HUE032197T2 - Synthetic and purification methods for phosphaplatin compounds and uses thereof - Google Patents
Synthetic and purification methods for phosphaplatin compounds and uses thereof Download PDFInfo
- Publication number
- HUE032197T2 HUE032197T2 HUE13793812A HUE13793812A HUE032197T2 HU E032197 T2 HUE032197 T2 HU E032197T2 HU E13793812 A HUE13793812 A HU E13793812A HU E13793812 A HUE13793812 A HU E13793812A HU E032197 T2 HUE032197 T2 HU E032197T2
- Authority
- HU
- Hungary
- Prior art keywords
- platinum
- complex
- dach
- reaction mixture
- pyrophosphate
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 130
- 150000001875 compounds Chemical class 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 238000000746 purification Methods 0.000 title claims abstract description 18
- 230000015572 biosynthetic process Effects 0.000 title description 22
- 238000003786 synthesis reaction Methods 0.000 title description 22
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 121
- 238000006243 chemical reaction Methods 0.000 claims description 70
- 239000011541 reaction mixture Substances 0.000 claims description 69
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 51
- 239000000203 mixture Substances 0.000 claims description 48
- 229910052697 platinum Inorganic materials 0.000 claims description 45
- ZZMFAAPZGBNYRP-UHFFFAOYSA-J phosphonato phosphate platinum(4+) Chemical compound [Pt+4].[O-]P([O-])(=O)OP([O-])([O-])=O ZZMFAAPZGBNYRP-UHFFFAOYSA-J 0.000 claims description 42
- 230000008569 process Effects 0.000 claims description 40
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 39
- 239000002244 precipitate Substances 0.000 claims description 37
- -1 aliphatic amines Chemical class 0.000 claims description 36
- 229910017604 nitric acid Inorganic materials 0.000 claims description 35
- 235000011180 diphosphates Nutrition 0.000 claims description 31
- 229940048084 pyrophosphate Drugs 0.000 claims description 30
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- 238000003756 stirring Methods 0.000 claims description 24
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- 238000002955 isolation Methods 0.000 description 16
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- VZWGHDYJGOMEKT-UHFFFAOYSA-J sodium pyrophosphate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O VZWGHDYJGOMEKT-UHFFFAOYSA-J 0.000 description 12
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- 238000000113 differential scanning calorimetry Methods 0.000 description 1
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- NDBYXKQCPYUOMI-UHFFFAOYSA-N platinum(4+) Chemical compound [Pt+4] NDBYXKQCPYUOMI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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| US201261651200P | 2012-05-24 | 2012-05-24 |
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| HUE16203851A HUE046327T2 (hu) | 2012-05-24 | 2013-03-15 | Tisztítási eljárás foszfaplatin vegyületekhez |
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| WO2013176764A1 (en) * | 2012-05-24 | 2013-11-28 | Phosplatin Therapeutics Llc | Synthetic and purification methods for phosphaplatin compounds and uses thereof |
| CN109310663B (zh) * | 2016-04-06 | 2022-05-31 | 弗斯普拉廷治疗有限公司 | 磷铂液体制剂 |
| US10668080B2 (en) | 2017-01-06 | 2020-06-02 | Phosplatin Therapeutics Llc | Phosphaplatin compounds as therapeutic agents for treatment of bone or blood cancers |
| EP3679046B1 (en) * | 2017-09-08 | 2023-11-08 | Promontory Therapeutics Inc. | Phosphaplatin compounds as immuno-modulatory agents and therapeutic uses thereof |
| CN113861036B (zh) * | 2021-11-08 | 2024-04-02 | 合肥工业大学 | 一种乙二胺高氯酸铜配合物的制备及用途 |
| US11673904B1 (en) | 2021-12-09 | 2023-06-13 | L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude | Low pressure process for synthesis of Pt(PF3)4 involving a soluble intermediate and storage of obtained Pt(PF3)4 |
| CN119822568B (zh) * | 2025-02-19 | 2025-08-19 | 扬州宏鑫环保科技有限公司 | 一种高效纯化水制备装置及制备方法 |
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| US4234500A (en) * | 1979-03-07 | 1980-11-18 | Engelhard Minerals & Chemicals Corporation | Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes |
| CA2530279A1 (en) | 2003-06-27 | 2005-01-06 | Akira Odani | Bisphosphonate complexes |
| JP2009525273A (ja) * | 2006-01-30 | 2009-07-09 | プラットコー テクノロジーズ （プロプライエタリー） リミテッド | 白金（ｉｉ）錯体の調製 |
| JP5489988B2 (ja) * | 2007-05-18 | 2014-05-14 | Ｔｔｉ・エルビュー株式会社 | 有効成分の生体界面への改善された放出を確保する経皮送達装置 |
| CN101801369B (zh) | 2007-08-06 | 2012-09-19 | 俄亥俄大学 | 磷铂及其在治疗顺铂和卡铂耐药性癌中的用途 |
| EP2575802B1 (en) * | 2010-06-04 | 2016-11-16 | Ohio University | Phosphaplatins and their use for treatment of cancers |
| US9012669B2 (en) * | 2011-10-05 | 2015-04-21 | The University Of Houston System | Efficient processes for large scale preparation of phosphaplatins antitumor agents |
| WO2013176764A1 (en) * | 2012-05-24 | 2013-11-28 | Phosplatin Therapeutics Llc | Synthetic and purification methods for phosphaplatin compounds and uses thereof |
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