HUE035347T2 - Antitumor agent and therapeutic effect prediction method for patients with kras-mutated colorectal cancer - Google Patents

Antitumor agent and therapeutic effect prediction method for patients with kras-mutated colorectal cancer Download PDF

Info

Publication number
HUE035347T2
HUE035347T2 HUE12824342A HUE12824342A HUE035347T2 HU E035347 T2 HUE035347 T2 HU E035347T2 HU E12824342 A HUE12824342 A HU E12824342A HU E12824342 A HUE12824342 A HU E12824342A HU E035347 T2 HUE035347 T2 HU E035347T2
Authority
HU
Hungary
Prior art keywords
patient
tas
kras
kras gene
patients
Prior art date
Application number
HUE12824342A
Other languages
English (en)
Hungarian (hu)
Inventor
Masanobu Ito
Hiroyuki Okabe
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of HUE035347T2 publication Critical patent/HUE035347T2/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
HUE12824342A 2011-08-16 2012-08-15 Antitumor agent and therapeutic effect prediction method for patients with kras-mutated colorectal cancer HUE035347T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011177838 2011-08-16

Publications (1)

Publication Number Publication Date
HUE035347T2 true HUE035347T2 (en) 2018-05-02

Family

ID=47715182

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12824342A HUE035347T2 (en) 2011-08-16 2012-08-15 Antitumor agent and therapeutic effect prediction method for patients with kras-mutated colorectal cancer

Country Status (21)

Country Link
US (1) US9371380B2 (enExample)
EP (1) EP2746404B1 (enExample)
JP (1) JP5832541B2 (enExample)
KR (1) KR101693090B1 (enExample)
CN (1) CN103764847B (enExample)
AU (1) AU2012295841B2 (enExample)
CY (1) CY1119869T1 (enExample)
DK (1) DK2746404T3 (enExample)
ES (1) ES2659264T3 (enExample)
HR (1) HRP20180130T1 (enExample)
HU (1) HUE035347T2 (enExample)
LT (1) LT2746404T (enExample)
NO (1) NO2746404T3 (enExample)
PL (1) PL2746404T3 (enExample)
PT (1) PT2746404T (enExample)
RS (1) RS56911B1 (enExample)
RU (1) RU2585528C2 (enExample)
SI (1) SI2746404T1 (enExample)
SM (1) SMT201800108T1 (enExample)
TW (1) TWI550089B (enExample)
WO (1) WO2013024865A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2998742A4 (en) * 2013-05-17 2017-01-18 Taiho Pharmaceutical Co., Ltd. Therapeutic effect prediction method for colorectal cancer patient in whom expression of tk1 protein has increased
EP3328394A4 (en) 2015-07-30 2019-03-13 ModernaTX, Inc. CONCATEMEE peptide epitope RNAs
UA123403C2 (uk) * 2016-02-05 2021-03-31 Тайхо Фармасьютікал Ко., Лтд. Спосіб лікування хворих на рак з тяжкою нирковою недостатністю
AU2017397458B2 (en) * 2017-02-01 2025-07-10 Modernatx, Inc. RNA cancer vaccines
WO2018170245A1 (en) 2017-03-15 2018-09-20 Modernatx, Inc. Broad spectrum influenza virus vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1849470T5 (pl) 2005-01-26 2024-06-10 Taiho Pharmaceutical Co., Ltd. Lek przeciwrakowy zawierający alfa,alfa,alfa-trifluorotymidynę i inhibitor fosforylazy tymidynowej
US7799783B2 (en) 2005-01-26 2010-09-21 Taiho Pharmaceutical Co., Ltd. Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor

Also Published As

Publication number Publication date
JPWO2013024865A1 (ja) 2015-03-05
JP5832541B2 (ja) 2015-12-16
ES2659264T3 (es) 2018-03-14
NO2746404T3 (enExample) 2018-05-05
TW201319257A (zh) 2013-05-16
WO2013024865A1 (ja) 2013-02-21
RU2585528C2 (ru) 2016-05-27
TWI550089B (zh) 2016-09-21
EP2746404B1 (en) 2017-12-06
EP2746404A1 (en) 2014-06-25
SMT201800108T1 (it) 2018-05-02
RU2014109999A (ru) 2015-10-10
SI2746404T1 (en) 2018-04-30
DK2746404T3 (en) 2018-01-15
CY1119869T1 (el) 2018-06-27
HK1197086A1 (zh) 2015-01-02
HRP20180130T1 (hr) 2018-04-06
CN103764847B (zh) 2016-05-11
PT2746404T (pt) 2018-01-10
PL2746404T3 (pl) 2018-04-30
CN103764847A (zh) 2014-04-30
KR20140057328A (ko) 2014-05-12
AU2012295841B2 (en) 2015-12-10
RS56911B1 (sr) 2018-05-31
EP2746404A4 (en) 2015-04-08
US9371380B2 (en) 2016-06-21
AU2012295841A1 (en) 2014-04-03
LT2746404T (lt) 2018-04-25
US20140213602A1 (en) 2014-07-31
KR101693090B1 (ko) 2017-01-04

Similar Documents

Publication Publication Date Title
AU2018329925B2 (en) Diagnostic and therapeutic methods for cancer
KR20200008598A (ko) 혈소판 유래 성장 인자 수용체 알파의 유전적 이상과 연관된 암 치료를 위한 1-[4-브로모-5-[1-에틸-7-(메틸아미노)-2-옥소-1,2-다이히드로-1,6-나프티리딘-3-일]-2-플루오로페닐]-3-페닐우레아 및 유사체의 용도
JP2019518426A (ja) がんの診断及び治療方法
CN114395624A (zh) 用于癌症的治疗和诊断方法
DK2746404T3 (en) ANTITUMOR AGENT AND PROCEDURE FOR PREVENTING THERAPEUTIC EFFECT FOR PATIENTS WITH CRASMUTORED COLORECTAL CANCER
KR20200101951A (ko) 암을 치료하기 위한 방법 및 병용 요법
JP2023512181A (ja) 癌を治療するためのegfr阻害剤とror1阻害剤の組み合わせ
EP3908282B1 (en) Treatment of cancer having gnaq or gna11 genetic mutations with protein kinase c inhibitors
CA3148858A1 (en) Therapeutic agent for cancer having resistance to anti-ccr4 antibody
WO2017160568A1 (en) Combination therapy comprising the cdk4/6 inhibitor necitumumab and the egfr inhibitor abemaciclib for use in treating cancer
US20190216923A1 (en) Methods and combination therapy to treat cancer
US20200368205A1 (en) Methods and combination therapy to treat cancer
US20130005747A1 (en) Method for selecting a cancer therapy
HK1197086B (en) Antitumor agent and therapeutic effect prediction method for patients with kras-mutated colorectal cancer
WO2025075211A1 (en) Alisertib and paclitaxel for treating small cell lung cancer
CA3245212A1 (en) PRECISION THERAPY FOR CANCER TREATMENT
WO2010074241A1 (ja) 併用化学療法の治療効果予測方法