HUE032165T2 - N-actil-béta-alanin alkalmazásának módjai - Google Patents
N-actil-béta-alanin alkalmazásának módjai Download PDFInfo
- Publication number
- HUE032165T2 HUE032165T2 HUE12771428A HUE12771428A HUE032165T2 HU E032165 T2 HUE032165 T2 HU E032165T2 HU E12771428 A HUE12771428 A HU E12771428A HU E12771428 A HUE12771428 A HU E12771428A HU E032165 T2 HUE032165 T2 HU E032165T2
- Authority
- HU
- Hungary
- Prior art keywords
- alanine
- beta
- acetyl
- beta alanine
- aktiv
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 26
- LJLLAWRMBZNPMO-UHFFFAOYSA-M N-acetyl-beta-alaninate Chemical compound CC(=O)NCCC([O-])=O LJLLAWRMBZNPMO-UHFFFAOYSA-M 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 claims abstract description 30
- 238000010521 absorption reaction Methods 0.000 claims abstract description 18
- 230000008569 process Effects 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 claims description 3
- 230000017531 blood circulation Effects 0.000 claims 1
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract description 191
- 229940000635 beta-alanine Drugs 0.000 abstract description 92
- 239000000203 mixture Substances 0.000 abstract description 72
- 208000035824 paresthesia Diseases 0.000 abstract description 26
- 241000282414 Homo sapiens Species 0.000 abstract description 20
- 230000001965 increasing effect Effects 0.000 abstract description 18
- 238000009792 diffusion process Methods 0.000 abstract description 15
- 210000004369 blood Anatomy 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 10
- 210000000170 cell membrane Anatomy 0.000 abstract description 10
- 230000035699 permeability Effects 0.000 abstract description 10
- 230000009056 active transport Effects 0.000 abstract description 8
- 230000037147 athletic performance Effects 0.000 abstract description 8
- LJLLAWRMBZNPMO-UHFFFAOYSA-N N-acetyl-beta-alanine Chemical compound CC(=O)NCCC(O)=O LJLLAWRMBZNPMO-UHFFFAOYSA-N 0.000 description 82
- 230000009469 supplementation Effects 0.000 description 25
- 108010087806 Carnosine Proteins 0.000 description 24
- 229940044199 carnosine Drugs 0.000 description 24
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 23
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 23
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 23
- 239000000654 additive Substances 0.000 description 22
- 239000000126 substance Substances 0.000 description 21
- -1 vapor Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 20
- 150000001875 compounds Chemical class 0.000 description 17
- 238000004519 manufacturing process Methods 0.000 description 17
- 210000003205 muscle Anatomy 0.000 description 17
- 239000002904 solvent Substances 0.000 description 17
- 239000003826 tablet Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 14
- 230000003712 anti-aging effect Effects 0.000 description 11
- 108090000790 Enzymes Proteins 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 10
- 239000011230 binding agent Substances 0.000 description 10
- 229940060367 inert ingredients Drugs 0.000 description 10
- 241000282412 Homo Species 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 238000012549 training Methods 0.000 description 9
- 206010067484 Adverse reaction Diseases 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000002552 dosage form Substances 0.000 description 8
- 230000032258 transport Effects 0.000 description 8
- 230000000996 additive effect Effects 0.000 description 7
- 229960003767 alanine Drugs 0.000 description 7
- 230000008901 benefit Effects 0.000 description 7
- 229920002678 cellulose Polymers 0.000 description 7
- 235000010980 cellulose Nutrition 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 239000000470 constituent Substances 0.000 description 7
- 230000003387 muscular Effects 0.000 description 7
- 230000008499 blood brain barrier function Effects 0.000 description 6
- 210000001218 blood-brain barrier Anatomy 0.000 description 6
- 239000001913 cellulose Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000013589 supplement Substances 0.000 description 6
- 208000010444 Acidosis Diseases 0.000 description 5
- 230000007950 acidosis Effects 0.000 description 5
- 208000026545 acidosis disease Diseases 0.000 description 5
- 229940024606 amino acid Drugs 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 239000000314 lubricant Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 235000014268 sports nutrition Nutrition 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 150000001408 amides Chemical class 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 230000000949 anxiolytic effect Effects 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 230000001351 cycling effect Effects 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 235000005911 diet Nutrition 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 230000004060 metabolic process Effects 0.000 description 4
- 230000002232 neuromuscular Effects 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 108030006799 N-acetyl-beta-alanine deacetylases Proteins 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000006172 buffering agent Substances 0.000 description 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 235000015872 dietary supplement Nutrition 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 235000019359 magnesium stearate Nutrition 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 230000037078 sports performance Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- OIVLITBTBDPEFK-UHFFFAOYSA-N 5,6-dihydrouracil Chemical compound O=C1CCNC(=O)N1 OIVLITBTBDPEFK-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- 229920002785 Croscarmellose sodium Polymers 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 2
- 239000004606 Fillers/Extenders Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 125000003047 N-acetyl group Chemical group 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 239000007767 bonding agent Substances 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 229940105329 carboxymethylcellulose Drugs 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 239000002577 cryoprotective agent Substances 0.000 description 2
- 230000006196 deacetylation Effects 0.000 description 2
- 238000003381 deacetylation reaction Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000002270 ergogenic effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000008240 homogeneous mixture Substances 0.000 description 2
- 230000003054 hormonal effect Effects 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000012216 imaging agent Substances 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 210000000663 muscle cell Anatomy 0.000 description 2
- 230000001722 neurochemical effect Effects 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- MBSCHHMCRIMBDZ-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid;nitric acid Chemical compound O[N+]([O-])=O.NC(=N)N(C)CC(O)=O MBSCHHMCRIMBDZ-UHFFFAOYSA-N 0.000 description 1
- NKDFYOWSKOHCCO-YPVLXUMRSA-N 20-hydroxyecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)(O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 NKDFYOWSKOHCCO-YPVLXUMRSA-N 0.000 description 1
- HXWZQRICWSADMH-SEHXZECUSA-N 20-hydroxyecdysone Natural products CC(C)(C)CC[C@@H](O)[C@@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C HXWZQRICWSADMH-SEHXZECUSA-N 0.000 description 1
- BTKUVAFAEJMOIG-UHFFFAOYSA-N 3-(butylazaniumyl)propanoate Chemical compound CCCCNCCC(O)=O BTKUVAFAEJMOIG-UHFFFAOYSA-N 0.000 description 1
- 229960000549 4-dimethylaminophenol Drugs 0.000 description 1
- 102000004092 Amidohydrolases Human genes 0.000 description 1
- 108090000531 Amidohydrolases Proteins 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 108010085443 Anserine Proteins 0.000 description 1
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- DCEFCUHVANGEOE-UHFFFAOYSA-N Ecdysterone Natural products CC(CC(C)(C)O)C(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C DCEFCUHVANGEOE-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 206010028289 Muscle atrophy Diseases 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- 208000029549 Muscle injury Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 241000210053 Potentilla elegans Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 229930003571 Vitamin B5 Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000007172 age related pathology Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 description 1
- 230000008503 anti depressant like effect Effects 0.000 description 1
- 230000002448 anti-glycating effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229940086704 ascorbic acid 200 mg Drugs 0.000 description 1
- 230000000386 athletic effect Effects 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001576 beta-amino acids Chemical class 0.000 description 1
- NKDFYOWSKOHCCO-UHFFFAOYSA-N beta-ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C)(O)C(O)CCC(C)(O)C)CCC33O)C)C3=CC(=O)C21 NKDFYOWSKOHCCO-UHFFFAOYSA-N 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960002079 calcium pantothenate Drugs 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000007942 carboxylates Chemical group 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 1
- 239000005516 coenzyme A Substances 0.000 description 1
- 229940093530 coenzyme a Drugs 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 229960005168 croscarmellose Drugs 0.000 description 1
- 229960001681 croscarmellose sodium Drugs 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000003826 endocrine responses Effects 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000006266 etherification reaction Methods 0.000 description 1
- FYEUHDBLBXQIOV-UHFFFAOYSA-N ethyl 3-acetamidopropanoate Chemical compound CCOC(=O)CCNC(C)=O FYEUHDBLBXQIOV-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- LRBQNJMCXXYXIU-QWKBTXIPSA-N gallotannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@H]2[C@@H]([C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-QWKBTXIPSA-N 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 230000003189 isokinetic effect Effects 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 235000019136 lipoic acid Nutrition 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- FDIFXCFYMLCGNA-UHFFFAOYSA-N methyl 3-acetamidopropanoate Chemical compound COC(=O)CCNC(C)=O FDIFXCFYMLCGNA-UHFFFAOYSA-N 0.000 description 1
- 229960002900 methylcellulose Drugs 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 201000000585 muscular atrophy Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 230000003961 neuronal insult Effects 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000005453 pelletization Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000012254 powdered material Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000024977 response to activity Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000005563 spheronization Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000009492 vitamin B5 Nutrition 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (5)
1. KisÂêay sdslblipás äääs â|{s$ip:«^8lUKény tokox&sâba*» arsely kmkméîsv N-acefib >X m da'xo h.*'C' isxnsx «s*ÿs s 5 vrt&föxeva v*dkd fö'ps rsv.
VkhdMPm p««"< >«dr ''U> S Κ.ΛΐίΜχΜνίοΐ! π « '“î'î vdoP* w Mid*,; -^;· dk'Ukv^ <eM'‘kxi\x MoM^nty ;xx kïk hog> srd· psmrrédát okozna.
3. Késx«inên^.à»ely bföaedtl^m'Siläsu· £y%v*saat«ag kaâsos fnemayisé&iH tæn&Èma&ïa, gyógy v.3r-k<-ot történő alk&ÎHî&Âra bë?&-akn«> abszorpciójának és. s<sJlîOômbréô^ïnj«sà>iiit&iàRâk Elativ őiíföztö #·. mr< rraoszport áftaK »oráéáföm, e/à&é ewberbôa è< állasbanm. Mmlsljexhnföny foko^lsáM« andkól feogy tî^ilé^s^M«ïii:|^ïeÂaiàî ok>»»&.
4. N«açenbbèta»aten gyégys.;«îrkàni rörtöaő föMmasások * kövsrtkozfc törőprás ésA-agy n*g«i&xâ toc-Msrsí fsssziv dlfei /aktiv b&sszpM ékstL MpsMo Mta-aianm «Μχοφοΐό *K »«jtmmbrân-pettÂIfl!^· ®?J'tthi Viharban és áliátbsa m &ömt«|sslímá5y àitessâss s«éÉils 'S^::ï»eHèkhs{àskêm'.^ô^é okozrur
5. Eljárás b&a-alsma absytfrpcsőjaaaL & &ej^«mbràa»p»rm«!ôbiiiütsà»éâ£' jpassaâv- bílEMás ás akov irm%zpun âh&h ibküæâsâra« c^âiiai emberben «s âttetba« aEsHkus^ports^EestoÄfs^liteisa· saîslkib bogy mclk-i.hnuWkéet p^osatöziát öksabas .'.ta* ,t <!.-' I so' ' ïi.'\ sag' áihí'vK iibiâssIra^ïîÿpxïsElly Mbb5p1;sk||ks;:&lfj|a gy|gy§gs«iÍ3g: InUákony ^enayíségd íá^Sííöiá^k:#í^%·· bcis jelenlévő hem-danln fök-idkiejének dVdeVbeí· íbrídfö dkdnnmáxrce esábd enn-erben es állatban ez <' kljpsl \ Λ' ím l u‘‘ I > V ' <A' >. i X v k Sf 'kv ti '% bj <& „írbbota'S'amn g\og\ayufc»b»t törv v> tkaH^a^fa, .*s.<aráía»ib«n. jéjéktáy'é: bébiyakágh : föléseudvbéod; »uaeiése terápiás éV vsgy taagalözd kezdésben. e rábai emKroeí· e\> à! Un ban -tr s^^ivbesk' óíépy íbbüéása anélkül, hogy nKdkíkhaíáshéoí parészîézüî nkczna B. Eljárás véráramba«! jelenlévő báts-sMm föléld ideiéi növelésére, erálta! emberben és aïïaîban sa gEÄwsporsteljesifmdky ft^|[S5i ^8ÍMUkb^»lfö^a»á5ként arn^Jy magábaa h>gkdj» N*acehi-bek>-tdanin ha(ûs«s πκίϊλχ i;-.-.ígáoek hissbSsd a.-: «»sbersíík vagy áüatsrnk.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161475179P | 2011-04-13 | 2011-04-13 | |
US13/446,416 US8802731B2 (en) | 2011-04-13 | 2012-04-13 | N-acetyl beta alanine methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE032165T2 true HUE032165T2 (hu) | 2017-09-28 |
Family
ID=47006851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE12771428A HUE032165T2 (hu) | 2011-04-13 | 2012-04-13 | N-actil-béta-alanin alkalmazásának módjai |
Country Status (8)
Country | Link |
---|---|
US (3) | US8802731B2 (hu) |
EP (1) | EP2696865B1 (hu) |
AU (1) | AU2012242565B2 (hu) |
CA (1) | CA2833159C (hu) |
HU (1) | HUE032165T2 (hu) |
PL (1) | PL2696865T3 (hu) |
WO (1) | WO2012142474A2 (hu) |
ZA (1) | ZA201308467B (hu) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2903000C (en) | 2013-01-28 | 2021-10-12 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor |
Family Cites Families (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1916983A (en) | 1933-07-04 | Gas bubneb | ||
US2176144A (en) | 1939-02-04 | 1939-10-17 | Corn Prod Refining Co | Method of curing meat |
US2553533A (en) | 1950-06-17 | 1951-05-15 | Griffith Laboratories | Curing process for bacon |
US3230036A (en) | 1963-09-18 | 1966-01-18 | Frederick A Kappelmann | Method for separating americium and curium from the lanthanide rare earths and yttrium |
IL25140A (en) | 1965-02-15 | 1970-01-29 | Vaessen Schoemaker Holding Bv | Additives and methods for improving the quality of protein containing nutrients |
DK119643C (da) | 1965-04-12 | 1978-03-13 | Ajinomoto Kk | Middel til behandling af kod,fortrinsvis i ra tilstand,til forbedring af dets saftighed,farve og morhed |
US3997659A (en) | 1971-03-30 | 1976-12-14 | The Procter & Gamble Company | Hair bleaching compositions containing an arginine compound |
JPS531832B2 (hu) | 1972-07-03 | 1978-01-23 | ||
US4113715A (en) | 1977-01-17 | 1978-09-12 | E. R. Squibb & Sons, Inc. | Amino acid derivatives |
IE51711B1 (en) | 1977-11-03 | 1987-03-04 | Sigma Tau Ind Farmaceuti | Carnitine derivatives |
US4379177A (en) | 1979-07-05 | 1983-04-05 | The Procter & Gamble Company | Stable dehydrated cocrystalline amino acid food additives |
US4687782A (en) | 1984-12-10 | 1987-08-18 | Nutri-Fuels Systems, Inc. | Nutritional composition for enhancing skeletal muscle adaptation to exercise training |
AU5410786A (en) | 1985-03-04 | 1986-09-11 | Fujisawa Pharmaceutical Co., Ltd. | Amino acid derivatives and processes for preparation thereof |
US4871550A (en) | 1986-09-05 | 1989-10-03 | Millman Phillip L | Nutrient composition for athletes and method of making and using the same |
IL80783A0 (en) | 1986-10-17 | 1987-02-27 | Univ Bar Ilan | Food supplements |
EP0351760B1 (en) | 1988-07-19 | 1994-12-28 | Mitsubishi Kasei Corporation | Feed additive for ruminants |
US5026721A (en) | 1989-06-05 | 1991-06-25 | Dudrick Stanley J | Amino acid nutritional supplement and regimen for enhancing physical performance through sound nutrition |
US5576351A (en) | 1989-12-29 | 1996-11-19 | Mcgaw, Inc. | Use of arginine as an immunostimulator |
US6451341B1 (en) | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
US5026071A (en) | 1990-03-05 | 1991-06-25 | Miraglia Jr Humbert G | Word game |
CN1049824A (zh) | 1990-03-25 | 1991-03-13 | 何森 | 水彩笔芯 |
CN1022456C (zh) | 1990-05-04 | 1993-10-20 | 师春生 | 一种高能营养滋补饮料的制造方法 |
US5242697A (en) | 1990-10-26 | 1993-09-07 | Maurizio Luca | Method of preparing nutrified food products |
DE4125400C2 (de) | 1991-07-31 | 2000-08-17 | Edwin Klaus | Verwendung von unlöslichem Kollagen zur Behandlung von degenerativen, nicht entzündlichen Gelenkprozessen |
US6608109B2 (en) | 1991-11-20 | 2003-08-19 | Allen Ann De Wees | Composition comprising L-arginine as a muscle growth stimulant and use thereof |
DE4222980A1 (de) | 1992-07-13 | 1994-01-20 | Cassella Ag | Verwendung von 2-(N-(2-Aminoethyl)amino)-essigsäure-derivaten |
US5631031A (en) | 1994-06-13 | 1997-05-20 | Meade; Thomas L. | Water-insoluble amino acid salt |
US6239172B1 (en) | 1997-04-10 | 2001-05-29 | Nitrosystems, Inc. | Formulations for treating disease and methods of using same |
US20110196039A9 (en) | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
US5543430A (en) | 1994-10-05 | 1996-08-06 | Kaesemeyer; W. H. | Method and formulation of stimulating nitric oxide synthesis |
DE19539574A1 (de) | 1995-10-25 | 1997-04-30 | Boehringer Mannheim Gmbh | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
US5965596A (en) | 1997-08-12 | 1999-10-12 | Harris; Roger | Methods and compositions for increasing the anaerobic working capacity in tissue |
IT1291127B1 (it) | 1997-04-01 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica |
IT1291134B1 (it) | 1997-04-08 | 1998-12-29 | Sigma Tau Ind Farmaceuti | Composizioni solide atte alla somministrazione orale comprendenti una alcanoil l-carnitina magnesio citrato |
US20010002269A1 (en) | 1997-05-06 | 2001-05-31 | Zhao Iris Ginron | Multi-phase food & beverage |
DK176196B1 (da) | 1997-10-07 | 2007-01-08 | Ejvind Jersie Pedersen | Mundhygejnepræparat til behandling af halitosis samt anvendelse af et chelat omfattende en metaliondel og en aminosyredel som en komponent i præparatet |
US5904924A (en) | 1997-11-04 | 1999-05-18 | Oncologics, Inc. | Green nutritional powder composition |
US6063432A (en) | 1998-05-19 | 2000-05-16 | Cooke Pharma | Arginine or lysine containing fruit healthbar formulation |
US6277884B1 (en) | 1998-06-01 | 2001-08-21 | Nitromed, Inc. | Treatment of sexual dysfunction with N-hydroxyguanidine compounds |
US6136339A (en) | 1998-08-21 | 2000-10-24 | Gardiner; Paul T. | Food supplements and methods comprising lipoic acid and creatine |
US6159485A (en) * | 1999-01-08 | 2000-12-12 | Yugenic Limited Partnership | N-acetyl aldosamines, n-acetylamino acids and related n-acetyl compounds and their topical use |
US20020119933A1 (en) | 2000-07-28 | 2002-08-29 | Butler Terri L. | Compositions and methods for improving cardiovascular function |
WO2000069470A2 (en) | 1999-05-17 | 2000-11-23 | Aesgen, Inc. | Improved cellular uptake of bioactive agents |
GB2354441A (en) | 1999-08-06 | 2001-03-28 | Mccormack Ltd | Composition for treating dentine hypersensitivity |
US6562869B1 (en) | 1999-09-23 | 2003-05-13 | Juvenon, Inc. | Nutritional supplement for increased energy and stamina |
US6784209B1 (en) | 1999-10-18 | 2004-08-31 | Muscletech Research And Development Inc. | Food supplement for increasing lean mass and strength |
US7235237B2 (en) | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
IL149907A0 (en) | 1999-12-16 | 2002-11-10 | Mark Nutritionals Inc | Nutritional composition, methods of producing said composition and methods of using said composition |
US20020006532A1 (en) | 2000-04-26 | 2002-01-17 | Arnaud Robin | Bonded LTD-resistant zirconia dental components |
US6812215B2 (en) | 2000-06-02 | 2004-11-02 | MERCK Patent Gesellschaft mit beschränkter Haftung | Compositions for the treatment of inflammatory joint diseases and osteoporosis |
WO2001095897A1 (en) | 2000-06-15 | 2001-12-20 | University Of Kentucky Research Foundation | Agmatine and agmatine analogs in the treatment of epilepsy, seizure, and electroconvulsive disorders |
US20020176881A1 (en) | 2001-01-26 | 2002-11-28 | George Verlaan | Rehydration composition |
US6859771B2 (en) | 2001-04-23 | 2005-02-22 | Microsoft Corporation | System and method for identifying base noun phrases |
US20040097401A1 (en) | 2002-11-14 | 2004-05-20 | Debatosh Datta | Lysine in therapeutic angiogenesis, particularly in treating ischaemic conditions |
ITRM20010445A1 (it) | 2001-07-25 | 2003-01-27 | Sigma Tau Healthscience Spa | Alfa-chetoglutarati di principi attivi e composizioni che li contengono. |
US7740878B2 (en) | 2001-10-22 | 2010-06-22 | Danisco A/S | Use of betaine to enhance exercise performance |
US7054925B2 (en) | 2001-11-21 | 2006-05-30 | International Business Machines Corporation | Efficient method for determining record based I/O on top of streaming protocols |
WO2003063789A2 (en) | 2002-01-30 | 2003-08-07 | House Ear Institute | L-carnitine for treatment of hearing loss |
EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
US20040057926A1 (en) | 2002-03-12 | 2004-03-25 | Lsu Medical Center | Modulation of the immune response through the manipulation of arginine levels |
EP1567180A4 (en) | 2002-06-04 | 2010-03-10 | Avicena Group Inc | METHODS OF TREATING COGNITIVE DYSFUNCTIONS BY MODULATING BRAIN ENERGY METABOLISM |
GB0220182D0 (en) | 2002-08-30 | 2002-10-09 | Cardiovascular Res Inst Maastr | Organic compounds |
WO2005035001A1 (en) | 2003-09-29 | 2005-04-21 | Enos Pharmaceuticals, Inc. | Sustained release l-arginine formulations and methods of manufacture and use |
KR20050083827A (ko) | 2002-10-24 | 2005-08-26 | 이노스 파마슈티칼스, 인코포레이티드 | 서방성 l-아르기닌 포뮬레이션 및 이의 제조방법 및 용도 |
US20050288373A1 (en) | 2002-10-24 | 2005-12-29 | Ron Eyal S | Methods of treating various conditions by administration of sustained release L-arginine |
US20060029668A1 (en) | 2002-10-24 | 2006-02-09 | Ron Eyal S | Sustained release L-arginine formulations and methods of manufacture and use |
US7186692B2 (en) * | 2002-12-17 | 2007-03-06 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity |
DE60332163D1 (de) | 2002-12-27 | 2010-05-27 | Daiichi Sankyo Healthcare Co | Zusammensetzung zur hautaufhellung |
JPWO2004064866A1 (ja) * | 2003-01-20 | 2006-05-18 | イノヴェイティブ ヴィジョン プロダクツ インコーポレーテッド | カルノシナーゼ阻害剤とl−カルノシン類との併用および組成物 |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
US20060063827A1 (en) * | 2004-09-23 | 2006-03-23 | Yu Ruey J | Systemic administration of therapeutic amino acids and N-acetylamino acids |
JP5564158B2 (ja) | 2003-07-09 | 2014-07-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 亜硝酸塩によって特定の心臓血管状態を処置する方法 |
US20050043274A1 (en) | 2003-08-22 | 2005-02-24 | Howard Murad | Pharmaceutical compositions and methods for lowering blood pressure and pulse rate |
US20050053673A1 (en) | 2003-09-05 | 2005-03-10 | Shrirang Netke | Composition and method for facilitating bone healing |
US20050136509A1 (en) | 2003-09-10 | 2005-06-23 | Bioimagene, Inc. | Method and system for quantitatively analyzing biological samples |
WO2005055947A2 (en) * | 2003-12-08 | 2005-06-23 | Yu Ruey J | Enlargement of mucocutaneous or cutaneous organs and sites with topical compositions |
WO2005062713A2 (en) | 2003-12-31 | 2005-07-14 | Yosi Shevach | Beta vulgaris-based products |
JP4813023B2 (ja) | 2004-03-03 | 2011-11-09 | 日本新薬株式会社 | 保健食品、及び薬剤 |
CA2564886A1 (en) | 2004-04-30 | 2005-11-17 | Pump Formulations, Ltd. | Nutritional composition for enhancing lean muscle stimulus, growth, strength and recovery, creating and prolonging intense muscle pumps, supporting endurance, strength, performance, size and stamina, providing a transducer effect for nitric oxide, increasing nutrient delivery and/or promoting increased vascular response in an individual |
GB0411985D0 (en) | 2004-05-28 | 2004-06-30 | Howard Foundation Holdings Ltd | Food compositions containing creatine |
US7362274B1 (en) | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
US7873012B2 (en) | 2004-07-26 | 2011-01-18 | Avaya Communication Israel Ltd. | Roaming wireless client communication |
CA2579032C (en) | 2004-09-02 | 2011-11-29 | Cosmo Oil Co., Ltd. | Use of an .delta.-amino acid as thymocyte growth agent |
CN1631539A (zh) | 2004-12-03 | 2005-06-29 | 北京大学 | 氨基酸盐离子液体及其制备方法 |
US20070141174A1 (en) | 2005-01-13 | 2007-06-21 | Navitas Pharma, Inc. | Enantiomeric compositions of cicletanine, in combination with other agents, for the treatment of hypertension |
CA2537647A1 (en) | 2005-03-01 | 2006-09-01 | Six Star Formulations Ltd. | Supplemental dietary composition for supporting muscle growth, recovery and strength |
WO2006127761A1 (en) | 2005-05-26 | 2006-11-30 | Pediatrix Medical Group, Inc. | Nutrition formulations and methods of providing nutrition formulations |
WO2007000985A1 (ja) | 2005-06-27 | 2007-01-04 | Kyowa Hakko Kogyo Co., Ltd. | ヘモグロビン尿症またはミオグロビン尿症の予防または治療用組成物 |
US20070105817A1 (en) | 2005-11-09 | 2007-05-10 | Jim Page | Use of cicletanine and other furopyridines for treatment of systolic-predominant hypertension, isolated systolic hypertension, elevated pulse pressure, and general hypertension |
CN101340905B (zh) | 2005-12-05 | 2012-05-16 | 协和发酵生化株式会社 | 用于防止或改善皮肤干燥的口服制剂 |
EP1889625A1 (en) | 2006-07-17 | 2008-02-20 | Pharmaton S.A. | Dietary supplement for supporting mental and physical performance |
CA2609626A1 (en) | 2006-12-06 | 2008-02-05 | H3 Formulations Ltd. | Composition comprising l-arginine, crataegus, artichoke flavonoids and citruilline for improving blood flow in working muscles |
EP2114417A4 (en) | 2007-02-26 | 2014-04-02 | Heartbeet Ltd | NOVEL USE OF NITRATES AND NITRATES AND COMPOSITIONS COMPRISING THE SAME |
EP3159000A1 (en) | 2007-02-26 | 2017-04-26 | HeartBeet Ltd. | Performance enhancing composition |
US7850997B2 (en) | 2007-03-21 | 2010-12-14 | Tim Romero | Dietary compositions and methods of enhancing lean body mass and exercise performance |
EP1982604A1 (de) | 2007-04-20 | 2008-10-22 | Naturheilzentrum Allgäu | Nahrungsergänzungsmittel zum Ausgleich von Nährstoffmangel |
US8569369B2 (en) | 2007-09-18 | 2013-10-29 | Thermolife International, Llc | Amino acid compounds |
US8569368B2 (en) | 2007-09-18 | 2013-10-29 | Thermolife International, Llc | Amino acid compounds |
US7777074B2 (en) | 2007-09-18 | 2010-08-17 | Thermolife International, Llc | Amino acid compounds |
US8455531B2 (en) | 2007-09-18 | 2013-06-04 | Thermolife International, Llc | Amino acid compositions |
US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
US8048921B2 (en) | 2007-09-18 | 2011-11-01 | Ronald Kramer | Amino acid compounds |
US20090280199A1 (en) | 2007-11-01 | 2009-11-12 | Aaken Laboratories, Inc. | Neuroprotective Compositions and Methods of Using Same |
EP2303040A1 (en) | 2008-06-06 | 2011-04-06 | PhytoLab GmbH & Co. KG | Synergistic enhancement of cellular ergogenic nutrient uptake, like creatine or carnitine, with tarragon |
US8916612B2 (en) | 2008-09-11 | 2014-12-23 | Gad Gilad | Agmatine containing dietary supplements, nutraceuticals, and foods |
US8703719B1 (en) | 2009-05-18 | 2014-04-22 | Bio-Engineered Supplements And Nutrition, Inc. | Method and composition for improved muscle performance |
KR20110015141A (ko) | 2009-08-07 | 2011-02-15 | 주식회사 셀트리온제약 | 피페라진 다이티옥트산염 및 아세틸-l-카르니틴을 포함하는 약제학적 조성물 |
US20110064720A1 (en) | 2009-09-16 | 2011-03-17 | Daniel Moses Amato | Dietary Supplement Compositions and Methods of Making and Using the Same |
US9271983B2 (en) | 2010-03-26 | 2016-03-01 | Bioadatp, Llc | Composition for enhancing athletic performance |
GB2523578A (en) | 2014-02-28 | 2015-09-02 | Daniel Nelson | A nutritional supplement |
US10624921B2 (en) | 2016-11-15 | 2020-04-21 | Berkeley Nox Limited | Dietary supplements |
EP3975754A1 (en) | 2019-05-28 | 2022-04-06 | Mayo Foundation for Medical Education and Research | Nutritional health supplements |
-
2012
- 2012-04-13 US US13/446,416 patent/US8802731B2/en active Active
- 2012-04-13 AU AU2012242565A patent/AU2012242565B2/en active Active
- 2012-04-13 PL PL12771428T patent/PL2696865T3/pl unknown
- 2012-04-13 HU HUE12771428A patent/HUE032165T2/hu unknown
- 2012-04-13 EP EP12771428.5A patent/EP2696865B1/en active Active
- 2012-04-13 WO PCT/US2012/033610 patent/WO2012142474A2/en active Application Filing
- 2012-04-13 CA CA2833159A patent/CA2833159C/en active Active
-
2013
- 2013-11-11 ZA ZA2013/08467A patent/ZA201308467B/en unknown
-
2014
- 2014-08-11 US US14/456,680 patent/US20140350109A1/en not_active Abandoned
- 2014-08-11 US US14/456,637 patent/US11534419B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2012142474A3 (en) | 2012-12-27 |
AU2012242565B2 (en) | 2017-05-11 |
EP2696865A2 (en) | 2014-02-19 |
US8802731B2 (en) | 2014-08-12 |
ZA201308467B (en) | 2014-08-27 |
PL2696865T3 (pl) | 2017-07-31 |
US20140350108A1 (en) | 2014-11-27 |
US20140350109A1 (en) | 2014-11-27 |
CA2833159A1 (en) | 2012-10-18 |
AU2012242565A1 (en) | 2013-11-07 |
US11534419B2 (en) | 2022-12-27 |
WO2012142474A2 (en) | 2012-10-18 |
EP2696865A4 (en) | 2014-10-15 |
EP2696865B1 (en) | 2016-12-21 |
CA2833159C (en) | 2019-08-06 |
US20120264826A1 (en) | 2012-10-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6077305B2 (ja) | アミノ酸および植物を含む調製物およびアルコール解毒におけるその活性 | |
US20060269617A1 (en) | Supplement compositions and method of use for enhancement of insulin sensitivity | |
TWI517793B (zh) | Contains the composition of imidazole peptides and quercetin glycosides | |
CA2556305A1 (en) | Rapidly dissolving solid oral dosage form for delivery of composition for increasing nitric oxide activity | |
JPH11500725A (ja) | ピペリンのバイオアベイラビリティ増強剤としての使用 | |
WO2008134645A1 (en) | Compositions and approaches for increasing diet induced thermogenesis, inducing weight loss and maintaining muscles mass and strength | |
MX2010009015A (es) | Extracto de hojas de especie panax, proceso para hacer el mismo y usos del mismo. | |
JP6441825B2 (ja) | フィラーの効能維持用組成物 | |
US20080076721A1 (en) | Use of branched chain fatty acid amino acid salts and compositions thereof | |
JP4253296B2 (ja) | 健康美容食品 | |
US11534419B2 (en) | N-acetyl beta alanine methods of use | |
JP6196847B2 (ja) | 防已含有組成物 | |
AU2011300376B2 (en) | Ingredients derived from Sphaeranthus indicus | |
JP4011594B2 (ja) | 安定性及び生物学的利用率が高められた複合体及びその製造方法 | |
JP2009001507A (ja) | 体脂肪減少剤およびその利用 | |
AU2006347124B2 (en) | Composition for preventing and/or treating itching containing component originating in the bark of tree belonging to the genus Acacia | |
CA2878190A1 (en) | Pharmaceutical composition for reducing the trimethylamine n-oxide level | |
JP5294194B2 (ja) | 脳血管性認知症の治療薬 | |
JP2004018446A (ja) | 美肌用内服剤組成物 | |
JPWO2009110464A1 (ja) | 栄養改善用組成物 | |
WO2002069956A2 (en) | Use of carnitine for increasing testosteron |