HUE034996T2 - Ivabradin-hidroklorid IV-es forma - Google Patents
Ivabradin-hidroklorid IV-es forma Download PDFInfo
- Publication number
- HUE034996T2 HUE034996T2 HUE12766056A HUE12766056A HUE034996T2 HU E034996 T2 HUE034996 T2 HU E034996T2 HU E12766056 A HUE12766056 A HU E12766056A HU E12766056 A HUE12766056 A HU E12766056A HU E034996 T2 HUE034996 T2 HU E034996T2
- Authority
- HU
- Hungary
- Prior art keywords
- legalább legalább
- ivabradine hydrochloride
- ivabradine
- hydrochloride
- defined above
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Claims (3)
- IVÂllRÂOIMIÔROKi,OKID IV-ES FORMA Szahadahm igénypontok 1, b .mrumn-bcörnkimid l\-cs fonna, noels eg> okán poy-r'mrgt-ud'fftskei'ívut ,,utsgeb.d „powder X-ray diffraction”) rendelkezik, amely a következő 2-théts fok (.* 0.2 > csúcsokkal tendelkec:k >-,7-1 15,^, 1",I7, 1^,8^ és .bhöfo the·' ? iomgendr'ftAl-eio t uku sugárzás alkalma/’Ai.a\?l ',,m mérve X Ivabradiu-hidroklorid IV-es fonna az I. igénypont szerint amely egy olyan por-letttgendrtiiAkeno.ö modelkivV, ΑΠινΙι a kowtkc/o 2 íheta tok -, * 0?! csúcsokkal rendelkezik: 8.11, 8.74, 15,55, 17,17, 19,lk, 19,89, 21,82, 22/10. 24,29 és 24,53, ahol a röntgend!brake tő CuKo. sugárzás alkalmazásával van mérve, 3, I",ab:achmbtötok-otté Λ-es homa ,r 1 »ags 2 \eer\podók vnsmcl\f\e ,-,/-,1mt cmeO kg\ olyan por-rontgunhíftakcmval wodetkczih, rosnt amthcn lényegében a ' ! ábian ' au ábrázolva. 4, h ib:a,ï5n4vdo'kh'rO D es fonoa az 1 -fol S -'g igénypontok ó trsneb, ike szenei amely egy olyun Du terein, tabs Pásztázó K tfoiímefr.n termogtannmrl (angolai „DdTercnttal Scanning Calorimetry thermogram”) rendelkezik, amely egy endotenn csúccsal (angolul: vu to h». u s pea\u'twILeui 1-Vf tol mt ( „ 5, ls,ihvx(nn'!odto\h'"d ik-e* h<'t'.ta az 1 told g sgcneoontok harmehtfo sz<mn, au'tb, egy olyan Differenciális Pásztázó Kaiorimetria tenir ogr;mum.il rendelkezik, mint amilyen lényegében a 2. ábrán van ábrázolva.
- 6, Eljárás az. I.-töl 5.-ig igénypontok bármelyike szerinti ís^abradin-hidrokíorid IV-es forrna előállítására., ahol az. magában foglalja a következő lépést; a> jvubradin-hidroklorid szuszpendálása (angolul; „slurrying”) egy oldószer-rendszerben, ahol az oldószer-rendszer a következőket tartalmazza: toluol, etanol, acélon, melil-etil-keton, melildzobutil-keton, efil-aeetát, izopropil-acetáí és azok keverékei. I b nas a o tgervpom scettnt, ahol ac oides,e* tetu’szet ae legesben íatmima teátok és egy második oldószert, amely a következők közöl van választva: etanol, acélon és etil* acetát, vagy az a toluol. 8, 1 boros a o igcmpont sceimp ahol a hőmérséklet az ta) lépésben alacsonyabb, nom 60cC, előnyösen 10°C és 60°C között van, előnyösebben Itk'C és 30°C között van, és még előnyösebben 2O'JC és 25°C között vau. 9. au ws. nouns ,e,uJy a \,nefke/oket ι,ίΓΑΐη,ΑΖζ t ,ο I \Ί a ’pun r,Aomok bármelyike szerinti ivabradiu-hidroklorid IV-es formát és legalább egy gyógyászat tlag elfogadható segédanyagot (e.xcipienst) lő, G\og\as.-,ut készítmény a igénypont szermt orabs ad omlásta, és ahol uz előnyösen f.g\ ftlmbe\ luntfu tab'en ásták a torta yab„n all fetuleike 'este H, Gvogvaszati készítmény a 9. vagy 10. igénypontok bármelyike szemű, ahol a nevezett készítmény körülbelül 5 tng-tól körülbelül 9 sng-íg ivabradm-hidrokiorid IV-cs formát tartalmaz, es Jonyosen kómíbehtí 5,3^0 mg r,abtadm-lmirokiend IV-es format \ag\ kerülhetni 'yPS? mg ixabtadn-atdroklomt IV-es tóimat hatalmaz.
- 12, Eljárás a 9,-töl II -tg igénypontok bármelyike szerinti készítménynek az előállítására, azzal jelitnu'ZYt, hogy a reiezeh ehatas mamiban toitlal a u koret\C/o \c':mkd alk.Vm'4,as,u; direkt kompresszió (közvetlen préselés), száraz granulálás és/vugy nedves granttktlas 13« Eljárás a 12. igénypont szerint, azzal jellemezve, hogy a nedves granulálási eljárás magában foglalja szerves oldószereknek, előnyősön acetonnak, alkoholoknak vagy azok kombinációjának. az alkalmazását. H h ibmdt bobok'ess. ÍV s emm r í oi > g teetoroe.k batn'Jvlo \ -, i g\eg' ,o va kevmoem a 0 ό1 U g igetu-por.ok -'enni, lot tptaban tomme alkalmazásra. B habiadét 'bob olios d l\ ", loon* ee to' ' ,g tge'onontok ouiiit mm g'.moam.m 1 évin nem a *-<' 4,0 π og igénypontok x.m^oo, a lo\mke, vkoek a kezeimében tömve atka;utazásra: bradikatdia (lassú szívverés), tnlokardiabs iszkésnia, szopravenlnktdáris ritmuszavarok, krónikus stabil angina pectoris koszorúér-betegségtől szenvedő felnőtteknél. amelyeknek normális szinoszriímustik van, míokardiális infarktus, s »eCegteiersep es azokhoz kapmo’ódó ntmoszavarok
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11382339.7A EP2589594A1 (en) | 2011-11-04 | 2011-11-04 | Ivabradine hydrochloride Form IV |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE034996T2 true HUE034996T2 (hu) | 2018-05-02 |
Family
ID=46934559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE12766056A HUE034996T2 (hu) | 2011-11-04 | 2012-09-21 | Ivabradin-hidroklorid IV-es forma |
Country Status (21)
Country | Link |
---|---|
US (3) | US9139531B2 (hu) |
EP (3) | EP2589594A1 (hu) |
JP (3) | JP6359971B2 (hu) |
KR (1) | KR102050117B1 (hu) |
AU (1) | AU2012331395B2 (hu) |
BR (1) | BR112014010767B1 (hu) |
CA (1) | CA2854549C (hu) |
CY (1) | CY1119798T1 (hu) |
DK (1) | DK2773620T3 (hu) |
ES (1) | ES2562843T3 (hu) |
HR (1) | HRP20171511T1 (hu) |
HU (1) | HUE034996T2 (hu) |
LT (1) | LT2773620T (hu) |
MX (1) | MX359288B (hu) |
PL (1) | PL2773620T3 (hu) |
PT (1) | PT2773620T (hu) |
RS (1) | RS56464B1 (hu) |
RU (1) | RU2619121C2 (hu) |
SI (1) | SI2773620T1 (hu) |
WO (1) | WO2013064307A1 (hu) |
ZA (1) | ZA201403073B (hu) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2589594A1 (en) * | 2011-11-04 | 2013-05-08 | Urquima S.A. | Ivabradine hydrochloride Form IV |
EP3156399A1 (en) * | 2011-11-14 | 2017-04-19 | Cadila Healthcare Limited | Polymorphic forms of ivabradine hydrochloride |
ITMI20130684A1 (it) * | 2013-04-24 | 2014-10-25 | Chemo Res S L | Nuovo polimorfo del cloridrato di ivabradina e metodo per la sua preparazione |
HRP20200300T4 (hr) | 2013-03-19 | 2023-09-15 | Chemo Research, S.L. | Novi polimorf ivabradin hidroklorida i metoda za njegovu pripremu |
CZ305096B6 (cs) | 2013-10-02 | 2015-04-29 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice |
MX363389B (es) | 2013-12-12 | 2019-03-20 | Synthon Bv | Composicion farmaceutica que comprende ivabradina amorfa. |
EP2774606B1 (en) | 2014-02-14 | 2019-01-30 | Synthon B.V. | Pharmaceutical composition comprising ivabradine hydrochloride polymorph IV |
CZ305436B6 (cs) | 2014-07-10 | 2015-09-16 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice |
GR1008821B (el) | 2015-06-11 | 2016-08-01 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο σκευασμα που περιλαμβανει υδροχλωρικη ιβαμπραδινη και μεθοδος παρασκευης αυτου |
TR201703066A2 (tr) | 2017-02-28 | 2018-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari |
EP3366282A1 (en) | 2017-02-28 | 2018-08-29 | Sanovel Ilac Sanayi ve Ticaret A.S. | Solid oral pharmaceutical compositions of ivabradine |
US11294199B2 (en) | 2017-09-19 | 2022-04-05 | Mitsui Chemicals, Inc. | Eyewear |
US20230181472A1 (en) * | 2018-10-30 | 2023-06-15 | Amgen Inc. | Process of making ivabradine hydrochloride drug product |
IT202000025312A1 (it) | 2020-10-26 | 2022-04-26 | Cambrex Profarmaco Milano S R L | Processi per la preparazione di polimorfi di ivabradina hcl |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
FR2868777B1 (fr) | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2882555B1 (fr) | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2882553B1 (fr) | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2882556B1 (fr) | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2891827B1 (fr) * | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2891826B1 (fr) | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
ATE544754T1 (de) * | 2006-11-30 | 2012-02-15 | Cadila Healthcare Ltd | Verfahren zur herstellung von ivabradinhydrochlorid |
WO2008125006A1 (fr) * | 2007-04-12 | 2008-10-23 | Utopharm (Shanghai) Co., Ltd | Procédés de préparation du chlorhydrate d'ivabradine et de sa forme cristalline stable |
WO2008146308A2 (en) | 2007-05-30 | 2008-12-04 | Ind-Swift Laboratories Limited | Process for the preparation of ivabradine hydrochloride and polymorph thereof |
CN101597261A (zh) | 2008-06-06 | 2009-12-09 | 北京深蓝海生物医药科技有限公司 | 无定形盐酸伊伐布雷定 |
US20100323471A1 (en) | 2008-08-21 | 2010-12-23 | Applied Materials, Inc. | Selective Etch of Laser Scribed Solar Cell Substrate |
CN101768117B (zh) | 2008-12-29 | 2014-05-07 | 北京德众万全药物技术开发有限公司 | 一种盐酸伊伐布雷定晶型及其制备方法 |
CN101463008A (zh) | 2009-01-11 | 2009-06-24 | 山东鲁抗辰欣药业有限公司 | 盐酸伊伐布雷定无定型物及其制备方法 |
CN101805289A (zh) | 2009-02-17 | 2010-08-18 | 成都威克药业有限责任公司 | 伊伐布雷定盐酸盐的ω-晶型、其制备方法和药物组合物 |
CN102050784B (zh) | 2009-11-04 | 2014-07-09 | 扬子江药业集团北京海燕药业有限公司 | 一种无定型盐酸伊伐布雷定的制备方法 |
SI23290A (sl) | 2010-02-12 | 2011-08-31 | Krka D.D., Novo Mesto | Nove oblike ivabradin hidroklorida |
WO2012025940A1 (en) | 2010-08-25 | 2012-03-01 | Cadila Healthcare Limited | Polymorphic form of ivabradine hydrochloride and process for preparation thereof |
EP2589594A1 (en) * | 2011-11-04 | 2013-05-08 | Urquima S.A. | Ivabradine hydrochloride Form IV |
EP3156399A1 (en) * | 2011-11-14 | 2017-04-19 | Cadila Healthcare Limited | Polymorphic forms of ivabradine hydrochloride |
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2011
- 2011-11-04 EP EP11382339.7A patent/EP2589594A1/en not_active Withdrawn
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2012
- 2012-09-21 EP EP17184888.0A patent/EP3263556A1/en active Pending
- 2012-09-21 MX MX2014005362A patent/MX359288B/es active IP Right Grant
- 2012-09-21 CA CA2854549A patent/CA2854549C/en active Active
- 2012-09-21 ES ES12766056.1T patent/ES2562843T3/es active Active
- 2012-09-21 JP JP2014539268A patent/JP6359971B2/ja active Active
- 2012-09-21 WO PCT/EP2012/068615 patent/WO2013064307A1/en active Application Filing
- 2012-09-21 US US14/356,240 patent/US9139531B2/en active Active
- 2012-09-21 LT LTEP12766056.1T patent/LT2773620T/lt unknown
- 2012-09-21 SI SI201231092T patent/SI2773620T1/sl unknown
- 2012-09-21 BR BR112014010767-0A patent/BR112014010767B1/pt active IP Right Grant
- 2012-09-21 KR KR1020147015092A patent/KR102050117B1/ko active IP Right Grant
- 2012-09-21 DK DK12766056.1T patent/DK2773620T3/en active
- 2012-09-21 PL PL12766056T patent/PL2773620T3/pl unknown
- 2012-09-21 RU RU2014122261A patent/RU2619121C2/ru active
- 2012-09-21 EP EP12766056.1A patent/EP2773620B1/en active Active
- 2012-09-21 PT PT127660561T patent/PT2773620T/pt unknown
- 2012-09-21 HU HUE12766056A patent/HUE034996T2/hu unknown
- 2012-09-21 RS RS20171010A patent/RS56464B1/sr unknown
- 2012-09-21 AU AU2012331395A patent/AU2012331395B2/en active Active
-
2014
- 2014-04-25 ZA ZA2014/03073A patent/ZA201403073B/en unknown
-
2015
- 2015-07-22 US US14/806,224 patent/US9309201B2/en active Active
-
2016
- 2016-04-02 US US15/089,495 patent/US20160289192A1/en not_active Abandoned
-
2017
- 2017-05-30 JP JP2017106708A patent/JP2017178965A/ja not_active Withdrawn
- 2017-10-09 HR HRP20171511TT patent/HRP20171511T1/hr unknown
- 2017-10-12 CY CY20171101069T patent/CY1119798T1/el unknown
-
2018
- 2018-04-09 JP JP2018074972A patent/JP2018123154A/ja active Pending
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