HUE029420T2 - Crystalline PI3 kinase inhibitors - Google Patents

Crystalline PI3 kinase inhibitors Download PDF

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Publication number
HUE029420T2
HUE029420T2 HUE13711105A HUE13711105A HUE029420T2 HU E029420 T2 HUE029420 T2 HU E029420T2 HU E13711105 A HUE13711105 A HU E13711105A HU E13711105 A HUE13711105 A HU E13711105A HU E029420 T2 HUE029420 T2 HU E029420T2
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HU
Hungary
Prior art keywords
compound
formula
lactose
anhydrous form
solid crystalline
Prior art date
Application number
HUE13711105A
Other languages
English (en)
Hungarian (hu)
Inventor
Rudy Laurent Maria Broeckx
Walter Ferdinand Maria Filliers
Patrick Hubert J Nieste
Alex Herman Copmans
Filip Marcel C Vanhoutte
Carina Leys
Original Assignee
Respivert Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49160309&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE029420(T2) "Global patent litigation datasetโ€ by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Respivert Ltd filed Critical Respivert Ltd
Publication of HUE029420T2 publication Critical patent/HUE029420T2/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HUE13711105A 2012-03-13 2013-03-13 Crystalline PI3 kinase inhibitors HUE029420T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261610012P 2012-03-13 2012-03-13
US201261610023P 2012-03-13 2012-03-13

Publications (1)

Publication Number Publication Date
HUE029420T2 true HUE029420T2 (en) 2017-02-28

Family

ID=49160309

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13711105A HUE029420T2 (en) 2012-03-13 2013-03-13 Crystalline PI3 kinase inhibitors

Country Status (35)

Country Link
US (3) US20150099768A1 (cg-RX-API-DMAC7.html)
EP (2) EP2834244B1 (cg-RX-API-DMAC7.html)
JP (3) JP2015509973A (cg-RX-API-DMAC7.html)
KR (2) KR20140131971A (cg-RX-API-DMAC7.html)
CN (2) CN104284679B (cg-RX-API-DMAC7.html)
AU (2) AU2013234080B2 (cg-RX-API-DMAC7.html)
CA (2) CA2864652A1 (cg-RX-API-DMAC7.html)
CL (2) CL2014002386A1 (cg-RX-API-DMAC7.html)
CO (2) CO7051030A2 (cg-RX-API-DMAC7.html)
CR (2) CR20140416A (cg-RX-API-DMAC7.html)
CY (1) CY1118565T1 (cg-RX-API-DMAC7.html)
DK (1) DK2834244T3 (cg-RX-API-DMAC7.html)
EA (2) EA023715B1 (cg-RX-API-DMAC7.html)
EC (2) ECSP14018142A (cg-RX-API-DMAC7.html)
ES (2) ES2650791T3 (cg-RX-API-DMAC7.html)
GT (2) GT201400182A (cg-RX-API-DMAC7.html)
HR (1) HRP20161383T1 (cg-RX-API-DMAC7.html)
HU (1) HUE029420T2 (cg-RX-API-DMAC7.html)
IL (2) IL233886A (cg-RX-API-DMAC7.html)
IN (2) IN2014MN02000A (cg-RX-API-DMAC7.html)
LT (1) LT2834244T (cg-RX-API-DMAC7.html)
MX (2) MX355299B (cg-RX-API-DMAC7.html)
MY (1) MY171125A (cg-RX-API-DMAC7.html)
NI (2) NI201400100A (cg-RX-API-DMAC7.html)
NZ (2) NZ628072A (cg-RX-API-DMAC7.html)
PE (2) PE20142342A1 (cg-RX-API-DMAC7.html)
PH (2) PH12014501713A1 (cg-RX-API-DMAC7.html)
PL (1) PL2834244T3 (cg-RX-API-DMAC7.html)
PT (1) PT2834244T (cg-RX-API-DMAC7.html)
SG (2) SG11201404522VA (cg-RX-API-DMAC7.html)
SI (1) SI2834244T1 (cg-RX-API-DMAC7.html)
TW (2) TWI617561B (cg-RX-API-DMAC7.html)
UA (1) UA115544C2 (cg-RX-API-DMAC7.html)
WO (2) WO2013136076A1 (cg-RX-API-DMAC7.html)
ZA (2) ZA201407373B (cg-RX-API-DMAC7.html)

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GB0918249D0 (en) 2009-10-19 2009-12-02 Respivert Ltd Compounds
UY33337A (es) 2010-10-18 2011-10-31 Respivert Ltd DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
SG11201404522VA (en) 2012-03-13 2014-10-30 Respivert Ltd Crystalline pi3 kinase inhibitors
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
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AR095353A1 (es) 2013-03-15 2015-10-07 Respivert Ltd Compuesto
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WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR102787845B1 (ko) 2015-09-14 2025-03-31 ํŠธ์›ฐ๋ธŒ ํ…Œ๋ผํ“จํ‹ฑ์Šค, ์•„์ด์—”์”จ. ์ด์†Œํ€ด๋†€๋ฆฌ๋…ผ์˜ ๊ณ ์ฒดํ˜•, ๊ทธ์˜ ์ œ์กฐ ๋ฐฉ๋ฒ•, ์ด๋ฅผ ํฌํ•จํ•˜๋Š” ์กฐ์„ฑ๋ฌผ ๋ฐ ์ด๋ฅผ ์‚ฌ์šฉํ•˜๋Š” ๋ฐฉ๋ฒ•
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JP7166929B2 (ja) * 2016-04-15 2022-11-08 ใƒใ‚ข ใ‚ฟใ‚ค ใƒ†ใ‚ฃใ‚จใƒณใƒใƒณ ใƒ•ใ‚กใƒผใƒžใ‚ทใƒฅใƒผใƒ†ใ‚ฃใ‚ซใƒซ ใ‚ฐใƒซใƒผใƒ— ใ‚ซใƒณใƒ‘ใƒ‹ใƒผ ใƒชใƒŸใƒ†ใƒƒใƒ‰ ใ‚คใ‚ฝใ‚ฐใƒชใƒใƒซใƒชใƒใƒณ้…ธใพใŸใฏใใฎๅกฉใฎๅธๅ…ฅ่ฃฝๅ‰คใŠใ‚ˆใณๅ‘ผๅธๅ™จ็–พๆ‚ฃใ‚’ๆฒป็™‚ใ™ใ‚‹่–ฌ็‰ฉใฎ่ฃฝ้€ ใซใŠใ‘ใ‚‹ใใ‚Œใ‚‰ใฎไฝฟ็”จ
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof

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