BR112014010767A2 - Forma iv do cloridrato de ivabradina - Google Patents
Forma iv do cloridrato de ivabradinaInfo
- Publication number
- BR112014010767A2 BR112014010767A2 BR112014010767A BR112014010767A BR112014010767A2 BR 112014010767 A2 BR112014010767 A2 BR 112014010767A2 BR 112014010767 A BR112014010767 A BR 112014010767A BR 112014010767 A BR112014010767 A BR 112014010767A BR 112014010767 A2 BR112014010767 A2 BR 112014010767A2
- Authority
- BR
- Brazil
- Prior art keywords
- chloridate
- ivabradine
- ivabradine chloridate
- chloridate form
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11382339.7A EP2589594A1 (en) | 2011-11-04 | 2011-11-04 | Ivabradine hydrochloride Form IV |
EP11382339.7 | 2011-11-04 | ||
PCT/EP2012/068615 WO2013064307A1 (en) | 2011-11-04 | 2012-09-21 | Ivabradine hydrochloride form iv |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014010767A2 true BR112014010767A2 (pt) | 2017-06-13 |
BR112014010767B1 BR112014010767B1 (pt) | 2021-03-09 |
Family
ID=46934559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014010767-0A BR112014010767B1 (pt) | 2011-11-04 | 2012-09-21 | forma iv do cloridrato de ivabradina |
Country Status (21)
Country | Link |
---|---|
US (3) | US9139531B2 (pt) |
EP (3) | EP2589594A1 (pt) |
JP (3) | JP6359971B2 (pt) |
KR (1) | KR102050117B1 (pt) |
AU (1) | AU2012331395B2 (pt) |
BR (1) | BR112014010767B1 (pt) |
CA (1) | CA2854549C (pt) |
CY (1) | CY1119798T1 (pt) |
DK (1) | DK2773620T3 (pt) |
ES (1) | ES2562843T3 (pt) |
HR (1) | HRP20171511T1 (pt) |
HU (1) | HUE034996T2 (pt) |
LT (1) | LT2773620T (pt) |
MX (1) | MX359288B (pt) |
PL (1) | PL2773620T3 (pt) |
PT (1) | PT2773620T (pt) |
RS (1) | RS56464B1 (pt) |
RU (1) | RU2619121C2 (pt) |
SI (1) | SI2773620T1 (pt) |
WO (1) | WO2013064307A1 (pt) |
ZA (1) | ZA201403073B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2589594A1 (en) * | 2011-11-04 | 2013-05-08 | Urquima S.A. | Ivabradine hydrochloride Form IV |
WO2013102919A1 (en) | 2011-11-14 | 2013-07-11 | Cadila Healthcare Limited | Polymorphic forms of ivabradine hydrochloride |
ITMI20130684A1 (it) * | 2013-04-24 | 2014-10-25 | Chemo Res S L | Nuovo polimorfo del cloridrato di ivabradina e metodo per la sua preparazione |
PL2781509T5 (pl) | 2013-03-19 | 2023-09-25 | Chemo Research, S.L. | Nowy polimorf chlorowodorku iwabradyny i sposób jego otrzymywania |
CZ2013767A3 (cs) | 2013-10-02 | 2015-04-29 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice |
ES2672472T3 (es) | 2013-12-12 | 2018-06-14 | Synthon Bv | Composición farmacéutica que comprende ivabradina amorfa |
PT2774606T (pt) | 2014-02-14 | 2019-05-06 | Synthon Bv | Composição farmacêutica compreendendo polimorfo de cloridrato de ivabradina iv |
CZ2014478A3 (cs) | 2014-07-10 | 2015-09-16 | Zentiva, K.S. | Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice |
GR1008821B (el) | 2015-06-11 | 2016-08-01 | Φαρματεν Ανωνυμος Βιομηχανικη Και Εμπορικη Εταιρεια Φαρμακευτικων Ιατρικων Και Καλλυντικων Προϊοντων | Φαρμακευτικο σκευασμα που περιλαμβανει υδροχλωρικη ιβαμπραδινη και μεθοδος παρασκευης αυτου |
TR201703066A2 (tr) | 2017-02-28 | 2018-09-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari |
EP3366282A1 (en) | 2017-02-28 | 2018-08-29 | Sanovel Ilac Sanayi ve Ticaret A.S. | Solid oral pharmaceutical compositions of ivabradine |
EP3686655A4 (en) | 2017-09-19 | 2021-06-16 | Mitsui Chemicals, Inc. | GLASSES |
WO2020092288A1 (en) * | 2018-10-30 | 2020-05-07 | Amgen Inc. | Process of making ivabradine hydrochloride drug product |
IT202000025312A1 (it) | 2020-10-26 | 2022-04-26 | Cambrex Profarmaco Milano S R L | Processi per la preparazione di polimorfi di ivabradina hcl |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2681862B1 (fr) | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
FR2868777B1 (fr) | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2882554B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2882553B1 (fr) | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2882556B1 (fr) | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2882555B1 (fr) * | 2005-02-28 | 2007-05-04 | Servier Lab | Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2891827B1 (fr) | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
FR2891826B1 (fr) | 2005-10-11 | 2007-12-28 | Servier Lab | Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
EP2097383B1 (en) | 2006-11-30 | 2012-02-08 | Cadila Healthcare Limited | Process for preparation of ivabradine hydrochloride |
WO2008125006A1 (fr) * | 2007-04-12 | 2008-10-23 | Utopharm (Shanghai) Co., Ltd | Procédés de préparation du chlorhydrate d'ivabradine et de sa forme cristalline stable |
ES2528026T3 (es) * | 2007-05-30 | 2015-02-03 | Ind-Swift Laboratories Limited | Sales de oxalato de ivabridina cristalino y polimorfos de los mismos |
CN101597261A (zh) | 2008-06-06 | 2009-12-09 | 北京深蓝海生物医药科技有限公司 | 无定形盐酸伊伐布雷定 |
US20100323471A1 (en) | 2008-08-21 | 2010-12-23 | Applied Materials, Inc. | Selective Etch of Laser Scribed Solar Cell Substrate |
CN101768117B (zh) | 2008-12-29 | 2014-05-07 | 北京德众万全药物技术开发有限公司 | 一种盐酸伊伐布雷定晶型及其制备方法 |
CN101463008A (zh) | 2009-01-11 | 2009-06-24 | 山东鲁抗辰欣药业有限公司 | 盐酸伊伐布雷定无定型物及其制备方法 |
CN101805289A (zh) | 2009-02-17 | 2010-08-18 | 成都威克药业有限责任公司 | 伊伐布雷定盐酸盐的ω-晶型、其制备方法和药物组合物 |
CN102050784B (zh) | 2009-11-04 | 2014-07-09 | 扬子江药业集团北京海燕药业有限公司 | 一种无定型盐酸伊伐布雷定的制备方法 |
PL2902384T3 (pl) | 2010-02-12 | 2018-04-30 | Krka, D.D., Novo Mesto | Postać chlorowodorku iwabradyny |
WO2012025940A1 (en) | 2010-08-25 | 2012-03-01 | Cadila Healthcare Limited | Polymorphic form of ivabradine hydrochloride and process for preparation thereof |
EP2589594A1 (en) * | 2011-11-04 | 2013-05-08 | Urquima S.A. | Ivabradine hydrochloride Form IV |
WO2013102919A1 (en) * | 2011-11-14 | 2013-07-11 | Cadila Healthcare Limited | Polymorphic forms of ivabradine hydrochloride |
-
2011
- 2011-11-04 EP EP11382339.7A patent/EP2589594A1/en not_active Withdrawn
-
2012
- 2012-09-21 EP EP17184888.0A patent/EP3263556A1/en not_active Withdrawn
- 2012-09-21 EP EP12766056.1A patent/EP2773620B1/en active Active
- 2012-09-21 CA CA2854549A patent/CA2854549C/en active Active
- 2012-09-21 WO PCT/EP2012/068615 patent/WO2013064307A1/en active Application Filing
- 2012-09-21 JP JP2014539268A patent/JP6359971B2/ja active Active
- 2012-09-21 PL PL12766056T patent/PL2773620T3/pl unknown
- 2012-09-21 ES ES12766056.1T patent/ES2562843T3/es active Active
- 2012-09-21 KR KR1020147015092A patent/KR102050117B1/ko active IP Right Grant
- 2012-09-21 RU RU2014122261A patent/RU2619121C2/ru active
- 2012-09-21 PT PT127660561T patent/PT2773620T/pt unknown
- 2012-09-21 DK DK12766056.1T patent/DK2773620T3/en active
- 2012-09-21 RS RS20171010A patent/RS56464B1/sr unknown
- 2012-09-21 MX MX2014005362A patent/MX359288B/es active IP Right Grant
- 2012-09-21 LT LTEP12766056.1T patent/LT2773620T/lt unknown
- 2012-09-21 US US14/356,240 patent/US9139531B2/en active Active
- 2012-09-21 BR BR112014010767-0A patent/BR112014010767B1/pt active IP Right Grant
- 2012-09-21 SI SI201231092T patent/SI2773620T1/sl unknown
- 2012-09-21 AU AU2012331395A patent/AU2012331395B2/en active Active
- 2012-09-21 HU HUE12766056A patent/HUE034996T2/en unknown
-
2014
- 2014-04-25 ZA ZA2014/03073A patent/ZA201403073B/en unknown
-
2015
- 2015-07-22 US US14/806,224 patent/US9309201B2/en active Active
-
2016
- 2016-04-02 US US15/089,495 patent/US20160289192A1/en not_active Abandoned
-
2017
- 2017-05-30 JP JP2017106708A patent/JP2017178965A/ja not_active Withdrawn
- 2017-10-09 HR HRP20171511TT patent/HRP20171511T1/hr unknown
- 2017-10-12 CY CY20171101069T patent/CY1119798T1/el unknown
-
2018
- 2018-04-09 JP JP2018074972A patent/JP2018123154A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B06F | Objections, documents and/or translations needed after an examination request according art. 34 industrial property law | ||
B07E | Notice of approval relating to section 229 industrial property law | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure | ||
B09A | Decision: intention to grant | ||
B09X | Decision of grant: republication | ||
B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/09/2012, OBSERVADAS AS CONDICOES LEGAIS. |