HUE033397T2 - Eljárás biciklikus vegyületek optikai szétválasztására enzimmel - Google Patents

Eljárás biciklikus vegyületek optikai szétválasztására enzimmel Download PDF

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Publication number
HUE033397T2
HUE033397T2 HUE13775061A HUE13775061A HUE033397T2 HU E033397 T2 HUE033397 T2 HU E033397T2 HU E13775061 A HUE13775061 A HU E13775061A HU E13775061 A HUE13775061 A HU E13775061A HU E033397 T2 HUE033397 T2 HU E033397T2
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HU
Hungary
Prior art keywords
formula
compound represented
die
hagy
formule
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HUE13775061A
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English (en)
Inventor
Yoshitaka Nakamura
Yukito Furuya
Kousei Shimada
Yoshiyuki Onishi
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Daiichi Sankyo Co Ltd
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Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of HUE033397T2 publication Critical patent/HUE033397T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (2)

  1. tea&h&dsligl ; igésiygegigk 1, £jpÁ képiéi (I) .sæe«a# '¥«^?SktrVStV' kègte) -CÎI) seengii vsgÿôl^iilMIIjlésât».
    b)
    «*> Sites! Ite Pbi export, sa élj ;teà\ gmâlissasa (1) msgeuggájtek a Régler (Il *?.enî?iî vegyéke es kcpte; fin yaensei \egude; keverekeneR. hegy re&pijg«: a küvcäka/dk jeterééteteee: ft) isskâktâs; vag y alkuból ífebldfogíííás;, (n) koerosm. êa {un hangya-vív vagy aïomte slys ékvagy gisàtes puller ôldaîb&p, hagy àiaiakuaea vagy képiéitel) s/enun vesyékse; a Régler (F) aaerisb \egyëk?te vagy a Régler (11) steerldg vagypleisi a képiéi (ΙΓ) sgeiéteii ypgyüteiie; vagy
    telteti R' kill saopoxî, la smlteo il) eteájasrlsuk a képle; ; I · aassiaíi vegyillalet a. képlet (111 sgariHii vegyàltefól vagy tevéiaseusk a képiéi Cíl) agerlgk yegyutetki a képiéi (I') aasrteb ve a vétetted, hogy a kép;ci Ili aééiipil yégyüteiei vagy >1 képiéi 111) ssmati vegylltere;. állítsak etek. .é< l.ijàîéï. kupiéi (l.i veerjott v«gÿfièl
    (I) g&amp;Oiéte éill >. seperi.
  2. .«2 ellátás. iamlpsagye (!) ipkgkíígpd|gk Régieséi) saerteg vegyidéi és a Régtet (ííl sseriiter vegygtertpeégi RéRéléRégdte kugy reag«i}oa a teovgiRasote jelentésébe se ; ' S*'. ' >i' >eJXi'M-\, VAoh'': sMs\ÍO\..v'i-ta \ Uä> ia's"4,''0i' »'s dli) hasxgyasso· vagy «mak vus és/vagy ghkôï pnHVr hogy x»«x»'>*utso&amp; ä k^pfex ikk sg;eï'n'iîs vegyüiettt a kép kn aIP) afttfintt vc$yälvif?
    ahol R* pl iïMp», és azután . '1 e!'--,:U!S"giik .s kv.'îi't {V xis-Hun vcyxoL'n-s ,¾ ká-fki <ΙΡ s.o»»««» 's-pynk'î’Ok Iktyi ,s kçinct yky^sb vcgysHexox iHK:.suk eib. jg 3 a<e !. vagy ?.. igértypx*«izeruaieljárás« alio! a felhasznált rolblta; xayy azaJkoho* oeîmlmg««**. SQM) rfkiiçH-Sômsgyàt^îxànî-v), ès s felimiasált koeozi»; oxk<>rxnwf«*<l adoain dmnkleoua (teAlï v:!ïk \ XHHs 4. s i 'nt'k "-»Jv*v . << {«a >x> ' sx "X- u'dxu. < isr ï *»' 5 vigysHîiÎ vagy >x kèykn ΠΠ s.íínsm vígykfcx ;vsgáí:Xs.S! dkhku, vxxsßhtxtndxM. béais jck-ntot'^ n. asnoox» ; p dküknxiíéa kftvet. I, % i~4. sgenvponk'k bárnk'lytke s^nnti sauras ahol a rcakok· a fcpésbwj 11 < hÖHMMkMexí van mogxaloskxa. 4 .\y i .5 }g<.'oypt»xix4 Unnn'lyike azerisns eljárás, ah·:;! a kp-seen Π) ;5 xxxsxiKtáz ' ''»>' v^s-s.» áehiórogsíiUk 4·····$ k^ssfk· mennyeiket:; van ídhasen.aiva képet !·0 kzstÄ ^fygfeiíe ex-VxIgy 4 ixx-yl«': ®Ö Ok vontík xxg'kko»' -X« ^·Χ"'ϊ..!ν s , e» * k\>v»n* 'X i'O's (.'ksmxk'xt' ménjükén χ-χμχ !, ' x --b-'xs- x>»χ í:í ϊb.ítt·:51x ΐί ana vonatkoztatva. % m w<. ;h§mel>iy *s«*fc*&amp; eljárás. ahol « Í»iyssav vagy istmk·· *$%&amp; .kalhsmthnnsát 8 V/ I v V v‘VO 's » I c- <iis v\ Xi H s'Î *<í S h I Ϊ ' ^ Ps tv P* ^ 'í'*4», '8 "M: fes»fái yiíffsr oklat koncwtvaek·,« SO mwA vagy nagyobb. íy A M. 4 "<'P' v « Orvhi\' * »'ont* »lj«as altok » tej*'' (-'i 4 ·-sí&amp;Ioíus sísvantxkxíM pxayäßsäy;Ä|dbi vagy Äa*atPPóik brktefe %t®tsf:stíA: 10 t »s ss' 11\ X s ,. í .m s s’\ s » <js s μ s oa*!1 s X ’ ‘ *s X' ‘ svf>völct tèH^?Jxâlàaâk aaiely 2-0. jg^ypon-ok bánnciylko s/^'nixs djànssssi vx» eU>sh«s:». * l' * ' ’-TvS·
    iîshsi! R ' sás?
HUE13775061A 2012-04-10 2013-04-08 Eljárás biciklikus vegyületek optikai szétválasztására enzimmel HUE033397T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012089481 2012-04-10

Publications (1)

Publication Number Publication Date
HUE033397T2 true HUE033397T2 (hu) 2017-12-28

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ID=49327629

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HUE13775061A HUE033397T2 (hu) 2012-04-10 2013-04-08 Eljárás biciklikus vegyületek optikai szétválasztására enzimmel

Country Status (14)

Country Link
US (1) US9394235B2 (hu)
EP (1) EP2837689B1 (hu)
JP (1) JP6023794B2 (hu)
KR (1) KR101976891B1 (hu)
CN (1) CN104245951B (hu)
BR (1) BR112014025158B1 (hu)
CA (1) CA2869994C (hu)
ES (1) ES2624314T3 (hu)
HK (1) HK1205192A1 (hu)
HU (1) HUE033397T2 (hu)
IL (1) IL235002B (hu)
IN (1) IN2014DN07923A (hu)
TW (1) TWI639702B (hu)
WO (1) WO2013154066A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI635071B (zh) * 2013-07-08 2018-09-11 第一三共股份有限公司 光學活性二環γ－胺基酸衍生物及其製造方法
JP6775009B2 (ja) * 2015-05-27 2020-10-28 ノヴァッセイ ソシエテ アノニムＮｏｖａｓｓａｙ Ｓａ ３−ビシクロ［３．２．０］ヘプ−３−エン−６オンエンの鏡像異性体の分離
CN116903468B (zh) * 2023-07-14 2024-01-26 山东新时代药业有限公司 一种米洛巴林中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60169434A (ja) * 1984-02-14 1985-09-02 Ube Ind Ltd 光学活性なビシクロケトン類の製法
TR200001170T2 (tr) 1997-10-27 2000-10-23 Warner-Lambert Company Farmasötik maddeler olarak faydalı siklo amino asitler ve bunların türevleri
HN2000000224A (es) 1999-10-20 2001-04-11 Warner Lambert Co Aminoacidos biciclicos como agentes farmaceuticos
PL366406A1 (en) 2001-04-19 2005-01-24 Warner-Lambert Company Llc Fused bicyclic or tricyclic amino acids
CA2492022A1 (en) 2002-07-11 2004-01-22 Merck & Co., Inc. Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds
MY172034A (en) 2007-09-28 2019-11-12 Daiichi Sankyo Co Ltd Intermediate for producing bicyclic ?-amino acid derivative
WO2010084798A1 (ja) * 2009-01-21 2010-07-29 第一三共株式会社 ３環性化合物
BRPI1013482B8 (pt) * 2009-03-26 2021-05-25 Daiichi Sankyo Co Ltd método para produzir um composto
CA2838651C (en) * 2011-06-08 2016-05-17 Daiichi Sankyo Company, Limited Method for producing bicyclic compound via claisen rearrangement
HUE037046T2 (hu) 2011-06-08 2018-08-28 Daiichi Sankyo Co Ltd Eljárás biciklusos vegyület elõállítására iminium són keresztül

Also Published As

Publication number Publication date
HK1205192A1 (en) 2015-12-11
KR101976891B1 (ko) 2019-05-09
CN104245951B (zh) 2018-08-24
KR20150004804A (ko) 2015-01-13
BR112014025158A2 (pt) 2017-07-18
TW201346036A (zh) 2013-11-16
EP2837689B1 (en) 2017-02-15
IN2014DN07923A (hu) 2015-05-01
EP2837689A4 (en) 2015-09-09
US9394235B2 (en) 2016-07-19
CN104245951A (zh) 2014-12-24
CA2869994A1 (en) 2013-10-17
EP2837689A1 (en) 2015-02-18
CA2869994C (en) 2017-05-30
BR112014025158B1 (pt) 2021-09-21
IL235002B (en) 2018-04-30
ES2624314T3 (es) 2017-07-13
WO2013154066A1 (ja) 2013-10-17
JPWO2013154066A1 (ja) 2015-12-17
US20150038738A1 (en) 2015-02-05
JP6023794B2 (ja) 2016-11-09
TWI639702B (zh) 2018-11-01

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