HUE045359T2 - Kollaterális gén inaktiváló biomarkerek és célsejtek a rákterápiában - Google Patents

Kollaterális gén inaktiváló biomarkerek és célsejtek a rákterápiában

Info

Publication number
HUE045359T2
HUE045359T2 HUE12858619A HUE12858619A HUE045359T2 HU E045359 T2 HUE045359 T2 HU E045359T2 HU E12858619 A HUE12858619 A HU E12858619A HU E12858619 A HUE12858619 A HU E12858619A HU E045359 T2 HUE045359 T2 HU E045359T2
Authority
HU
Hungary
Prior art keywords
biomarkers
targets
cancer therapy
gene inactivation
collateral
Prior art date
Application number
HUE12858619A
Other languages
English (en)
Inventor
Florian Muller
Eliot Fletcher-Sananikone
Simona Colla
Elisa Aquilanti
Ronald Depinho
Original Assignee
Univ Texas
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Dana Farber Cancer Inst Inc filed Critical Univ Texas
Publication of HUE045359T2 publication Critical patent/HUE045359T2/hu

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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/53—Physical structure partially self-complementary or closed
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
HUE12858619A 2011-12-14 2012-12-14 Kollaterális gén inaktiváló biomarkerek és célsejtek a rákterápiában HUE045359T2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161570366P 2011-12-14 2011-12-14
US201261652738P 2012-05-29 2012-05-29

Publications (1)

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HUE045359T2 true HUE045359T2 (hu) 2019-12-30

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Family Applications (1)

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HUE12858619A HUE045359T2 (hu) 2011-12-14 2012-12-14 Kollaterális gén inaktiváló biomarkerek és célsejtek a rákterápiában

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Country Link
US (1) US9452182B2 (hu)
EP (2) EP3603678A3 (hu)
JP (2) JP6820653B2 (hu)
KR (2) KR102355121B1 (hu)
CN (3) CN115177727A (hu)
DK (1) DK2790738T3 (hu)
ES (1) ES2746058T3 (hu)
HR (1) HRP20191607T1 (hu)
HU (1) HUE045359T2 (hu)
IN (1) IN2014DN05803A (hu)
WO (1) WO2013090732A2 (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10188708B2 (en) 2014-01-13 2019-01-29 Berg Llc Enolase 1 (Eno1) compositions and uses thereof
CN104894229A (zh) * 2014-03-04 2015-09-09 中南大学 己糖激酶2作为鼻咽癌放疗预后预测的生物标志物
JP6585721B2 (ja) * 2014-12-31 2019-10-02 ディヴェロップメント センター フォー バイオテクノロジー ヒト化α−エノラーゼ特異的抗体及びがん治療におけるその使用方法
ES2910024T3 (es) 2015-03-09 2022-05-11 Univ Texas Inhibidores de la enolasa y procedimientos de tratamiento con los mismos
US11492670B2 (en) 2015-10-27 2022-11-08 The Broad Institute Inc. Compositions and methods for targeting cancer-specific sequence variations
CA2937896A1 (en) * 2016-08-02 2018-02-02 Universite De Montreal Use of mubritinib for the treatment of poor prognosis acute myeloid leukemia
CN107217054B (zh) * 2017-04-25 2020-08-14 中山大学肿瘤防治中心 G6pd基因及其表达产物在治疗结直肠癌中的应用
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