HUE040682T2 - Eljárás rekombináns proteinek mannóztartalmának növelésére - Google Patents

Eljárás rekombináns proteinek mannóztartalmának növelésére

Info

Publication number
HUE040682T2
HUE040682T2 HUE14714521A HUE14714521A HUE040682T2 HU E040682 T2 HUE040682 T2 HU E040682T2 HU E14714521 A HUE14714521 A HU E14714521A HU E14714521 A HUE14714521 A HU E14714521A HU E040682 T2 HUE040682 T2 HU E040682T2
Authority
HU
Hungary
Prior art keywords
methods
recombinant proteins
mannose content
increasing
increasing mannose
Prior art date
Application number
HUE14714521A
Other languages
English (en)
Inventor
Jian Wu
Sean Davern
Simina Petrovan
Michael Brandenstein
Katherine Lindahl
Shawn Lillie
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50397323&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE040682(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of HUE040682T2 publication Critical patent/HUE040682T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • C12N5/0037Serum-free medium, which may still contain naturally-sourced components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/34Sugars
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
HUE14714521A 2013-03-14 2014-03-10 Eljárás rekombináns proteinek mannóztartalmának növelésére HUE040682T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361784639P 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
HUE040682T2 true HUE040682T2 (hu) 2019-03-28

Family

ID=50397323

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE14714521A HUE040682T2 (hu) 2013-03-14 2014-03-10 Eljárás rekombináns proteinek mannóztartalmának növelésére
HUE18194714A HUE063435T2 (hu) 2013-03-14 2014-03-10 Eljárások rekombináns fehérjék mannóztartalmának növelésére

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE18194714A HUE063435T2 (hu) 2013-03-14 2014-03-10 Eljárások rekombináns fehérjék mannóztartalmának növelésére

Country Status (17)

Country Link
US (6) US9822388B2 (hu)
EP (3) EP2970874B1 (hu)
AR (1) AR095418A1 (hu)
CY (1) CY1120824T1 (hu)
DK (2) DK3434760T3 (hu)
ES (2) ES2691801T3 (hu)
FI (1) FI3434760T3 (hu)
HR (1) HRP20230667T1 (hu)
HU (2) HUE040682T2 (hu)
LT (2) LT3434760T (hu)
PL (2) PL3434760T3 (hu)
PT (2) PT3434760T (hu)
RS (1) RS64326B1 (hu)
SI (2) SI2970874T1 (hu)
TR (1) TR201815892T4 (hu)
TW (4) TWI771890B (hu)
WO (1) WO2014159259A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI120045B (fi) 2005-12-22 2009-06-15 Roal Oy Selluloosamateriaalin käsittely ja siinä käyttökelpoiset entsyymit
LT2837680T (lt) 2011-07-01 2020-07-10 Amgen Inc. Žinduolių ląstelių kultūra
EP2809773B1 (en) 2012-01-30 2020-09-02 Dr. Reddy's Laboratories Limited Process of modulating man5 and/or afucosylation content of glycoprotein composition
TWI771890B (zh) 2013-03-14 2022-07-21 美商安美基公司 用於增加重組蛋白質之甘露糖含量之方法
US11130980B2 (en) * 2013-10-31 2021-09-28 Amgen Inc. Use of monensin to regulate glycosylation of recombinant proteins
US20200263220A1 (en) * 2015-12-15 2020-08-20 Csl Behring Recombinant Facility Ag Method for increasing the heterogeneity of o-glycosylation of recombinant factor vii
US11597911B2 (en) 2017-02-27 2023-03-07 Life Technologies Corporation Expansion of populations of T cells by the use of modified serum free media
MA50911A (fr) * 2017-11-13 2020-09-23 Amgen Inc Procédés de production de produits protéiniques
CN111527214A (zh) 2017-12-20 2020-08-11 阿雷斯贸易股份有限公司 用聚醚离子载体调整蛋白质甘露糖基化状况的方法
CA3099163A1 (en) * 2018-05-01 2019-11-07 Amgen Inc. Antibodies with modulated glycan profiles

Family Cites Families (36)

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US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
AU588819B2 (en) 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4968607A (en) 1987-11-25 1990-11-06 Immunex Corporation Interleukin-1 receptors
US5075222A (en) 1988-05-27 1991-12-24 Synergen, Inc. Interleukin-1 inhibitors
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
US5395760A (en) 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
DK0417563T3 (da) 1989-09-12 2000-11-06 Hoffmann La Roche TNF-bindende proteiner
US6204363B1 (en) 1989-10-16 2001-03-20 Amgen Inc. Stem cell factor
US5272064A (en) 1989-12-19 1993-12-21 Amgen Inc. DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
US5149792A (en) 1989-12-19 1992-09-22 Amgen Inc. Platelet-derived growth factor B chain analogs
US5350683A (en) 1990-06-05 1994-09-27 Immunex Corporation DNA encoding type II interleukin-1 receptors
AU651596B2 (en) 1990-06-05 1994-07-28 Immunex Corporation Type II interleukin-1 receptors
CA2146559A1 (en) 1992-10-23 1994-05-11 Melanie K. Spriggs Methods of preparing soluble, oligomeric proteins
JPH06292592A (ja) * 1993-02-09 1994-10-21 Snow Brand Milk Prod Co Ltd 糖蛋白質の生産方法
US5554512A (en) 1993-05-24 1996-09-10 Immunex Corporation Ligands for flt3 receptors
US5981713A (en) 1994-10-13 1999-11-09 Applied Research Systems Ars Holding N.V. Antibodies to intereleukin-1 antagonists
DK0835305T3 (da) 1995-06-29 2006-02-13 Immunex Corp Cytokin som inducerer apoptose
US6613544B1 (en) 1995-12-22 2003-09-02 Amgen Inc. Osteoprotegerin
US6096728A (en) 1996-02-09 2000-08-01 Amgen Inc. Composition and method for treating inflammatory diseases
US6271349B1 (en) 1996-12-23 2001-08-07 Immunex Corporation Receptor activator of NF-κB
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
US6673575B1 (en) * 1997-12-03 2004-01-06 Roche Diagnostics Gmbh Method for preparing polypeptides with appropriate glycosilation
US6337072B1 (en) 1998-04-03 2002-01-08 Hyseq, Inc. Interleukin-1 receptor antagonist and recombinant production thereof
WO2001036637A1 (en) 1999-11-17 2001-05-25 Immunex Corporation Receptor activator of nf-kappa b
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
PT1543106E (pt) 2002-07-15 2007-05-31 Immunex Corp Métodos e meios para controlar a sialilação de proteínas produzidas por células de mamíferos
BR0316882A (pt) * 2002-12-23 2005-10-25 Bristol Myers Squibb Co Melhora na qualidade de produtos em processos de cultura de células de mamìferos para a produção de proteìnas
DE102005046225B4 (de) 2005-09-28 2012-01-05 Cellca Gmbh Verbessertes Zellkulturmedium
US20070190057A1 (en) 2006-01-23 2007-08-16 Jian Wu Methods for modulating mannose content of recombinant proteins
AU2010240569A1 (en) 2009-04-20 2011-10-20 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
BR112013009275A2 (pt) 2010-10-20 2017-06-20 Morphotek Inc glicoformas de anticorpo alfa de receptor anti-folato
WO2012145682A1 (en) 2011-04-21 2012-10-26 Amgen Inc. A method for culturing mammalian cells to improve recombinant protein production
EP2702077A2 (en) * 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
LT2837680T (lt) * 2011-07-01 2020-07-10 Amgen Inc. Žinduolių ląstelių kultūra
TWI771890B (zh) 2013-03-14 2022-07-21 美商安美基公司 用於增加重組蛋白質之甘露糖含量之方法
US9481901B2 (en) * 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins

Also Published As

Publication number Publication date
US20220136026A1 (en) 2022-05-05
EP3434760A1 (en) 2019-01-30
US11952605B2 (en) 2024-04-09
TWI625390B (zh) 2018-06-01
TW202142685A (zh) 2021-11-16
TW201441368A (zh) 2014-11-01
US9822388B2 (en) 2017-11-21
PT2970874T (pt) 2018-11-16
US20220213522A1 (en) 2022-07-07
TWI720289B (zh) 2021-03-01
ES2691801T3 (es) 2018-11-28
US20160032343A1 (en) 2016-02-04
US20180002733A1 (en) 2018-01-04
PL3434760T3 (pl) 2023-09-11
EP2970874B1 (en) 2018-09-19
PT3434760T (pt) 2022-07-05
SI3434760T1 (sl) 2022-08-31
US20230193340A1 (en) 2023-06-22
TWI771890B (zh) 2022-07-21
WO2014159259A1 (en) 2014-10-02
HUE063435T2 (hu) 2024-01-28
CY1120824T1 (el) 2019-12-11
DK2970874T3 (en) 2018-11-19
EP2970874A1 (en) 2016-01-20
HRP20230667T1 (hr) 2023-10-13
RS64326B1 (sr) 2023-08-31
EP4141104A1 (en) 2023-03-01
TWI832345B (zh) 2024-02-11
LT3434760T (lt) 2022-06-27
TW202311525A (zh) 2023-03-16
US11459595B2 (en) 2022-10-04
EP3434760B1 (en) 2023-04-26
SI2970874T1 (sl) 2019-01-31
LT2970874T (lt) 2018-12-10
ES2949507T3 (es) 2023-09-29
TW201831677A (zh) 2018-09-01
US11319568B2 (en) 2022-05-03
DK3434760T3 (da) 2023-07-24
PL2970874T3 (pl) 2019-03-29
TR201815892T4 (tr) 2018-11-21
AR095418A1 (es) 2015-10-14
US20200087698A1 (en) 2020-03-19
FI3434760T3 (fi) 2023-06-12

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