HUE029966T2 - Formulations and methods for increasing iron absorption - Google Patents
Formulations and methods for increasing iron absorption Download PDFInfo
- Publication number
- HUE029966T2 HUE029966T2 HUE08861633A HUE08861633A HUE029966T2 HU E029966 T2 HUE029966 T2 HU E029966T2 HU E08861633 A HUE08861633 A HU E08861633A HU E08861633 A HUE08861633 A HU E08861633A HU E029966 T2 HUE029966 T2 HU E029966T2
- Authority
- HU
- Hungary
- Prior art keywords
- iron
- composition
- peptides
- animal
- human
- Prior art date
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 259
- 229910052742 iron Inorganic materials 0.000 title claims description 126
- 239000000203 mixture Substances 0.000 title claims description 99
- 238000010521 absorption reaction Methods 0.000 title description 29
- 238000000034 method Methods 0.000 title description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 70
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 62
- 241001465754 Metazoa Species 0.000 claims description 43
- 241000282414 Homo sapiens Species 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 230000029087 digestion Effects 0.000 claims description 10
- 239000003674 animal food additive Substances 0.000 claims description 8
- 235000005911 diet Nutrition 0.000 claims description 7
- 230000037213 diet Effects 0.000 claims description 7
- 208000035475 disorder Diseases 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 5
- 235000021323 fish oil Nutrition 0.000 claims description 5
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims description 3
- 239000013589 supplement Substances 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 2
- 208000019505 Deglutition disease Diseases 0.000 claims 1
- 206010019909 Hernia Diseases 0.000 claims 1
- 241000545744 Hirudinea Species 0.000 claims 1
- 206010000269 abscess Diseases 0.000 claims 1
- 235000015218 chewing gum Nutrition 0.000 claims 1
- 239000003349 gelling agent Substances 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 23
- 102000004169 proteins and genes Human genes 0.000 description 23
- 108090000623 proteins and genes Proteins 0.000 description 23
- 208000007502 anemia Diseases 0.000 description 21
- 102000004338 Transferrin Human genes 0.000 description 19
- 108090000901 Transferrin Proteins 0.000 description 19
- 230000037406 food intake Effects 0.000 description 18
- 239000012581 transferrin Substances 0.000 description 18
- 102000008857 Ferritin Human genes 0.000 description 17
- 108050000784 Ferritin Proteins 0.000 description 17
- 238000008416 Ferritin Methods 0.000 description 17
- 241000282472 Canis lupus familiaris Species 0.000 description 14
- 230000002950 deficient Effects 0.000 description 11
- 241000251468 Actinopterygii Species 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 10
- 235000019688 fish Nutrition 0.000 description 10
- 235000013305 food Nutrition 0.000 description 9
- 244000052769 pathogen Species 0.000 description 9
- 235000015872 dietary supplement Nutrition 0.000 description 8
- 241000972773 Aulopiformes Species 0.000 description 7
- 241000282412 Homo Species 0.000 description 7
- 238000003556 assay Methods 0.000 description 7
- 230000007071 enzymatic hydrolysis Effects 0.000 description 7
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 7
- 235000019515 salmon Nutrition 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 150000003278 haem Chemical class 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 241000607598 Vibrio Species 0.000 description 4
- 229940088598 enzyme Drugs 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 235000013372 meat Nutrition 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 229940119224 salmon oil Drugs 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- XMGJGSKRRWXOIF-UHFFFAOYSA-N 2-(azepan-1-yl)ethyl 2-cyclohexyl-2-thiophen-3-ylacetate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C1CCCCC1C(C1=CSC=C1)C(=O)OCCN1CCCCCC1 XMGJGSKRRWXOIF-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000005018 casein Substances 0.000 description 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 3
- 235000021240 caseins Nutrition 0.000 description 3
- 235000013330 chicken meat Nutrition 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000099 in vitro assay Methods 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 235000013594 poultry meat Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000700198 Cavia Species 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010022971 Iron Deficiencies Diseases 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108010009736 Protein Hydrolysates Proteins 0.000 description 2
- 102000005158 Subtilisins Human genes 0.000 description 2
- 108010056079 Subtilisins Proteins 0.000 description 2
- 208000022440 X-linked sideroblastic anemia 1 Diseases 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 235000020940 control diet Nutrition 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 208000037765 diseases and disorders Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229960001781 ferrous sulfate Drugs 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- -1 for instance Chemical compound 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 208000007475 hemolytic anemia Diseases 0.000 description 2
- 208000006278 hypochromic anemia Diseases 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000031891 intestinal absorption Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 2
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 108010009355 microbial metalloproteinases Proteins 0.000 description 2
- 244000000010 microbial pathogen Species 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 235000019629 palatability Nutrition 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000003531 protein hydrolysate Substances 0.000 description 2
- 230000007065 protein hydrolysis Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- XXDVUVPHJGZWQC-QHTZZOMLSA-L (2s)-2-amino-5-hydroxy-5-oxopentanoate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)[C@@H](N)CCC(O)=O.[O-]C(=O)[C@@H](N)CCC(O)=O XXDVUVPHJGZWQC-QHTZZOMLSA-L 0.000 description 1
- GDTWSDAEFQZUPS-UHFFFAOYSA-N 4-[[(3-aminonaphthalen-2-yl)amino]methyl]benzoic acid Chemical compound NC1=CC2=CC=CC=C2C=C1NCC1=CC=C(C(O)=O)C=C1 GDTWSDAEFQZUPS-UHFFFAOYSA-N 0.000 description 1
- 206010002065 Anaemia megaloblastic Diseases 0.000 description 1
- 206010002965 Aplasia pure red cell Diseases 0.000 description 1
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 241000195628 Chlorophyta Species 0.000 description 1
- 241000193155 Clostridium botulinum Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- 102000018389 Exopeptidases Human genes 0.000 description 1
- 108010091443 Exopeptidases Proteins 0.000 description 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 1
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 description 1
- 108010028690 Fish Proteins Proteins 0.000 description 1
- 101000766307 Gallus gallus Ovotransferrin Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010019902 Hereditary sideroblastic anaemia Diseases 0.000 description 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 1
- 102000008133 Iron-Binding Proteins Human genes 0.000 description 1
- 108010035210 Iron-Binding Proteins Proteins 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 241000316144 Macrodon ancylodon Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 108010070551 Meat Proteins Proteins 0.000 description 1
- 208000000682 Megaloblastic Anemia Diseases 0.000 description 1
- 206010027527 Microangiopathic haemolytic anaemia Diseases 0.000 description 1
- 208000036696 Microcytic anaemia Diseases 0.000 description 1
- 102000008934 Muscle Proteins Human genes 0.000 description 1
- 108010074084 Muscle Proteins Proteins 0.000 description 1
- 241000282339 Mustela Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108010019160 Pancreatin Proteins 0.000 description 1
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 208000031845 Pernicious anaemia Diseases 0.000 description 1
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 description 1
- 102000029797 Prion Human genes 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 241000277263 Salmo Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000277299 Salmoniformes Species 0.000 description 1
- 241001125046 Sardina pilchardus Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 206010047400 Vibrio infections Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 241000607447 Yersinia enterocolitica Species 0.000 description 1
- 241000607477 Yersinia pseudotuberculosis Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037037 animal physiology Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000011942 biocatalyst Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- MDXRFOWKIZPNTA-UHFFFAOYSA-L butanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)CCC([O-])=O MDXRFOWKIZPNTA-UHFFFAOYSA-L 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- IVLSEFOVPQFJBB-UHFFFAOYSA-L disodium;5-[3-pyridin-2-yl-6-(5-sulfonatofuran-2-yl)-1,2,4-triazin-5-yl]furan-2-sulfonate Chemical compound [Na+].[Na+].O1C(S(=O)(=O)[O-])=CC=C1C1=NN=C(C=2N=CC=CC=2)N=C1C1=CC=C(S([O-])(=O)=O)O1 IVLSEFOVPQFJBB-UHFFFAOYSA-L 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 229940066758 endopeptidases Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 239000011552 falling film Substances 0.000 description 1
- MSNWSDPPULHLDL-UHFFFAOYSA-K ferric hydroxide Chemical compound [OH-].[OH-].[OH-].[Fe+3] MSNWSDPPULHLDL-UHFFFAOYSA-K 0.000 description 1
- 239000011773 ferrous fumarate Substances 0.000 description 1
- 235000002332 ferrous fumarate Nutrition 0.000 description 1
- 229960000225 ferrous fumarate Drugs 0.000 description 1
- 239000004222 ferrous gluconate Substances 0.000 description 1
- 235000013924 ferrous gluconate Nutrition 0.000 description 1
- 229960001645 ferrous gluconate Drugs 0.000 description 1
- 235000013925 ferrous lactate Nutrition 0.000 description 1
- 239000004225 ferrous lactate Substances 0.000 description 1
- 229940037907 ferrous lactate Drugs 0.000 description 1
- 229960001604 ferrous succinate Drugs 0.000 description 1
- 108010007119 flavourzyme Proteins 0.000 description 1
- 201000008909 folic acid deficiency anemia Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 208000037824 growth disorder Diseases 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 235000006486 human diet Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000010874 in vitro model Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- UBUHAZKODAUXCP-UHFFFAOYSA-N iron(2+);oxygen(2-);hydrate Chemical class O.[O-2].[Fe+2] UBUHAZKODAUXCP-UHFFFAOYSA-N 0.000 description 1
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- 230000005977 kidney dysfunction Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100001016 megaloblastic anemia Toxicity 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000012569 microbial contaminant Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229940055695 pancreatin Drugs 0.000 description 1
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 235000020989 red meat Nutrition 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 208000031162 sideroblastic anemia Diseases 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000036435 stunted growth Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- UYPYRKYUKCHHIB-UHFFFAOYSA-N trimethylamine N-oxide Chemical compound C[N+](C)(C)[O-] UYPYRKYUKCHHIB-UHFFFAOYSA-N 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 208000002670 vitamin B12 deficiency Diseases 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 229940098232 yersinia enterocolitica Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fodder In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1387307P | 2007-12-14 | 2007-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE029966T2 true HUE029966T2 (en) | 2017-04-28 |
Family
ID=40796108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE08861633A HUE029966T2 (en) | 2007-12-14 | 2008-12-12 | Formulations and methods for increasing iron absorption |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2231171B1 (enExample) |
| JP (1) | JP5554719B2 (enExample) |
| KR (1) | KR101669291B1 (enExample) |
| CA (1) | CA2709159C (enExample) |
| DK (1) | DK2231171T3 (enExample) |
| ES (1) | ES2607144T3 (enExample) |
| HR (1) | HRP20161618T1 (enExample) |
| HU (1) | HUE029966T2 (enExample) |
| LT (1) | LT2231171T (enExample) |
| PL (1) | PL2231171T3 (enExample) |
| PT (1) | PT2231171T (enExample) |
| SI (1) | SI2231171T1 (enExample) |
| WO (1) | WO2009079401A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6646309B2 (ja) * | 2015-03-25 | 2020-02-14 | テルモ株式会社 | ヘプシジン−25産生抑制剤 |
| CN107814832B (zh) * | 2017-10-19 | 2020-10-16 | 中国计量大学 | 一种马鲛鱼蛋白来源的铁螯合肽及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04158761A (ja) * | 1990-10-19 | 1992-06-01 | Nippon Kayaku Co Ltd | ペプタイド含有鉄分強化食品 |
| US5662922A (en) * | 1992-01-20 | 1997-09-02 | Christensen; Borge Holm | Iron-containing composition for the prevention of anaemia and a method for producing the composition |
| JP3167402B2 (ja) * | 1992-02-25 | 2001-05-21 | 仙味エキス株式会社 | 鉄吸収促進組成物 |
| JP2683529B2 (ja) * | 1994-02-08 | 1997-12-03 | 静次 片野 | ゲル状食品 |
| WO2003055901A1 (en) * | 2001-12-25 | 2003-07-10 | Senmi Ekisu Co., Ltd. | Novel peptide sy |
| DK175501B1 (da) | 2002-12-02 | 2004-11-15 | Green Earth | Anlæg og fremgangsmåde til kontinuerlig hydrolyse af et proteinholdigt animalsk eller vegetabilsk råmateriale |
| JP4715078B2 (ja) * | 2003-04-16 | 2011-07-06 | 大正製薬株式会社 | 鉄化合物配合内服用液体組成物 |
| CN1270638C (zh) * | 2004-03-13 | 2006-08-23 | 中国水产科学研究院黄海水产研究所 | 功能食品的基料液及其制备方法 |
| US7495076B2 (en) * | 2005-10-13 | 2009-02-24 | Gu Jennifer L | Mineral collagen chelates and methods of making and using same |
| JP5229959B2 (ja) | 2009-02-24 | 2013-07-03 | 富士フイルム株式会社 | 投写レンズおよびこれを用いた投写型表示装置 |
-
2008
- 2008-12-12 LT LTEP08861633.9T patent/LT2231171T/lt unknown
- 2008-12-12 SI SI200831723A patent/SI2231171T1/sl unknown
- 2008-12-12 DK DK08861633.9T patent/DK2231171T3/en active
- 2008-12-12 EP EP08861633.9A patent/EP2231171B1/en active Active
- 2008-12-12 CA CA2709159A patent/CA2709159C/en active Active
- 2008-12-12 KR KR1020107015618A patent/KR101669291B1/ko active Active
- 2008-12-12 HU HUE08861633A patent/HUE029966T2/en unknown
- 2008-12-12 JP JP2010538203A patent/JP5554719B2/ja active Active
- 2008-12-12 PL PL08861633T patent/PL2231171T3/pl unknown
- 2008-12-12 ES ES08861633.9T patent/ES2607144T3/es active Active
- 2008-12-12 HR HRP20161618TT patent/HRP20161618T1/hr unknown
- 2008-12-12 WO PCT/US2008/086668 patent/WO2009079401A2/en not_active Ceased
- 2008-12-12 PT PT88616339T patent/PT2231171T/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2607144T3 (es) | 2017-03-29 |
| SI2231171T1 (sl) | 2017-03-31 |
| WO2009079401A3 (en) | 2009-10-01 |
| KR101669291B1 (ko) | 2016-10-25 |
| PT2231171T (pt) | 2016-12-21 |
| EP2231171B1 (en) | 2016-10-05 |
| CA2709159C (en) | 2017-04-11 |
| DK2231171T3 (en) | 2017-01-09 |
| EP2231171A4 (en) | 2011-04-06 |
| CA2709159A1 (en) | 2009-06-25 |
| JP5554719B2 (ja) | 2014-07-23 |
| EP2231171A2 (en) | 2010-09-29 |
| JP2011506479A (ja) | 2011-03-03 |
| LT2231171T (lt) | 2017-01-25 |
| WO2009079401A2 (en) | 2009-06-25 |
| HRP20161618T1 (hr) | 2017-01-13 |
| KR20100112133A (ko) | 2010-10-18 |
| PL2231171T3 (pl) | 2017-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU753725B2 (en) | Canine milk substitute | |
| Choi et al. | Effectiveness of phosvitin peptides on enhancing bioavailability of calcium and its accumulation in bones | |
| CA1088425A (en) | Bio-available essential metals | |
| US20240382453A1 (en) | Protein hydrolysates | |
| Falowo | A comprehensive review of nutritional benefits of minerals in meat and meat products | |
| Payne et al. | Studies of protein digestion in the chicken: 1. Investigation of apparent amino acid digestibility of fish meal protein using cecectomized, adult male chickens | |
| El-Shenawy et al. | Effect of Iron Nanoparticles on the Development of Fish Farm Feeds. | |
| RU2079307C1 (ru) | Противоанемическое средство | |
| JP2012152220A (ja) | 猫における甲状腺機能亢進症を予防する方法並びに限定されたセレン及びヨウ素を含む組成物 | |
| CN101179953B (zh) | 含哺乳动物初乳或乳汁的乳清级分的生长促进用食品组合物 | |
| EP2231171B1 (en) | Compositions and methods for increasing iron absorption | |
| EP1593312A1 (en) | Antiobesity or antihyperlipidemic food, feeding stuff or supplement containing lysine | |
| RU2352143C2 (ru) | Композиции и способы для восстановления функции щитовидной железы у кошек | |
| Tahergorabi et al. | Seafood proteins and human health | |
| Sidransky | Chemical pathology of nutritional deficiency induced by certain plant proteins | |
| JP3223958B2 (ja) | 金属結合ラクトフェリン及びその用途 | |
| JP2006271377A (ja) | 動物肝臓の酵素分解物および該酵素分解物を含有する食品 | |
| Bethi et al. | Utilization of lactobacillus fermented proteins from meat processing wastewaters as a dietary protein source in poultry feed | |
| JPH0379979B2 (enExample) | ||
| KR20040077682A (ko) | 변형 메티오닌 풍부 식품 및 그의 제조방법 | |
| Muwalla et al. | Use of dried poultry litter in the diet of pregnant and lactating Awassi ewes | |
| Nagbila et al. | Research Application Summary | |
| AU4016001A (en) | Composition and method | |
| MXPA01002440A (en) | Canine milk substitute |