HUE034042T2 - N-Heteroaryl Compounds - Google Patents

N-Heteroaryl Compounds Download PDF

Info

Publication number
HUE034042T2
HUE034042T2 HUE11761595A HUE11761595A HUE034042T2 HU E034042 T2 HUE034042 T2 HU E034042T2 HU E11761595 A HUE11761595 A HU E11761595A HU E11761595 A HUE11761595 A HU E11761595A HU E034042 T2 HUE034042 T2 HU E034042T2
Authority
HU
Hungary
Prior art keywords
alkyl
compounds
amino
group
mmol
Prior art date
Application number
HUE11761595A
Other languages
English (en)
Hungarian (hu)
Inventor
Michael Berger
Christopher Kern
Marko Eck
Joerg Schroeder
Original Assignee
Intervet Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv filed Critical Intervet Int Bv
Publication of HUE034042T2 publication Critical patent/HUE034042T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HUE11761595A 2010-09-29 2011-09-28 N-Heteroaryl Compounds HUE034042T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10181553 2010-09-29
US38846610P 2010-09-30 2010-09-30

Publications (1)

Publication Number Publication Date
HUE034042T2 true HUE034042T2 (en) 2018-01-29

Family

ID=44719930

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE11761595A HUE034042T2 (en) 2010-09-29 2011-09-28 N-Heteroaryl Compounds

Country Status (17)

Country Link
US (1) US8877934B2 (enExample)
EP (1) EP2621903B1 (enExample)
JP (1) JP5791725B2 (enExample)
KR (1) KR101916481B1 (enExample)
CN (2) CN105294549B (enExample)
AR (1) AR083200A1 (enExample)
AU (1) AU2011310592B2 (enExample)
BR (1) BR112013006030B1 (enExample)
CA (1) CA2811369C (enExample)
CO (1) CO6710926A2 (enExample)
ES (1) ES2622881T3 (enExample)
HU (1) HUE034042T2 (enExample)
MX (1) MX340985B (enExample)
NZ (1) NZ607580A (enExample)
PL (1) PL2621903T3 (enExample)
RU (1) RU2596185C2 (enExample)
WO (1) WO2012041873A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10842144B2 (en) * 2011-05-13 2020-11-24 The Climate Corporation Method and system to map biological pests in agricultural fields using remotely-sensed data for field scouting and targeted chemical application
US10096073B2 (en) 2011-05-13 2018-10-09 The Climate Corporation Systems to prescribe and deliver fertilizer over agricultural fields and related methods
AU2013241853B2 (en) 2012-03-28 2017-11-09 Intervet International B.V. Heteroaryl compounds with A-cyclic bridging unit
MX2015007526A (es) * 2012-12-13 2015-10-14 Dow Agrosciences Llc Proceso para la preparacion de 4-amino-5-fluoro-3-cloro-6-picolina tos (sustituidos).
WO2014093591A1 (en) * 2012-12-13 2014-06-19 Dow Agrosciences Llc Processes for the preparation of 4-amino-3-halo-6- (substituted)picolinates and 4-amino-5-fluoro-3-halo-6- (substituted)picolinates
WO2015177179A1 (en) 2014-05-21 2015-11-26 Intervet International B.V. Improved process for preparing substituted crotonic acids
WO2016020288A1 (en) 2014-08-04 2016-02-11 Nuevolution A/S Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases
BR112018012696A2 (pt) * 2015-12-23 2018-12-04 Intervet Int Bv processo aperfeiçoado para fabricação de crotonilaminopiridinas
AR111260A1 (es) 2017-03-31 2019-06-19 Intervet Int Bv Formulación farmacéutica de la sal de crotonil amino piridina
JP7292394B2 (ja) 2018-12-21 2023-06-16 サルティゴ・ゲーエムベーハー ２－アルコキシ－４－アミノ－５－メチル－ピリジン及び／又は２－アルコキシ－４－アルキルアミノ－５－メチル－ピリジンを調製するためのプロセス
JP7644121B2 (ja) 2019-12-18 2025-03-11 インターベット インターナショナル ベー． フェー． アザインドール構造を含む駆虫剤化合物
JOP20220160A1 (ar) 2019-12-20 2023-01-30 Nuevolution As مركبات فعّالة نحو مستقبلات نووية
EP4076657A1 (en) 2019-12-20 2022-10-26 Nuevolution A/S Compounds active towards nuclear receptors
CN110960485B (zh) * 2020-01-06 2021-02-02 安丘市人民医院 一种用于治疗角膜炎的药物及其制备方法
MX2022012260A (es) 2020-03-31 2022-11-30 Nuevolution As Compuestos activos frente a receptores nucleares.
MX2022012259A (es) 2020-03-31 2022-12-08 Nuevolution As Compuestos activos frente a receptores nucleares.
WO2025152919A1 (en) * 2024-01-15 2025-07-24 Impact Therapeutics (Shanghai) , Inc. Crystal forms of a weel inhibitor and preparation method thereof

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1131225A (en) * 1977-03-02 1982-09-07 Werner Muller Dyestuffs as affine residues
DE2709094C2 (de) * 1977-03-02 1984-11-22 Boehringer Mannheim Gmbh, 6800 Mannheim Adsorbens für die affinitätsspezifische Trennung von Nukleinsäuren, Verfahren zu seiner Herstellung und seine Verwendung
DE2758036A1 (de) * 1977-12-24 1979-07-05 Boehringer Mannheim Gmbh Adsorbens fuer die affinitaetsspezifische trennung von makromolekularen stoffen, verfahren zu seiner herstellung und seine verwendung
US5098462A (en) 1985-08-20 1992-03-24 Sandoz Ltd. Substituted semi-carbazones and related compounds
EP0539588A1 (en) 1990-07-05 1993-05-05 Nippon Soda Co., Ltd. Amine derivative
JP2986187B2 (ja) * 1990-08-31 1999-12-06 コニカ株式会社 感熱転写材料による画像形成方法
FR2683817B1 (fr) * 1991-11-18 1994-02-25 Upsa Laboratoires Nouveaux derives d'alpha-amino n-pyridyl benzene propanamide, leurs procedes de preparation, compositions pharmaceutiques les contenant.
US5399582A (en) 1993-11-01 1995-03-21 Merck & Co., Inc. Antiparasitic agents
US6221894B1 (en) 1995-03-20 2001-04-24 Merck & Co., Inc. Nodulisporic acid derivatives
US5595991A (en) 1995-03-20 1997-01-21 Merck & Co., Inc. Anthelmintic use of nodulisporic acid and analogs thereof
US5962499A (en) 1995-03-20 1999-10-05 Merck & Co., Inc. Nodulisporic acid derivatives
PL185563B1 (pl) 1995-03-20 2003-06-30 Merck & Co Inc Pochodne kwasu nodulisporowego oraz zawierające je kompozycje farmaceutyczne
AU1618697A (en) * 1996-02-06 1997-08-28 Japan Tobacco Inc. Novel compounds and pharmaceutical use thereof
DE19624659A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
DE19624668A1 (de) * 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
US5834260A (en) 1996-08-30 1998-11-10 Merck & Co., Inc. Antiparasitic agents
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
RU2325387C2 (ru) * 2001-12-21 2008-05-27 Анормед Инк. Гетероциклические соединения с повышенной эффективностью, связывающиеся с рецептором хемокина
TW200418863A (en) 2002-10-17 2004-10-01 Upjohn Co Novel anthelmintic and insecticidal compositions
KR100470076B1 (ko) 2002-11-27 2005-02-05 씨제이 주식회사 1,2,4-트리아졸 유도체, 그 제조방법 및 약제학적 조성물
WO2004052871A1 (ja) 2002-12-06 2004-06-24 Toray Industries, Inc. ベンゾモルホリン誘導体
WO2005066119A2 (en) 2003-12-31 2005-07-21 Schering-Plough Ltd. Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof
CA2551867C (en) 2003-12-31 2010-08-17 Schering-Plough Ltd. Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives
BRPI0508140B1 (pt) 2004-03-05 2015-03-17 Nissan Chemical Ind Ltd Composto benzamida substituída por isoxazolina da fórmula (1); da fórmula (2) substituído por 3,5-bis (aril substituído); da fórmula (4) substituída por alquinibenzeno ou um sal do mesmo; "pesticida, agroquímico, inseticida, parasiticida contendo como ingrediente ativo um ou mais composto benzamida substituída por isoxazolina e sal do mesmo"
WO2006010084A2 (en) * 2004-07-06 2006-01-26 Segev Laboratories Limited A system for delivering therapeutic agents into living cells and cell nuclei
CN101065352A (zh) 2004-09-23 2007-10-31 先灵-普劳有限公司 使用新的三氟甲磺酰苯胺肟醚衍生物控制动物中的寄生虫
DE602005017419D1 (de) 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
WO2006060461A1 (en) 2004-12-03 2006-06-08 Schering Corporation Substituted piperazines as cb1 antagonists
ES2515099T3 (es) * 2004-12-07 2014-10-29 Merial Limited 1-fenil-3-piperazin-pirazoles y composiciones pesticidas de los mismos
US20060147847A1 (en) * 2004-12-30 2006-07-06 Guire Patrick E Antimicrobial compositions and methods
WO2006105056A2 (en) * 2005-03-28 2006-10-05 Fmc Corporation Insecticidal 2,4-diaminoquinazolines and related derivatives
CN101180273A (zh) 2005-05-25 2008-05-14 惠氏公司 合成6-烷基氨基喹啉衍生物的方法
US20060281695A1 (en) 2005-06-09 2006-12-14 Schering-Plough Animal Health Corporation Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
ES2443690T3 (es) 2005-09-02 2014-02-20 Nissan Chemical Industries, Ltd. Compuesto de benzamida sustituido con isoxazolina y agente controlador de organismos dañinos
AU2006326449A1 (en) 2005-12-14 2007-06-21 E. I. Du Pont De Nemours And Company Isoxazolines for controlling invertebrate pests
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
DE602007006288D1 (de) 2006-03-10 2010-06-17 Nissan Chemical Ind Ltd Substituierte isoxazolin-verbindung und schädlingsbekämpfungsmittel
DE102006015470A1 (de) 2006-03-31 2007-10-04 Bayer Cropscience Ag Substituierte Enaminocarbonylverbindungen
EP2010506B1 (en) * 2006-04-20 2010-08-04 F. Hoffmann-La Roche AG Diazepan derivatives modulators of chemokine receptors
WO2007125984A1 (ja) 2006-04-28 2007-11-08 Nihon Nohyaku Co., Ltd. イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法
JP2008044880A (ja) 2006-08-15 2008-02-28 Bayer Cropscience Ag 殺虫性イソオキサゾリン類
DE102006039283A1 (de) 2006-08-22 2008-02-28 Henkel Kgaa Formfixierung faserhaltiger Materialien durch Polymere
EP1903038A1 (de) 2006-09-07 2008-03-26 Bayer Schering Pharma Aktiengesellschaft N-(1-Hetaryl-piperidin-4-yl)-(het)arylamide als EP2-Rezeptor Modulatoren
EP1900731A1 (de) 2006-09-07 2008-03-19 Bayer Schering Pharma Aktiengesellschaft N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren
US8372867B2 (en) 2007-04-10 2013-02-12 Bayer Cropscience Ag Insecticidal aryl isoxazoline derivatives
DE602008004650D1 (de) 2007-04-12 2011-03-03 Hoffmann La Roche Pyrimidinderivate als inhibitoren von phosphatidylinositol-3-kinase
TW200900398A (en) 2007-05-31 2009-01-01 Du Pont 3-cyano-4-triazolyl phenylisoxazoline invertebrate pest control agents
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
EP2957284B1 (en) 2007-06-27 2018-01-17 E. I. du Pont de Nemours and Company Animal pest control method
CA2700598C (en) 2007-08-10 2012-11-20 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent
JP5365806B2 (ja) 2007-09-10 2013-12-11 日産化学工業株式会社 置換イソキサゾリン化合物及び有害生物防除剤
AU2008308907B2 (en) 2007-10-03 2014-08-14 Corteva Agriscience Llc Naphthalene isoxazoline compounds for control of invertebrate pests
WO2009051956A2 (en) 2007-10-16 2009-04-23 E. I. Du Pont De Nemours And Company Pyrazole-substituted isoxazoline insecticides
CN101284812A (zh) * 2008-06-05 2008-10-15 中山大学 他克林-阿魏酸杂联体,其制备方法及其药物组合物
WO2010053517A2 (en) 2008-10-29 2010-05-14 Aroian Raffi V Combination therapy to combat helminth resistance
US8007761B2 (en) 2008-12-24 2011-08-30 Praxair Technology, Inc. Carbon dioxide emission reduction method

Also Published As

Publication number Publication date
KR101916481B1 (ko) 2018-11-07
JP5791725B2 (ja) 2015-10-07
PL2621903T3 (pl) 2017-08-31
NZ607580A (en) 2015-01-30
RU2596185C2 (ru) 2016-08-27
AR083200A1 (es) 2013-02-06
RU2013119681A (ru) 2014-11-10
CN105294549B (zh) 2017-12-26
CA2811369C (en) 2019-09-03
ES2622881T3 (es) 2017-07-07
CA2811369A1 (en) 2012-04-05
US20130196993A1 (en) 2013-08-01
CN103189356A (zh) 2013-07-03
CO6710926A2 (es) 2013-07-15
MX340985B (es) 2016-08-01
EP2621903B1 (en) 2017-03-01
KR20130139889A (ko) 2013-12-23
JP2014500235A (ja) 2014-01-09
BR112013006030A2 (pt) 2016-06-07
US8877934B2 (en) 2014-11-04
AU2011310592A1 (en) 2013-03-14
CN103189356B (zh) 2015-11-25
WO2012041873A1 (en) 2012-04-05
BR112013006030B1 (pt) 2020-03-17
MX2013003635A (es) 2013-05-22
AU2011310592B2 (en) 2015-01-22
EP2621903A1 (en) 2013-08-07
CN105294549A (zh) 2016-02-03

Similar Documents

Publication Publication Date Title
HUE034042T2 (en) N-Heteroaryl Compounds
EP2621923A1 (en) N-heteroaryl compounds with cyclic bridging unit for the treatment of parasitic diseases
JP2024037954A (ja) Ｒｉｐ１阻害化合物ならびにそれを作製および使用するための方法
KR102804113B1 (ko) 알킬 다이하이드로퀴놀린 설폰아마이드 화합물
AU2017248514B2 (en) Heteroaryl compounds with a-cyclic bridging unit
EP2739626B1 (en) Novel spiroindoline compounds
US9598412B2 (en) Spiroindoline compounds for use as anthelminthics
AU2013241854B2 (en) Heteroaryl compounds with cyclic bridging unit for use in the treatment helminth infection
US20130267536A1 (en) Substituted methyl amines, serotonin 5-ht6 receptor antagonists, methods for production and use thereof
JPS61197580A (ja) イミダゾリン化合物，その製法および除草剤