DK2746404T3 - ANTITUMOR AGENT AND PROCEDURE FOR PREVENTING THERAPEUTIC EFFECT FOR PATIENTS WITH CRASMUTORED COLORECTAL CANCER - Google Patents

ANTITUMOR AGENT AND PROCEDURE FOR PREVENTING THERAPEUTIC EFFECT FOR PATIENTS WITH CRASMUTORED COLORECTAL CANCER Download PDF

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Publication number
DK2746404T3
DK2746404T3 DK12824342.5T DK12824342T DK2746404T3 DK 2746404 T3 DK2746404 T3 DK 2746404T3 DK 12824342 T DK12824342 T DK 12824342T DK 2746404 T3 DK2746404 T3 DK 2746404T3
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Prior art keywords
colorectal cancer
patients
kras gene
tas
chemotherapy
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DK12824342.5T
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Danish (da)
English (en)
Inventor
Masanobu Ito
Hiroyuki Okabe
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Taiho Pharmaceutical Co Ltd
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Publication of DK2746404T3 publication Critical patent/DK2746404T3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241Tumor Necrosis Factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
DK12824342.5T 2011-08-16 2012-08-15 ANTITUMOR AGENT AND PROCEDURE FOR PREVENTING THERAPEUTIC EFFECT FOR PATIENTS WITH CRASMUTORED COLORECTAL CANCER DK2746404T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011177838 2011-08-16
PCT/JP2012/070745 WO2013024865A1 (ja) 2011-08-16 2012-08-15 Kras遺伝子変異型の結腸直腸癌患者に対する抗腫瘍剤及び治療効果予測方法

Publications (1)

Publication Number Publication Date
DK2746404T3 true DK2746404T3 (en) 2018-01-15

Family

ID=47715182

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12824342.5T DK2746404T3 (en) 2011-08-16 2012-08-15 ANTITUMOR AGENT AND PROCEDURE FOR PREVENTING THERAPEUTIC EFFECT FOR PATIENTS WITH CRASMUTORED COLORECTAL CANCER

Country Status (21)

Country Link
US (1) US9371380B2 (enExample)
EP (1) EP2746404B1 (enExample)
JP (1) JP5832541B2 (enExample)
KR (1) KR101693090B1 (enExample)
CN (1) CN103764847B (enExample)
AU (1) AU2012295841B2 (enExample)
CY (1) CY1119869T1 (enExample)
DK (1) DK2746404T3 (enExample)
ES (1) ES2659264T3 (enExample)
HR (1) HRP20180130T1 (enExample)
HU (1) HUE035347T2 (enExample)
LT (1) LT2746404T (enExample)
NO (1) NO2746404T3 (enExample)
PL (1) PL2746404T3 (enExample)
PT (1) PT2746404T (enExample)
RS (1) RS56911B1 (enExample)
RU (1) RU2585528C2 (enExample)
SI (1) SI2746404T1 (enExample)
SM (1) SMT201800108T1 (enExample)
TW (1) TWI550089B (enExample)
WO (1) WO2013024865A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101928618B1 (ko) 2013-05-17 2018-12-12 다이호야쿠힌고교 가부시키가이샤 Tk1 단백질의 발현이 항진된 결장직장암 환자에 대한 치료효과 예측 방법
MA42543A (fr) 2015-07-30 2018-06-06 Modernatx Inc Arn épitope peptidiques concatémériques
EP3412295A4 (en) 2016-02-05 2019-09-25 Taiho Pharmaceutical Co., Ltd. METHOD FOR THE TREATMENT OF CANCER PATIENTS WITH HEAVY NIER FUNCTION TROUBLESHOOTING
KR20190120233A (ko) * 2017-02-01 2019-10-23 모더나티엑스, 인크. Rna 암 백신
EP3609534A4 (en) 2017-03-15 2021-01-13 ModernaTX, Inc. WIDE SPECTRUM INFLUENZA VIRUS VACCINE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1849470T (pt) 2005-01-26 2017-09-22 Taiho Pharmaceutical Co Ltd Fármaco anticancro contendo alfa, alfa, alfa-trifluorotimidina e inibidor da timidina-fosforilase
US7799783B2 (en) * 2005-01-26 2010-09-21 Taiho Pharmaceutical Co., Ltd. Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor

Also Published As

Publication number Publication date
RU2585528C2 (ru) 2016-05-27
HK1197086A1 (zh) 2015-01-02
ES2659264T3 (es) 2018-03-14
US9371380B2 (en) 2016-06-21
NO2746404T3 (enExample) 2018-05-05
SMT201800108T1 (it) 2018-05-02
SI2746404T1 (en) 2018-04-30
HRP20180130T1 (hr) 2018-04-06
US20140213602A1 (en) 2014-07-31
WO2013024865A1 (ja) 2013-02-21
CN103764847A (zh) 2014-04-30
PT2746404T (pt) 2018-01-10
CN103764847B (zh) 2016-05-11
EP2746404B1 (en) 2017-12-06
KR101693090B1 (ko) 2017-01-04
AU2012295841B2 (en) 2015-12-10
JP5832541B2 (ja) 2015-12-16
EP2746404A4 (en) 2015-04-08
JPWO2013024865A1 (ja) 2015-03-05
HUE035347T2 (en) 2018-05-02
EP2746404A1 (en) 2014-06-25
TWI550089B (zh) 2016-09-21
PL2746404T3 (pl) 2018-04-30
RU2014109999A (ru) 2015-10-10
RS56911B1 (sr) 2018-05-31
CY1119869T1 (el) 2018-06-27
AU2012295841A1 (en) 2014-04-03
LT2746404T (lt) 2018-04-25
TW201319257A (zh) 2013-05-16
KR20140057328A (ko) 2014-05-12

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