HUE037046T2 - Eljárás biciklusos vegyület elõállítására iminium són keresztül - Google Patents
Eljárás biciklusos vegyület elõállítására iminium són keresztülInfo
- Publication number
- HUE037046T2 HUE037046T2 HUE12796329A HUE12796329A HUE037046T2 HU E037046 T2 HUE037046 T2 HU E037046T2 HU E12796329 A HUE12796329 A HU E12796329A HU E12796329 A HUE12796329 A HU E12796329A HU E037046 T2 HUE037046 T2 HU E037046T2
- Authority
- HU
- Hungary
- Prior art keywords
- compound via
- bicyclic compound
- iminium salt
- producing bicyclic
- via iminium
- Prior art date
Links
- -1 bicyclic compound Chemical class 0.000 title 1
- 150000007975 iminium salts Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/48—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation involving decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/30—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having nitrogen atoms of imino groups quaternised
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/52—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition by dehydration and rearrangement involving two hydroxy groups in the same molecule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/417—Saturated compounds containing a keto group being part of a ring polycyclic
- C07C49/423—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system
- C07C49/427—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
- C07C49/433—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system having two rings the condensed ring system containing seven carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
- C07C51/38—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups by decarboxylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011127957 | 2011-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE037046T2 true HUE037046T2 (hu) | 2018-08-28 |
Family
ID=47296037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE12796329A HUE037046T2 (hu) | 2011-06-08 | 2012-06-05 | Eljárás biciklusos vegyület elõállítására iminium són keresztül |
Country Status (11)
Country | Link |
---|---|
US (1) | US9206104B2 (hu) |
EP (1) | EP2719676B1 (hu) |
JP (1) | JP5922118B2 (hu) |
KR (1) | KR101816336B1 (hu) |
CN (1) | CN103582622B (hu) |
BR (1) | BR112013031360B1 (hu) |
CA (1) | CA2838650C (hu) |
ES (1) | ES2659162T3 (hu) |
HU (1) | HUE037046T2 (hu) |
IL (1) | IL229800A (hu) |
WO (1) | WO2012169474A1 (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2719677B1 (en) * | 2011-06-08 | 2017-09-06 | Daiichi Sankyo Company, Limited | Method for producing bicyclic compound via claisen rearrangement |
CA2859003C (en) * | 2011-12-15 | 2016-11-01 | Daiichi Sankyo Company, Limited | Optical resolution method for bicyclic compound using asymmetric catalyst |
WO2013089189A1 (ja) * | 2011-12-16 | 2013-06-20 | 第一三共株式会社 | ヒドロキシスルホン酸を経由する二環性化合物の光学分割方法 |
CN104245951B (zh) * | 2012-04-10 | 2018-08-24 | 第一三共株式会社 | 使用酶对二环化合物光学拆分的方法 |
TWI635071B (zh) * | 2013-07-08 | 2018-09-11 | 第一三共股份有限公司 | 光學活性二環γ-胺基酸衍生物及其製造方法 |
CA2986954C (en) * | 2015-05-27 | 2023-06-27 | Novassay Sa | Separation of enantiomers of 3-ethylbicyclo[3.2.0]hept-3-en-6-one |
WO2017183539A1 (ja) * | 2016-04-18 | 2017-10-26 | 第一三共株式会社 | メルドラム酸を用いる二環性化合物の製造方法 |
CN114195661B (zh) * | 2021-12-21 | 2023-12-22 | 苏州楚凯药业有限公司 | 一种苯磺酸米洛巴林的制备方法 |
CN115745764B (zh) * | 2022-12-08 | 2024-03-12 | 重庆华森制药股份有限公司 | 一种米洛巴林中间体的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1250638B (it) * | 1991-07-04 | 1995-04-21 | Donegani Guido Ist | Procedimento per la preparazione di biciclo (3.2.0) ept-2-en-7-oni. |
SI1032555T1 (sl) | 1997-10-27 | 2006-08-31 | Warner Lambert Co | Ciklicne aminokisline in njihovi derivati, uporabni kot farmacevtska sredstva |
HN2000000224A (es) | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
DE60235619D1 (de) | 2001-04-19 | 2010-04-22 | Warner Lambert Co | Kondensierte bizyklische oder trizyklische aminosäuren |
JP2005536507A (ja) | 2002-07-11 | 2005-12-02 | メルク エンド カムパニー インコーポレーテッド | 6H−ピロロ[3,4−d]ピリダジン化合物による神経障害性疼痛の治療 |
PT2192109E (pt) * | 2007-09-28 | 2013-12-09 | Daiichi Sankyo Co Ltd | Derivado de -aminoácido bicíclico |
JP5336751B2 (ja) | 2007-12-12 | 2013-11-06 | 日東電工株式会社 | 液晶性コーティング液および偏光膜 |
WO2010084798A1 (ja) | 2009-01-21 | 2010-07-29 | 第一三共株式会社 | 3環性化合物 |
JP2010241796A (ja) * | 2009-03-17 | 2010-10-28 | Daiichi Sankyo Co Ltd | 二環性γ−アミノ酸誘導体含有医薬組成物 |
KR101674700B1 (ko) | 2009-03-26 | 2016-11-09 | 다이이찌 산쿄 가부시키가이샤 | 2고리성 γ-아미노산 유도체의 제조 방법 |
-
2012
- 2012-06-05 ES ES12796329.6T patent/ES2659162T3/es active Active
- 2012-06-05 CN CN201280027526.8A patent/CN103582622B/zh active Active
- 2012-06-05 BR BR112013031360-9A patent/BR112013031360B1/pt active IP Right Grant
- 2012-06-05 JP JP2013519489A patent/JP5922118B2/ja active Active
- 2012-06-05 KR KR1020137032256A patent/KR101816336B1/ko active IP Right Grant
- 2012-06-05 HU HUE12796329A patent/HUE037046T2/hu unknown
- 2012-06-05 WO PCT/JP2012/064415 patent/WO2012169474A1/ja active Application Filing
- 2012-06-05 CA CA2838650A patent/CA2838650C/en active Active
- 2012-06-05 EP EP12796329.6A patent/EP2719676B1/en active Active
-
2013
- 2013-12-05 IL IL229800A patent/IL229800A/en active IP Right Grant
- 2013-12-09 US US14/100,647 patent/US9206104B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US20140094624A1 (en) | 2014-04-03 |
CA2838650A1 (en) | 2012-12-13 |
US9206104B2 (en) | 2015-12-08 |
WO2012169474A1 (ja) | 2012-12-13 |
IL229800A (en) | 2017-06-29 |
CN103582622A (zh) | 2014-02-12 |
CA2838650C (en) | 2016-07-12 |
ES2659162T3 (es) | 2018-03-14 |
BR112013031360A2 (pt) | 2017-10-17 |
EP2719676B1 (en) | 2017-12-13 |
JP5922118B2 (ja) | 2016-05-24 |
EP2719676A1 (en) | 2014-04-16 |
EP2719676A4 (en) | 2015-03-11 |
BR112013031360B1 (pt) | 2022-01-25 |
KR101816336B1 (ko) | 2018-01-08 |
JPWO2012169474A1 (ja) | 2015-02-23 |
CN103582622B (zh) | 2015-06-10 |
KR20140041523A (ko) | 2014-04-04 |
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