CA3153438C/en active Active
- 2007-09-07 EP EP17151480.5A patent/EP3207941B3/en active Active
- 2007-09-07 CA CA3053981A patent/CA3053981C/en active Active
- 2007-09-07 DK DK07837840.3T patent/DK2063907T3/da active
- 2007-09-07 SI SI200732148T patent/SI3207941T1/sl unknown
- 2007-09-07 CA CA2923381A patent/CA2923381A1/en not_active Abandoned
- 2007-09-07 LT LTEP17151480.5T patent/LT3207941T/lt unknown
- 2007-09-07 HU HUE17151480A patent/HUE048356T2/hu unknown
- 2007-09-07 DK DK17151480.5T patent/DK3207941T6/da active
- 2007-09-07 US US11/899,747 patent/US7763242B2/en active Active
- 2007-09-07 PT PT171514805T patent/PT3207941T/pt unknown
- 2007-09-07 AU AU2007293047A patent/AU2007293047B2/en active Active
- 2007-09-07 CA CA2698595A patent/CA2698595C/en active Active
- 2007-09-07 ES ES17151480T patent/ES2781402T7/es active Active
- 2007-09-07 CA CA3007075A patent/CA3007075C/en active Active
- 2007-09-07 WO PCT/US2007/019481 patent/WO2008030539A2/en active Application Filing
- 2007-09-07 ES ES07837840.3T patent/ES2646545T3/es active Active
- 2007-09-07 JP JP2009527415A patent/JP5550905B2/ja active Active
- 2007-09-07 PL PL07837840T patent/PL2063907T3/pl unknown
- 2007-09-07 PL PL17151480T patent/PL3207941T6/pl unknown
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2009
- 2009-02-09 US US12/368,048 patent/US8470307B2/en active Active
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2013
- 2013-05-17 US US13/896,923 patent/US9181317B2/en active Active
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2014
- 2014-04-01 JP JP2014075847A patent/JP5902223B2/ja active Active
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2015
- 2015-07-17 US US14/802,398 patent/US9631006B2/en active Active
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2016
- 2016-03-09 JP JP2016045210A patent/JP6336500B2/ja active Active
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2017
- 2017-03-10 US US15/455,420 patent/US10259853B2/en active Active
- 2017-11-03 CY CY20171101153T patent/CY1119654T1/el unknown
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2018
- 2018-05-02 JP JP2018088719A patent/JP6654660B2/ja active Active
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2019
- 2019-02-08 US US16/271,456 patent/US11130792B2/en active Active
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2020
- 2020-01-30 JP JP2020013230A patent/JP2020079260A/ja active Pending
- 2020-03-23 CY CY20201100271T patent/CY1123035T1/el unknown
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2021
- 2021-04-22 HU HUS2100013C patent/HUS2100013I1/hu unknown
- 2021-05-11 FR FR21C1017C patent/FR21C1017I2/fr active Active
- 2021-05-12 LT LTPA2021507C patent/LTC3207941I2/lt unknown
- 2021-05-12 NL NL301103C patent/NL301103I2/nl unknown
- 2021-05-12 LU LU00206C patent/LUC00206I2/en unknown
- 2021-08-25 US US17/411,947 patent/US20220235108A1/en active Pending
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2022
- 2022-02-15 JP JP2022020917A patent/JP2022065089A/ja active Pending
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